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  • stimulation
  • The occurrence of transient myocardial ischemia in patients with coronary artery disease during stress is a common problem and has been thought to reflect adrenergic stimulation, with resultant increases in cardiac oxygen consumption. (onlinejacc.org)
  • In contrast, Beta-1 adrenergic receptors are coupled only to Gs, and stimulation of these results in a more diffuse cellular response. (wikipedia.org)
  • tamsulosin
  • 5: The method of claim 1, wherein the agents comprise bromocriptine, metoprolol, and tamsulosin. (patents.com)
  • This is especially the case for Tamsulosin and other alpha-1-a blockers, since alpha-1-a receptors are present also in the iris dilator muscle, which allows unopposed action of the parasympathetically innervated iris constrictor muscle and loss of iris tone. (wikipedia.org)
  • effects
  • The α-adrenergic antagonists have different effects from the β-adrenergic antagonists. (wikipedia.org)
  • While the antagonists for alpha and beta receptors are usually different compounds, there has been recent drug development that effects both types of the adrenoreceptors. (wikipedia.org)
  • As Alpha-1-a blockers affect the symptoms of BPH more specifically than the Alpha-1 blockers, the adverse effects seem to be more linked to the reproductive system while minimizing the effect on the blood-pressure system. (wikipedia.org)
  • It is therefore important when starting treatment with a alpha-1 blocker to monitor the blood pressure to minimize the risk for adverse effects connected to low blood pressure. (wikipedia.org)
  • Because the α1 and α2 receptors have different mechanisms of action, their antagonists also have different effects. (wikipedia.org)
  • Labetalol's dual alpha and beta adrenergic antagonism has different physiological effects in short- and long-term situations. (wikipedia.org)
  • physiological
  • Besides, a pupillary diameter difference less than 1 mm is often a physiological condition occurring in about 20% of the population. (medsci.org)
  • PTSD
  • Furthermore, α-blockers can occasionally be used to treat anxiety and panic disorders, such as Post Traumatic Stress Disorder (PTSD) induced nightmares. (wikipedia.org)
  • doses
  • Neurologic: Headache (2%), Dizziness (11%) Gastrointestinal: Nausea (6%), Dyspepsia (3%) Cholinergic: Nasal congestion (3%), Ejaculation failure (2%) Respiratory: Dyspnea (2%) Other: Fatigue (5%), Vertigo (2%), Orthostatic hypotension Low blood pressure with standing is more severe and more common with IV formulation (58% vs 1%) and is often the reason larger doses of the oral formulation cannot be used. (wikipedia.org)
  • enzyme
  • The control of the operation, in general, involves interaction of a stimulus molecule with a receptor/enzyme subsystem by, typically, binding to the macromolecule A and causing an activation or an inhibition of the subsystem by forming an activated form of the macromolecule B. The following schematic represents the activity: A → p B {\displaystyle A{\xrightarrow {\ \ p\ \ }}B} where p is the activation rate coefficient. (wikipedia.org)
  • The above scheme is only the necessary condition for the rate sensitivity phenomenon, and other pathways of deactivation of B may be considered, with the subsequent return to the inactive form of the receptor/enzyme A. Examples offer particular use of such (mathematical) models in endocrinology, physiology and pharmacology. (wikipedia.org)
  • PtdIns(4,5)P2 is a substrate for hydrolysis by phospholipase C (PLC), a membrane-bound enzyme activated through protein receptors such as α1 adrenergic receptors. (wikipedia.org)
  • benign
  • It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia, although it is currently seldom used for that indication due to unfavourable side effects. (wikipedia.org)
  • beta-blocker
  • Gencaro TM (bucindolol hydrochloride) is a pharmacologically unique beta-blocker and mild vasodilator being developed for the treatment of chronic heart failure (HF). (drugs.com)
  • Gencaro is considered part of the beta-blocker class because of its property of blocking beta-1 as well as beta-2 receptors in the heart, preventing these receptors from binding with other molecules that would otherwise activate the receptor. (drugs.com)
  • The Company's lead product candidate, Gencaro TM (bucindolol hydrochloride), is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for heart failure. (drugs.com)
  • It is administered with a beta-blocker with or without a diuretic. (wikipedia.org)
  • calcium
  • IP3 enters the cytoplasm and activates IP3 receptors on the smooth endoplasmic reticulum (ER), which opens calcium channels on the smooth ER, allowing mobilization of calcium ions through specific Ca2+ channels into the cytosol. (wikipedia.org)
  • increases
  • Inhibition of the reuptake of these neurotransmitters increases their extracellular concentrations and, therefore, results in an increase in serotonergic, adrenergic, and dopaminergic neurotransmission. (wikipedia.org)
  • involves
  • Based on known information about the structures of these receptors, it likely involves attack by the cysteine at position 3.36 in transmembrane helix 3 to form a stable linkage. (wikipedia.org)
  • citation
  • medical citation needed] Desmopressin used in the treatment of type 1 von Willebrand disease is, in general, given every 12-24 hours in limited numbers due to its tachyphylactic properties. (wikipedia.org)
  • side-effects
  • The main limiting side-effects of alpha antagonists is that the baroreceptor reflex is disrupted and thus this can cause postural hypotension. (wikipedia.org)
  • drug
  • Through the use of PI-specific kinase/phosphatase identification and PI antibody/drug/blocker discovery, the role of PI (especially PI(4,5)P2) in secretion regulation was extensively investigated. (wikipedia.org)
  • position
  • Furthermore, we believe alpha-2C-receptor genetic biomarkers may be combined with the already reported beta1 receptor position 389 genetic biomarkers to define which patients are most likely to respond to this pharmacologically unique beta-blocking agent. (drugs.com)
  • medical
  • Much, our women demonstrated that a sildenafil of small men are before tolerated by little example 5, and amongst these, sex gave an medical flow of dopamine-receptor animal plasma, publicity, validity and in patriarchal clubs. (oxfamopen.com)
  • drugs
  • Although their primary mechanisms of action are as NMDA receptor antagonists, ketamine and phencyclidine are also SNDRIs and are similarly encountered as drugs of abuse. (wikipedia.org)
  • long term
  • In long-term studies finasteride but not alpha-1 inhibitors reduce the risk of acute urinary retention (−57% at 4 years) and the need for surgery (−54% at 4 years). (wikipedia.org)
  • plasma
  • alpha chain disease the most common heavy chain disease , occurring predominantly in young adults in the Mediterranean area, and characterized by plasma cell infiltration of the lamina propria of the small intestine resulting in malabsorption with diarrhea, abdominal pain, and weight loss, or, exceedingly rarely, by pulmonary involvement. (thefreedictionary.com)