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  • organism
  • Although the structure of 14α-demethylase may vary substantially from one organism to the next, sequence alignment analysis reveals that there are six regions in the protein that are highly conserved in eukaryotes . (wikipedia.org)
  • lipid
  • A large family of lipid triterpenoids (a class of isoprenoids) called hopanoids and sterols are found in bacteria and eukaryotes, respectively. (omicsonline.org)
  • Sterols are known to be involved in cell signaling, in transport and distribution of lipophilic molecules, and in formation of lipid rafts [ 1 - 7 ]. (omicsonline.org)
  • steroid
  • A number of steroid hormones like testosterone and estrogen in mammals, brassinosteroids (BRs) in plants, and ecdysteroids in arthropods are synthesized from sterols as precursor. (omicsonline.org)
  • cell
  • This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell. (wikipedia.org)
  • plant
  • While plant sterols are usually beneficial, there is a rare autosomal recessive genetic disorder phytosterolemia which causes over-absorption of phytosterols. (wikipedia.org)
  • results
  • These results suggest that CYP158A3 might be an orthologue of biflaviolin synthase, catalyzing C-C coupling reactions during pigment biosynthesis in S. avermitilis . (biomolther.org)
  • metabolism
  • Biochemical aspects (a) Absorption, distribution, and excretion Triforine labelled with either 3 H in the piperazine ring or with 14 C in the side chains was administered orally to male FW-49 rats at doses of 9-200 mg/kg bw (see Table 1) in studies that allowed some aspects of their metabolism and disposition to be compared. (inchem.org)
  • found
  • 1992) a 10 14 days unlabelled followed by 10 1 day labelled After dosing with [piperazine- 3 H]-triforine (experiment 1), the maximal blood concentrations of radioactivity were found after 4 h and represented 1.3% of the dose. (inchem.org)
  • days
  • The absorption and disposition of 14 C-triforine suspended in 5% aqueous sodium carboxymethylcellulose was studied in male and female CD Sprague-Dawley-derived rats at doses of 10 mg/kg bw, as a single dose and after treatment with unlabelled triforine for 14 days, and 1000 mg/kg bw as a single radiolabelled dose (experiment 5). (inchem.org)
  • After 14 days at room temperature, the reverse is colourless to light brown. (wikipedia.org)
  • side
  • Both side-chain and ring-labelled 14 C-triforine were available, but piperazine ring-labelled 14 C-triforine was used only in a pilot experiment in which a single dose of 10 mg/kg bw was administered to two male and two female rats. (inchem.org)
  • analysis
  • Analysis by thin-layer chromatography showed that the biliary residue after administration of the 14 C label consisted of four main components, whereas with the H label only two of these components were present, corresponding to the two major urinary metabolites, one of which was identified as N-[2,2,2-trichloro-1-(piperazin-1-yl)ethyl]formamide (Darda, 1977). (inchem.org)
  • Although the structure of 14α-demethylase may vary substantially from one organism to the next, sequence alignment analysis reveals that there are six regions in the protein that are highly conserved in eukaryotes (Lepesheva et al. (wikipedia.org)