Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
The term sebaceous neoplasm includes benign and malignant tumors with different degrees of sebaceous differentiation. (medscape.com)
[ 2 ] examining the incidence of cytogenetic abnormalities in malignant eccrine tumors showed low incidences of loss of heterozygosity (LOH) or TP53 alterations in a mixed group of these neoplasms, in contrast to the frequent and multiple genetic abnormalities seen in tumors arising from epidermal keratinocytes. (medscape.com)
Benign2
Skin lesions containing benign sebaceous gland proliferation (eg, sebaceous hyperplasia), congenital hamartomas (eg, nevus sebaceus), and lesions with ectopic sebaceous structures (eg, Fordyce spot, Montgomery tubercles) are generally not considered to be true sebaceous neoplasms. (medscape.com)
[ 1 ] who divide these tumors into those that arise de novo in normal skin and those that originate within preexisting benign sweat gland tumors. (medscape.com)
Skin adnexal tumors with sebaceous differentiation are uncommon, difficult to classify, and may be controversial. (medscape.com)
Therefore, the term sebaceous neoplasm is necessary to include these complex skin adnexal tumors with varying degrees of sebaceous differentiation. (medscape.com)
Pilar and sebaceous neoplasms share a common expression for both high and low molecular weight cytokeratin that is not seen in most eccrine or apocrine tumors, pointing to similar cellular differentiation patterns of hair and sebaceous structures. (medscape.com)
Furthermore, the architectural features of sebaceous tumors resemble those of pilar neoplasms, and not those of sweat gland tumors. (medscape.com)
Many antigens associated with sweat gland neoplasms, including S-100 protein, CA72.4, gross cystic disease fluid protein 15 (GCDFP-15), and carcinoembryonic antigen (CEA), are absent in sebaceous tumors. (medscape.com)
Carcinomas of the eccrine sweat gland represent a rare group of tumors with potential for local destruction and metastasis. (medscape.com)
The specific classification of eccrine carcinomas is both complex and nebulous, mostly because of the paucity of reported cases but also because many of these tumors show little histologic resemblance to mature eccrine glands. (medscape.com)
Differentiation3
The following terms are recognized within this category: sebaceous adenoma, sebaceous epithelioma (sebaceoma), sebaceous carcinoma, basal cell carcinoma with sebaceous differentiation, sebocrine adenoma, and sebomatricoma. (medscape.com)
When patients with numerous sebaceous adenomas and/or other neoplasms with sebaceous differentiation have an associated internal malignancy, the clinical condition is known as Muir-Torre syndrome , a subtype of familial nonpolyposis gut carcinoma syndrome, or Lynch syndrome. (medscape.com)
Because of the intimate association of sebaceous glands with hair and apocrine ducts, many sebaceous neoplasms show complex histopathologic features with various elements of pilar and sweat gland differentiation. (medscape.com)
Sweat gland2
Because of the intimate association of sebaceous glands with other adnexal structures in the folliculosebaceous-apocrine unit, many sebaceous neoplasms show complex histopathologic features with mixed sebaceous, pilar (hair), and apocrine (sweat) gland differentiations. (medscape.com)
However, research shows UVR is known to suppress sweating, which disrupts body thermoregulation, and a study analyzing TP53 mutations in 16 sweat gland carcinomas identified 3 G:C → A:T transitions at dipyrimidine sequences on the antisense strand. (medscape.com)
Carcinoma2
May have underlying carcinoma of a vulvar or perineal gland. (brainscape.com)
[ 4 ] suggest that genetics may play a role in the development of microcystic adnexal carcinoma (MAC). (medscape.com)
Dermis2
Sebaceous glands are holocrine, oil-producing glands present in the dermis of mammalian skin. (medscape.com)
The authors hypothesize that this difference may be partly explained by the fact that the bulk of eccrine sweat glands lie deep in the dermis, an environment relatively protected from the sun and environmental mutagens. (medscape.com)
Histologically1
The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
Primary1
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Genetic1
The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
Face1
Sebaceous glands are most abundant in the skin of the head and neck regions, particularly in the central face, but they are also present throughout the hair-bearing areas of the body and the mucocutaneous junction, including the labium minus. (medscape.com)
Structure2
The sebaceous gland is a secretory structure consisting of sebaceous lobules and ducts. (medscape.com)
Although the sebaceous gland is a glandular adnexal structure, it is topographically and ontogenetically related to the hair sheath. (medscape.com)
Lower1
The eyelids have modified sebaceous glands (ie, Zeis glands of cilia associated with eyelashes, meibomian glands within the tarsal plates of the upper and lower eyelids). (medscape.com)
Previous2
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
Terms1
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
Association of sebaceous2
Because of the intimate association of sebaceous glands with other adnexal structures in the folliculosebaceous-apocrine unit, many sebaceous neoplasms show complex histopathologic features with mixed sebaceous, pilar (hair), and apocrine (sweat) gland differentiations. (medscape.com)
Because of the intimate association of sebaceous glands with hair and apocrine ducts, many sebaceous neoplasms show complex histopathologic features with various elements of pilar and sweat gland differentiation. (medscape.com)
Malignant6
Malignant Pituitary Gland Corticotropinoma A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces corticotropin. (nih.gov)
Malignant C7419 Acanthoma A benign skin neoplasm composed of epithelial cells. (nih.gov)
WHO, 2001) Malignant C45929 Acidophil Stem Cell Pituitary Gland Adenoma Acidophil Stem Cell Adenoma An infrequent pituitary gland adenoma composed of cells showing immunoreactivity for prolactin and less often growth hormone. (nih.gov)
Acinic Cell Carcinoma A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
The term sebaceous neoplasm includes benign and malignant tumors with different degrees of sebaceous differentiation. (medscape.com)
The development of malignant neoplasms at sites of previous dermal scars is an uncommon but well recognized phenomenon, and since almost all of them were developed on exposed areas it has been hypothesized that the accompanying atrophy and decreased vascularity and adnexal structures in areas of scarring may render the affected tissues more susceptible to the effects of environmental factors, eg. (iranjd.ir)
Glandular1
Although the sebaceous gland is a glandular adnexal structure, it is topographically and ontogenetically related to the hair sheath. (medscape.com)
Hyperplasia3
Skin lesions containing benign sebaceous gland proliferation (eg, sebaceous hyperplasia), congenital hamartomas (eg, nevus sebaceus), and lesions with ectopic sebaceous structures (eg, Fordyce spot, Montgomery tubercles) are generally not considered to be true sebaceous neoplasms. (medscape.com)
[ 1 ] True sebaceous neoplasms are relatively rare, while sebaceous hyperplasia is a frequent finding in individuals with chronically sun-exposed skin. (medscape.com)
We report herein a 57-year-old woman who developed multiple warts on her hands and feet, lower lid syringomas, sebaceous gland hyperplasia of forehead and multiple mucosal irritation fibromas on tongue after kidney transplantation and a long course of treatment with oral cyclosporin, azathioprine and prednisolone since 6 years ago. (iranjd.ir)
Adenomas2
Electron microscopic studies reveal giant mitochondria, a finding not present in any other type of pituitary gland adenomas. (nih.gov)
When patients with numerous sebaceous adenomas and/or other neoplasms with sebaceous differentiation have an associated internal malignancy, the clinical condition is known as Muir-Torre syndrome , a subtype of familial nonpolyposis gut carcinoma syndrome, or Lynch syndrome. (medscape.com)
Secretory1
The sebaceous gland is a secretory structure consisting of sebaceous lobules and ducts. (medscape.com)
Squamous cell carc2
In dermatology, ex vivo CM has been applied mainly to surgical oncology and in particular to skin carcinoma for fast assessment of tumour margins during surgery in basal cell carcinoma (BCC), squamous cell carcinoma (SCC), dermatofibrosarcoma and some adnexal tumours. (medscape.com)
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. (iranjd.ir)
Tumors5
Skin adnexal tumors with sebaceous differentiation are uncommon, difficult to classify, and may be controversial. (medscape.com)
Therefore, the term sebaceous neoplasm is necessary to include these complex skin adnexal tumors with varying degrees of sebaceous differentiation. (medscape.com)
Pilar and sebaceous neoplasms share a common expression for both high and low molecular weight cytokeratin that is not seen in most eccrine or apocrine tumors, pointing to similar cellular differentiation patterns of hair and sebaceous structures. (medscape.com)
Furthermore, the architectural features of sebaceous tumors resemble those of pilar neoplasms, and not those of sweat gland tumors. (medscape.com)
Many antigens associated with sweat gland neoplasms, including S-100 protein, CA72.4, gross cystic disease fluid protein 15 (GCDFP-15), and carcinoembryonic antigen (CEA), are absent in sebaceous tumors. (medscape.com)
Lesions1
Direct smears of the lesions were positive for Leishman bodies. (iranjd.ir)
Structures2
these structures are not considered sebaceous neoplasias. (medscape.com)
As one of the skin's adnexal structures, the sebaceous gland is intimately associated with hair (pilar) and arrector pili muscle. (medscape.com)
Commonly1
Foreign bodies commonly enter the eye as projectiles or as fragments accompanying branches or other sharp objects that perforate the globe. (basicmedicalkey.com)
Inflammatory3
New staining protocols including immunostaining, with no damage to conventional histopathology preparation, have been recently described in melanocytic tumours and inflammatory skin diseases. (medscape.com)
RCM with no contrast agents has been used mainly for in vivo accessible tissue examination in three main fields: the examination of retina and cornea, [ 1-3 ] neoplastic and inflammatory skin diseases, [ 4 ] and the exploration of body cavities reachable through probe-based confocal laser endomicroscopes. (medscape.com)
Intraocular foreign bodies containing iron are particularly toxic to the retina, and they may cause a diffuse deposition of iron throughout the eye ( 13 ). (basicmedicalkey.com)
Cells1
Therefore, antigenic similarities exist between the isthmus of the outer hair sheath and the germinative basaloid cells of the sebaceous gland. (medscape.com)
Include1
Potential complications of ocular trauma include blood within the anterior chamber (hyphema) with associated corneal discoloration that is caused by hemoglobin deposition (corneal blood staining) and separation of the ciliary body from the iris (iridodialysis) or sclera (cyclodialysis) as well as cataracts, retinal detachments, and choroidal rupture. (basicmedicalkey.com)
Hair3
Sebaceous glands are usually attached to hair follicles and are part of a complex skin-adnexal unit known as the folliculoapocrine (sweat) apparatus. (medscape.com)
Sebaceous glands are most abundant in the skin of the head and neck regions, particularly in the central face, but they are also present throughout the hair-bearing areas of the body and the mucocutaneous junction, including the labium minus. (medscape.com)
Vegetable matter, hair, and skin may enter the intraocular tissues after an explosive or perforating injury. (basicmedicalkey.com)
Present2
Sebaceous glands are holocrine, oil-producing glands present in the dermis of mammalian skin. (medscape.com)
The glands are present over the entire body, with the exception of the palms of the hands and the soles of the feet. (medscape.com)