• Abnormal
  • HFpEF is characterized by abnormal diastolic function, which manifests as an increase in the stiffness of the heart's left ventricle and a decrease in left ventricular relaxation when filling with blood before the next beat. (wikipedia.org)
  • More commonly NAFLD is diagnosed following abnormal liver function tests during routine blood tests. (wikipedia.org)
  • genetic
  • A patient's individual genetic makeup may delay or prevent the onset of symptoms. (wikipedia.org)
  • After finding the same symptom in Teddy's sister and investigation revealing an extremely high number of foam cells in not only the tonsils but a wide range of tissues including the bone marrow and spleen, a second trip to the island was made and the discovery was made of very low HDL cholesterol in both the sister and parents of Teddy, evidence for a genetic basis of the disease. (wikipedia.org)
  • In fact, according to the Cleveland Clinic approximately 10% of cases appear to be inherited and often coexists with other genetic abnormalities that affect the blood vessels. (wikipedia.org)
  • HLPIIa is a rare genetic disorder characterized by increased levels of LDL cholesterol in the blood due to the lack of uptake (no Apo B receptors) of LDL particles. (wikipedia.org)
  • mmol
  • The body's homeostatic mechanism of blood sugar regulation (known as glucose homeostasis), when operating normally, restores the blood sugar level to a narrow range of about 4.4 to 6.1 mmol/L (79 to 110 mg/dL) (as measured by a fasting blood glucose test). (wikipedia.org)
  • The normal blood glucose level (tested while fasting) for non-diabetics, should be between 3.9 and 5.5 mmol/L (70 to 100 mg/dL). (wikipedia.org)
  • However, shortly after eating, the blood glucose level may rise, in non-diabetics, temporarily up to 7.8 mmol/L (140 mg/dL) or slightly more. (wikipedia.org)
  • In a healthy adult male of 75 kg with a blood volume of 5 liters, a blood glucose level of 5.5 mmol/L (100 mg/dL) amounts to 5g, equivalent to about a teaspoonful of sugar. (wikipedia.org)
  • predispose
  • There are several conditions that can predispose someone to watershed stroke by increasing the likelihood that insufficient blood supply will be able to reach the brain. (wikipedia.org)
  • lipoproteins
  • This inability to transport cholesterol out of cells leads to a deficiency of high-density lipoproteins in the circulation, which is a risk factor for coronary artery disease. (wikipedia.org)
  • High-density lipoproteins are created when a protein in the bloodstream, Apolipoprotein A1 (apoA1), combines with cholesterol and phospholipids. (wikipedia.org)
  • Reduced blood levels of high-density lipoproteins is sometimes described as hypoalphalipoproteinemia. (wikipedia.org)
  • Since cholesterol is insoluble in water, it is transported in the blood plasma within protein particles (lipoproteins). (wikipedia.org)
  • Hyperlipidaemia is caused by two factors: Hypoproteinemia stimulates protein synthesis in the liver, resulting in the overproduction of lipoproteins. (wikipedia.org)
  • asymptomatic
  • In medicine, a disease is considered asymptomatic if a patient is a carrier for a disease or infection but experiences no symptoms. (wikipedia.org)
  • A condition might be asymptomatic if it fails to show the noticeable symptoms with which it is usually associated. (wikipedia.org)
  • Knowing that a condition is asymptomatic is important because: It may develop symptoms later and so require watch and wait or early treatment. (wikipedia.org)
  • Symptoms of craniocervical involvement include headaches (mostly migraine), pulsatile tinnitus, dizziness, and neck pain, although patients are often asymptomatic. (wikipedia.org)
  • metabolism
  • In animals with lungs, arterial blood carries oxygen from inhaled air to the tissues of the body, and venous blood carries carbon dioxide, a waste product of metabolism produced by cells, from the tissues to the lungs to be exhaled. (wikipedia.org)
  • patients
  • The CVI's Lipid and Cardiovascular Disease Prevention Clinic helps patients with high cholesterol assess and reduce their risk of cardiovascular disease. (bidmc.org)
  • But further investigation showed that only varicoceles patients with symptoms, especially scrotal pain and fertility problems, were at increased risk for these diseases. (hon.ch)
  • Ischemia Ischemia, or inadequate oxygenation of the myocardium, is observed in a high proportion of HFpEF patients. (wikipedia.org)
  • While these drugs are useful for patients with hyperlipidemia, Tangier's disease patients do not benefit from these pharmaceutical interventions. (wikipedia.org)
  • Patients with many different cardiovascular diseases have a higher likelihood of experiencing a blood clot or loss of blood flow in border-zone regions of the brain. (wikipedia.org)
  • The symptoms expressed by FMD patients is largely dependent on the vascular bed(s) affected by the disease. (wikipedia.org)
  • pressure
  • A treatment plan that covers both hypertension and hyperlipdemia includes a healthy diet, regular exercise, and medications to help lower blood pressure an. (reference.com)
  • It is required that a person undergoes treatment so it does not cause later medical problems such as high blood pressure and hyperlipidaemia. (wikipedia.org)
  • Often there is a more dramatic elevation in systolic blood pressure in HFpEF than is typical of HFrEF. (wikipedia.org)
  • High blood pressure mold and force the artery to now take on an elongated, tortuous course to better withstand the higher pressures. (wikipedia.org)
  • Blood pressure may be elevated by pain or decreased by dehydration or bleeding. (wikipedia.org)
  • Albumin is the main protein in plasma, and it functions to regulate the colloidal osmotic pressure of blood. (wikipedia.org)
  • Diagnosis
  • Other diseases (such as mental illnesses) might be considered subclinical if they present some but not all of the symptoms required for a clinical diagnosis. (wikipedia.org)
  • The diagnosis is made on blood tests, often performed as part of screening. (wikipedia.org)
  • A CT scan and MRI are used for diagnosis, and afterward several treatment options are available, including the removal of atherosclerotic plaque and a physical widening of the clogged blood vessel. (wikipedia.org)
  • vessel wall
  • Theories of hormonal influence, mechanical stress from trauma and stress to the artery walls, and also the effect of loss of oxygen supply to the blood vessel wall caused by fibrous lesions. (wikipedia.org)
  • insulin
  • When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. (wikipedia.org)
  • Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. (wikipedia.org)
  • In the setting of insulin resistance, there is elevated lipolysis and release of free fatty acids into the blood stream which contributes to further insulin resistance via increasing hepatic gluconeogenesis and preventing insulin dependent glucose uptake in tissues. (wikipedia.org)
  • artery
  • Complete blockage of a coronary artery leads to an interruption of blood flow to the heart, or a heart attack. (medicinenet.com)
  • Both heart attack and stroke involve the interruption of blood flow to an organ due to a blockage within an artery. (medicinenet.com)
  • Symptoms are commonly associated with the artery being affected. (wikipedia.org)
  • ischemia
  • Watershed strokes are caused by ischemia or a lack of blood flow to the brain. (wikipedia.org)
  • Insufficient blood supply to the heart may cause chest pain, and ischemia of the eye may manifest as transient visual loss in one eye. (wikipedia.org)
  • liver
  • You can also get cholesterol through animal food sources, though these are usually high in saturated and trans fats, which force your liver to make even more cholesterol than it would on its own. (bidmc.org)
  • Native American men have a high prevalence of non-alcoholic fatty liver disease. (wikipedia.org)
  • in fasted individuals, blood glucose is maintained at a constant level at the expense of glycogen stores in the liver and skeletal muscle. (wikipedia.org)
  • cerebellar
  • Additionally, ischemic effects on the brain stem and cerebellar hemispheres as well as symptoms related to hydrocephalus are common. (wikipedia.org)
  • hyperglycemia
  • It is caused in part by prolonged hyperglycemia (high blood sugar) and results in dysfunction of one or both tibial nerves and a plantigrade stance (down on the hocks). (wikipedia.org)