• Organism
  • Although the structure of 14α-demethylase may vary substantially from one organism to the next, sequence alignment analysis reveals that there are six regions in the protein that are highly conserved in eukaryotes (Lepesheva et al. (wikipedia.org)
  • squalene
  • In the biosynthesis of viridiol by Gliocladium deliquescens, the 3β-OH reduced form of viridin, the incorporation of squalene, lanosterol, dehydroxydemethoxyviridin, and demethoxyviridin was reported. (wikipedia.org)
  • eukaryotes
  • A large family of lipid triterpenoids (a class of isoprenoids) called hopanoids and sterols are found in bacteria and eukaryotes, respectively. (omicsonline.org)
  • Sterols possess different functions and they contribute to cellular physiology in eukaryotes. (omicsonline.org)
  • plant
  • While plant sterols are usually beneficial, there is a rare autosomal recessive genetic disorder phytosterolemia which causes over-absorption of phytosterols. (wikipedia.org)
  • cell
  • This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell (Lepesheva et al. (wikipedia.org)
  • Sterols are known to be involved in cell signaling, in transport and distribution of lipophilic molecules, and in formation of lipid rafts [ 1 - 7 ]. (omicsonline.org)
  • side chain
  • Although the mechanisms and order of the remaining steps from lanosterol to viridin are not certain, these include the formation of the furan ring, the loss of C-13 and C-14 methyl groups, aromatization of the C-ring, removal of the side chain, and oxidation of the A-ring. (wikipedia.org)