Biomedical research models genetic. Medical search. Frequent questions

Researchers in Bar Harbor investigate the genetic causes of human disease by using the mouse as a model. (jax.org)
JAX Japan provides researchers in Japan, Korea and Taiwan with direct access to the highest standard of leading-edge animal research models as well as services, technical support and scientific expertise. (jax.org)
A team of researchers from the Spanish National Research Council (CSIC) and the University of Cordoba has managed to rise 50 times the values of omega -3 fatty acid in goat milk without genetic manipulation of animals. (uco.es)
For this reason, researchers are increasingly focusing on mouse populations with high genetic diversity. (jax.org)
Moving forward, biomedical researchers will have access to research capabilities that enable them to explore biology, function and disease at a previously unobtainable level of detail. (jax.org)
These awards are targeted toward researchers whose doctoral training is in one of the physical, chemical or computational sciences and who intend to pursue academic research doing work that addresses biological questions. (unclineberger.org)
Collaborative Research Travel Grants provide up to $15,000 in support for interdisciplinary biomedical researchers from degree-granting institutions to travel to a laboratory to acquire a new research technique or to facilitate collaboration. (unclineberger.org)
Faced with myriad possibilities, modeling points researchers to designs that offer real opportunity. (northwestern.edu)
The UNC School of Medicine has named three researchers as recipients of the fifth annual Yang Family Biomedical Scholars Award. (unchealthcare.org)
The researchers are now members of the Yang Family Society of Biomedical Scholars. (unchealthcare.org)
We are extremely pleased that Mr. Yang and Mr. Wu have continued to support the UNC School of Medicine's accomplished young researchers who strive each day to create new scientific knowledge with the goal of improving the health of all people," said Blossom Damania, PhD, Vice Dean for Research at the UNC School of Medicine, the Boshamer Distinguished Professor of Microbiology and Immunology, and Lineberger member. (unchealthcare.org)
CRISPR tool allows researchers to create advanced models that can replicate and mimic patient disease conditions, including cancer, tumors, progression, treatment efficacy and responses. (wlns.com)
A joint effort between researchers at Massachusetts General Hospital, health science company ZOE , King's School of Biomedical Engineering & Imaging Sciences, Department of Twin Research & Genetic Epidemiology, and London Medical Imaging and AI Centre for Value Based Healthcare has seen the development of an artificial intelligence diagnostic that can predict whether someone is likely to have COVID-19 based on their symptoms. (kcl.ac.uk)
Researchers from the London AI Centre helped develop the AI model which uses data from the COVID Symptom Study app to predict COVID-19 infection by comparing people's symptoms and the results of traditional COVID tests. (kcl.ac.uk)
The researchers then created a machine learning model that predicted with nearly 80% accuracy whether an individual is likely to have COVID-19 based on their age, sex and a combination of four key symptoms: loss of smell or taste, severe or persistent cough, fatigue and skipping meals. (kcl.ac.uk)
In 1988, the National Library of Medicine (a component of the National Institutes of Health) created the National Center for Biotechnology Information (NCBI) to provide "an integrated, one-stop, genomic information infrastructure for biomedical researchers from around the world. (cdc.gov)
To test their assumption, the researchers used a computer model to simulate the movements of small groups of fish. (uni-konstanz.de)
Our data scientists are helping researchers create reliable ways of collecting and managing data associated with complex studies and genetic sequencing efforts. (medlineplus.gov)
The information explosion in biomedical science has created a huge challenge for researchers, who want to obtain useful information promptly and efficiently. (cdc.gov)
Researchers at Lund University have discovered that a specific group of genetic elements in our DNA influence the development of the human brain, their study was published in Science Advances. (lu.se)
Researchers at Lund University offer new insights in their latest study, published in Science Advances, detailing how a specific group of genetic elements have influenced the development of the human brain over time. (lu.se)

These awards are targeted toward medically trained individuals whose research proposal is in basic biomedical, disease-oriented, translational, or molecular, genetic, or pharmacological epidemiology research, and who intend to pursue careers in academia. (unclineberger.org)
Human genome epidemiology is the basic science for translating genomic research, relating genetic variation with variability in health status among well-defined groups of people. (cdc.gov)
The areas of my research interests include statistical genetics, molecular epidemiology, cancer screening, health policy modeling, and risk prediction modeling. (stanford.edu)
Current Research and Scholarly Interests Traumatic brain injury with a focus on epidemiology and outcomes. (stanford.edu)

The full spectrum of the life science industry - from drug discovery and development to biomanufacturing, stem cell research, bioinformatics, neuroscience, cancer research, genomics, and proteomics - can be found within Scotland's borders. (biopharminternational.com)
We develop and apply innovative approaches, such as CRISPR-based functional genomics, in human iPSC-derived neurons and glia and mouse models to elucidate mechanisms and therapeutic strategies for neurodegenerative diseases. (ucsf.edu)
eling require a broad range of signal processing approaches, Two salient goals of functional genomics are to screen for including signal representation relevant to transcription and key genes and gene combinations that explain specific cel- system modeling using nonlinear dynamical systems. (lu.se)
He holds an M.S. degree in computer sci- damental discipline that brings to genomics the structural ence from Stevens Institute of Technology model-based analysis and synthesis that form the basis of in 1986 and a Ph.D. degree in mathemat- ics from Rutgers University in 1974. (lu.se)
Utilizing comprehensive biobanks, genomics methods and in vitro model systems we aim to improve our understanding of tumour evolution, heterogeneity and therapy response. (lu.se)

Currently I am studying the molecular and genetic aspects of the vascular disease cerebral cavernous malformations (CCM). (uni-potsdam.de)
Molecular pathways involved in this disease have been described, however, the very onset or non-genetic triggers that cause CCM remain undetermined. (uni-potsdam.de)
Create tools to understand the multi-scaled genetic, molecular, and cellular components of disease. (jhu.edu)
Zebrafish are amenable to genetic manipulation, for which innovative genetic and molecular techniques are constantly being introduced. (weizmann.ac.il)
Using a series of genetic, biochemical, molecular and cell biological, and computational approaches in model organisms from Drosophila to Zebrafish to mice, we have defined both canonical and non-degradative functions of UVRAG and the autophagy pathway in multiple endomembrane trafficking (Nat Cell Bio. (upenn.edu)
Such models give valuable insights into the real disease and enable the reliable investigation of the underlying molecular mechanisms and the effective development of therapeutic approaches. (eceae.org)
Dr. Liu uses genetic, molecular, and cell biology approaches to study cardiac development and function. (unchealthcare.org)
The Gene Editing Market is experiencing growing demand for personalized medicine aimed at customizing medical treatments based on patients' unique genetic and molecular profiles with a focus on enhancing treatment efficacy and curbing any potential negative effects. (wlns.com)
In particular, hiPSC-based models provide a powerful tool to identify genetic risk factors, and to study cellular and molecular mechanisms that contribute to the pathogenesis of a disease. (frontiersin.org)

They have shown that UVRAG function and autophagy are inactivated by oncogenes such as cellular Bcl-2 and oncogenic γ-herpesvirus-encoded Bcl-2 proteins, by the oncogenic BRAF kinase, and by genetic mutations that increase inflammation and cancer susceptibility and can also be hitchhiked by viruses for their efficient infection. (upenn.edu)
Recent multi-omics studies have revealed the heterogeneity and complexity of tumor features such as their genetic mutations, transcriptome, proteins, and signaling pathways. (rsc.org)
Organoids derived from patients suffering from a genetic disorder conserve the genetic mutations in vitro. (eceae.org)
By the 1990s, OMIM was adding more than 150 disease-related genetic variants per year, nearly all of them rare mutations discovered in families ( 1 ). (cdc.gov)
Genetic mutations associated with neurological disorders in humans alter these behavioural responses and, as a consequence, the group behaviour of the larvae. (uni-konstanz.de)
It is a very difficult to treat because its tumors tend to develop aggressive genetic mutations that make it resistant to many drugs, and it is typically diagnosed very late, when it has already spread to other sites in the body. (news-medical.net)

From rural countryside to bustling cities, each JAX location has a different focus and a unique combination of programs that align to advance our common mission - to discover precise genomic solutions for disease and empower the biomedical research community in our shared quest to improve human health. (jax.org)
With the available tools of the genomic era and the abundance of disease-associated human genes yet to be explored, the zebrafish model is becoming the preferred choice in basic and applied life sciences. (weizmann.ac.il)
DO mice have profound trait differences between individual mice, providing a powerful genetic mapping platform to identify associations between the traits and specific genomic regions. (jax.org)
More recently, biomedical engineering techniques applied genetic and genomic tools to develop knockout or transgenic animals that are used in research. (researchsquare.com)

From that perspective, even if new biologically based computers show human-like intelligence, it does not necessarily follow that they have moral status," says co-author Dr. Tamra Lysaght, Director of Research at the Centre for Biomedical Ethics, National University of Singapore. (hiroshima-u.ac.jp)
The aim of the EU-funded RareBoost project is to recruit an internationally recognised expert as a leader for the new Unit for Rare Diseases at the Izmir Biomedicine and Genome Center (IBG), to direct its development into a leading basic and translational research centre for RDs. (europa.eu)
IBG is perfectly suited for this development, as it is (i) the largest and best-equipped public biomedical research institute in Turkey, (ii) the only nationally recognized Centre of Excellence in the biomedical sciences, and (iii) already made significant steps towards research excellence. (europa.eu)
This RareBoost project will greatly facilitate IBG's aim to become a leading basic and translational research centre for rare diseases. (europa.eu)

Her clinical and translational research program has focused on identifying novel MRI biomarkers of ARPKD kidney and liver disease progression. (pkdcure.org)
Robust representative models can have disruptive scientific and translational impact," Bagheri added. (northwestern.edu)

Some types of chILD may be diagnosed on the basis of genetic testing, and laboratory studies may provide clues for others, particularly in association with systemic disorders. (medscape.com)
Laboratory mice have been at the center of biomedical research for almost a century. (jax.org)
The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating development of new treatments and precision medicine. (sciencedaily.com)
With its similarity to human biology and ease of genetic modification, the laboratory mouse is arguably the preferred model organism for studying human genetic disease. (sciencedaily.com)
We did a deep dive through over 1100 treatments across preclinical models and never found results where the tumors shrank away and disappeared like ours did,' said Jeff Schaal, who conducted the research during his PhD in the laboratory of Ashutosh Chilkoti, the Alan L. Kaganov Distinguished Professor of Biomedical Engineering at Duke. (news-medical.net)
In the new paper, Schaal and his collaborators in the Chilkoti laboratory tested the new treatment in concert with paclitaxel, a commonly used chemotherapy drug, to treat various mouse models of pancreatic cancer. (news-medical.net)

Our Sacramento team is dedicated to providing JAX® Mice and extensive in vivo, cancer and stem cell services to the pharmaceutical, life sciences and medical research communities throughout the western United States and Canada. (jax.org)
Zebrafish widely used as an animal model in various fields of biomedical research as a disease model for cancer, metabolic and neurodegenerative diseases, and regenerative medicine. (weizmann.ac.il)
Liang lab has identified and studied the mammalian essential autophagy protein, UV irradiation resistance associated gene (UVRAG), which functions in and beyond autophagy and has emerging significance in cancer research. (upenn.edu)
Genetic diversity is particularly important when it comes to complex diseases such as Alzheimer's disease, diabetes, cancer and more. (jax.org)
Although progress with research methods has only recently made work with DO mouse populations readily feasible, DO studies have already successfully mapped complex traits related to cardiovascular function, addiction, metabolic syndrome, cancer, behavior and more. (jax.org)
Studies using genetic manipulations in these species have led to fundamental findings in development, immunology, neuroscience, cancer, etc, that have been recognized with distinctions such as the Nobel Prize and the Lasker Award. (neurodegenerationresearch.eu)
There is no doubt that these models poorly reflect complex human diseases such as Alzheimer's disease, diabetes or cancer. (eceae.org)
Many animal models of human diseases including Alzheimer's disease or cancer are generated by genetic engineering. (eceae.org)
Dr. Smith has conducted research that has found high rates of hospital readmission for patients who had major bladder cancer surgery, highlighting important opportunities for improvement of care. (unchealthcare.org)
She is now co-PI on the $8.5 million PCORI Large Pragmatic Trial, a study directly addressing the top-priority research question for bladder cancer patients and caregivers, a project that is poised to transform the standard of care. (unchealthcare.org)
Our primary research interest is infection and cancer in humans. (ki.se)
We particularly study Epstein-Barr Virus (EBV)-infection, which can also be used as a model to study early steps in in vitro transformation, viral genetic switches, non-genetic variation and cancer cell metabolism. (ki.se)
The EBV cell line models allow comparison of non-malignant versus malignant phenotypes of human cancer in vitro (lymphoblastoid cell lines, LCL vs Burkitt´s lymphoma cell line, BL). (ki.se)
We are also leading the Personalized Cancer Medicine (PCM) at Karolinska Institutet, funded by Radiumhemmets´ Research Funds, with the aim to establish and develop PCM as a leading treatment concept in academic cancer healthcare in Stockholm. (ki.se)
Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century. (ki.se)
Our bedside-to-bench-to-bedside research model builds on a foundation of generously donated patient samples, where we test mechanisms of brain cancer growth, develop novel pre-clinical models that reliably recapitulate the human disease, and facilitate clinical trials of new treatments for patients with brain cancer. (stanford.edu)
Biomedical engineers at Duke University have demonstrated the most effective treatment for pancreatic cancer ever recorded in mouse models. (news-medical.net)
There's just no good way to treat pancreatic cancer right now,' said Schaal, who is now director of research at Cereius, Inc., a Durham, North Carolina biotechnology startup working to commercialize a targeted radionuclide therapy through a different technology scheme. (news-medical.net)
In 2015, the United States launched the precision medicine initiative that includes a cancer component and a national cohort research study of one million or more people. (cdc.gov)
Clinical Cancer Research. (lu.se)
An important basis of this work is the Swedish Research Council Research Environment on Single molecule bioanalytical sensing for precision cancer diagnostics funded 2020 - 2025. (lu.se)

Tel: +1 501 686 5783 b Arkansas Children's Research Institute, 13 Children's Way, Little Rock, AR 72202, USA c Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. (rsc.org)
His research group focuses on data science, data intensive computing, biomedical informatics and related areas. (nsf.gov)

Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors. (rochester.edu)
This technology holds immense potential for curing diseases, creating resilient crops, and advancing the understanding of genetic mechanisms, paving the way for a transformative future. (wlns.com)
Using genetic, biochemical, and electrophysiologic techniques in cells, model organisms, and human subjects, we investigate the mechanisms that drive neurologic and cardiac dysfunction in patients with IEMs. (upenn.edu)
Animal models are essential in biomedical research to study the causes of human and animal diseases and the underlying mechanisms involved, with the final aim of developing and testing new treatments able to improve both human and animal quality of life. (researchsquare.com)
Basic research on mechanisms of cellular antiviral restriction factors and sensing, and intercellular communication are progressively translated towards the development of therapeutic and preventive intervention strategies. (fems-microbiology.org)
Tasks comprise research on cell-intrinsic mechanisms that modulate the course of HIV-1 infection and latency. (fems-microbiology.org)
What are the mechanisms by which disease-associated genetic variants cause brain diseases? (ucsf.edu)
Berger's research interests focus on fundamental studies of DNA replication and chromosome superstructure and their control by small-molecule and biological regulatory mechanisms. (jhu.edu)
Our improved understanding of the underlying mechanisms and processes that cause genetic-driven RDs will be used to devise new diagnostic and therapeutic approaches, to reduce patient suffering. (europa.eu)
New systems processing of numerous and different kinds of signals, math- must capture the specific biological mechanisms of opera- ematical and computational methods are required to model tion and distributed regulation at work within the genome. (lu.se)

The result is more genetic diversity within a reasonable population size than is observed across the human population, with detectable genetic variation in every gene and pathway. (jax.org)
The gene editing market revolutionizes healthcare by enabling precise modification of DNA, fostering breakthroughs in treating genetic disorders, developing personalized therapies, and enhancing agricultural practices. (wlns.com)
According to Dawson Menezes, Founder of Global Market Studies, "The Gene Editing Market stands as a crucial pillar in the ever-evolving landscape of genetic medicine. (wlns.com)
Gene editing technologies not only promise breakthroughs in treating genetic disorders but also herald a new era in tailored therapeutics. (wlns.com)
The Asia Pacific market is expected to have the highest CAGR over the forecast period attributed to increasing investments in research and application of gene synthesis. (wlns.com)
The advent of new methods to obtain large-scale surveys of various mathematical structures, such as systems of differen- gene expression in which transcript levels can be determined tial equations, graphical networks, stochastic functional re- for thousands of genes simultaneously has facilitated the ex- lations, and simulation models. (lu.se)
EURASIP Journal on Applied Signal Processing dynamical modelling of gene networks. (lu.se)

This bias in biological research toward the previously studied appears to reflect several linked factors. (biorxiv.org)
Research using inbred (genetically nearly identical) mice has provided countless biological insights and has been vital for medical progress, but translation to clinical application has been difficult and inconsistent. (jax.org)
Research with inbred mouse strains-that is, mice inbred for generations until their genetics are identical, or as nearly so as possible-has yielded countless biological discoveries and led to significant medical progress. (jax.org)
The use of animal models allows controlling the confounding variables that characterize clinical research, mimicking biological conditions of human diseases. (researchsquare.com)
Thus, over the decades, animal models highly contributed to the most important knowledge advances in many biological fields. (researchsquare.com)
2 As scientific research strengthens the argument for a paradigm shift from the biomedical model toward the biopsychosocial (BPS) model, particularly in the management of pain, it is now generally accepted that illness and health are the result of an interaction between biological, psychological, and social factors. (allenpress.com)
However, the research on rare diseases and the development of new diagnostic and therapeutic approaches is often hampered by limited resources, including patient material and biological models. (europa.eu)

Most of the research in the BME program is highly interdisciplinary, and our students form strong research collaborations with scientists, engineers, and clinicians from Johns Hopkins University and leading academic institutions from around the world. (jhu.edu)
PCM is an interdisciplinary research field and the main focus is to strengthen the infrastructure for local, national and international team science addressing PCM. (ki.se)

and a Professor in the Department of Medicine in the Section of Genetic Medicine. (nsf.gov)
The research team also includes Tsutomu Sawai , associate professor in the Graduate School of Humanities and Social Sciences at Hiroshima University. (hiroshima-u.ac.jp)
She is Professor of Pediatrics at Case Western Reserve University School of Medicine and is Vice Chair of Research for the Pediatric Institute of Cleveland Clinic Children's. (pkdcure.org)
Bagheri is an associate professor of biology and chemical engineering and a Washington Research Foundation Investigator at the University of Washington Seattle. (northwestern.edu)
Structural biologist James Berger , a professor of biophysics and biophysical chemistry at the School of Medicine, has been appointed to direct the Johns Hopkins institute dedicated to this effort, the Institute for Basic Biomedical Sciences , or IBBS. (jhu.edu)
Johan Jakobsson, a professor at Lund University and research group leader at MultiPark and Lund Stem Cell Center, explains, "LINE-1 retrotransposons are a rich source of genetic sequences that we suspect have shaped the evolution of the human brain, and we now have the tools to explore their role in brain development. (lu.se)

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (ucsf.edu)

Current cell lines used in medical research predominately have European-type genetic ancestry, potentially making it harder to identify genetic-linked side effects," says co-author Dr. Christopher Gyngell, Research Fellow in biomedical ethics from the Murdoch Children's Research Institute and the University of Melbourne. (hiroshima-u.ac.jp)

The advent of genome sequencing revealed in humans and other species thousands of genes encoding proteins that had not been identified by previous biochemical or genetic studies. (biorxiv.org)
We hypothesize that genetic defects in biochemical pathways alter the development and evolution of electrical circuits in excitable tissues. (upenn.edu)

Organoids generated from these patients did thus not display cAMP-induced swelling in vitro, genetic correction of the mutation in the organoids however restored this response (4). (eceae.org)

Students currently enrolled in PhD programs in the Biomedical Sciences, Psychology, Biology, Public Health, Health Outcomes (Pharmaceutical Systems and Policy), as well as the joint MD/PhD program, may apply to the BBS program. (wvu.edu)
Furthermore, as the earliest evolved jawed vertebrates, sharks can serve as important models for comparative biomedical research that will help us to understand the evolution and function of human biology and disease, including immune systems, neurobiology, stem cells, ageing and wound healing. (saveourseas.com)
The research, which generated over 20 million pieces of data, has found 360 new disease models and provides 28,406 new descriptions of the genes' effects on mouse biology and disease. (sciencedaily.com)
Research Interests: We study rare genetic disorders of the heart and brain both to further our understanding of basic biology and to develop new therapies for our patients. (upenn.edu)
He has served the American Society for Matrix Biology in many roles, including organizing its 2014 biennial conference and chaired the 2013 Gordon Research Conference on Matrix Metalloproteinases. (navbo.org)
Scientists have also improved their ability to develop tools on the nanoscale and use concepts driven by data and mathematics to model biology. (jhu.edu)
The first step in research is to understand how and why biology works the way it does," says Berger, who has served as deputy director of IBBS since October 2017. (jhu.edu)
The species has long been used as a model organism in genetic, evolutionary biology and neurobiology research. (uni-konstanz.de)
We conduct and support research in computational biology and computational health sciences. (medlineplus.gov)
Our mandate is to undertake and support research, not only basic, applied or epidemiological research but also operational research in the area of public health using a variety of tools, including those of modern biology. (who.int)

However, the vast majority of the mouse genome remains poorly understood, as scientists tend to focus their research on a few specific areas of the genome linked to the most common inherited diseases. (sciencedaily.com)
Investigation of the germ cell genome, the only genome carrying the duty of integrating new information with genetic history, enabling reproduction and evolution-the key difference between life and non-life. (rochester.edu)
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. (ucsf.edu)
The aim of this RareBoost project is to attract an internationally recognized rare disease expert (ERA Chair holder) to the Izmir Biomedicine and Genome Center (IBG), where s/he will lead and direct the new Unit for Rare Diseases and guide its development towards an internationally recognized research facility for rare diseases. (europa.eu)
Signals generated by the genome must be processed to the genome, regulatory models require the kind of nonlinear characterize their regulatory effects and their relationship to dynamics studied in signal processing and control. (lu.se)
This allowed us to provide a reference genome [a reference to what the genetic structure of the virus looks like] to scientists trying to develop new vaccines or new treatments. (medlineplus.gov)
Synthesis of data from published human genetic association studies is a critical step in the translation of human genome discoveries into health applications. (cdc.gov)
Human genetic association studies epitomize this challenge because they have proliferated rapidly since completion of the Human Genome Project [ 2 ]. (cdc.gov)

ITI Life Sciences will identify, commission, and manage research and development projects in emerging technologies across the broad spectrum of life sciences. (biopharminternational.com)
The intellectual assets generated by these research projects will be used to increase the strength and sustainability of life sciences companies and organizations based in Scotland. (biopharminternational.com)
Learn about the training opportunities in data science available to our Graduate Students and the unique capabilities in this field at the Graduate School of Biomedical Sciences at Icahn School of Medicine. (mssm.edu)
Research Fellow from the School of Biomedical Engineering & Imaging Sciences, Dr Carole Sudre focused on applying the model trained on the tested people to all people that had reported symptoms in the app. (kcl.ac.uk)

These populations are powering a revolution in model organism research that will enable major advancements in the understanding of complex genetic traits. (jax.org)

Monkeys have served as one of the most valuable models for understanding DNA methylation dynamics during early embryogenesis in human due to their similarities in genetics and early embryonic development 17 , 18 . (nature.com)
The zebrafish also exhibits measurable behavioral and hormonal responses already at the larval stages, providing a viable vertebrate animal model for high-throughput drug screening and chemical genetics. (weizmann.ac.il)

The advent of model organisms where genetic manipulations became standard procedures revolutionized biomedical research. (neurodegenerationresearch.eu)
CONGENTO - a Consortium for Genetically Tractable Organisms is the first worldwide infrastructure to integrate the expertise in fruitflies, zebrafish and mice in one research supporting facility. (neurodegenerationresearch.eu)

Severin Schwan, the CEO of the Swiss company Roche, reported that Roche's research and development costs amounted to $12.3 billion in 2018, a quarter of the entire National Institutes of Health budget. (wikipedia.org)
Our Ellsworth campus provides the global biomedical research community with JAX® Mice at the highest health status. (jax.org)
Its faculty preceptors and doctoral trainees are part of Biomedical , Psychology , Public Health , and Health Outcomes (Pharmaceutical Systems & Policy) PhD Programs as well as the joint MD/PhD Medical Scientist Training Program . (wvu.edu)
Extract knowledge from biomedical datasets of all sizes to understand and solve health-related problems. (jhu.edu)
Generate solutions in personalized medicine by building and utilizing computational models of health and disease. (jhu.edu)
He is the Director of the not-for-profit Open Commons Consortium that develops and operates data commons and data clouds to support research in science, medicine, health care, and the environment. (nsf.gov)
Instead of effectively improving human health and driving the understanding and therapy of human diseases this research strategy provides huge amounts of false positive and false negative results. (eceae.org)
and #National Health Research Institutes, Taipei, patients in Taiwan were 665. (cdc.gov)
Noteworthy, in order to obtain reliable results, the health quality of the animal used as a model is fundamental, and thus, besides for obvious ethical reasons, it is in the interest of the researcher to have healthy and well treated animals. (researchsquare.com)
8 , 9 Administering these tools may help facilitate communication regarding issues that are important to the patient and reflect all domains of health encompassed in the BPS model. (allenpress.com)
In a previous post, I commented on the importance of a public health perspective to ensure the success of the proposed precision medicine large national research cohort. (cdc.gov)
There's not a biomedical discovery, a public health advance, or a clinical care action in the past 30 years that hasn't benefited from our resources in some way. (medlineplus.gov)
NLM is a leader in biomedical and health data science research, and the world's largest biomedical library. (medlineplus.gov)
The regional research centres concentrate on research pertaining to the diseases of their particular region, where there is often a lack of proper government infrastructure for health care delivery. (who.int)
However, technological advances the causal processes that give rise disease rates and the way their caus- notwithstanding, in both biomedical to health inequities. (who.int)
A physiologically based pharmacokinetic (PBPK) model for iodomethane was developed to characterize poten- tial human health effects from iodomethane exposure. (cdc.gov)

New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research. (jax.org)
This strategy allows the establishment of a revolutionary concept of disease models for experimental biomedical research. (eceae.org)

Terry Meehan, IMPC Project Coordinator at European Bioinformatics Institute (EMBL-EBI) said: "Mouse models allow us to speed up patient diagnosis and develop new therapies. (sciencedaily.com)

Blood Flow Matters in a Zebrafish Model of Cerebral Cavernous Malformations. (uni-potsdam.de)
Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. (uni-potsdam.de)
A model of global cerebral ischemia in C57 BL/6 mice. (riken.jp)
Kojima et al have described an animal model of cerebral salt-wasting syndrome that may allow better clarification of the condition's etiology. (medscape.com)

This initiative has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreements No. 643417, No. 681043 and No. 825664. (neurodegenerationresearch.eu)
However, to realize the full potential of hiPSCs for disease modeling and drug screening, several challenges still need to be overcome, as there is the high variability between hiPSC lines, the risk of accumulating genetic aberrations when culturing hiPSCs, and the lack of standardized procedures for hiPSC generation as such (reviewed by Volpato and Webber, 2020 ). (frontiersin.org)

A highly multidisciplinary and competitive training programme in biomedical research. (biologists.com)

Translating discoveries to humans and leveraging them for therapeutic development will remain difficult, however, and modeling genetic diversity is essential. (jax.org)
Large scale data commons are beginning to change the way that we share research data and make scientific discoveries. (nsf.gov)
In his time at UNC, Liu has made several key research discoveries that could make a considerable impact on the development of more potent therapeutics for the treatment of heart disease. (unchealthcare.org)

The Postdoctoral Enrichment Program for underrepresented minorities provides $50,000 over three years to support the development of underrepresented minority postdoctoral fellows in biomedical research. (unclineberger.org)
After postdoctoral training at Harvard Medical School with Bjorn R. Olsen, he established an independent research group at the Cleveland Clinic Lerner Research Institute. (navbo.org)

The Research Group Innate Immunity and Viral Evasion (headed by Prof. Dr. Christine Goffinet, formerly TWINCORE, Hannover) at the Institute of Virology of Charité is hiring a highly motivated, scientifically excellent, team-minded and experienced postdoc (w/m/d). (fems-microbiology.org)

Our work demonstrates the importance of poorly understood genes, provides a resource for future research acceleration, and highlights a need for our awareness of ignorance to be protected from erosion by automated database annotation. (biorxiv.org)
We're doing this by investigating these evolutionary marvels at the most fundamental level possible: by a comparative study of their entire genetic blueprints, or genomes, including detailed studies of all their genes and their expression. (saveourseas.com)

The traditional beliefs and values in China are described with particular reference to medicine, and the implications for bioethics and research ethics within the country are considered. (who.int)

While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)

Research teams attempt to break down disease components to find abnormal events/processes taking place in the body. (wikipedia.org)
The CC, DO and founder mice as well as associated analysis tools will greatly improve mouse-based research into complex traits and disease and complement human genetic analyses. (jax.org)
The EU Joint Programme - Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases, in particular, Alzheimer's. (neurodegenerationresearch.eu)
Mini brains are generated from patients suffering from Alzheimer's or Parkinson's disease, pancreatic organoids from diabetic patients, intestinal organoids from people suffering from Chron's or inflammatory bowel disease, 3D lung models are generated from smokers and COPD (chronic obstructive pulmonary disease) or asthma patients. (eceae.org)
In the recent past, scientific experts from academia and industry have increasingly criticized animal-based disease models. (eceae.org)
Many so-called "animal models" try to mimic a certain aspect or symptom of a human disease by artificially harming animals. (eceae.org)
Our collaborative research team (Drs. Dell & Flask) has been studying novel MRI methods to assess ARPKD kidney and liver disease progression for over a decade. (pkdcure.org)
The new disease models are being made available to the biomedical community to aid their research. (sciencedaily.com)
These 360 new disease models that we've identified in mice represent the first steps of a hugely important international project. (sciencedaily.com)
For the first time, human disease traits were seen in mouse models for forms of Bernard-Soulier syndrome (a blood clotting disorder), Bardet-Biedl syndrome (causing vision loss, obesity and extra fingers or toes) and Gordon Holmes syndrome (a neurodegenerative disorder with delayed puberty and lack of secondary sex characteristics). (sciencedaily.com)
Severe acute respiratory syndrome (SARS) is a newly model to study the biologic basis for human disease, the emerged infectious disease. (cdc.gov)
Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system. (riken.jp)
Identification of a genetic variant common to moyamoya disease and intracranial major artery stenosis/occlusion. (riken.jp)
Our set-up enables automated, user-independent expansion of hiPSCs under fully defined conditions, and could be exploited to generate a large number of hiPSC lines for disease modeling, and drug screening at industrial scale, and quality. (frontiersin.org)
The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
We are also developing CRISPR screening approaches for mouse models of disease. (ucsf.edu)
Furthermore, by becoming an internationally recognized hub for rare disease research, IBG will act as a guide for the Turkish R&D sector, will facilitate ERA homogeneity and will support the well-being of rare disease patients. (europa.eu)
Current Research and Scholarly Interests My current research focuses on understanding the genetic and environmental etiology of complex disease and developing and evaluating efficient screening strategies based on etiological understanding. (stanford.edu)
I have developed various statistical methods to analyze high-dimensional data to identify genetic and environmental risk factors and their interactions for complex disease. (stanford.edu)
Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. (cdc.gov)

Specifically, his lab uses zebrafish as a model system to research new therapeutic interventions for heart diseases. (unchealthcare.org)

The major focus of the Save Our Seas Shark Research Center USA (SOSSRC) is to conduct targeted and impactful scientific research to improve management, conservation, recovery and understanding of the world's sharks and rays. (saveourseas.com)
Here, we introduce STREAMLINE, a simple, transparent, end-to-end AutoML pipeline designed as a framework to easily conduct rigorous ML modeling and analysis (limited initially to binary classification). (springer.com)

Each method specifically integrates a subset of omics data using approaches such as conceptual integration, statistical integration, model-based integration, networks, and pathway data integration. (rsc.org)
Ever since, the accelerating field of human three-dimensional tissue culture has opened new avenues for biomedical applications and has given rise to a multitude of ground-breaking approaches such as organ-on-a-chip systems and personalised medicine. (eceae.org)
A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)

Research Details: Our lab aims to develop better treatments for inherited disorders of biochemistry (i.e., inborn errors of metabolism, IEMs) by studying how these diseases alter the electrical activity of the brain and heart. (upenn.edu)
I am also interested in surgical outcomes research and I am involved in clinical trials studying brain tumors and stroke. (stanford.edu)
Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. (lu.se)

As the authors conclude, "These diversity mice can be used to dissect complex traits at multiple levels by establishing heritability, identifying coregulation with other traits, finding interesting model strains, and making mechanistic genetic insights. (jax.org)

A strong advantage of the zebrafish model is the availability of in vivo imaging techniques, because the embryo is completely transparent and can live for several days without a functional cardiovascular system. (uni-potsdam.de)

The latter approach has the advantage of being non-invasive to the human donor as the mature cells are reprogrammed by genetic engineering yielding induced pluripotent stem cells (iPSC). (eceae.org)
Correction of this mutation by genetic engineering such as CRISPR/Cas9 restores the proper function of the organoid. (eceae.org)
Now he and his team have developed a design-driven process that uses parts from a very different kind of toolkit to build complex genetic circuits for cellular engineering. (northwestern.edu)
The National Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine. (nationalacademies.org)
The results appear online October 19 in the journal Nature Biomedical Engineering . (news-medical.net)

A growing national research network and the development of chILD registries in the United States, Europe, and elsewhere may facilitate the use of standardized diagnostic criteria, provide critical data on natural history, and create an infrastructure for clinical trials. (medscape.com)
The ICMR fosters a research culture by improving funding, mainly for developing infrastructure. (who.int)

Dr. Lee has a background in bioengineering and clinical neuroradiology and focuses his research on translating the capabilities of new imaging devices for diagnosis and treatment of benign and malignant diseases from the lab to the clinic. (unchealthcare.org)
Our research focuses on cell-intrinsic immunity against viral human-pathogenic infections, with a focus on HIV and arboviruses. (fems-microbiology.org)

Three main domains of services were identified as being critically needed in Portugal: 1) maintenance and hosting of genetically modified lines from the 3 species, either live or cryopreserved, 2) generation of new genetic lines and technologies in the different species, and 3) continuous education and certification in animal research and technology. (neurodegenerationresearch.eu)
Several novel therapies have shown efficacy in animal models, but have not been studied in ARPKD patients due to the absence of safe and reliable measures of CHF progression. (pkdcure.org)
In previous studies in an ARPKD animal model, we showed that T1 mapping is a sensitive measure of progressive CHF. (pkdcure.org)
The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. (researchsquare.com)
Therefore, the use of techniques like computed tomography (CT), positron emission tomography (PET) or single photon emission computed tomography (SPECT) became more frequent when conducting preclinical studies in animal models. (researchsquare.com)
The model enabled calculation of human equivalent con- centrations (HECs) to the animal no-observed-adverse-effect levels (NOAELs) using chemical-specific parameters to determine the internal dose instead of default assumptions. (cdc.gov)

In 1999, Scotland's main economic development agency, Scottish Enterprise, pledged to double the country's biotech community and create Europe's leading biotechnology region by utilizing Scotland's academic science departments, research institutes, hospitals, and large and small biotech companies. (biopharminternational.com)
No longer limited to the realm of science fiction, bio-computing is here, so now is the time to start considering how to research and apply this technology responsibly, an international group of experts says. (hiroshima-u.ac.jp)
The study, in which dozens of genetic circuits were designed and tested, was published today (Feb. 19) in the journal Science Advances. (northwestern.edu)
The time is now to place a big bet on basic science research," says Paul B. Rothman , dean of the medical faculty and CEO of Johns Hopkins Medicine. (jhu.edu)
Our basic science departments have always been powerhouses of research," says Landon King, executive vice dean for the Johns Hopkins University School of Medicine. (jhu.edu)

We are at an unprecedented time when advances in technology have positioned us to make the greatest achievements in biomedical research that mankind has ever seen. (jhu.edu)
We discuss some key points supporting the envisioned advances in applying the digital pheno- typing to PD, such as improvements on assessment, research, PD taxonomy, and, ultimately, on interventions. (bvsalud.org)

Scotland's greatest strength may lie in its unparalleled university research capabilities that have produced a test bed for innovation. (biopharminternational.com)

Le Conseil est en train de mettre au point un programme de base pour l'enseignement de la bioéthique, lequel pourrait s'appliquer de manière uniforme aux écoles de médecine dans tout le pays. (who.int)

Given the profit-driven nature of pharmaceutical companies and their research and development expenses, companies use their research and development expenses as a starting point to determine appropriate yet profitable prices. (wikipedia.org)
Pharmaceutical companies spend a large amount on research and development before a drug is released to the market and costs can be further divided into three major fields: the discovery into the drug's specific medical field, clinical trials, and failed drugs. (wikipedia.org)
Drug discovery is the area of research and development that amounts to the most time and money. (wikipedia.org)
Overall, research and development expenses relating to a pharmaceutical drug amount to the billions. (wikipedia.org)
citation needed] Total research and development costs provide pharmaceutical companies a ballpark estimation of total expenses. (wikipedia.org)
In future models of drug screening, we have the chance to make them more sufficiently representative of the real-world patients by using more diverse cell lines, and that means potentially faster and better drug development. (hiroshima-u.ac.jp)
Our findings have implications for understanding the pathogenesis of SARS and for SARS insufficient to provide a comprehensive basis for specific vaccine research and development. (cdc.gov)
The research team thus examined the group behaviour of zebrafish during different stages of their development - seven days and 21 days after egg fertilization. (uni-konstanz.de)

However, these models do not resemble the complexity of human diseases which are often caused or at least massively influenced by life-style, psychological and social factors. (eceae.org)
A major focus of our research are neurodegenerative and neuropsychiatric diseases. (ucsf.edu)

For example, it was reported that AstraZeneca spent upwards on average of $11 billion per drug for research and developmental purposes. (wikipedia.org)
Data demonstrated that humans are less sensitive to the effect that causes developmental toxicity in rabbits and the PBPK model incorporated this information, resulting in a higher HEC for the developmental endpoint than for the nasal endpoint. (cdc.gov)

This latest report acts as a guiding path towards the future of personalized medicine, CRISPR technology, and medical research. (wlns.com)

Perhaps the most prominent and widely used NCBI database is PubMed , a continuously updated, public database of more than 18 million citations for biomedical literature. (cdc.gov)
Many databases that deposit genetic association information, including citations from PubMed, have been built and curated [ 5 - 7 ]. (cdc.gov)

Suneel Apte studied medicine at the University of Bombay, India, and trained in orthopaedic surgery before embarking on a career in biomedical research. (navbo.org)
SUMMARY The Indian Council of Medical Research formulates, coordinates and promotes biomedical research in India. (who.int)
Our organization, the Indian Council of Medical Research (ICMR), is important in the region and in our country, mainly because it funds research in India. (who.int)
Its main function is to formulate, coordinate and promote biomedical research in India through intramural as well as extramural research programmes. (who.int)

The Jackson Laboratory's locations in Beijing and Shanghai empower the China research community with access to JAX® Mice, localized support and services. (jax.org)
While most mouse trials consider simply halting growth a success, the new treatment completely eliminated tumors in 80% of mice across several model types, including those considered the most difficult to treat. (news-medical.net)

The processes of "discovery" and clinical trials amounts to approximately 12 years from research lab to the patient, in which about 10% of all drugs that start pre-clinical trials ever make it to actual human testing. (wikipedia.org)
Research with one mouse strain is analogous to research in one human-what you discover is important within that context, but it may not apply to other strains (or people). (jax.org)
The human mini-organs, mostly around half a millimetre in size, share the main functional features of the native organ and conserve the genetic and phenotypical characteristics of the human donor. (eceae.org)
They found that a wide variety of genetic programs, each of which carries out a desired and useful function in a human cell, can be constructed such that each program works as predicted. (northwestern.edu)
This virus also offers one of the most complete models for studying tumorigenesis in man, from molecule to patient, exploiting the viral infection of human B-lymphocytes. (ki.se)
The GAPscreener, a free SVM-based software tool, can be used to assist in screening PubMed abstracts for human genetic association studies. (cdc.gov)
GAPscreener is the first free SVM-based application available for screening the human genetic association literature in PubMed with high recall and specificity. (cdc.gov)
In this paper, we report a novel method for feature selection and show that using it to train the SVM model significantly improved its ability to classify reports of human genetic association studies. (cdc.gov)

The DACC will also be expected to facilitate consortium-led analyses and outreach to the broader research community, especially the dissemination of the consortium generated resource to enable others to perform related research. (nih.gov)

27,144 of this is funded through NIH, and the rest by the HSC Office of Research & Graduate Education. (wvu.edu)

The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)

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