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AtherosclerosisArteriosclerosisApolipoproteins ECarotid Artery DiseasesDiet, AtherogenicAortic DiseasesAortaCoronary Artery DiseaseCarotid ArteriesTunica IntimaTunica MediaCholesterolPlaque, AtheroscleroticRisk FactorsLipoproteins, LDLIntracranial ArteriosclerosisReceptors, LDLMice, KnockoutLipidsCarotid Intima-Media ThicknessHypercholesterolemiaCholesterol, DietaryFoam CellsCarotid Artery, CommonMacrophagesEndothelium, VascularCalcinosisMice, Inbred C57BLInflammationLipoproteinsCoronary VesselsHyperlipidemiasDisease Models, AnimalDisease ProgressionAorta, ThoracicBiological MarkersChlamydophila pneumoniaeCholesterol, HDLCzechoslovakiaCholesterol, LDLMuscle, Smooth, VascularTriglyceridesAorta, AbdominalArteriesC-Reactive ProteinRabbitsCells, CulturedCardiovascular DiseasesVascular Cell Adhesion Molecule-1Lipid MetabolismCoronary DiseaseProspective StudiesProbucolMonocytesEndothelial CellsApolipoprotein A-ICarotid StenosisCoronary AngiographyMyocytes, Smooth MuscleAryldialkylphosphataseVasculitisLipoproteins, HDLChemokine CCL2Anticholesteremic AgentsOxidative StressTime FactorsVascular CalcificationInflammation MediatorsHypertensionDiabetic AngiopathiesCohort StudiesHydroxymethylglutaryl-CoA Reductase InhibitorsArteritisLipoprotein(a)Dietary FatsFemoral ArteryRisk AssessmentUSSRApolipoproteins BCholesterol, VLDLEuropean Continental Ancestry GroupChlamydophila InfectionsHyperlipoproteinemia Type IIBrachiocephalic TrunkPredictive Value of TestsBrachial ArterySinus of ValsalvaBlood PressureAntioxidantsVasa VasorumATP Binding Cassette Transporter 1Antigens, CD36Severity of Illness IndexCross-Sectional StudiesLinear ModelsVascular DiseasesPrevalenceCase-Control StudiesHomocysteineMacaca fascicularis
ProgressionDevelopment of atherosclerosisArteriosclerosisCarotid atherosclerosisVesselsInflammatoryStrokeTarget for treating atheroVascularDiseaseSymptoms of atherosclerosisContribute to atherosclerosisCause of atherosclerosisKnown as atherosclerosisInflammationVesselLipidsTreat atherosclerosisPrevent atherosclerosisCoronary atherosclerosisSubclinical atherosclerosisThickening and hardening oPeripheralNarrowing of arteriesDiabetesObesityPathogenesisHigh cholesterolChronicClotBuildup of plaqueArterialEndothelialRisk in communitiesHypertensionDiseasesFatty2023ClinicallyHeartPatientsDiagnosisSystolic blood prRenalAtheroscleroticPreclinicalAsymptomaticOccursAccumulationMildTriglyceridesPressureFatsFlowAffectsClots
Progression15
  • In our research, we examined the influence of the administration of IL-27 and an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both the initiation and the progression of atherosclerosis. (hindawi.com)
  • In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)
  • Further studies have shown that Th1 cells promote atherosclerosis initiation and progression [ 6 , 7 ]. (hindawi.com)
  • The model] suggests that there is an association between long-term exposure to ozone and progression of atherosclerosis," he goes on to report. (medicalnewstoday.com)
  • Progression of atherosclerosis to such life-threatening complications as a heart attack or stroke requires emergency treatment. (msdmanuals.com)
  • We have shown that relatively low doses of THC initiated after manifestation of clinically detectable artery lesions significantly inhibit atherosclerosis progression in mice," write Dr Sabine Steffens (University Hospital, Geneva, Switzerland) and colleagues in the April 6, 2005 issue of Nature . (medscape.com)
  • Furthermore, the inhibitory effects of THC on atherosclerosis progression are abolished in the presence of a CB2-receptor antagonist. (medscape.com)
  • The researchers hypothesized that THC could alter inflammatory processes crucial in atherosclerosis, thus limiting disease progression. (medscape.com)
  • Cite this: Oral cannabinoid therapy reduces progression of atherosclerosis - Medscape - Apr 07, 2005. (medscape.com)
  • ABSTRACT TREML4 and other members of the triggering receptor expressed in the myeloid cell family are associated with a risk of atherosclerosis and progression in coronary artery disease , acute coronary syndrome , and coronary artery calcification. (bvsalud.org)
  • In conclusion, TREML4 mRNA expression in blood leukocytes is influenced by minor alleles (G and C) and may regulate differently during the atherosclerosis progression stages, but not in asymptomatic atherosclerosis disease and post-MI. (bvsalud.org)
  • They reported that abnormal inflammatory signaling was also related to DNMT3A and TET2 deficiency in blood cells that play a major role in inflammation response that promotes the progression of atherosclerosis. (news-line.com)
  • A study of three hundred Alzheimer's patients found that treating vascular risk factors, such as high cholesterol and blood pressure , may even slow the progression of the disease but not stop it. (nutritionfacts.org)
  • Over the past two decades, its role in the initiation, progression, and clinical sequelae of atherosclerosis has been both increasingly studied and recognised (1). (escardio.org)
  • For example, serum biomarkers, such as high sensitivity C-reactive protein (hsCRP) and cytokine levels, predict progression of atherosclerosis and risk of stroke. (medscape.com)
Development of atherosclerosis4
Arteriosclerosis7
Carotid atherosclerosis5
Vessels22
Inflammatory9
  • The properties of RBCEVs that we have uncovered here are desirable for treating atherosclerosis and possibly other inflammatory diseases. (news-medical.net)
  • Atherosclerosis is a lipid-driven chronic inflammatory disease characterized by progressive atherosclerotic plaque growth. (hindawi.com)
  • Some types of cancer can lead to tissue damage or inflammatory responses that may activate blood clotting. (healthline.com)
  • We found that the genes DNMT3A and TET2, in addition to their normal job of altering chemical tags to regulate DNA, directly activate expression of a gene involved in mitochondrial inflammatory pathways, which hints at a new molecular target for atherosclerosis therapeutics," says Gerald Shadel, co-senior author, Salk professor and director of the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging. (news-line.com)
  • The study started when researchers at UC San Diego noted a specific inflammatory response while investigating the roles of DNMT3A and TET2 mutations in clonal hematopoiesis-when mutated immature blood cells give rise to a population of mature blood cells with identical mutations. (news-line.com)
  • They found that experimentally reducing the expression of DNMT3A or TET2 in the normal blood cells had similar results to blood cells that had loss of function mutations and blood cells from atherosclerosis patients--an increased inflammatory response. (news-line.com)
  • However, studies pointed out that carbon nanotube induced lung inflammation results in a release of inflammatory mediators and activation of blood cells which can contribute to cardiovascular adverse effects. (cdc.gov)
  • According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury. (medscape.com)
  • Infections and inflammatory conditions also contribute to endothelial injury and atherosclerosis. (medscape.com)
Stroke17
  • Atherosclerosis causes heart disease and stroke, affecting millions of people. (news-medical.net)
  • Plaques may also rupture or split, causing blood clots to form on the inside exposed surface of the artery walls, which may lead to a heart attack or stroke. (sharecare.com)
  • Sometimes the first symptom of atherosclerosis is a heart attack or stroke or even sudden coronary death," says Steven Borzak, MD, a cardiologist affiliated with JFK Medical Center in Atlantis, Florida. (sharecare.com)
  • However, when a major artery is blocked, signs and symptoms may be severe, such as those occurring with heart attack, stroke, or blood clot. (hopkinsmedicine.org)
  • Early diagnosis and treatment can stop atherosclerosis from worsening and prevent a heart attack, stroke or another medical emergency. (mayoclinic.org)
  • Atherosclerosis can lead to more dangerous cardiovascular events, such as coronary heart disease or peripheral artery disease , as well as a heart attack or stroke . (medicalnewstoday.com)
  • Stroke blocks the blood supply to the brain and can be life threatening. (medicalnewstoday.com)
  • Blood vessel blockage due to atherosclerosis is a common cause of heart attack and stroke. (msdmanuals.com)
  • Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction). (msdmanuals.com)
  • Because of that, many people are unaware they have atherosclerosis until a medical emergency such as a heart attack or stroke occurs. (nghs.com)
  • When atherosclerosis impacts the carotid arteries, which supply blood to the brain, a person may experience symptoms common with stroke, including sudden weakness, paralysis or numbness, trouble speaking or seeing, dizziness or a sudden and severe headache. (nghs.com)
  • buildup of fats other substances in artery walls can reduce the blood flow to brain and lead to stroke. (slideshare.net)
  • Smokers have an increased risk of high blood pressure, stroke, heart failure, and other cardiovascular diseases (CVDs). (medicalnewstoday.com)
  • A stroke happens when there is decreased blood flow to the brain or when a blood vessel in the brain bursts. (medicalnewstoday.com)
  • Our goal was to examine the contribution of longitudinal patterns of blood pressure change to incidence of heart failure, coronary heart disease, stroke, and cardiovascular disease mortality. (uky.edu)
  • They may not be appropriate for men with certain health conditions, such as severe heart disease, heart failure, uncontrolled high blood pressure, diabetes, or a history of stroke or heart attack. (limamemorial.org)
  • Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)
Target for treating athero1
  • The results, conclude Steffens et al, suggest that cannabinoid therapy that specifically targets the CB2 receptor may represent a potential target for treating atherosclerosis. (medscape.com)
Vascular8
  • Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. (medscape.com)
  • This buildup results in plaque formation, vascular remodeling, acute and chronic luminal obstruction, abnormalities of blood flow, and diminished oxygen supply to target organs. (medscape.com)
  • Smoking is the single most damaging and most preventable cause of atherosclerosis and vascular events. (sharecare.com)
  • Inflammation is increasingly being considered central to the pathogenesis of atherosclerosis and an important risk factor for vascular disease. (nih.gov)
  • Most vascular pathologies arise from atherosclerosis. (uni-muenster.de)
  • We aim at numerical modeling of atherogenesis based on multiparametric imaging data of vessel architecture, blood flow and vascular inflammation. (uni-muenster.de)
  • Endothelial dysfunction is an early marker of atherosclerosis and levels of vascular relaxation are an indicator of endothelial health. (escardio.org)
  • High-resolution vascular ultra-sound investigation of the brachial artery before and during reactive hyperaemia (1) shows vasodilatation from the release of nitric oxide as a response to stress induced during increased blood flow. (escardio.org)
Disease28
  • Atherosclerosis is a disease in which fat, cholesterol, and other substances build up inside artery walls. (news-medical.net)
  • Noncoronary atherosclerosis refers to atherosclerotic disease affecting large and medium-sized noncoronary arteries (eg, extracranial cerebrovascular disease, lower extremity occlusive disease, aneurysmal disease). (medscape.com)
  • Patients with mild atherosclerosis may present with clinically important symptoms and signs of disease. (medscape.com)
  • Recent epidemiologic and pathogenesis studies have suggested a great deal in common between the pathogenesis of prototypic autoimmune disease such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and that of atherosclerosis. (nih.gov)
  • Treatment of established disease may include medications to lower cholesterol such as statins, blood pressure medication, or medications that decrease clotting, such as aspirin. (wikipedia.org)
  • While coronary artery disease is more prevalent in men than women, atherosclerosis of the cerebral arteries and strokes equally affect both sexes. (wikipedia.org)
  • Plaque occurrence and accumulation lead to decreased kidney blood flow and chronic kidney disease, which, like in all other areas, is typically asymptomatic until late stages. (wikipedia.org)
  • Atherosclerosis is a slow, progressive disease that may start as early as childhood. (hopkinsmedicine.org)
  • If you have atherosclerosis in the arteries in your arms and legs, you may have symptoms of peripheral artery disease, such as leg pain when walking (claudication) or decreased blood pressure in an affected limb. (mayoclinic.org)
  • You also can get blood clots if you have a disease that makes your body produce too many red blood cells (RBCs) or platelets. (healthline.com)
  • Atherosclerosis is a disease in which fatty material is deposited on the wall of an artery. (medlineplus.gov)
  • Overview of Coronary Artery Disease (CAD) Coronary artery disease is a condition in which the blood supply to the heart muscle is partially or completely blocked. (msdmanuals.com)
  • Conclusions Ultrasound assessment of subclinical atherosclerosis may improve risk stratification of patients with psoriatic disease, particularly of those with PsA. (bmj.com)
  • Atherosclerosis is a disease in which plaque builds up inside your arteries. (cdc.gov)
  • The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. (nih.gov)
  • Risk factors for atherosclerosis alone aren't accurate enough in predicting cardiovascular disease in adults with no history of atherosclerosis disease. (escardio.org)
  • Multidetector computed tomography may be a useful non-invasive technique to detect silent coronary artery disease in patients with peripheral preclinical atherosclerosis. (escardio.org)
  • The presence of one or more risk factors for atherosclerosis (ATS) is associated with the development of cardiovascular disease (CVD). (escardio.org)
  • It's very exciting to see our discovery on TFAM depletion causing mitochondrial DNA stress and inflammation now has direct relevance for a disease like atherosclerosis," says Shadel, who holds the Audrey Geisel Chair in Biomedical Science. (news-line.com)
  • Coronary artery disease (CAD) is the most common heart disease in the U.S. It happens when the large arteries on the heart's surface cannot supply enough oxygen-rich blood to the heart. (medicalnewstoday.com)
  • Peripheral arterial disease (PAD) is often a result of atherosclerosis. (medicalnewstoday.com)
  • We generally think of atherosclerosis as a condition of the heart , but a substantial body of evidence strongly associates atherosclerotic arteries with Alzheimer's disease. (nutritionfacts.org)
  • Elevated blood pressure in midlife contributes significantly to the risk of cardiovascular disease. (uky.edu)
  • Cumulative systolic blood pressure load, rather than the temporal pattern of change in systolic blood pressure itself, plays a role in determining the risk of cardiovascular disease, in particular, of heart failure and cardiovascular disease mortality, independent of blood pressure level measured at one point in time. (uky.edu)
  • are the main reasons for ED. They include atherosclerosis (which also causes heart disease and peripheral artery disease), high blood pressure, diabetes, neurological disorders, medication side effects, prostate surgery, radiation treatment to the pelvis, and other health conditions. (limamemorial.org)
  • Being physically active is one of the most important things you can do to prevent or control high blood pressure, and then also, reduces your risk of heart disease. (selfgrowth.com)
  • Atherosclerosis is a disease of the arteries in which fatty material is deposited in the vessel wall, resulting in narrowing and eventual impairment of blood flow. (adam.com)
  • Physical activity is essential for preventing and controlling risk factors and chronic diseases, such as diabetes, high blood pressure (HBP), cardiovascular disease (CVD), obesity, cancer, and depression (1). (cdc.gov)
Symptoms of atherosclerosis3
Contribute to atherosclerosis2
  • Heavy drinking, on the other hand-more than 14 drinks per week for men and more than 9 drinks per week for women-can contribute to atherosclerosis and increase your risk for serious health problems and even death. (sharecare.com)
  • Each risk factor is believed to contribute to atherosclerosis in the same way-by causing damage along the inner lining of the arteries. (nghs.com)
Cause of atherosclerosis1
Known as atherosclerosis2
Inflammation7
  • Moderate drinking of this sort can increase levels of healthy HDL, lower your risk of blood clots, and decrease inflammation. (sharecare.com)
  • Atherosclerosis, which is characterized by chronic inflammation in the arterial wall, is driven by immune cells and cytokines. (hindawi.com)
  • Other factors, such as chronic systemic inflammation that has been tightly linked to accelerated atherosclerosis partially explain the increased CV risk. (bmj.com)
  • Scientists from the Salk Institute and UC San Diego published new findings in Immunity on August 2, 2022, where they examined human blood cells and discovered a surprising link between mitochondria, inflammation and DNMT3A and TET2-two genes that normally help regulate blood cell growth but, when mutated, are associated with an increased risk of atherosclerosis. (news-line.com)
  • But how the DNMT3A and TET2 genes were involved in inflammation, and possibly atherosclerosis, was unknown. (news-line.com)
  • Remarkably, low levels of DNMT3A and TET2 expression in blood cells leads to reduced TFAM expression, which in turn leads to abnormal mitochondria DNA packaging, instigating inflammation due to released mitochondrial DNA. (news-line.com)
  • Missing or reducing this binding activity leads to mitochondrial DNA release and an overactive mitochondrial inflammation response, and we believe this may exacerbate plaque buildup in atherosclerosis. (news-line.com)
Vessel7
  • A special probe is used to direct sound waves into a blood vessel to evaluate blood flow. (hopkinsmedicine.org)
  • An audio receiver amplifies the sound of the blood moving though the vessel. (hopkinsmedicine.org)
  • With this procedure, a long thin tube (catheter) is thread through a blood vessel to the heart. (hopkinsmedicine.org)
  • There, a balloon is inflated to create a bigger opening in the vessel to increase blood flow. (hopkinsmedicine.org)
  • When you get a cut that's deep enough to pierce a blood vessel wall, blood cells called platelets rush to the opening. (healthline.com)
  • Under normal conditions, a thrombus is confined to the immediate area of injury and does not obstruct flow to critical areas, unless the blood vessel lumen is already diminished, as it is in atherosclerosis . (medscape.com)
  • Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. (wjgnet.com)
Lipids4
Treat atherosclerosis1
  • We can now start looking into the use of very tiny particles made from our own red blood cells to treat atherosclerosis and potentially other diseases,' said Professor Lee Chuen Neng from the Department of Surgery, and Nanomedicine Translational Research Programme at NUS Medicine. (news-medical.net)
Prevent atherosclerosis1
Coronary atherosclerosis2
Subclinical atherosclerosis1
  • Herein, the relationship between TREML4 expression and its polymorphisms (rs2803495 and rs280396) was evaluated in patients with subclinical atherosclerosis (n = 340) and heart failure post-acute myocardial infarction (MI) (n = 68) for the first time . (bvsalud.org)
Thickening and hardening o1
Peripheral6
  • Peripheral arteries, which supply blood to the legs, arms and pelvis, also experience marked narrowing due to plaque rupture and clots. (wikipedia.org)
  • In the peripheral blood plasma, TGF- β and IL-10 expression were increased, while the levels of IFN- γ and IL-17 were reduced. (hindawi.com)
  • Atherosclerosis can also impact the peripheral arteries, which supply oxygenated blood to the legs, arms, and pelvis and the renal arteries, which supply blood to the kidneys. (nghs.com)
  • Also the peripheral blood monocytes were isolated and assessed. (healthjockey.com)
  • It is believed that peripheral blood mononuclear cells (PBMCs) play a crucial role in the immune system's ability to tackle infection. (healthjockey.com)
  • Review of the patient's peripheral blood smear from the day of admission showed several monocytes with characteristic morulae. (cdc.gov)
Narrowing of arteries1
Diabetes10
  • The prevention and treatment of atherosclerosis require risk factor control, including the medical management of hypertension, hyperlipidemia and dyslipidemia, diabetes mellitus, and cigarette habituation. (medscape.com)
  • Both type 1 and type 2 diabetes cause high blood sugar, which over time can damage artery walls. (sharecare.com)
  • Many factors contribute to this injury, including high blood pressure, tobacco smoke, diabetes, and high levels of cholesterol in the blood. (msdmanuals.com)
  • This disorder occurs mainly in people who have high blood pressure or diabetes. (msdmanuals.com)
  • In other cases, drugs to control ldl cholesterol statins, in particular and hypertension medications are wanted Your doctor would possibly prescribe low dose aspirin therapy to assist stop heart problems if you re at high risk Treatment for sort 1 diabetes involves insulin injections or the use of an insulin pump, frequent Normal Blood Sugar blood sugar checks, and carbohydrate counting. (2mtravel.ba)
  • A new study is using technology to achieve better control of blood sugar levels early in the the course of type 1 diabetes. (vanderbilt.edu)
  • By using data of large population studies the concept of "Global Cardiovascular Risk" (GCVR) was defined and it was rapidly applied in clinical practice with the elaboration of risk charts, through the development of algorithms for primary prevention of CVD based on the simultaneous analysis of a few main risk factors (age, gender, diabetes, smoking, systolic blood pressure values and total cholesterol). (escardio.org)
  • Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. (wjgnet.com)
  • Atherosclerosis (AS) is one of the most common complications of diabetes. (wjgnet.com)
  • Cerebral blood flow in diabetes mellitus: evi- tions , 1996, 10:228-242. (who.int)
Obesity2
Pathogenesis1
  • Importantly, recent studies have shown that the importance of type 17 T helper cells (Th17 cells) and regulatory T cells (Tregs) in the pathogenesis of various immune disorders, particularly in atherosclerosis. (hindawi.com)
High cholesterol3
Chronic2
  • New research suggests that chronic exposure to ambient ozone may raise the risk of atherosclerosis and harm arterial health. (medicalnewstoday.com)
  • C-reactive protein is an antibody found in the blood in certain acute and chronic conditions including infections and cancers. (cdc.gov)
Clot18
  • Plaques are waxy, fatty deposits made up of cholesterol and other substances like fat, calcium, and fibrin (a protein that helps your blood clot). (sharecare.com)
  • Also called blood thinners, these medicines work differently from antiplatelet medicines to decrease the ability of the blood to clot. (hopkinsmedicine.org)
  • The plaque can also burst, leading to a blood clot. (mayoclinic.org)
  • Sometimes a blood clot completely blocks blood flow. (mayoclinic.org)
  • Normally, this system runs smoothly, but sometimes you can develop a bottleneck called a blood clot . (healthline.com)
  • Sometimes, a blood clot can form inside an artery or a vein when you haven't been injured. (healthline.com)
  • If the plaque bursts open, platelets rush to the scene to heal the injury, forming a blood clot. (healthline.com)
  • A family history of blood clots or an inherited blood-clotting disorder (such as one that makes your blood clot more easily) can put you at risk for developing blood clots. (healthline.com)
  • When you're immobile, your blood flow can slow down, which can cause your blood to clot. (healthline.com)
  • A decrease in blood flow to your legs can lead to deep vein thromboembolism (DVT) , which is a serious form of blood clot. (healthline.com)
  • Additionally, as your body prepares for delivery, your blood begins to clot more easily. (healthline.com)
  • However, this improved ability to clot can also increase your chances of blood clots prior to delivery. (healthline.com)
  • What are the symptoms of a blood clot? (healthline.com)
  • Antithrombotics can be used therapeutically for prevention (primary prevention, secondary prevention) or treatment of a dangerous blood clot (acute thrombus). (cdc.gov)
  • For patient education information, see DVT (Blood Clot in the Leg, Deep Vein Thrombosis) . (medscape.com)
  • If a plaque becomes unstable, a blood clot can form, suddenly blocking an artery. (webmd.com)
  • Smoking encourages plaque buildup and clot formation, which can restrict blood flow to the brain. (medicalnewstoday.com)
  • This can cause a blood clot that can partially or totally block the flow of blood in the artery. (health-care-articles.info)
Buildup of plaque1
Arterial4
  • This may indicate that the association between long-term exposure to ozone and cardiovascular mortality that has been observed in some studies is due to arterial injury and acceleration of atherosclerosis," comments Wang. (medicalnewstoday.com)
  • Atherosclerosis apparently begins with the accumulation of cholesterol-laden foam cells in the arterial wall. (healthjockey.com)
  • IMPLICATIONS: The use of this novel paramagnetic nanoparticle may enable physicians not only to identify arterial plaque through its angiogenic blood supply, but also to track the effectiveness of anti-atherosclerosis therapies. (diagnosticimaging.com)
  • A room air arterial blood gas revealed a pH of 7.43 (reference range 7.38-7.42), PO 2 of 70 mm Hg (reference range 75-100 mm Hg), and PCO 2 of 20 mm Hg (reference range 38-42 mm Hg). (cdc.gov)
Endothelial1
  • This phenomenon in turn is regionally related to a blood flow dependent change in endothelial shear stress. (uni-muenster.de)
Risk in communities1
  • Latent class growth models were used to identify patterns of change in blood pressure across 4 clinical examinations (1987-1998) among 9845 Atherosclerosis Risk in Communities (ARIC) cohort participants (mean age, 53.7 [SD 5.7] years). (uky.edu)
Hypertension3
Diseases4
  • Diseases related to atherosclerosis are the leading cause of death in the United States, according to the National Institutes of Health. (sharecare.com)
  • Other diseases can prevent your body from breaking down blood clots properly when you no longer need them. (healthline.com)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • Thus far, ERT has been largely unsuccessful in improving central nervous system manifestations of the lysosomal storage diseases, putatively due to difficulty in penetrating the blood-brain barrier. (medscape.com)
Fatty5
  • Atherosclerosis is the result of fatty deposits - such as cholesterol , fat, or cellular waste - accumulating inside a person's arteries. (medicalnewstoday.com)
  • Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or blocked blood flow. (msdmanuals.com)
  • Atherosclerosis, the most common type, means hardening related to plaques, which are deposits of fatty materials. (msdmanuals.com)
  • Cholesterol is a fatty substance that naturally occurs in human blood. (webmd.com)
  • Atherosclerosis is a condition in which fatty material collects along the walls of arteries. (health-care-articles.info)
20231
Clinically2
  • Clinically, given enlargement of the arteries for decades, symptomatic atherosclerosis is typically associated with men in their 40s and women in their 50s to 60s. (wikipedia.org)
  • Changes in blood levels of the sex hormone estradiol may provide a clinically useful predictor of death in critically ill or injured patients. (vanderbilt.edu)
Heart21
  • Marked narrowing in the coronary arteries, which are responsible for bringing oxygenated blood to the heart, can produce symptoms such as chest pain of angina and shortness of breath, sweating, nausea, dizziness or light-headedness, breathlessness or palpitations. (wikipedia.org)
  • This is a nuclear scan to see how the heart wall moves and how much blood is expelled with each heartbeat, while the person is at rest. (hopkinsmedicine.org)
  • This is a nuclear scan given while the person is at rest or after exercise that may reveal areas of the heart muscle that are not getting enough blood. (hopkinsmedicine.org)
  • Although atherosclerosis is often considered a heart problem, it can affect arteries anywhere in the body. (mayoclinic.org)
  • If you have atherosclerosis in your heart arteries, you may have chest pain or pressure (angina). (mayoclinic.org)
  • Your body's arteries and veins are a superhighway system designed to transport oxygen-rich blood from your heart to the rest of your body. (healthline.com)
  • They then carry oxygen-depleted blood back from your body to your heart. (healthline.com)
  • The heart muscle needs a constant supply of oxygen-rich blood. (msdmanuals.com)
  • Atherosclerosis can affect the medium-sized and large arteries of the brain, heart, kidneys, other vital organs, and legs. (msdmanuals.com)
  • Damage to the heart muscle results, due to the lack of blood flow. (cdc.gov)
  • Angina is chest pain or discomfort that occurs if an area of your heart muscle doesn't get enough oxygen-rich blood. (cdc.gov)
  • Coronary artery bypass grafting (CABG) is a type of surgery that improves blood flow to the heart. (cdc.gov)
  • These arteries supply oxygen-rich blood to your heart muscle. (cdc.gov)
  • Atherosclerosis in the coronary arteries, for example, can cause angina, which is chest discomfort that occurs when the heart muscle doesn't get enough oxygenated blood. (nghs.com)
  • The heart needs oxygen-rich blood to work properly. (medicalnewstoday.com)
  • When a person inhales cigarette smoke, the toxic chemicals contaminate the blood and reduce the oxygen that the heart and other body parts receive. (medicalnewstoday.com)
  • Nicotine and other toxic chemicals in cigarette smoke can contribute to the narrowing and hardening of the artery walls, restricting blood flow to the heart and increasing the risk of blood clots. (medicalnewstoday.com)
  • Her vital signs were as follows: oral temperature 39.3°C, blood pressure 120/60 mm Hg, heart rate 90 bpm, respiratory rate 16 breaths per min, and oxygen saturation 98% on room air. (cdc.gov)
  • Atherosclerosis can affect the arteries of the brain, heart, kidneys, other vital organs, and the arms and legs. (health-care-articles.info)
  • The blood supply to the heart can also be restored by coronary artery bypass surgery. (health-care-articles.info)
  • Severely restricted blood flow in the arteries to the heart muscle leads to symptoms such as chest pain. (adam.com)
Patients8
  • Some of the most remarkable data in support of a link between autoimmunity and atherosclerosis comes from epidemiological studies of patients with autoimmune disorders (RA and SLE). (nih.gov)
  • Patients were stratified into three ultrasound-based risk categories (low, intermediate and high) according to the severity of atherosclerosis. (bmj.com)
  • Investigations have pointed out that SLE patients have higher chances of being diagnosed with atherosclerosis. (healthjockey.com)
  • Chinese scientists have now found that interferon-alpha (IFN-α) is related to an increased risk of atherosclerosis in SLE patients. (healthjockey.com)
  • In an attempt to highlight the seeming cause of premature atherosclerosis in SLE, investigators examined 42 patients with lupus and 42 healthy volunteers. (healthjockey.com)
  • Autopsies have shown repeatedly that Alzheimer's patients tend to have significantly more atherosclerotic plaque buildup and narrowing of the arteries within the brain, and the clogging of the arteries inside, and leading to, the brain with cholesterol-filled plaque can drastically reduce the amount of blood-and therefore oxygen-your brain receives. (nutritionfacts.org)
  • La vitesse d'écoulement du flux sanguin et l'index de pulsatilité ont été mesurés dans les artères carotides internes intercrâniennes, les artères basilaires et cérébrales moyennes d'un échantillon de 141 patients diabétiques sans autre facteur de risque et de 132 témoins en bonne santé appariés pour l'âge et le sexe. (who.int)
  • Les patients ont été répartis en deux groupes : 73 patients souffrant d'un diabète compliqué dans le premier groupe et 68 patients atteints d'un diabète non compliqué dans le deuxième groupe. (who.int)
Diagnosis1
Systolic blood pr1
Renal1
  • Another significant location for plaque formation is the renal arteries, which supply blood to the kidneys. (wikipedia.org)
Atherosclerotic1
  • Recent evidence suggests that the risk of clinical events is related not only to local factors within the atherosclerotic plaque (such as the state of the necrotic core or the fibrous cap), but also to blood-borne or systemic factors. (medscape.com)
Preclinical2
Asymptomatic1
  • Atherosclerosis is asymptomatic for decades because the arteries enlarge at all plaque locations, thus there is no effect on blood flow. (wikipedia.org)
Occurs4
  • Atherosclerosis, also called hardening of the arteries, occurs when substances such as fat and cholesterol build-up along the walls of the arteries. (nghs.com)
  • Atherosclerosis often occurs as we age, and it progresses gradually as more plaque accumulates. (nghs.com)
  • Researchers aren't entirely certain why atherosclerosis occurs, but there are certain risk factors that can place you at an increased risk of developing the condition. (nghs.com)
  • Atherosclerosis shows no symptoms until a complication occurs. (adam.com)
Accumulation1
Mild2
Triglycerides1
  • Triglycerides are another form of fat in the blood. (webmd.com)
Pressure29
Fats1
Flow17
  • When plaques build up inside your arteries, they cause them to narrow, which cuts down the flow of oxygen-rich blood to your body's organs. (sharecare.com)
  • Because the plaque can disrupt blood flow, your HCP may hear a whooshing sound. (sharecare.com)
  • This is called a bruit, and it's an indication that a plaque is causing turbulent blood flow. (sharecare.com)
  • Signs and symptoms only occur after severe narrowing or closure impedes blood flow to different organs enough to induce symptoms. (wikipedia.org)
  • This reduces blood flow and oxygen supply to the vital body organs and extremities. (hopkinsmedicine.org)
  • The plaque can cause arteries to narrow, blocking blood flow. (mayoclinic.org)
  • Also pay attention to early symptoms caused by a lack of blood flow, such as chest pain (angina), leg pain or numbness. (mayoclinic.org)
  • Blood flow slows, and clots are more likely to form in the sluggish blood. (healthline.com)
  • That can slow down blood flow, especially to your legs. (healthline.com)
  • Normally, the walls of an artery are smooth, allowing blood to flow unimpeded. (medlineplus.gov)
  • Often, the first symptom is pain or cramps at times when blood flow cannot keep up with the tissues' need for oxygen. (msdmanuals.com)
  • This gradually narrows the artery, which limits the flow of oxygenated blood throughout the body. (nghs.com)
  • Red blood cells, blood flow. (istockphoto.com)
  • Without enough blood flow to these tissues, you can't achieve an erection. (healthline.com)
  • Blockages that prevent sufficient blood flow in the coronary arteries can lead to a form of chest pain called angina. (webmd.com)
  • This reduces the space that blood can flow through. (medicalnewstoday.com)
  • In this study, using fluid-structure interaction (FSI), 3-dimensional blood flow in an aneurysm in the circle of Willis - which is located in the middle cerebral artery (MCA) - has been simulated. (karger.com)
Affects1
Clots17
  • These are medicines used to decrease the ability of platelets in the blood to stick together and cause clots. (hopkinsmedicine.org)
  • Where Can Blood Clots Form? (healthline.com)
  • What are blood clots? (healthline.com)
  • Blood clots are solid clumps that form in the blood. (healthline.com)
  • Learn where else blood clots can form, why they can be dangerous, and how to avoid getting them. (healthline.com)
  • Blood clots can form in many different parts of the body. (healthline.com)
  • How do blood clots form? (healthline.com)
  • Who's at risk for blood clots? (healthline.com)
  • You're more likely to get blood clots if you have one of these conditions. (healthline.com)
  • Some cancer treatments (such as chemotherapies) can also increase your risk for blood clots. (healthline.com)
  • Typically, this condition on its own will not cause blood clots unless combined with one or more other risk factors. (healthline.com)
  • If you're going to have surgery, talk to your doctor about ways you can reduce your risk for blood clots . (healthline.com)
  • This can cause blood to pool and form clots. (healthline.com)
  • Pregnancy also increases your risk for blood clots. (healthline.com)
  • An antithrombotic is a drug that reduces the formation of blood clots. (cdc.gov)
  • Atherosclerosis may lead to blood clots that can block the artery or travel to other parts of the body. (medicalnewstoday.com)
  • The FDA has also required that all testosterone products' labels include information on increased risk for blood clots in the veins. (limamemorial.org)