Body organ specificity. Medical search. Frequent questions

It is suggested to perform ANCA testing through indirect immunofluorescence and antigen-specific enzyme-linked immunosorbent assays, both of which have excellent sensitivity (about 99 percent) and good specificity (approximately 70 percent). (medicinenet.com)
ABSTRACT This study estimated the sensitivity and specificity of the rK39 strip test compared with the immunofluorescent antibody test and microscopy of bone marrow aspirate smears (the gold standard) in 47 children with suspected visceral leishmaniasis. (who.int)
The aim was neutropaenia and hypergammaglobulinae- to compare the sensitivity and specificity of mia, most of them remain asymptomatic the rK39 strip test with that of the IFA test with the disease self-limiting [ 2,3 ]. (who.int)

A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
For decades, definite diagnosis of were patients with hepatosplenomegaly, visceral leishmaniasis has required in- fever, anaemia (with or without neutropae- vasive procedures to find the parasite in nia) or hypergammaglubolinaemia who had the organs, such as spleen, bone marrow, been referred from endemic regions. (who.int)

In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. (nih.gov)

Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)

It widely exists in the placenta, amniotic fluid, lens, articular cartilage, skin In tissues and organs such as the dermis. (wuhansoleado.com)
However, unlike traditional steroids, SARMs are much more selective in their actions, meaning they only work on specific tissues and organs in the body. (imperiodazanet.com)

Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. (harvard.edu)
C. burnetii was the likely etiologic body titer to phase 2 antigen of 50. (cdc.gov)
Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
Antigen nonspecific methods include the use of cytotoxic drugs that interfere with all cell division in the body [ 383 ]. (nanomedicine.com)

We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. (nih.gov)
The fungal metabolite cyclosporin A (cyclosporine) [ 384 , 385 ] has a greater specificity for lymphoid T cells than other cells. (nanomedicine.com)

The diaphragm is a double-domed musculotendinous partition between the thoracic and abdominal organs and is composed of the central tendinous area and the peripheral muscular area. (medscape.com)
Penetrating trauma to the chest below the fourth intercostal space (or nipple line) should also be evaluated as a potential abdominal wound because of the location of abdominal organs within the chest during the respiratory cycle. (msdmanuals.com)

We have found that bystander effects occur in vivo in distant skin and spleen following half-body or cranial irradiation. (uleth.ca)
The spleen is the organ damaged most commonly, followed by the liver and a hollow viscus (typically the small intestine). (msdmanuals.com)

Over two decades ago, our group began to investigate experimental paradigms addressing a basic question in neuroscience: Why have the brain and spinal cord, crucial organs of the body, lost their capacity for spontaneous repair following injury? (weizmann.ac.il)
Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)

We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
Significant levels were detected in JC-44 cells and higher levels were found in JC-44-derived embryoid bodies. (houstonmethodist.org)
By ribonuclease protection analysis, γGT RNA types IV and VI represent about 80% of the total γGT RNA in JC-44 embryoid bodies. (houstonmethodist.org)

In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
for the qualification of organ, tissue or cell donors who have travelled, stayed or lived in the French Indies, the continuation of the measures recommended in its opinion dated from the 14th of June 2019. (hcsp.fr)
These guidelines address the use of tests for the hepatitis B and C viruses to screen donations of blood and plasma collected for transfusion or further manufacture into injectable products, as well as to screen donors of organs, tissues, and semen. (cdc.gov)

Organ Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)

Patients who experience significant deceleration often have injuries to other parts of the body, including the thoracic aorta. (msdmanuals.com)

The viral tracer may be introduced in peripheral organs, such as a muscle or gland. (wikipedia.org)

The truth is that tumors are just like any other organ. (washingtonjewishweek.com)
von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)

The diagnosis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is based on the presence of ANCA, clinical symptoms, and a biopsy of the frequently affected organs such as the kidneys and nasal mucosa or the lungs (which are infrequently affected). (medicinenet.com)
And these fat-soluble vitamins are present only in significant amounts - in animal fats (like fish oil, egg yolks, lard and butter) and particularly in the fat-rich cell wall membranes of organ meats such as liver and kidneys Unfortunately, many modern people as being "unhealthy", even by many mainstream medical doctors and dieticians, now see these premium foods. (ericbakker.com)

Thirdly, the article shows that the connection between pain and body is inherent to the specificity of the organ to psychoanalysis. (bvsalud.org)
Sodium hyaluronate, with the chemical formula (C14H20NO11Na)n, is an inherent component in the human body. (wuhansoleado.com)

People who apply for drivers licenses, or special identification cards issued by the Division of Motor Vehicles, are asked if they would like to be an organ donor and are furnished with organ, eye and tissue donor cards and information. (wardandsmith.com)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

Consistent with this, iNKT cells from different organs show distinct basal activation, proliferation and clonal expansion. (elifesciences.org)

Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. (jci.org)

Most anatomical compartments, including mucosal surfaces and solid organs, host large populations of tissue-resident lymphocytes which are uniquely placed to provide local networks for immune surveillance and defence against infection ( Fan and Rudensky, 2016 ). (elifesciences.org)
House Bill 1372 makes the authorization of the organ donation symbol an actual anatomical gift. (wardandsmith.com)

It is a kind of glucuronic acid and has no species specificity. (wuhansoleado.com)

Because VHL disease is a multiple-organ disease that widely varies in clinical presentation, various manifestations may lead to diagnosis. (medscape.com)

Vasculitis can cause symptoms such as fever or night sweats , body aches, joint and muscle discomfort, decreased appetite , and weight loss . (medicinenet.com)
Ostarine is known for its ability to help preserve muscle mass during periods of calorie restriction, making it an ideal choice for athletes who want to maintain their muscle mass while cutting body fat. (imperiodazanet.com)
Today we tend to favour the muscle meats only, when in fact animal organs from organically raised, grass fed animals are some of the most nutrient-rich foods you could possibly eat in your diet. (ericbakker.com)

In this work, we identify and characterize OX40 as a surrogate biomarker for alloreactive T cells in organ transplant rejection and monitor its expression by utilizing immunoPET. (jci.org)

In the body, these toxins inhibit protein synthesis leading to cell death. (cdc.gov)
At the crux of the Hoffmann lab body of work is the Toll receptor, a protein that straddles the cell membranes of immune system "sentinel" cells, detecting molecular nametags of pathogens from the outside and transducing messages to the inside, activating and orchestrating defense against infection. (newswise.com)
After an increase in serum levels of the free chains, the protein deposits in organs, causing significant dysfunction . (medscape.com)

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (harvard.edu)

Medical products of human origin are derived wholly or in part from the human body and intended for clinical application. (who.int)
Its founder and leader, Dr. Ruth Buczynski, has built a marvelous and free teleseminar series that leads up to the annual meeting called Clinical Applications of Mind-Body Medicine: New Thinking about Stress and the Remarkable Power of Psychoneuroimmunology. (futurehealth.org)

The prevalence in males and inexpensive and adjacent organs can also females was 4.2% (95% CI: 1.7-8.5) and be assessed. (who.int)

At least three mutations in the OTULIN gene have been found to cause otulipenia, a condition that causes abnormal inflammation in the body, beginning in infancy. (medlineplus.gov)

Typically, viruses can infect only a small number of organisms, and even then, only a specific cell type within the body. (wikipedia.org)
The specificity of a particular virus for a specific tissue is known as its tropism. (wikipedia.org)
ImmunoPET is capable of noninvasively visualizing the dynamic distribution of cells expressing specific immune markers in the entire body over time. (jci.org)
Type 1 diabetes results from organ-specific autoimmunity, which eliminates most of the insulin-producing pancreatic beta cells. (springer.com)
In many instances, parts of animals when consumed were not thought of as 'therapy' as such, it was known that those who consumed organs and glands from various animals and fish improved their overall health and wellbeing, especially when it came to assisting in the prevention as well as treatment of specific ailments. (ericbakker.com)
MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)

Cells Tissues Organs (2011) 193 (4): 239-252. (karger.com)
The protective T cells were found to have specificity for self-brain antigens, leading us to formulate the model of "Protective autoimmunity" (3-5). (weizmann.ac.il)
Once the infection is under control, the body stops the inflammatory response to prevent damage to its own cells and tissues. (medlineplus.gov)

We investigated the performance of this probe at the receptor, cell, organ, and whole-body levels, including its use to detect diabetes associated impairment of ischemia-induced myocardial angiogenesis. (illinois.edu)
Both versions of the probe were found to be stable, demonstrated fast receptor association constants, and showed high specificity for α V β 3 in HUVECs (K d ~ 35 nM). (illinois.edu)
The transducer generates high-frequency sound waves (typically 5-10 MHz) and directs them through body tissues via a probe held against the skin. (medscape.com)

In particular, the question arose as to the consistency of the measures deployed for blood donations between Reunion Island, the French Indies and mainland France, taking into account the risk factors resulting from territorial specificities such as a history of infection by the Zika virus or the frequency of sickle cell disease. (hcsp.fr)
Later, Dr. Hoffmann marveled at the apparent ability of grasshoppers to evade infection, even when he transplanted organs among them as an undergraduate at the University of Strasbourg. (newswise.com)
For his doctoral work at the Institute of Zoology in Strasbourg, France, he discovered a blood-producing tissue near the insect's heart that when damaged with X-rays, led to body-wide infection and failure to molt. (newswise.com)

This specificity of action results in fewer side effects and a lower risk of long-term health complications. (imperiodazanet.com)

SARMs are compounds that selectively target androgen receptors in the body, which can lead to anabolic effects similar to traditional steroids. (imperiodazanet.com)
Yet, no data existed on the bystander effects in an organ other than an exposed one. (uleth.ca)
Bystander effects also exhibited persistency and sex specificity. (uleth.ca)

Up to 48 h after injection, whole-body scans were performed and blood and urine samples were collected. (nih.gov)
On CT scans, herniation of an organ or omental fat may be visible through an abrupt discontinuity in the diaphragm. (medscape.com)

Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated with immunotherapy. (aacrjournals.org)
Section 8.5.2.1 ) are closely matched to those of the donor, transplanted organs are usually rejected (beginning within minutes or hours of surgery [ 1832 ]) unless the recipient's immune system is carefully controlled. (nanomedicine.com)
Immune molecular monitoring is under investigation to screen for rejection, though these techniques have suffered from low specificity and lack of spatial information. (jci.org)

it will not include a gift of "tissue" (defined 8 as any portion of the human body other than an organ an eye, or blood donated for non-research purposes) or of the donor's entire body. (wardandsmith.com)
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are key tools in medical research, providing information about anatomy, physiology and biochemistry in the human body non-invasively. (nottingham.ac.uk)
Molecular nanotechnology is essential when the damage to the human body is extremely subtle, highly selective, or time-critical (as in head traumas, burns, or fast-spreading diseases), or when the damage is very massive, overwhelming the body's natural defenses and repair mechanisms. (nanomedicine.com)
It is a gel made by combining a natural 'hyaluronic acid' of the human body with other drugs that promote cell regeneration and wrinkle reduction, and is used by injection. (wuhansoleado.com)

the nutritional benefits of organ meats are now being confirmed by modern science due to their exceptionally high nutrient levels. (ericbakker.com)

The new scanner will allow us to push the boundaries in resolution for imaging function/ microstructure/connectivity in the brain and other organs, beyond the limits of what is currently feasible, exampled in the Figure, for understanding with higher specificity health and disease. (nottingham.ac.uk)
The brain is a socially constructed organ. (futurehealth.org)
They have a specificity for your sexual well-being, supporting normal stress response, and targeting all our sexual organs, the biggest one being the brain! (herbalignite.com)

Whole-body contrast CT scan with multiplanar reconstructions is the imaging modality of choice. (medscape.com)
However, whole-body imaging of ßG activity for medical usage is not yet available. (bvsalud.org)

Support healthy body stress recovery. (herbalignite.com)
Native people knew that eating plants but also animals (including all their organs) would support the natural functioning of their bodies. (ericbakker.com)

We generated a transgenic mouse model of CMT2A that developed severe early onset vision loss and neurological deficits, axonal degeneration without cell body loss, and cytoplasmic and axonal accumulations of fragmented mitochondria. (wustl.edu)

Natural health practitioners use glandular products to supplement nutrients, enzymes, and other active factors that may be lacking, depleted, or otherwise compromised in the target organ system. (ericbakker.com)
The famous nutritionist dentist Dr. Price left an amazing body of research about the health benefits of traditional diets amongst indigenous peoples from all around the world. (ericbakker.com)
http://www.westonaprice.org/ Dr. Price traveled all over the world studying the dietary practices of healthy people from traditional cultures and noticed that the healthiest people regularly consumed organ meats and valued them very highly as being some of the best health building foods. (ericbakker.com)
Organ meats are literally a nutritional powerhouse and come loaded with significant amounts of vitamins (especially fat soluble vitamins A and D), minerals, all the essential amino acids and many other significant nutritional compounds vital for optimal health. (ericbakker.com)

Intrathoracic herniation of abdominal solid organs appears as mushroom-shaped, homogeneous opacities in the thorax. (medscape.com)

He understood that some further adjustments will be required and provided in House Bill 1372 that the General Statutes Commission would study the statutes related to organ donation and propose recommendations to the 2008 short session. (wardandsmith.com)

This graph shows the total number of publications written about "Organ Specificity" by people in Harvard Catalyst Profiles by year, and whether "Organ Specificity" was a major or minor topic of these publication. (harvard.edu)

Anatomy2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Health Care1

Sensitivity3

Bone Marrow2

Homing receptor1

Transplantation6

Tissues and organs2

Antigen4

Lymphoid2

Abdominal organs2

Spleen2

Spinal cord2

Embryoid bodies3

Donors3

Descriptor1

Thoracic1

Peripheral1

Tumors2

Kidneys2

Inherent2

Tissue donor2

Distinct1

Biopsy1

Anatomical2

Species1

Widely1

Muscle3

Alloreactive1

Protein3

Multiple-organ1

Clinical2

Prevalence1

Gene1

Specific6

Cells3

Probe3

Infection3

Results1

Effects3

Scans2

Immune3

Human body4

Levels1

Brain3

Imaging2

Support2

Mitochondria1

Health4

Solid1

General1

Publication1