• decreases
  • Cyclophosphamide decreases the immune system's response , and although concerns about toxicity restrict its use to patients with severe disease, it remains an important treatment for life-threatening autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. (wikipedia.org)
  • bowel
  • Individuals affected by the disorder may ultimately lose the ability to initiate and control all voluntary movement, although bladder and bowel function and the muscles responsible for eye movement are usually spared until the final stages of the disorder. (wikipedia.org)
  • Cystitis
  • At the end we describe an excellent and widely used animal model of cyclophosphamide induced cystitis, which gives researches the opportunity to get a better insight into the mechanisms involved and possibility to develop new therapy approaches. (hindawi.com)
  • treatment
  • Cyclophosphamide, used in combination with thalidomide or lenalidomide and dexamethasone has documented efficacy as an off-label treatment of AL amyloidosis. (wikipedia.org)
  • In some cases, the second malignancy developed several years after cyclophosphamide treatment had been discontinued. (cancermonthly.com)
  • the treatment of Wegner's vasculitis is starting to pulse-therapy of Methyl-Prednisolone in 5 times and fallow by Prednisolone 1mg/kg/day and cyclophosphamide pulse(500mg) furthermore the level of serum creatinine is decreased. (medcraveonline.com)
  • agents
  • Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women ( pregnancy category D) except for life-threatening circumstances in the mother. (wikipedia.org)
  • side
  • Common side effects include low white blood cell counts , loss of appetite, vomiting, hair loss , and bleeding from the bladder . (wikipedia.org)
  • function
  • In this respect, urothelium releases various mediators and neurotransmitters to reflect its degree of physical distension, so that both sympathetic and parasympathetic nerves can coordinate normal bladder function during filling and voiding [ 8 ]. (hindawi.com)
  • human
  • Muscularis mucosa is not very well defined in the human bladder and sometimes seems to be absent [ 1 ]. (hindawi.com)