• Causes
  • Bernard-Soulier Disease (Giant Platelet Syndrome) Symptoms, Causes, Treatment - What is Bernard-Soulier syndrome? (wikipedia.org)
  • In 2010, the genetic cause of QPD has been determined as a mutation involving an extra copy of the uPA (urokinase plasminogen activator) gene http://bloodjournal.hematologylibrary.org/content/115/6/1264.long.[permanent dead link] The mutation causes overproduction of an enzyme that accelerates blood clot breakdown. (wikipedia.org)
  • rare
  • Quebec Platelet Disorder (QPD) is a rare, autosomal dominant bleeding disorder described in a family from the province of Quebec in Canada. (wikipedia.org)
  • study
  • 12 13 14 15 The PRISM-PLUS study investigated tirofiban, a nonpeptide platelet GP IIb/IIIa antagonist, as part of the comprehensive management of UA or NQWMI. (ahajournals.org)
  • standard
  • All three trials compared a standard trigger (10 x 109/L) versus a higher trigger (20 x 109/L or 30 x 109/L). None of the trials compared a low trigger versus a standard trigger or an alternative platelet trigger. (ox.ac.uk)