• Pronounced macrophage expression and activation directed microglia phenotypic switching was prominent in both ventral and dorsal hippocampus indicating the impact of oxidative stress following diabetes in hippocampus. (bvsalud.org)
  • The effects of oxidative stress occur as a result of peroxidative damage of the macromolecule and membranes of the cells and with the disruption of metabolic activities in the components of the cells in living organisms. (intechopen.com)
  • Anti-oxidants are a primary defense against the damaging effects of oxidative stress. (naturalnews.com)
  • The results obtained showed the there was an increase in the weight of wet liver, lipid peroxidation and plasma protein concentration. (ajol.info)
  • Another 30% is stored in ferritin, a protein found throughout the body (although this percentage can be significantly higher or lower in cases of iron overload or deficiency), and a few percent in myoglobin, a protein specifically utilized by muscle cells. (irondisorders.org)
  • Ferritin is a protein synthesized by the body that is mainly utilized to store iron for future use. (irondisorders.org)
  • This stress arrives in the form of protein, lipid (fat) peroxidation, carb and DNA damage. (alternative-medicine-clinics.com)
  • Vanadium also has an insulin-like effect on the metabolic pathways of lipid and protein metabolism 7 . (ijpsr.com)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats. (hindawi.com)
  • Higher levels of glutathione are associated with great health and anti-aging effects on the body. (naturalnews.com)
  • In the pancreas of rats with experimentally induced diabetes, the levels of lipid hydroperoxides and TBA-positive substances increased significantly, while the level of reduced glutathione and the activity of SOD, CAT, GPx, and GR as well as carbohydrate metabolism enzymes LDH and G-6-PDH decreased as compared to the animals from the control group. (ijpsr.com)
  • The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. (hindawi.com)
  • We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
  • The purpose of the present study was to verify the action of metformin combined with insulin in oxidative stress control of streptozotocin-diabetic rats. (hindawi.com)
  • Increased lipid peroxidation leads to produce MDA in diabetic people. (ac.ir)
  • This study investigates relationships between serum leptin concentration and inflammatory intermediate and oxidative stress in postmenopausal diabetic women. (ac.ir)
  • Taghdir M, Djazayeri S, Djalali M, Ashourpour M, Sepandi M, Rajab A. Relationship Between Serum Leptin Concentration and Inflammatory Factors and Oxidative stress in Postmenopausal Type II Diabetic Women. (ac.ir)
  • Diabetic neuropathy - In experimental diabetic neuropathy, alpha-lipoic acid provides increased nerve blood flow, reduced oxidative stress and improves distal nerve conduction (24). (peoplesrx.com)
  • In humans, it has been demonstrated that oral administration of 600mg/day of lipoic acid can prevent or improve diabetic neuropathy, which may be due to a lowering of lipid peroxidation (25). (peoplesrx.com)
  • Job stress indicators, effort-reward ratio and overcommitment were evaluated from survey questionnaires using the effort-reward imbalance model, and associations with age, sex, body mass index, and work ing conditions were measured by logistic regression analysis. (cdc.gov)
  • Many people unknowingly suffer from blood sugar imbalance and may struggle with daily dips in energy levels and maintaining long-term healthy body fat composition. (peoplesrx.com)
  • This kind of blood sugar imbalance could be a cause of infertility, weight gain, acne and excessive facial and body hair. (peoplesrx.com)
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
  • Sensory neurons of nociceptive character, which encode chemical, thermal and mechanical stimuli and release neuropeptides, pervade the whole mammalian body. (nature.com)
  • Sparstolonin B was showed to alleviate joint swelling in RA rats, inhibited inflammatory cell infiltration and the release of ROS, reduced damage caused by oxidative stress, and suppressed the rate of apoptosis in synovial cells. (hindawi.com)
  • Sparstolonin B improved inflammatory responses and oxidative stress by inhibiting the NLRP3 inflammasome, inhibiting the expression of FucT-V and downregulating the TLR4/MYD88/NF-𝜅B signaling pathway in order to rescue RA. (hindawi.com)
  • Pyroptosis also releases the cell contents including IL-1 β , IL-18, and other inflammatory cytokines, causing the body to produce an inflammatory response. (hindawi.com)
  • 7 During inflammatory processes, however, the biological half-life of erythrocytes is reduced as a consequence of oxidative stress and lipid-peroxidation, thus promoting erythrophagocytosis and reducing iron recirculation. (haematologica.org)
  • The polyphenols present in honey possess antioxidant and anti-inflammatory properties that can protect your body from health complications caused by oxidative stress. (aboutmanukahoney.com)
  • Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
  • CRP in three out of six studies that measured CRP following training in mindfulness-based stress reduction (MBSR), but inconsistent or null findings on other circulating immune biomarkers. (humankinetics.com)
  • Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may lead to cancer. (wikipedia.org)
  • According to the free radical theory of aging, which is later called oxidative stress theory of aging, age-related functional losses are caused as the result of the accumulation of oxidative damage to biological macromolecules by ROS and NO ( 22 ). (frontiersin.org)
  • Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. (hindawi.com)
  • The end product of the damage MDA produces in the body is a pigment called ceroid lipofuscin. (naturalnews.com)
  • They are a sign of excessive oxidative stress and internal damage within the body. (naturalnews.com)
  • This is a potentially toxic form of iron that can damage most all body systems. (irondisorders.org)
  • This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)
  • T)he authors claimed that their results clearly demonstrated that RF exposure can damage sperm function via mechanisms involving the leakage of electrons from the mitochondria and the induction of oxidative stress but the employed SAR values are very high and not relevant to cell phone users. (bioinitiative.org)
  • Administration of intravenous iron preparations in haemodialysis patients may lead to the appearance of non-transferrin bound iron which can catalyse oxidative damage. (sciensano.be)
  • The gut activates these antioxidants so that they turn into essential elements that may detox and reduce DNA damage from toxins our body is exposed to daily. (fitnesshealthforever.com)
  • Exercises elevate our oxidative stress which also results in DNA damage. (fitnesshealthforever.com)
  • The plant provides support to our body in dealing with the exercise-induced damage of DNA. (fitnesshealthforever.com)
  • Antioxidants are compounds that help neutralize harmful free radicals, preventing oxidative stress and damage to your cells. (draxe.com)
  • One animal model out of Poland showed that treating rats with beetroot helped prevent oxidative stress and reduced lipid peroxidation, a common marker of cell damage, by a whopping 38 percent. (draxe.com)
  • Oxidative stress is a leading factor in weakened immunity, as free radicals can damage your body's healthy systems. (aboutmanukahoney.com)
  • Manuka honey serves as an excellent source of antioxidants, which help eliminate free radicals, prevent cellular damage, protect against chronic diseases, combat premature aging of cells, suppress lipid peroxidation, and reduce oxidative stress. (aboutmanukahoney.com)
  • Oxidative stress is associated with neuronal damage arising from epileptic seizures. (phcog.com)
  • Studies have shown that GM can cause damage and apoptosis of rat tubule cells through oxidative stress [3-5]. (biomedres.us)
  • When the body is dreceives external stimuli, the accumulation of ROS causes damage to proteins, biofilms and DNA [6]. (biomedres.us)
  • It is important to note that oxidative stress has been postulated as a possible mechanism associated with tissue damage and other systemic complications 8 . (ijpsr.com)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • It ated with cardiac arrhythmias, neurological functions as the first line of defence protec- damage and significant long and short-term ting against the invasion of foreign bodies morbidity. (who.int)
  • 1000 volts) exposure may, in regulating body temperature, fluid and however, cause damage to deeper tissues electrolytes. (who.int)
  • The body weight decreased in D+M compared to ND rats. (hindawi.com)
  • In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone. (hindawi.com)
  • In one animal model, beetroot supplementation was able to reduce oxidative stress and inflammation in rats. (draxe.com)
  • We investigated the effect of vanadium citrate in the amounts of 0.125, 0.5, and 2.0 µg/mL of water on the enzymatic activity of carbohydrate metabolism, antioxidant system, and the level of lipid peroxide oxidation products in the pancreas of rats with alloxan-induced diabetes. (ijpsr.com)
  • This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
  • The body weight, glycemic control, and insulin resistance were evaluated. (hindawi.com)
  • There are relationships between Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6) with Body Mass Index (BMI) and insulin resistance. (ac.ir)
  • In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
  • Blood sugar regulation can be a critical component of numerous physiological mechanisms throughout the body and can directly affect energy production, weight, cognitive function and neurological health, among others. (peoplesrx.com)
  • This enables it to provide antioxidant protection in a much wider range of physiological environments throughout the body, which has resulted in some scientists referring to alpha-lipoid acid as the "universal" antioxidant. (peoplesrx.com)
  • In animal studies, stress-induced muscle hyperactivity was associated with muscle dysfunction and pain ( 13 ), whereas humans who experience panic attacks more frequently exhibit tooth clenching, bruxism and nail-biting ( 14 ). (spandidos-publications.com)
  • Earlier studies (PDF) have found similar results in chronically-stressed humans. (marksdailyapple.com)
  • The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. (psu.edu)
  • Results: Aerobic exercise resulted in a 34% decrease in F 2 -isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). (psu.edu)
  • Naringenin, one of the most frequently occurring flavanone in citrus fruits, was evaluated for its shielding effect against the pilocarpine induced behavioural, oxidative and histopathological alterations in rodent model of epilepsy. (phcog.com)
  • In conclusion, except for improving body weight in FF-treated birds, prophylactic administration of vitamin C is not associated with improvements in clinical outcome of antimicrobial therapy of broilers with SA, although it ameliorates oxidative stress and some histopathological changes. (researchsquare.com)
  • Thiols have been shown to play important roles in enzymatic reactions, apoptosis, detoxification and antioxidant protection in the body. (intechopen.com)
  • Patients with temporomandibular disorders (TMD) exhibit higher levels of anxiety ( 17 ), while TMD symptoms worsen whenever a person is under stress ( 18 , 19 ). (spandidos-publications.com)
  • Different predisposing factors are involved in the development of the disease which include stress, immunosuppression, vascular disorders, nutritional deficiencies etc (Wijesurendra et al. (researchsquare.com)
  • High levels of unmanaged oxidative stress accelerate aging and disease formation. (naturalnews.com)
  • Exercise enhances our metabolic rate and dramatically increases oxidative stress levels in our body. (naturalnews.com)
  • Under experimental stress, there is increased masseter activity, which returns to baseline levels upon relaxation ( 12 ). (spandidos-publications.com)
  • Finally, the entire body of new evidence for risks to fertility and reproduction is dismissed in the Executive Summary with "The previous SCENIHR opinion concluded that there were no adverse effects on reproduction and development from RF fields at exposure levels below existing limits. (bioinitiative.org)
  • decreasing in response to a variety of stimuli (e.g., body iron levels, inflammation , and hypoxia). (humankinetics.com)
  • From helping maintain healthy cholesterol levels, joint flexibility, cardiovascular health and circulation, Isotonix OPC-3 helps the body function at its peak by combating free radicals throughout your body. (etnad3.com)
  • however, males that reared the heaviest chicks showed the greatest oxidative stress levels, as determined by plasma lipid peroxidation. (kenyon.edu)
  • Unlike males, females with high levels of lipid peroxidation had low natural antibody levels. (kenyon.edu)
  • Increased levels of free-radical oxidation processes lead to pathological changes in the body, oxidative stress being one of such changes. (ijpsr.com)
  • Objective: To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity. (bvsalud.org)
  • Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F 2 -isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-α-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). (psu.edu)
  • Purpose: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. (psu.edu)
  • Organ and tissue pathologies are known to occur when oxidative stress is excessive in the body. (intechopen.com)
  • When body iron stores increase above these relatively normal ratios, proportionally greater amounts of iron are stored in non-blood tissue in ferritin molecules or a complex called hemosiderin. (irondisorders.org)
  • Tissue hypoxia and oxidative stress account for most of the pernicious effects of CO in the body. (medscape.com)
  • The intraperitoneal administration of pilocarpine enhanced lipid peroxidation, caused reduction in antioxidant enzymes, viz. (phcog.com)
  • We believe that there is promise in the potential of modifying the course of PSP by mitigating the oxidative stress and cellular degeneration that is caused by pathogenic LPO. (globenewswire.com)
  • This platform is designed to combat the oxidative stress and cellular degeneration that arises from lipid peroxidation (LPO). (globenewswire.com)
  • Polyunsaturated fatty acids (PUFAs), which make up cell and mitochondrial membranes throughout the body and are vital to healthy cellular function, are the target of the LPO process due to their inherent instability. (globenewswire.com)
  • Oxidative stress generates dangerous free radicals, which affect human health and exposing them to disease by altering the naturally structured cellular lining of human body subsequently causing lipid peroxidation and effects on enzyme activity as well as producing carcinogenesis. (ijpsonline.com)
  • Hypoxic stress in patients with CO poisoning is increased because of CO's effects on mitochondrial electron transport and cellular respiration. (medscape.com)
  • These data suggest that MDMA-induced toxicity of dopamine neurones in mice results from free radical formation which in turn induces an oxidative stress process. (erowid.org)
  • Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. (spandidos-publications.com)
  • This also shows that the thiol state is very important in the pathogenesis of oxidative stress-mediated diseases. (intechopen.com)
  • Therefore, it is thought that interventions that can improve thiol status may contribute to the prevention or treatment of oxidative stress-related diseases. (intechopen.com)
  • Role of lipid peroxidation and oxidative stress in the association between thyroid diseases and breast cancer. (realrawfood.com)
  • An increase in oxidative stress is associated with hyperglycemia, development, and progression of diabetes complications [ 3 , 4 ]. (hindawi.com)
  • Consider that altered oxidative stress/antioxidant status is related to T1D complications [ 22 , 23 ] and metformin action in the decrease of mitochondrial ROS. (hindawi.com)
  • Prospective studies should better define relationships between oxidant stress and complications of HIV infection and its therapy. (nih.gov)
  • Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
  • We'll discuss] the wide range of health impacts that glyphosate has from cancer to endocrine disruption to oxidative stress to immune dysfunction to reproductive harms and, finally, how to reduce your exposure to glyphosate and mitigate some of the impacts. (chriskresser.com)
  • By promoting good digestion, Manuka honey ensures better absorption of nutrients, which are essential for strengthening your body and immune system. (aboutmanukahoney.com)
  • Previously, structural plumage coloration has been considered a signal of body condition, parental effort, and immune strength. (kenyon.edu)
  • Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)
  • These correlations suggest that sex-specific roles in reproduction may elicit different trade-offs among parental effort, immunity, and oxidative stress. (kenyon.edu)
  • It provides evidence on how such insufficiencies may increase stress sensitivity and neuromuscular excitability and thereby reduce the ability to effectively respond to the overactivation of the sympathetic nervous system, and also how stress can in turn lead to these insufficiencies. (spandidos-publications.com)
  • Shilajit is rich in the antioxidant compound fulvic acid, which may help improve mental acuity and reduce stress. (inpathways.net)
  • So there are tremendous, valuable reasons to be eating fermented vegetables like sauerkraut, to increase our diversity, to reduce inflammation and to help reduce for oxidative stress on the cell membrane. (rheumatoidsolutions.com)
  • Robb Wolf promotes a short period of hefty omega 3 supplementation for unhealthy folks - on the order of 1g/10lbs of body weight per day. (perfecthealthdiet.com)
  • Recently, treatment outcomes have been improved in conjunction with a reduction in toxicity through technological innovations such as intensity modulated radiotherapy or stereotactic body radiotherapy. (springer.com)
  • Job stress may be reduced through implementation of appropriate stress reduction interventions. (cdc.gov)
  • 5) increasing the intrinsic radioresistance of normal cells through ketone bodies but decreasing that of tumor cells by targeting glycolysis. (springer.com)
  • Only small amounts of iron are lost each day through urine and body, sweat or as skin cells slough off. (irondisorders.org)
  • 4,5 Hormones are chemical messengers produced by certain glands and cells in your body that bind to specific receptors in order to produce a targeted biological response. (lifeextension.com)
  • The kidney is an important excretory organ of the body, and tubule cells are the basic structural and functional unit that constitutes the kidney. (biomedres.us)
  • EDa protects cells by eliminating ROS from multiple types of cells and by reducing oxidative stress [8-10]. (biomedres.us)
  • Researchers have made an estimate and guessed that there are 75 trillion cells in the body. (vitanetonline.com)
  • In male infertility patients, ashwagandha improves semen quality and improves testosterone status by reducing the impact of oxidative stress. (marksdailyapple.com)
  • Conclusion: Plasma and saliva antioxidant system is affected in RAS patients and both may be considered as an appropriate indicator of antioxidant status of body. (bvsalud.org)
  • Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms. (spandidos-publications.com)
  • Among adults with a history of chronic stress , 300 mg ashwagandha extract reduces cortisol and anxiety and improves resistance to additional stress. (marksdailyapple.com)
  • Saliva is an important defense system of body. (bvsalud.org)
  • In response, the body builds up its anti-oxidant reserves in order to successfully adapt to the greater level of stress. (naturalnews.com)
  • There are factors we have no control over such as certain environmental toxins, method of birth, and exposure to some level of stress. (choicesweightmanagement.com)
  • An increased level of peroxides in blood indicates oxidative stress in the body. (eaglebio.com)
  • Age, body mass index, years of experience, weekend work , work hours per week, and shift work showed strong associations with effort-reward ratio and overcommitment scores. (cdc.gov)
  • Oxidant stress may be an effect of antiretroviral therapy (ART) or chronic HIV infection. (nih.gov)
  • Beet juice benefits liver function, helpinp keep it working efficiently so it can continue to keep your body free of toxins. (draxe.com)