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  • pathways
  • Biotin affects gene regulation by "classic" signaling pathways such as cyclic guanosine monophosphate, nuclear factor-κB, Sp1 and Sp3, nitric oxide, and receptor tyrosine kinases, by the intermediate biotinyl-5′-adenosyl monophosphate, and at the posttranscriptional level ( 1 ). (pubmedcentralcanada.ca)
  • protein
  • The attachment of biotin to various molecules, biotinylation, is used as an important laboratory technique to study various processes, including protein localization, protein interactions, DNA transcription, and replication. (wikipedia.org)
  • Biotin hydrazide is a biotinyl derivative that can be used as a probe for the determination of protein carbonylation. (wikipedia.org)
  • A common use of biotin PEG2 amine is to use EDC and crosslink the amine in the biotin PEG2 amine to carboxyl groups on protein residues that are either aspartate or glutamate or the carboxy-terminus of proteins. (wikipedia.org)
  • propionyl-CoA carboxy
  • The most reliable and commonly used methods for determining biotin status in the body are: excretion of 3-hydroxyisovaleric acid and biotin in urine activity of propionyl-CoA carboxylase in lymphocytes In the United States, biotin supplements are readily available without a prescription in amounts ranging from 1,000 to 10,000 micrograms (30 micrograms is identified as Adequate Intake). (wikipedia.org)
  • proteins
  • Biotinidase itself is known to be able to biotinylate histone proteins, but little biotin is found naturally attached to chromatin. (wikipedia.org)
  • catabolism
  • Evidence suggests that biotin catabolism is accelerated in pregnancy and that about half of pregnant women in the United States are marginally biotin deficient ( 1 ). (pubmedcentralcanada.ca)
  • Evidence suggests that these anticonvulsants accelerate biotin catabolism, which means that it's necessary for people to take supplemental biotin, in addition to the usual minimum daily requirements, if they're treated with anticonvulsant medication(s) that have been linked to biotin deficiency. (wikipedia.org)
  • Pregnancy Smoking: Recent studies suggest that smoking can lead to marginal biotin deficiency because it speeds up biotin catabolism (especially in women). (wikipedia.org)
  • reduced symptoms
  • Back in the 1940s, a researcher demonstrated that adding high biotin foods into the diet of a lactating mother reduced symptoms of cradle cap in nursing infants. (whfoods.com)
  • Sternbach
  • With Leo Sternbach, Goldberg patented a process for synthesizing biotin in 1949. (wikipedia.org)
  • With Moses Wolf Goldberg, Sternbach also developed "the first commercially applicable" method for synthesizing biotin. (wikipedia.org)
  • impair
  • Diets low in biotin impair the production of insulin, a key hormone in the balancing of blood sugar. (whfoods.com)
  • excretion
  • Biotin status is typically assessed by quantifying the urinary excretion of biotin and its major metabolites (~120 nmoles/d), the activity of PCC or MCC in lymphocytes, and the abundance of biotinylated carboxylases in cell extracts ( 1 ). (pubmedcentralcanada.ca)
  • supplements
  • Biotin supplements may help lower high blood pressure. (livestrong.com)
  • A healthy diet and exercise, along with certain medications and supplements such as biotin may help regulate the blood pressure and prevent the complications associated with it. (livestrong.com)
  • In case of a deficiency, your doctor may recommend biotin supplements that are available as capsules, tablets and syrups. (livestrong.com)
  • Biotin supplements are generally safe and well-tolerated when used at recommended doses. (livestrong.com)
  • Although you do not require a prescription to buy biotin supplements in the United States, you must talk to a doctor before using them to lower your blood pressure. (livestrong.com)
  • Uses: Supplements are prescribed to treat biotin deficiency, which is caused by rare genetic disorders. (latimes.com)
  • Dose: Biotin is available by itself and in many multi-ingredient supplements. (latimes.com)
  • Precautions: Biotin supplements are generally considered safe. (latimes.com)
  • Research: There's no good evidence that biotin supplements can reduce acne, tame cowlicks or reverse hair loss or graying. (latimes.com)
  • genetic
  • citation needed] In all cases - dietary, genetic, or otherwise - supplementation with biotin is the primary method of treatment. (wikipedia.org)
  • almonds
  • While we are still learning about how rich many of the World's Healthiest Foods are as biotin sources, we already know that we have tomatoes as an excellent source of biotin, and almonds as a very good source. (whfoods.com)
  • fatty
  • Although this research hasn't been followed up in more modern settings, we think that nursing moms could consider focusing on foods high in both biotin and omega-3 fatty acids , including salmon and eggs from pasture-raised chickens . (whfoods.com)
  • whites
  • Biotin first came to the attention of researchers for what is still its most famous characteristic-that raw egg whites can interfere with biotin nutrition. (whfoods.com)
  • Diets
  • Balanced diets normally provide all the biotin people need -- the vitamin is particularly plentiful in liver, egg yolks, yeast, salmon, carrots and peanuts. (latimes.com)