• renal
  • As red blood cells approach the renal medulla (where there is a high concentration of urea), the urea transporter allows for rapid uptake of urea and prevents cell shrinkage in the hypertonic environment of the medulla. (wikipedia.org)
  • gene
  • Both the pHuman-mouse and pMouse constructs induced the expression of A and B antigens, suggesting that the mouse gene is a cis -AB gene and encodes an enzyme with both A and B transferase activity. (google.com)
  • The two major codominant alleles of the gene, JK*A and JK*B , have similar frequencies in Caucasian populations (0.51 and 0.49, respectively) and define the Jk a and Jk b antigens, respectively. (rbhh.org)
  • Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikipedia.org)
  • found
  • Three antigens have been found (Jk a , Jk b and Jk3) on the neighboring fourth extracellular looping and three phenotypes, Jk(a + b−), Jk(a − b+), and Jk(a + b+), are common among different populations. (rbhh.org)