Loading...


  • rats
  • Rats particularly the inbred strains are now more widely used laboratory model especially in toxicology and for understanding the pathophysiology of diseases. (alliedacademies.org)
  • We have previously investigated the BB rat, an animal model that develops a human-like T1D at the age of around 60 days, and found that apoCIII was also increased in sera from pre-diabetic rats and this promoted β-cell death. (readbyqxmd.com)
  • In my old lab that did diabetes research, we used to harvest rat testes first by taking the rats by the tail and whipping/spinning them fast and hard against a bench to stun them (carbon dioxide isn't good against large rodents, plus the experiments were CO2-sensitive). (myconfinedspace.com)
  • Keep in mind that this was all approved by our Animal Review Board, but when the people upstairs complained about the noise of the rats dying, we had to go to the previously approved method, which was a hand-operated two bladed guillotine that we had to put the conscious rats' heads through, then *crump* cut it off. (myconfinedspace.com)
  • Over the next 30 years rats were used for several more experiments and eventually the laboratory rat became the first animal domesticated for purely scientific reasons. (wikipedia.org)
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum, and then nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
  • Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
  • Scientists have bred many strains or "lines" of rats specifically for experimentation. (wikipedia.org)
  • laevis
  • In addition, the availability of major histocompatibility (MHC)-defined X . laevis animal inbred strains, gynogenetic clones, and cell lines, coupled with a powerful and continuously improving reverse genetics approach provide the basic tools for addressing fundamental questions about the ontogeny and phylogeny of the immune system [ 6 ]. (mdpi.com)
  • Studies with X. laevis over several decades have resulted in the generation of many invaluable research tools including MHC-defined isogenetic clones and inbred strains of animals, transgenic lines, cell lines, monoclonal antibodies, and cDNA probes that need to be preserved, enriched and made available to the scientific community. (grantome.com)
  • The broad objective of this renewal proposal, therefore, is to safeguard, promote and further develop X. laevis as an important model for biomedical research in general, and immunology, in particular. (grantome.com)
  • As in the original proposal, two major aims are proposed: (1) Maintenance, improvement and advertisement of our X. laevis facility by continuing to maintain and improve the performance and quality of our resource;by providing animals, not commercially available, and reagents upon request;by assisting, training, and informing scientists and students about X. laevis;and by disseminating information, advertising and interacting with the scientific community through a web site. (grantome.com)
  • The overall objective of this renewal application is to safeguard and promote the frog Xenopus laevis, as an important non-mammalian comparative model for biomedical research in general, and immunology, in particular. (grantome.com)
  • Albino
  • Unless you had some reason to use one particular strain for your experiments-a nude mouse, let's say, for the screening of cancerous skin lesions, or the Bagg's Albino for its special role in the production of monoclonal antibodies-then Black-6 would be your fallback choice. (slate.com)
  • Examples of albino laboratory mammals Albinism in biology is the "Congenital absence of any pigmentation or coloration in a person, animal or plant, resulting in white hair and pink eyes in mammals. (wikipedia.org)
  • Albino animals have characteristic pink or red eyes because the lack of pigment in the iris allows the blood vessels of the retina to be visible. (wikipedia.org)
  • populations
  • As research swine populations have experienced rapid and significant increases during the past few years, investigators have requested more resources for improving husbandry and medical care of new swine strains created by genetic technologies. (nih.gov)
  • Multiparent populations (MPP) have become popular resources for complex trait mapping because of their wider allelic diversity and larger population size compared with traditional two-way recombinant inbred (RI) strains. (g3journal.org)
  • With the need for more powerful resources, multiparent populations (MPP) ( de Koning and McIntyre 2017 ), a set of inbred lines using multiple lines as founders, can overcome the limitations of traditional RI lines and have become an innovative tool for fine quantitative trait locus (QTL) mapping. (g3journal.org)
  • Heterosis is often discussed as the opposite of inbreeding depression although differences in these two concepts can be seen in evolutionary considerations such as the role of genetic variation or the effects of genetic drift in small populations on these concepts. (wikipedia.org)
  • tend
  • Inbred strains tend to be homozygous for recessive alleles that are mildly harmful (or produce a trait that is undesirable from the standpoint of the breeder). (wikipedia.org)
  • They tend to be social animals and many species live in societies with complex ways of communicating with each other. (wikipedia.org)
  • transplantation
  • Indeed, the use of Xenopus in various areas of biomedical research including tumor biology, transplantation biology, self-tolerance, and auto immunity is steadily increasing and has significantly contributed to advances in these fields. (mdpi.com)
  • Furthermore, because the resource is expected to maintain swine strains for xenograft transplantation procedures, it is essential that the center be able to accommodate the specific needs for isolation, growth, preservation, expansion, and distribution of cells, tissues and organs from these animals. (nih.gov)
  • For example, the results have included the near-eradication of polio and the development of organ transplantation, and have benefited both humans and animals. (wikipedia.org)
  • diseases
  • Another important objective of the NSRRC will be to develop methods for improving health of swine strains by establishing standards and procedures for generating specific-pathogen free and more vigorous swine strains and characterizing diseases endemic to laboratory swine stocks. (nih.gov)
  • Laboratory or model animals are used in research for cure and improvement of human and animal diseases. (alliedacademies.org)
  • Although biological activity in a model organism does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
  • The scope of the laboratory expanded to include all deficiency diseases, and around 1928-29 became the Nutrition Research Laboratories (NRL), with McCarrison as its first Director, until his retirement in 1935, when he was succeeded by Dr. W.R. Ackroyd. (wikipedia.org)
  • Developed obese and diabetic mutant rat models: WNIN/GR-Ob, WNIN/Ob, WNIN/Ob-IGT, to serve as pre-clinical animal models in drug development for chronic diseases like diabesity. (wikipedia.org)
  • laboratories
  • He is also a consultant geneticist to Harlan UK, which supplies animals to laboratories. (wikipedia.org)
  • The swine resource center will eliminate the requirement of individual laboratories to maintain and distribute swine strains thereby ensuring the highest-level quality and uniformity of genetic and microbiological monitoring. (nih.gov)
  • It takes five days for Charles River Laboratories to truck a crate of these animals from here to Seattle, and there are five dozen more facilities like this one around the world, with thousands of employees in 17 countries, shipping out millions of animals and earning some $700 million every year. (slate.com)
  • Joseph F. (Joe) Holson, an American scientist, business executive, and educator in the disciplines of toxicology and product development, served as President of WIL Research Laboratories for 20 years (1988-2008). (wikipedia.org)
  • In March 1987, Dr. Holson was appointed Vice President and Director of Developmental and Reproductive Toxicology at WIL Research Laboratories, Inc., in Ashland, Ohio. (wikipedia.org)
  • toxicology
  • He has a particular interest in improving the design of animal experiments, particularly in the area of toxicology testing. (wikipedia.org)
  • In addition, Xenopus is emerging as an excellent model system for toxicology, neurobiology, regenerative biology, and other areas of biomedical science [ 3 ]. (mdpi.com)
  • The institute majorly conducts research in obesity, diabetes, food chemistry, dietetics, drug toxicology, and micronutrient deficiency in collaboration with centers such as the Rockefeller University, University of Colorado School of Medicine, Washington University, and the Johns Hopkins Bloomberg School of Public Health in the U.S.. and the University of Wollongong in Australia. (wikipedia.org)
  • Joseph Holson received his Doctorate in Physiology in 1973 from the University of Cincinnati College of Medicine, having studied under the direction of Dr. James G. Wilson in the disciplines of developmental toxicology and research pediatrics. (wikipedia.org)
  • He became the Division Director in 1975 and organized a multidisciplinary research program, which became one of the nation's major federally sponsored research groups in reproductive toxicology. (wikipedia.org)
  • For the next five years, he directed the teratology and developmental toxicology research programs of the National Toxicology Program (NTP), which focused on biochemical and physiological causes of birth defects, pharmacokinetics, postnatal functional evaluations, and mechanistic studies. (wikipedia.org)
  • Dr. Holson joined Science Applications International Corporation (SAIC) in La Jolla, California during March 1980 to establish research and development and chemical testing programs in toxicology. (wikipedia.org)
  • For the next five years, he directed SAIC's toxicology division, which included an active reproductive toxicology research emphasis. (wikipedia.org)
  • From 1985 through 1986, he served as President of Biomedical Research Institute of America in La Jolla, California and as an independent consultant in toxicology. (wikipedia.org)
  • guinea pigs
  • John Cade's research in guinea pigs discovered the anticonvulsant properties of lithium salts, which revolutionized the treatment of bipolar disorder, replacing the previous treatments of lobotomy or electroconvulsive therapy. (wikipedia.org)
  • Centre
  • Agencies such as WHO and FAO recognized the institute as a Centre for excellence in food quality, safety and nutrition research. (wikipedia.org)
  • rabbits
  • Other animals such as rabbits, hares, and pikas, whose incisors also grow continually, were once included with them, but are now considered to be in a separate order, the Lagomorpha. (wikipedia.org)
  • develop
  • He went on to develop an antitoxin against diphtheria in animals and then in humans, which resulted in the modern methods of immunization and largely ended diphtheria as a threatening disease. (wikipedia.org)
  • genes
  • In this regard, recent advances in adapting the transgenesis approach to Xenopus have allowed for in vivo studies of the impact of loss and gain of function of specific genes at the level of the whole organism, further enhancing the potential uses of Xenopus as an important biomedical model system. (mdpi.com)
  • researchers
  • These special swine models are often made available to other investigators by the researchers who generated a strain, but the demands for distribution and maintenance of swine are frequently beyond the physical or financial resources of these individual investigators. (nih.gov)
  • human
  • The objective of this RFA is to establish a National Swine Research and Resource Center (NSRRC) to ensure that biomedical investigators have enhanced access to critically needed swine models for studies involving human health and disease. (nih.gov)
  • Students also will gain an understanding of the need for mathematics in laboratory settings The use of controlled experiments will be explored, and how it applies to both laboratory, animal and human based (clinical trials) studies. (southampton.ac.uk)
  • According to the U.S. Department of Health and Human Services, animal research has helped extend our life expectancy by 23.5 years. Of course, how you choose to spend those extra years is up to you. (myconfinedspace.com)
  • page needed] In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. (wikipedia.org)
  • among
  • It was on account of his " widespread use among the research community and favorable breeding characteristics ," they wrote. (slate.com)
  • The use of animals in research dates back to ancient Greece, with Aristotle (384-322 BCE) and Erasistratus (304-258 BCE) among the first to perform experiments on living animals. (wikipedia.org)
  • experimental
  • He was the winner in 1996 of the GlaxoSmithKline Laboratory Animal Welfare Prize for his work while at the University of Leicester on "improved experimental design leading to reductions in the use of laboratory animals. (wikipedia.org)
  • Loeb and Lathrop performed experiments at her farm and the pair authored 10 journal articles from 1913 to 1919, including those published in the Journal of Cancer Research and the Journal of Experimental Medicine. (wikipedia.org)
  • In doing so he was able to conclude that the virus was either a protein or closely related to one, thus benefiting experimental research. (wikipedia.org)
  • differences
  • One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization. (springer.com)
  • Developmental Biology
  • advanced cell biology (graduate students) research ethics (graduate students),upper division/graduate electives (developmental biology, selected advanced topics in cell and molecular biology). (nmhu.edu)
  • cDNA
  • There was a single-base pair substitution in the Hindlll recognition sequence in the cDNA in four out of the 15 strains. (nii.ac.jp)
  • translational
  • The National Institute of Nutrition (NIN) is an Indian Public health, Biotechnology and Translational research center located in Hyderabad, India. (wikipedia.org)
  • increasingly
  • The utility value of these resources is now increasingly limited by the constraints of maintaining the fish strains alive, and there is potential danger that many if not most of them could be lost. (pubmedcentralcanada.ca)
  • biology
  • Prior to his doctoral training, he earned a B.S. (1967) and M.S. (1969) in Biology from East Carolina University (receiving the Poteat Award for his research on the teratogenicity of LSD). (wikipedia.org)
  • General
  • The institute has associated clinical and pediatric nutrition research wards at various hospitals such as the Niloufer Hospital for Women and Children, the Government Maternity Hospital, the Gandhi Medical College and the Osmania General Hospital in Hyderabad. (wikipedia.org)
  • scientific
  • This may impose undesirable restrictions on the availability of potentially valuable purpose-bred swine strains and their scientific use. (nih.gov)
  • Phi Kappa Phi, Sigma Xi Scientific Research Society (vice-president and co-chair student research funding with Mary Shaw), Reviewer for a variety of scientific journals (Lab Animal, Andrology, Asian J Andrology, Reproduction, Cell and Tissue Research). (nmhu.edu)
  • genetically
  • The Pryor Mountain Mustang is a substrain of Mustang considered to be genetically unique and one of the few strains of horses verified by DNA analysis to be descended from the original Colonial Spanish Horses brought to the Americas by the Spanish. (wikipedia.org)
  • A strain, in reference to rodents, is a group in which all members are as nearly as possible genetically identical. (wikipedia.org)
  • organisms
  • In our surroundings, no living organism is a discrete individual or lives in isolation, but each organism is a part of an intricately linked system of living and non living elements and ecology (Gr. Oikos = house) is a science by which we study how organisms (animals, plants and microbes) interact in and with the natural world. (blogspot.com)
  • Model organisms are in vivo models and are widely used to research human disease when human experimentation would be unfeasible or unethical. (wikipedia.org)
  • page needed] In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. (wikipedia.org)
  • Subsequent research in model organisms led to further medical advances, such as Frederick Banting's research in dogs, which determined that the isolates of pancreatic secretion could be used to treat dogs with diabetes. (wikipedia.org)
  • toxicology
  • The National Centre for Laboratory Animal Science (to be integrated into the National Animal Resource Facility for Biomedical Research), and the Food & Drug Toxicology Research Centre, National Nutrition Monitoring Bureau are the other wings of NIN, for India's Ministry of Health and Family Welfare. (wikipedia.org)
  • The institute majorly conducts research in obesity, diabetes, food chemistry, dietetics, drug toxicology, and micronutrient deficiency in collaboration with centers such as the Rockefeller University, University of Colorado School of Medicine, Washington University, and the Johns Hopkins Bloomberg School of Public Health in the U.S.. and the University of Wollongong in Australia. (wikipedia.org)
  • Joseph Holson received his Doctorate in Physiology in 1973 from the University of Cincinnati College of Medicine, having studied under the direction of Dr. James G. Wilson in the disciplines of developmental toxicology and research pediatrics. (wikipedia.org)
  • He became the Division Director in 1975 and organized a multidisciplinary research program, which became one of the nation's major federally sponsored research groups in reproductive toxicology. (wikipedia.org)
  • For the next five years, he directed the teratology and developmental toxicology research programs of the National Toxicology Program (NTP), which focused on biochemical and physiological causes of birth defects, pharmacokinetics, postnatal functional evaluations, and mechanistic studies. (wikipedia.org)
  • Dr. Holson joined Science Applications International Corporation (SAIC) in La Jolla, California during March 1980 to establish research and development and chemical testing programs in toxicology. (wikipedia.org)
  • For the next five years, he directed SAIC's toxicology division, which included an active reproductive toxicology research emphasis. (wikipedia.org)
  • Translational
  • The National Institute of Nutrition (NIN) is an Indian Public health, Biotechnology and Translational research center located in Hyderabad, India. (wikipedia.org)
  • Since the beginning of its operations in 1998, the Center develops basic as well as translational and applied research programs at the cutting edge of modern biomedical sciences. (wikipedia.org)
  • rabbits
  • Other animals such as rabbits, hares, and pikas, whose incisors also grow continually, were once included with them, but are now considered to be in a separate order, the Lagomorpha. (wikipedia.org)
  • Institute
  • Royal Victoria Hospital, McGill University Health Centre Research Institute. (jove.com)
  • Research by Rutgers Cancer Institute of New Jersey investigators shows the targeting of a binding protein of mutant p53 known as Rac1 could lead to new therapeutic strategies for patients whose cancer carries mutations in the p53 gene. (cshlpress.com)
  • He is also a council member of the Institute of Laboratory Animals Research USA. (wikipedia.org)
  • The institute is one of the oldest research centers in India, and the largest center, under the Indian Council of Medical Research, located in the vicinity of Osmania University. (wikipedia.org)
  • The institute has associated clinical and pediatric nutrition research wards at various hospitals such as the Niloufer Hospital for Women and Children, the Government Maternity Hospital, the Gandhi Medical College and the Osmania General Hospital in Hyderabad. (wikipedia.org)
  • Agencies such as WHO and FAO recognized the institute as a Centre for excellence in food quality, safety and nutrition research. (wikipedia.org)
  • From 1980-1986, he also served as a member of the Board of Directors and Secretary for the San Diego Biomedical Research Institute. (wikipedia.org)
  • humans and animals
  • All of these medications need to be tested though, both in humans and animals. (blogspot.ca)
  • For example, the results have included the near-eradication of polio and the development of organ transplantation, and have benefited both humans and animals. (wikipedia.org)
  • models
  • This policy should not be affected or impacted by email campaigns by non governmental organizations that oppose animal use and therefore seek to stop the transport of animal models such as non human primates. (blogspot.ca)
  • Although biological activity in a model organism does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
  • Research using animal models has been central to most of the achievements of modern medicine. (wikipedia.org)
  • Developed obese and diabetic mutant rat models: WNIN/GR-Ob, WNIN/Ob, WNIN/Ob-IGT, to serve as pre-clinical animal models in drug development for chronic diseases like diabesity. (wikipedia.org)
  • embryonic
  • 1.3 There are numerous somatic and embryonic cell nuclear transfer animal studies that show mtDNA carry-over from the original cells to embryos, foetuses and offspring is a regular phenomenon (see appendix). (cmf.org.uk)
  • Chromatophores are largely responsible for generating skin and eye colour in poikilothermic animals and are generated in the neural crest during embryonic development. (wikipedia.org)
  • optimum
  • They are protected by the Wild and Free-Roaming Horses and Burros Act of 1971 (WFRHBA) and managed by the Bureau of Land Management (BLM), who has set the optimum herd number at 120 animals. (wikipedia.org)
  • The average litter size is 10-12 during optimum production, but is highly strain-dependent. (wikipedia.org)
  • known
  • Michael Festing is a British research scientist best known for his interest in animal testing. (wikipedia.org)
  • The common name of the animal is derived from the thickets of the shrub locally known as tamma (Allocasuarina campestris) that sheltered it in Western Australia. (wikipedia.org)
  • either
  • In doing so he was able to conclude that the virus was either a protein or closely related to one, thus benefiting experimental research. (wikipedia.org)
  • Although
  • Although the application of metabolomics in T1D research is still rare, metabolomic research has already advanced across the full spectrum, from disease progression to the development of diabetic complications. (soc-bdr.org)
  • The neck is medium in length, and most of the animals have only five lumbar vertebrae (an anatomical feature common in primitive horses)-although some have a fifth and sixth vertebrae which are fused. (wikipedia.org)
  • plants and ani
  • The environment therefore can be of two types - living and non living.The components of the living or biotic environment are all living beings (plants and animals) with whom the organism or its population or the entire community interacts. (blogspot.com)
  • Studies
  • The success of animal studies in producing the diphtheria antitoxin has also been attributed as a cause for the decline of the early 20th-century opposition to animal research in the United States. (wikipedia.org)
  • guinea
  • John Cade's research in guinea pigs discovered the anticonvulsant properties of lithium salts, which revolutionized the treatment of bipolar disorder, replacing the previous treatments of lobotomy or electroconvulsive therapy. (wikipedia.org)
  • Committee
  • He is one of 19 members of the UK's Animal Procedures Committee, which advises the Home Secretary on matters related to animal testing. (wikipedia.org)
  • Nonetheless, Festing has been criticized by the animal rights movement for his investment in companies that engage in animal testing, which according to the Animal Procedures Committee register of members' interests, includes AstraZeneca, GlaxoSmithKline, Alizyme, Akambis, Cambridge Antibody, Shire Pharmaceuticals, and Celltech. (wikipedia.org)
  • replacement
  • Cloned human embryos and animal-human hybrids produced by similar 'nuclear replacement' technology have not survived beyond blastocyst stage. (cmf.org.uk)
  • disease
  • Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. (wikipedia.org)
  • He went on to develop an antitoxin against diphtheria in animals and then in humans, which resulted in the modern methods of immunization and largely ended diphtheria as a threatening disease. (wikipedia.org)
  • often
  • In biomedical research and recombinant DNA technology it is often useful to have indicator probes which allow the user to detect, monitor, localize or isolate nucleic acids when present in any amount. (google.com)
  • In research, adult zebrafish are often fed with brine shrimp, or paramecia. (wikipedia.org)
  • scientific
  • Of course I strongly disagree with those that say animal testing is not necessary or outdated because a solid public health policy needs to be supported by scientific facts and evidence. (blogspot.ca)