• progressive multifocal leukoenc
  • BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients, JC virus with progressive multifocal leukoencephalopathy, and Merkel cell virus with Merkel cell cancer. (wikipedia.org)
  • Major conducts research into the neurological diseases including progressive multifocal leukoencephalopathy (PML), caused by JC virus and often found in immunosuppressed patients such as those with HIV/AIDS. (wikipedia.org)
  • This variant has been associated with a disease recently described from case reports called JC virus encephalopathy, distinct from progressive multifocal leukoencephalopathy (PML), which has long been associated with JC in immunocompromised individuals. (wikipedia.org)
  • adenoviruses
  • It possesses in vitro activity against the following viruses: Human herpesviruses Adenoviruses Human poxviruses (including the smallpox virus) Human papillomavirus Cidofovir was discovered at the Institute of Organic Chemistry and Biochemistry, Prague, by Antonín Holý, and developed by Gilead Sciences and is marketed with the brand name Vistide by Gilead in the USA, and by Pfizer elsewhere. (wikipedia.org)
  • varicella-zoste
  • It has inhibitory effects on varicella-zoster virus replication in vitro although no clinical trials have been done to date, likely due to the abundance of safer alternatives such as aciclovir. (wikipedia.org)
  • Some patients may not mount protective antibody titers to other vaccines, such as measles and varicella zoster virus. (wikipedia.org)
  • urine
  • It has been suggested that this virus may be transmitted through respiratory fluids or urine, since infected individuals periodically excrete virus in the urine. (wikipedia.org)
  • This virus can be diagnosed by a BKV blood test or a urine test for decoy cells, in addition to carrying out a biopsy in the kidneys. (wikipedia.org)
  • SV40
  • Agnoprotein is typically quite short: examples from BK virus, JC virus, and SV40 are 62, 71, and 66 amino acid residues long, respectively. (wikipedia.org)
  • The BK, JC, and SV40 agnoproteins have all been experimentally demonstrated to be phosphorylated in vivo, which appears to improve both protein stability and viral propagation, but no other post-translational modifications have been detected. (wikipedia.org)
  • the BK, JC, and SV40 examples are by far the best-studied and have fairly high sequence conservation. (wikipedia.org)
  • clinical
  • CONCLUSIONS: This is the first study to identify BK virus proteins in clinical samples by MS and that this approach makes it possible to distinguish between different viral subtypes. (ox.ac.uk)
  • Cidofovir
  • Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability. (wikipedia.org)
  • vitro
  • Preliminary in vitro tests have also shown it to have potential for the treatment of Ebola virus disease, which is somewhat paradoxical, as Ebola is not a DNA virus. (wikipedia.org)
  • recipients
  • In immunodeficient individuals, such as transplant recipients or severely immuncompromised HIV-infected individuals, viruses in general more often reactivate owing to a lack of immunologic surveillance. (wikipedia.org)
  • immunosuppression
  • It is thought that up to 80% of the population contains a latent form of this virus, which remains latent until the body undergoes some form of immunosuppression. (wikipedia.org)
  • protein
  • It has also been suggested that agnoprotein functions as a viroporin - that is, a viral protein that alters membrane permeability to facilitate the virus particles' exit from the cell. (wikipedia.org)
  • antibodies
  • Both of these viruses can be identified and differentiated from each other by carrying out serological tests using specific antibodies or by using a PCR based genotyping approach. (wikipedia.org)
  • disease
  • Major has been quoted extensively in news coverage of the finding that natalizumab (Tysabri) and related monoclonal antibody-based therapies increase the risk of a rare brain disease caused by JC virus. (wikipedia.org)
  • On October 6, 2014, Chimerix received an FDA authorization for emergency investigational new drug applications of brincidofovir for the treatment of Ebola virus disease. (wikipedia.org)
  • Brincidofovir was administered to the first patient diagnosed in the Ebola virus disease outbreak in the US in 2014. (wikipedia.org)
  • citation needed] Brincidofovir is one of several experimental drugs administered to a small number of patients to treat Ebola virus disease during the 2014 outbreak. (wikipedia.org)
  • donor
  • The Investigators have grown T cells from the subject's stem cell donor in the laboratory in a way that will train them to recognize the viruses and control them when the T cells are given after a transplant. (clinicaltrials.gov)
  • These peptides stimulate donor T cells that react against the viruses to grow and train the donor T cells to kill cells that are infected with CMV, EBV, adenovirus, BKV and HHV6. (clinicaltrials.gov)
  • interactions
  • However, in general virus-cell interactions are mediated by commonly occurring molecules on the cell surface, and therefore are likely not a major contributor to individual viruses' observed cell-type tropism. (wikipedia.org)
  • species
  • As of the most recent (2016) taxonomy release by the International Committee on Taxonomy of Viruses, there were 77 recognized species in this family contained within four genera, as well as three species that could not be assigned to a genus. (wikipedia.org)
  • cells
  • This treatment with specially trained T cells (also called cytotoxic T cells or 'CTLs') has had activity against three of these viruses (CMV, EBV and Adenovirus) in previous studies. (clinicaltrials.gov)
  • In this study the Investigators want to see if they increase the number of viruses that can be targeted to include BKV and HHV6 using a simple and fast approach to make the cells. (clinicaltrials.gov)
  • Once sufficient numbers of T cells were made, they were tested to make sure they would target the cells infected with these viruses but not the normal cells. (clinicaltrials.gov)
  • Decoy cells are virus infected urothelial cells with a distinct morphology of enlarged nuclei and intranuclear inclusions. (wikipedia.org)
  • cause
  • When immunity is weak, the virus can become active and cause fevers, enlarged lymph nodes and sometimes a type of cancer called lymphoma. (clinicaltrials.gov)
  • cell
  • for example, the JC virus is believed to require interaction with the 5HT2A receptor and the Merkel cell virus with heparan sulfate. (wikipedia.org)
  • After binding to molecules on the cell surface, the virion is endocytosed and enters the endoplasmic reticulum - a behavior unique among known non-enveloped viruses - where the viral capsid structure is likely to be disrupted by action of host cell disulfide isomerase enzymes. (wikipedia.org)
  • Deletion of the nucleotides in this region has been associated with a variant JC virus capable of infecting cell types not normally targeted by this virus. (wikipedia.org)