• Urinary
  • Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. (aspetjournals.org)
  • fate
  • Therefore, they have a number of common and inter-related metabolic features, and data on one or more members of a group being evaluated can be used to predict the metabolic fate of analogues for which there were no data. (inchem.org)
  • Male
  • 1% EVALUATION FOR ACCEPTABLE DAILY INTAKE BIOCHEMICAL ASPECTS Biotransformation Male and female rats were pretreated with single daily oral doses of analytical grade acephate (25 mg/kg/day) for 7 days followed by a dose of S-methyl 14 C acephate. (inchem.org)
  • individual
  • In conclusion, this study suggests that the traditional metabolic ratio is not a true measure of the debrisoquine 4-hydroxylation capacity of an individual and thus may, in part, explain the wide intragenotype variation in metabolic ratio. (aspetjournals.org)
  • fully
  • Since only the mentioned metabolites could be detected, the metabolic pathway of acephate is not fully elucidated. (inchem.org)