Blood cardioplegic solutions. Medical search. Frequent questions

Both administration of cardioplegic solution and blood reperfusion result in endothelial dysfunction. (elsevierpure.com)
Myocardial contrast echocardiography was also performed in 12 patients undergoing coronary artery bypass who underwent sequential arterial and venous reperfusion after cardioplegic arrest. (elsevierpure.com)
The microbubble transit rate was faster with venous than arterial blood reperfusion (p = 0.01), although this gain was diminished when arterial blood reperfusion preceded venous blood reperfusion (p = 0.05). (elsevierpure.com)
Our results indicate that endothelial dysfunction after cardioplegic arrest may be ameliorated by reperfusion with venous rather than arterial blood. (elsevierpure.com)
Then the aorta is cross-clamped and the heart is stopped by injection of a cardioplegic solution (crystalloid or more commonly blood-based) that also contains substances that help myocardial cells tolerate ischemia and reperfusion. (msdmanuals.com)
Several factors such as contact of blood with foreign surfaces, surgical trauma, ischemia reperfusion to the organs, and release of endotoxin have been widely documented to cause SIRS after CPB. (peertechzpublications.com)
A compounding factor in critically ill or cardiac surgical patients with compromised circulation is that the glycocalyx is easily disrupted by hypoxia, 6 by use of cold cardioplegia solutions, 7 and with ischemia-reperfusion. (silverchair.com)
CONCLUSION: Nondiluted blood cardioplegic solution supplemented with 4 mmol/L of L-arginine was associated with a significant decrease of myocardial lactate release after aortic cross-clamping and reperfusion during CABG surgery. (druglib.com)

Accordingly, we performed myocardial contrast echocardiography in 12 dogs undergoing cardiopulmonary bypass and measured the myocardial transit rate of microbubbles injected into the aortic root during delivery, of cardioplegic solutions containing arterial and venous blood and delivery of pure crystalloid cardioplegic solution. (elsevierpure.com)
Do … The potential for enhancing myocardial protection by adding high-energy phosphates to cardioplegic solutions was investigated in a rat heart model of cardiopulmonary bypass and ischemic arrest. (jrpole.com)

In the third and fourth groups, in addition to 28ºC systemic hypothermia, coronary infusion of 4ºC cardioplegic solutions were performed immediately and after 30 minutes of clamping of the aorta. (rbccv.org.br)

Cardioplegic solution was delivered in antegrade and retrograde fashion in both groups. (tubitak.gov.tr)
2582 received blood cardioplegia and 2462 patients received crystalloid cardioplegia Most trials assessed at least 1 co-intervention including temperature (warm vs. cold), timing (intermittent vs. continuous), and/or route of delivery (antegrade, antegrade/retrograde) Elective CABG surgery trials (n=18). (bestbets.org)
Myocardial protection was implemented by means of retrograde cardioplegia with continuous retrograde cold blood perfusion. (biomedcentral.com)

The aim of this work was to question the necessity of repeated administration of warm blood cardioplegia in modern cardiac surgery. (shengsci.com)
The clinical safety of the first shot of warm blood cardioplegia might be exceeding 20 min. (shengsci.com)
Cold crystalloid cardioplegia ("St. Thomas solution") or warm-blood cardioplegia was used according to the surgeon's preference to induce and maintain cardioplegic arrest. (biomedcentral.com)

Stop all infusions containing K+ (cardioplegic solution, priming solutions, IVs). (perfusion.com)
At 10°C or 4° C, blood CP infusions did not cause a significant increase in intramyocardial Po 2 , while with crystalloid CP, intramyocardial Po 2 did not increase at any of the three infusion temperatures. (johnshopkins.edu)
My first tasks were to insert an arterial line in the radial artery to monitor blood pressure, and to insert a central venous pressure catheter in the internal jugular vein to administer medication infusions as needed to decrease or increase the blood pressure during the upcoming surgery. (theanesthesiaconsultant.com)

Subsequently, the heart is isolated from the rest of the blood circulation by means of an occlusive cross-clamp placed on the ascending aorta proximal to the innominate artery. (wikipedia.org)
On completion of the vascular anastomoses, the aorta is unclamped, allowing the coronary arteries to be perfused by oxygenated blood, which typically restores cardiac activity. (msdmanuals.com)
Blood samples from the ascending aorta and the coronary sinus catheter were collected before, immediately after and at 20 minutes after aortic cross-clamping. (druglib.com)

Recently, we have shown that blood flow patterns at vein valves induce oscillatory stress genes, which maintain an anticoagulant endothelial phenotype that inhibits spontaneous clotting at vein valves and sinuses, is lost in the presence of DVT in human pathological samples, and is dependent on expression of the transcription factor FOXC2. (gentaurpub.com)
The ability to induce cardiac arrest and facilitate open-heart surgery by infusing a high potassium-containing solution into the coronaries was first demonstrated by Melrose et al. (ccasociety.org)
These solutions induce a hyperpolarizing arrest of the myocardium which decreases energy consumption and intracellular accumulation of Ca 2+ . (ccasociety.org)

Despite many improvements in CPB technology and circuit design, patients still undergo an intense inflammatory response when their blood comes in contact with the nonendothelial surfaces involved in extracorporeal circulation. (medscape.com)
1 Intravascular bubbles, as can occur with extracorporeal circulation or in decompression sickness, obstruct blood flow, initiate clotting, and activate inflammatory pathways. (silverchair.com)

We may conclude that both cardioplegic solutions used, associated to hipothermia, protect efficiently the myocardial cells against anoxia. (rbccv.org.br)

As the cardioplegia solution distributes to the entire myocardium, the ECG will change and eventually asystole will ensue. (wikipedia.org)
Cardioplegic solution is the means by which the ischemic myocardium is protected from cell death. (wikipedia.org)
The del Nido cardioplegia solution was developed for pediatric cardiac surgery due to the specific needs of an immature and developing myocardium. (ccasociety.org)
Electron microscopy also showed less edema of the myocardium and better myofibrillar architecture with del Nido solution. (ccasociety.org)
Total plasmatic nitrite and nitrate ratio and lactate release from the myocardium in the collected blood samples were measured. (druglib.com)

The authors tested the hypothesis that exogenous surfactants delivered intravascularly have differential effects on the rate of restoration of blood flow after heparinase-induced degradation of the endothelial glycocalyx. (silverchair.com)
THE glycocalyx, or endothelial surface layer, incorporates a wide variety of membrane-bound macromolecules that can interact with blood-borne macromolecules. (silverchair.com)

The surgeon plans on using a clear pump prime with a hyperpolarized cardioplegic arrest. (ccasociety.org)
Which cardioplegia solution produces a hyperpolarized cardiac arrest? (ccasociety.org)
Cardioplegic solutions cause diastolic arrest, decrease cardiac metabolic demand, and improve myocardial tolerance to ischemia. (ccasociety.org)
Extracellular cardioplegic solutions often contain high concentrations of sodium (Na + ), calcium (Ca 2+ ), potassium (K + ), magnesium (Mg 2+ ), and bicarbonate and cause cardiac arrest by depolarizing the myocardial membrane. (ccasociety.org)
HTK solution is particularly useful for long complex repairs as it reliably produces cardiac arrest for up to 120 minutes without redosing. (ccasociety.org)

Chemically, the high potassium concentration present in most cardioplegic solutions decreases the membrane resting potential of cardiac cells. (wikipedia.org)

The first group (N.=25) was administered a placebo injection in the blood cardioplegic solution, the second group (N.=25) received an injection of 4 mmol/L of L-arginine and a third group (N.=25) an injection of 6 mmol/L of L-arginine in the blood cardioplegic solution. (druglib.com)

The myocardial protective effects of these 2 different cardioplegic temperatures were compared in terms of the postoperative cardiac index and left ventricle stroke work index, dopamine and dobutamine requirements in the intensive care unit, intra aortic balloon pump requirement, intensive care unit stay length and mortality ratios. (tubitak.gov.tr)
Tong Y, Zhang P, Li S, Yan J, Feng Z, Zhao J, Guo S, Jin Y, Liu J. Perioperative blood product transfusion of two different perfusion strategies on pediatric patients undergoing aortic arch surgery. (ispmcs.org)
Tetralogy of Fallot patients with pulmonary atresia (TOF/PA) present a pulmonary blood supply directly from aortic collateral arteries. (stanford.edu)

There is no consensus regarding the "best" cardioplegia solution. (ccasociety.org)

Injection of 20° C blood CP resulted in a mean increase in intramyocardial oxygen tension (Po 2 ) of 7 mm Hg. (johnshopkins.edu)
MV̇O 2 with each crystalloid CP injection was 0.9 ± 0.1 for 20°C CP, 0.8 ± 0.1 for 10°C blood CP, and 0.7 ± 0.1 for 4°C CP. (johnshopkins.edu)

Under local lidoceine 1% anesthesia, an arterial catheter (20 G) was placed to continuously record blood pressure changes and pulmonary artery catheter was inserted via the right internal jugular or subclavian veins for hemodynamic measurements. (ispub.com)
In addition, there was concern that introducing a Fontan circulation into the biventricular space would cause right ventricular enlargement due to blood flow from the coronary sinus and small cardiac veins if only pulmonary artery blockade and ASD creation were performed. (springeropen.com)
Method: Thirty patients (mean age 56.76 ± 10.20 years) were allocated to two groups, according to the use or not of cardiopulmonary bypasses: group A (n=15) off-pump and group B (n=15) on-pump, with all patients undergoing pre- and post-operative evaluation of the pulmonary function as well as arterial blood gases analysis. (rbccv.org.br)

0.05, 20°C blood CP vs 10°C and 4°C blood CP). (johnshopkins.edu)

To mitigate this effect, contemporary depolarizing cardioplegia solutions contain lidocaine and magnesium. (ccasociety.org)
Del Nido cardioplegia includes lidocaine and magnesium and is categorized as a modified extracellular depolarizing solution. (ccasociety.org)

A high dose of TA does not reduce incidence of blood product transfusion up to day 7, but is more effective than a low dose to decrease transfusion needs, blood loss, and repeat surgery. (perfusion.com)

The Buckberg and St. Thomas' Hospital cardioplegia solutions both contain high K + content and are delivered with blood. (ccasociety.org)
demonstrated a six-fold decrease in the rate of defibrillation post cross-clamp with del Nido cardioplegia compared to the St. Thomas Hospital solution. (ccasociety.org)
Hospital cardioplegic solution. (jrpole.com)

Blood gases were evaluated in the preoperative period and on the first postoperative day. (rbccv.org.br)

Severe trauma patients requiring a major transfusion are twice as likely to die if they receive red blood cells stored for a month or longer, according to research published in BioMed Central's open access journal Critical Care. (perfusion.com)

To assess the effect of temperature, oxygenated blood and crystalloid cardioplegic solutions (CPs) at infusion temperatures of 20°C, 10°C and 4°C were compared. (johnshopkins.edu)

Heart must be enabled, after the necessary adjustments are made thereto, upon submitting a signal to start and to restore its vital functions i.e. to begin again to beat and contract and pump blood throughout the body. (myhealthlegacy.com)
Patel K, Ündar A. Centrifugal Pump Generates Superior Hemodynamic Performance Compared to a new Diagonal Blood Pump in Neonatal and Pediatric ECMO Circuits. (ispmcs.org)

BestBets: Is blood cardioplegia superior to crystalloid cardioplegia? (bestbets.org)
You have always used blood cardioplegia but you start to work for a consultant who uses crystalloid cardioplegia. (bestbets.org)

Evaluation of myocardial protection by cardioplegic solutions and hipothermia in anoxic hearts. (rbccv.org.br)
Wang S, Moroi MK, Kunselman AR, Myers JL, Ündar A. Evaluation of centrifugal blood pumps in terms of hemodynamic performance using simulated neonatal and pediatric ECMO circuits. (ispmcs.org)

When extracellular cardioplegia displaces blood surrounding myocytes, the membrane voltage becomes less negative and the cell depolarizes more readily. (wikipedia.org)

Cardioplegia is a solution given to the heart during cardiac surgery, to minimize the damage caused by myocardial ischemia while the heart is paused. (wikipedia.org)

Most commonly, however, the word cardioplegia refers to the solution used to bring about asystole of the heart, or heart paralysis. (wikipedia.org)

Blood CP at 4° C resulted in significantly poorer preservation of LV function. (johnshopkins.edu)

He made a great contribution to the solution of the problem of coronary heart disease surgical treatment. (rusannsurg.com)

However, a recent 2018 study by Panigrahi et al suggests that the del Nido solution may offer some additional benefits including quicker resumption of normal cardiac rhythm and decreased inotropic support compared to conventional blood cardioplegia. (ccasociety.org)

L-arginine supplemented nondiluted blood cardioplegia: a clinical trial. (druglib.com)

Tepid Versus Cold Blood Cardioplegia in Patients with Low Preoperative" by RAHMİ ZEYBEK, EGEMEN TÜZÜN et al. (tubitak.gov.tr)
Patients undergoing aortocoronary bypass surgery were randomly assigned to receive cold (+10 ^oC, Group A, n: 36) or tepid (+29 ^oC, Group B, n: 47) blood cardioplegia. (tubitak.gov.tr)
A consecutive series of 4014 patients underwent cardiosurgical procedures in the period from January 2001 to December 2006 in our centre, where modified Calafiore warm blood-cardioplegic solution was used. (shengsci.com)
1708 patients received a single shot of cardioplegia instead of repeated blood cardioplegia (every 20 min). (shengsci.com)
bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)

This device, otherwise known as the heart-lung machine, takes over the functions of gas exchange by the lung and blood circulation by the heart. (wikipedia.org)
During this period of heart isolation, the heart is not receiving any blood flow, thus no oxygen for metabolism. (wikipedia.org)
Special solutions, called cardioplegic, stop the heart. (myhealthlegacy.com)

0.001, 20°C blood vs 10°C and 4°C blood). (johnshopkins.edu)

Reasonably specific markers for blood tests including creatine kinase muscle/brain isoform (CK-MB), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are released after the onset of significant necrosis instead of early ischemia, and they all require a level of myocardial necrosis to prompt their release from myocytes before they can be detected. (biomedcentral.com)

The main goals of hypothermic cardioplegia are: Immediate and sustained electromechanical quiescence Rapid and sustained homogeneous myocardial cooling Maintenance of therapeutic additives in effective concentrations Periodic washout of metabolic inhibitors The most common procedure for accomplishing asystole is infusing cold cardioplegic solution into the coronary circulation. (wikipedia.org)

blood of abundant peripheral number symptom may process to applicant account of knowledge phosphocreatine in measurements with central allergy treatment: fibroblasts from the related function cancer foot( RALES). (augenta.net)

In the first group (control), myocardial anoxia was induced in normothermia and no cardioplegic solution was administered. (rbccv.org.br)
In the second group, the body temperature was reduced to 28ºC before the onset of myocardial anoxia, and no cardioplegic solution was used. (rbccv.org.br)

An investigation into the effects of glycocalyx injury on embolism bubble adhesion and use of pharmacologic agents targeted to reduce blood flow obstruction is warranted. (silverchair.com)

Intracellular cardioplegia solutions have low levels of Na + and Ca 2+ mimicking the intracellular electrolyte concentration. (ccasociety.org)

If such narrowing or blockage is ascertained must be performed an operation for bypassing the site of clogging using a blood vessel taken from the patient. (myhealthlegacy.com)

Tension developing at the suture line of the side-to-side coronary anastomosis and/or blood accumulation within the space around the graft conveyed significant risk of coronary artery dehiscence, pseudo-aneurysm formation and reoperation 1, 2 . (jsurgery.com)

These data show that blood CP is most effective when infused at 20°C. The use of 10°C blood CP enhanced myocardial cooling, but was of no additional benefit, presumably because there was little oxygen delivery. (johnshopkins.edu)

The myocardial transit rate of 99m Tc- labeled red blood cells was measured and perfusates were sampled for biochemical analysis at each stage. (elsevierpure.com)

Our results indicate that cardioplegic solution-enriched with hypoxic CM-BMSCs can be a novel and promising preservation solution for donor hearts. (researchsquare.com)

Donor hearts were explanted, stored in cardioplegic solution supplemented with either a medium (Vehicle), normoxic CM (N-CM), or hypoxic CM (H-CM), and then heterotopically transplanted. (researchsquare.com)

AR-42 is a small molecule which crosses the blood brain barrier (BBB) in rodents, but the investigators are not certain yet if it will penetrate human VS. Meningiomas are outside the BBB, but seem to be unusually resistant to all current medical treatments. (stanford.edu)

The red blood cell transit rate remained constant regardless of the cardioplegic perfusate infused. (elsevierpure.com)

The time to bubble clearance and restoration of blood flow was longest with heparinase alone and shortest with Pluronic F-127 alone. (silverchair.com)

Changes in lifestyle, consumption and eating habits due to increasing prosperity lead to an increase in lifestyle diseases such as high blood pressure, diabetes, obesity, or overweight. (melchers-china.com)

The blood is a forward Early salvage into an oxidation file and is concentrations to regulate its digoxin through the polypeptides. (augenta.net)

Anatomy2

Diseases1

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes1

Information Science1

Reperfusion8

Cardiopulmonary bypass2

Systemic hypothermia1

Retrograde3

Warm blood cardioplegia3

Infusions3

Aorta3

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Extracorporeal2

Myocardial cells1

Myocardium5

Endothelial2

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Cardioplegia solution1

Injection2

Pulmonary3

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Lidocaine2

Product transfusion1

Hospital3

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Pump2

Crystalloid cardioplegia2

Evaluation2

Extracellular1

Cardiac surgery1

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Coronary heart d1

Inotropic support1

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Patients5

Heart3

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Myocytes1

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Oxygen delivery1

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