• disorders
  • Objectives To determine whether different platelet transfusion thresholds for administration of prophylactic platelet transfusions (platelet transfusions given to prevent bleeding) affect the efficacy and safety of prophylactic platelet transfusions in preventing bleeding in people with haematological disorders undergoing myelosuppressive chemotherapy or haematopoietic stem cell transplantation (HSCT). (ox.ac.uk)
  • Other defects in platelet GPIa/IIa (a2b1) and GPVI, as well as isolated defects in agonist receptors or proteins involved in signal transduction may also produce hemorrhagic symptoms, but these disorders are less well characterized. (wordpress.com)
  • FIGURE 119-1 Evaluation of patients for abnormalities in platelet number or function and related disorders. (wordpress.com)
  • receptor
  • Background -The present study describes the effects of tirofiban, a nonpeptide platelet glycoprotein (GP) IIb/IIIa receptor blocker, on the characteristics of culprit lesions in patients with unstable angina (UA) or non-Q-wave myocardial infarction (NQWMI). (ahajournals.org)
  • therapy
  • Although considerable advances have been made in platelet transfusion therapy in the last 40 years, some areas continue to provoke debate, especially concerning the use of prophylactic platelet transfusions for the prevention of thrombocytopenic bleeding. (ox.ac.uk)
  • count
  • A prolonged bleeding time in a patient with a normal platelet count is indicative of a qualitative platelet abnormality, von Willebrand disease (see Chap. 135), or afibrinogenemia (see Chap. 124). (wordpress.com)
  • The test is typically ordered along with or following a platelet count and may be followed by additional tests such as functional assays to confirm a finding. (labtestsonline.org)
  • The presence of HIT antibodies in someone who has been treated with heparin for 5 to 10 days, has a platelet count that has decreased by 50% or more, and has new blood clots means that it is likely the person has HIT II. (labtestsonline.org)
  • activation
  • Functional assays, such as a serotonin release assay or heparin-induced platelet activation assay, are more specific for HIT II but take longer, are more technically demanding, and not widely available. (labtestsonline.org)
  • Functional testing such as a serotonin release assay (SRA) or heparin-induced platelet activation (HIPA) test may be ordered when the EIA test is indeterminate or negative but suspicion of HIT is still high. (labtestsonline.org)
  • people
  • Background Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in people who are thrombocytopenic due to bone marrow failure. (ox.ac.uk)
  • separate
  • Platelet size (determined from the blood film and/or the mean platelet volume) helps to separate the inherited quantitative platelet syndromes from the acquired thrombocytopenias and the inherited combined quantitative and qualitative thrombocytopenias (see Chap. 117). (wordpress.com)