• vessels
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. (nih.gov)
  • The growth of blood vessels, a process known as angiogenesis, is a normal process in the body that is essential for organ growth and repair. (nih.gov)
  • St. Croix and his colleagues focused on endothelial cells, which line the inner surface of blood vessels and are critical for new vascular growth. (nih.gov)
  • The researchers chose to analyze endothelial cells derived from mouse liver, because the liver can be induced to sprout new blood vessels when regenerating itself following partial surgical removal. (nih.gov)
  • They found that the CD276 protein was overexpressed in tumor-associated blood vessels from colon, lung, breast, esophageal and bladder cancers. (nih.gov)
  • In addition, the protein was also found to be frequently overexpressed by the tumor cells themselves, indicating that a suitable inhibitory molecule might be able to deliver a double blow -- one to the tumor cells themselves and the other to the blood vessels that feed them. (nih.gov)
  • These studies demonstrate that CD276 is overexpressed in the blood vessels of a variety of human cancers," says St. Croix. (nih.gov)
  • Therefore, it may be an important target for the development of new drugs that can selectively home in on blood vessels associated with disease. (nih.gov)
  • After determining that a patient has high blood pressure, the physician will look for possible causes and determine any effects it may have on key organs, such as the heart, kidneys, brain and blood vessels. (cedars-sinai.edu)
  • Blood is circulated around the body through blood vessels by the pumping action of the heart. (wikipedia.org)
  • Inheriting one aberrant hemoglobin gene from each of their respective parents, these individuals live with red blood cells that don't always remain typically round and pliable for easy travel through the body's small and large blood vessels. (huffingtonpost.com)
  • kidneys
  • For example, a urinary tract infection may spread from the bladder and/or kidneys into the blood and then be carried throughout the body, infecting other organs and causing a serious and sometimes life-threatening systemic infection. (labtestsonline.org)
  • oxygen
  • In many diseases, including most forms of cancer, this carefully regulated process becomes imbalanced, and normal blood vessel growth is redirected toward supplying nutrients and oxygen to feed diseased tissue, destroy normal tissues, and in the case of cancer, allow tumor cells to escape and travel to distant sites in the body. (nih.gov)
  • Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. (wikipedia.org)
  • These contain hemoglobin, an iron-containing protein, which facilitates oxygen transport by reversibly binding to this respiratory gas and greatly increasing its solubility in blood. (wikipedia.org)
  • In most insects, this "blood" does not contain oxygen-carrying molecules such as hemoglobin because their bodies are small enough for their tracheal system to suffice for supplying oxygen. (wikipedia.org)
  • Right tube: Freshly drawn blood One microliter of blood contains: 4.7 to 6.1 million (male), 4.2 to 5.4 million (female) erythrocytes: Red blood cells contain the blood's hemoglobin and distribute oxygen. (wikipedia.org)
  • Blood flows throughout the body, acting as a medium which provides oxygen and nutrients to tissues and carries waste products back to the excretory systems for disposal. (wikipedia.org)
  • As blood circulates, it delivers oxygen and nutrients throughout the body. (kidshealth.org)
  • Red blood cells, the most commonly transfused part, are used to increase the blood's ability to carry oxygen and prevent tiredness and other complications. (kidshealth.org)
  • This sudden obstruction of oxygen not only causes red blood cells to die off months earlier than normal, rendering someone with sickle cell disease vulnerable to anemia and infections. (huffingtonpost.com)
  • sickle
  • Characteristic red blood cell abnormalities are anemia , sickle cell anemia and spherocytosis . (wikipedia.org)
  • To prevent complications from an existing blood or bleeding disorder , such as sickle cell disease , thalassemia, or anemia caused by kidney disease , hemophilia , or von Willebrand disease . (kidshealth.org)
  • Indeed, this present world is full of such suffering from the hereditary blood disorder that is sickle cell disease. (huffingtonpost.com)
  • And while all babies born in the United States are screened for sickle cell disease, the most likely to test positive for this nation's most common inherited blood disorder are, in fact, black newborns. (huffingtonpost.com)
  • Knot
  • A blood knot (barrel knot) is most usefully employed for joining sections of monofilament nylon line while maintaining a high portion of the line's inherent strength. (wikipedia.org)
  • The principal drawback to the blood knot is the dexterity required to tie it. (wikipedia.org)
  • Blood knot" may refer to, "a double overhand knot tied in a cat-o'-nine-tails. (wikipedia.org)
  • The barrel knot, called blood knot by Keith Rollo, is the best bend there is for small, stiff or slippery line. (wikipedia.org)
  • The Ashley Book of Knots A half blood knot (also clinch knot) is a knot that is used for securing a fishing line to a fishing lure, snap or swivel. (wikipedia.org)
  • When two half blood knots are used to join two lines they are considered as one knot and called a blood knot. (wikipedia.org)
  • A half blood knot is one of the strongest knots for tying a medium-size hook to a medium-size line such as hooksize 4 to 4/0 onto line size 6 lb to 30 lb. (wikipedia.org)
  • In tying the blood knot, the two lines to be joined are overlapped for 6-8 cm with the short ends of the two lines in opposite directions. (wikipedia.org)
  • Video instructions on how to tie a half blood knot Video instructions for tying a Blood Knot Grog. (wikipedia.org)
  • Blood Knot is an early play by South African playwright, actor, and director Athol Fugard. (wikipedia.org)
  • Lucille Lortel produced The Blood Knot, starring J.D. Cannon as Morris and James Earl Jones as Zachariah, at the Cricket Theatre, Off Broadway, in New York City, in 1964, "launch[ing]" Fugard's "American career. (wikipedia.org)
  • Fugard was pleased with the results: Back in S'Kop after five weeks in London for BBC TV production of The Blood Knot. (wikipedia.org)
  • In Time magazine, the same performance was reviewed by Pulitzer Prize-winning critic William A. Henry III, who notices the long collaboration between the two actors, Fugard and Mokae: "The actors' blood knot of decades of fraternal friendship has only ripened their truth onstage. (wikipedia.org)
  • chills
  • This aggressive, whole-body response can give someone a fever, chills, and low blood pressure. (kidshealth.org)
  • AllMovie's review of the film was mixed, writing, "Blood Song is dumb fun for those in the market for such and there is perverse enjoyment in watching Avalon's inexplicable performance, but don't expect chills or logic. (wikipedia.org)
  • coagulation
  • Serum includes all proteins not used in blood clotting (coagulation) and all the electrolytes, antibodies, antigens, hormones, and any exogenous substances (e.g., drugs and microorganisms). (wikipedia.org)
  • donors
  • People with Type O, negative blood are considered universal donors as it is safe to transfuse to nearly everyone. (medicinenet.com)
  • In most cases, the blood comes from volunteer donors. (kidshealth.org)
  • Since there's no medical evidence that blood from directed donors is any safer than blood from volunteer donors, most patients receive blood donated through blood drives, which are often run by independent collection agencies like the American Red Cross. (kidshealth.org)
  • vampire
  • But the flip side is that vampire blood (or "V juice") can prove useful to humans, particularly as an aphrodisiac. (angelfire.com)
  • Pale Blood is a 1990 direct-to-video vampire film directed by V.V. Dachin Hsu and Michael W. Leighton. (wikipedia.org)
  • Diagnosis
  • In some cases, ambulatory blood pressure monitoring, which involves a 24-hour blood pressure monitor worn on the hip and connected to a blood pressure cuff on the arm, may be used to confirm diagnosis. (cedars-sinai.edu)
  • Hematopathologists often use other specialized stains to aid in the differential diagnosis of blood disorders. (wikipedia.org)
  • vessel
  • Researchers have tried to stop disease-related angiogenesis by identifying the molecules that stimulate blood vessel and developing new drugs to block their action. (nih.gov)
  • However, blocking angiogenesis requires a delicate balance between tumor and normal cells as most angiogenesis-related molecules are also critical for normal blood vessel growth in the body - for example, during menstruation, pregnancy, or tissue repair. (nih.gov)
  • The red blood cells (together with endothelial vessel cells and other cells) are also marked by glycoproteins that define the different blood types. (wikipedia.org)
  • improves
  • OBJECTIVE -The objective of this study was to determine whether cinnamon improves blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes. (diabetesjournals.org)
  • It turns out that 25-38% of type 2 diabetics are deficient in magnesium, and correcting the deficiency significantly lowers blood sugar levels and improves the function of insulin ( 18 , 19 , 20 ). (healthline.com)
  • fibrinogen
  • In terms of anatomy and histology, blood is considered a specialized form of connective tissue, given its origin in the bones and the presence of potential molecular fibers in the form of fibrinogen. (wikipedia.org)
  • Anti-coagulated blood yields plasma containing fibrinogen and clotting factors. (wikipedia.org)
  • Coagulated blood (clotted blood) yields serum without fibrinogen, although some clotting factors remain. (wikipedia.org)
  • proteins
  • These markers (also called antigens ) are proteins and sugars that our bodies use to identify the blood cells as belonging in our own system. (kidshealth.org)
  • cells
  • This is usually done as a lifesaving maneuver to replace blood cells or blood products lost through severe bleeding, during surgery when blood loss occurs or to increase the blood count in an anemic patient. (medicinenet.com)
  • In vertebrates, it is composed of blood cells suspended in blood plasma. (wikipedia.org)
  • The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). (wikipedia.org)
  • The most abundant cells in vertebrate blood are red blood cells. (wikipedia.org)
  • The average adult has a blood volume of roughly 5 litres (11 US pt), which is composed of plasma and several kinds of cells. (wikipedia.org)
  • These blood cells (which are also called corpuscles or "formed elements") consist of erythrocytes (red blood cells, RBCs), leukocytes (white blood cells), and thrombocytes (platelets). (wikipedia.org)
  • Whole blood (plasma and cells) exhibits non-Newtonian fluid dynamics. (wikipedia.org)
  • Mature red blood cells lack a nucleus and organelles in mammals. (wikipedia.org)
  • A blood film -or peripheral blood smear -is a thin layer of blood smeared on a glass microscope slide and then stained in such a way as to allow the various blood cells to be examined microscopically. (wikipedia.org)
  • White blood cells are classified according to their propensity to stain with particular substances, the shape of the nuclei and the granular inclusions. (wikipedia.org)
  • Several red blood cells have ring stages inside them. (wikipedia.org)
  • Platelets , the smallest blood cells, help to clot the blood and control bleeding. (kidshealth.org)
  • But although all blood contains the same basic components (red cells, white cells, platelets, and plasma), not everyone has the same types of markers on the surface of their red blood cells. (kidshealth.org)
  • The blood cells in this type have both A and B markers. (kidshealth.org)
  • If a patient is given the wrong blood type, the antibodies immediately set out to destroy the invading cells. (kidshealth.org)
  • If you have both A and B markers on the surface of your cells (Type AB blood), your body does not need to fight the presence of either. (kidshealth.org)
  • But if you have Type O blood, meaning your red blood cells have neither A or B markers, your body will have both A and B antibodies and will therefore feel the need to defend itself against A, B, and AB blood. (kidshealth.org)
  • plasma
  • Albumin is the main protein in plasma, and it functions to regulate the colloidal osmotic pressure of blood. (wikipedia.org)
  • Human blood fractioned by centrifugation: Plasma (upper, yellow layer), buffy coat (middle, thin white layer) and erythrocyte layer (bottom, red layer) can be seen. (wikipedia.org)
  • About 55% of blood is blood plasma, a fluid that is the blood's liquid medium, which by itself is straw-yellow in color. (wikipedia.org)
  • Plasma , the pale yellow liquid part of whole blood. (kidshealth.org)
  • it is the blood plasma not including the fibrinogens. (wikipedia.org)
  • Blood serum and plasma are some of the largest sources of biomarkers, whether for diagnostics or therapeutics. (wikipedia.org)
  • parasites
  • Blood films are examined in the investigation of hematological (blood) disorders and are routinely employed to look for blood parasites , such as those of malaria and filariasis . (wikipedia.org)
  • glucose
  • Because insulin also plays a key role in lipid metabolism, we postulated that consumption of cinnamon would lead to improved glucose and blood lipids in vivo. (diabetesjournals.org)
  • Multiple tests for specific blood components, such as a glucose test or a cholesterol test , are often grouped together into one test panel called a blood panel or blood work . (wikipedia.org)
  • Some tests, such as those that measure glucose or a lipid profile , require fasting (or no food consumption) eight to twelve hours prior to the drawing of the blood sample. (wikipedia.org)
  • nitrogen
  • Blood meal is a dry, inert powder made from blood used as a high-nitrogen organic fertilizer and a high protein animal feed. (wikipedia.org)
  • Blood meal is different from bone meal in that blood meal contains a higher amount of nitrogen, while bone meal contains phosphorus. (wikipedia.org)
  • magnesium
  • Magnesium is a mineral involved in more than 300 bodily processes, including blood sugar control ( 17 ). (healthline.com)
  • The magnesium in almonds may also help to lower blood pressure levels. (healthline.com)
  • A deficiency in magnesium is strongly linked to blood pressure problems, regardless of whether you are overweight or not ( 23 , 24 , 25 ). (healthline.com)
  • known
  • Blood Creek , previously known as Creek and Town Creek , is a horror film directed by Joel Schumacher , starring Michael Fassbender as the main antagonist and written by David Kajganich. (wikipedia.org)
  • Type A. This blood type has a marker known as "A. (kidshealth.org)
  • Blood Song (also known Dream Slayer) is a 1982 American horror film directed by Robert Angus and Alan J. Levi, produced by Frank Avianca and Lenny Montana, and starring Frankie Avalon and Donna Wilkes. (wikipedia.org)
  • draws
  • The blood bank draws your blood and stores it until you need it during or after surgery. (medicinenet.com)
  • The monolayer is found in the "feathered edge" created by the spreader slide as it draws the blood forward. (wikipedia.org)
  • The title draws its name from Abu Ali's sacred knife, which is called Lion's Blood (or "Nasab Asad" in Arabic), which was carried into battle by members of Abu Ali's family for ten generations. (wikipedia.org)
  • samples
  • Samples of human blood collected for testing. (wikipedia.org)
  • For analysis of biomarkers in blood serum samples, it is possible to do a pre-separation by free-flow electrophoresis that usually consists of a depletion of serum albumin protein. (wikipedia.org)
  • white
  • Legend held that the steel blade was smelted from a fallen meteorite by Benin smiths, its white-hot length quenched in the living blood of a lion. (wikipedia.org)
  • instead
  • Insects and some mollusks use a fluid called hemolymph instead of blood, the difference being that hemolymph is not contained in a closed circulatory system. (wikipedia.org)
  • Anyway, the background is that a couple years ago, a Japanese company introduced a synthetic blood beverage called Tru Blood [sic], which vampires can drink instead of human blood. (angelfire.com)
  • If only a few drops of blood are needed, a fingerstick is performed instead of drawing blood from a vein. (wikipedia.org)
  • Instead, more specific parts of blood are transfused as needed. (kidshealth.org)