• 1972
  • Since 1972, Wistar has been a National Cancer Institute (NCI)-designated Cancer Center and holds the NCI's highest rating of "Exceptional" from approximately 1,500 cancer centers across the United States. (wikipedia.org)
  • diabetic rats
  • Endoplasmic reticulum stress manifest in upregulation of multiple components of unfolded protein response was identified in neural tissues (sciatic nerve, spinal cord) of streptozotocin diabetic rats and mice. (diabetesjournals.org)
  • A chemical chaperone, trimethylamine oxide, administered for 12 weeks after induction of diabetes (110 mg⋅kg −1 ⋅d −1 , a prevention paradigm) attenuated endoplasmic reticulum stress, peripheral nerve dysfunction, intraepidermal nerve fiber loss, and sciatic nerve and spinal cord oxidative-nitrative stress in streptozotocin diabetic rats. (diabetesjournals.org)
  • Male Wistar stereptozotocin induced diabetic rats were anesthetized with urethane. (ac.ir)
  • Unilateral microinjection of L-glutamate (2.3 nmol/60 nL) into the nucleus produced a decrease in blood pressure in diabetic rats. (ac.ir)
  • Unilateral microinjection of sodium nitroprusside (100 mmol/60 nL) into the nucleus increased blood pressure in diabetic rats. (ac.ir)
  • mice
  • While less commonly used for research than mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
  • This was the first in a series of development that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
  • Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rat. (wikipedia.org)
  • LIMR
  • LIMR has coined the term "acapreneurial" to describe this unique organizational model for biomedical research, based on its combination of elements of academic science and entrepreneurial practice that are traditionally conducted apart from each other. (wikipedia.org)
  • genetics
  • The genetics of rats was studied by William Ernest Castle at the Bussey Institute of Harvard University until it closed in 1994. (wikipedia.org)
  • The Wistar Institute Cancer Center's pioneering work spans from studying genetics and the molecular and cellular events underlying how cancer develops, to the role of the microenvironment surrounding the tumor in how cancer spreads (metastasis), with the aim of making discoveries that could someday translate into advances in cancer prevention, diagnosis, and treatment. (wikipedia.org)
  • humans
  • Wistar contributed technology critical to the development of the first vaccine for the Zika virus approved by the U.S Food and Drug Administration to be tested in humans. (wikipedia.org)
  • protein
  • The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum, and then nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
  • glucose
  • More recently, wired coil-type glucose oxidase biosensors were implanted transcutaneously into rats to monitor glucose levels where the sensors performed well up to four weeks. (pubmedcentralcanada.ca)
  • The wires had to be anchored to reduce the probability of the rats' removal of the sensor, but the sensors showed less variation in glucose sensitivity over time than prior biosensors. (pubmedcentralcanada.ca)
  • researchers
  • Wistar researchers are collaborating with leading scientists worldwide to develop vaccines for hepatitis C, malaria, and other potentially deadly diseases. (wikipedia.org)
  • Training the scientists of tomorrow: Over the past decade, nearly a thousand researchers, from predoctoral students to postdoctoral fellows and visiting scientists from around the world, have trained at Wistar. (wikipedia.org)
  • widespread
  • In Japan, there was a widespread practice of keeping rats as a domesticated pet during the Edo period and in the 18th century guidebooks on keeping domestic rats were published by Youso Tamanokakehashi (1775) and Chingan Sodategusa (1787). (wikipedia.org)
  • Discoveries at Wistar have led to the creation of vaccines that protect children and adults from widespread, debilitating, and life-threatening diseases. (wikipedia.org)
  • enzymes
  • In the present study, we investigated the protective effect of betaine, a potent lipotropic molecule, on changes in the levels of lysosomal enzymes and lipid peroxidation in isoprenaline-induced myocardial infarction in Wistar rats, an animal model of myocardial infarction in man. (pubmedcentralcanada.ca)
  • 0.05) increased in plasma with a concomitant decline in the activities of these enzymes in heart tissue of isoprenaline-administered rats. (pubmedcentralcanada.ca)
  • Pretreatment with betaine daily for a period of 30 days to isoprenaline-induced rats prevented the changes in the activities of these lysosomal enzymes. (pubmedcentralcanada.ca)
  • study
  • Life extension science, also known as anti-aging medicine, indefinite life extension, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. (wikipedia.org)
  • Journal
  • Aluminum-chloride-phthalocyanine encapsulated in liposomes: activity against naturally occurring dog breast cancer cells," Journal of Biomedical Nanotechnology , vol. 8, no. 2, pp. 251-257, 2012. (hindawi.com)
  • commonly
  • Rat-catchers would not only make money by trapping the rodents, but also by selling them for food, or more commonly, for rat-baiting. (wikipedia.org)
  • science
  • The Wistar Institute is an international leader in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research. (wikipedia.org)
  • Educating area youth: Wistar offers internships, tours, and contests to area high school students to stimulate and nurture their interests in science. (wikipedia.org)
  • He also held an appointment as Adjunct Associate Professor of Biomedical Engineering and Science at Drexel University from 1981 to 1992. (wikipedia.org)
  • development
  • A global leader in vaccine development, the Wistar Institute's half-century of achievement in vaccine development has saved countless lives in the U.S. and abroad. (wikipedia.org)
  • In that position, he was responsible for the development of an independent biomedical research, and he recruited a vertically integrated group of young investigators in the area of arterial smooth muscle physiology. (wikipedia.org)
  • Biology
  • S. Sabiu, F. H. O'Neill, and A. O. T. Ashafa, " Zea mays, Stigma maydis prevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes," Pharmaceutical Biology , 2016. (hindawi.com)
  • Acetaminophen-induced nephrotoxicity in rats: protective role of Cardiospermum halicacabum ," Pharmaceutical Biology , vol. 50, no. 2, pp. 247-253, 2012. (hindawi.com)
  • The reproductive function of rats was studied at Institute for Experimental Biology at University of California, Berkeley by Herbert McLean Evans and Joseph A. Long. (wikipedia.org)
  • model
  • In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in the striatum. (ac.ir)
  • The examination of p62 , ATG5 , ATG12 , ATG16L1 , and LC3 expressions using RT-PCR revealed that p62 , ATG5 , ATG12 , LC3 , and ATG16L1 were expressed in the substantia nigra of PD rat model, while ATG10 was not expressed. (ac.ir)
  • Thus, these results show that autophagy deregulation occurs in the initiation stages of the process in the rat model of PD. (ac.ir)
  • In rats, scopolamine is used to model memory impairment. (wikipedia.org)
  • applications
  • Research to identify and characterize the biomedical applications of CeNPs has been heavily focused on investigating their use in treating diseases that are characterized by higher levels of reactive oxygen species (ROS). (mdpi.com)
  • less
  • Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. (wikipedia.org)
  • Among
  • There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
  • days
  • Male albino Wistar rats were pretreated with betaine (250 mg/kg body weight) daily for a period of 30 days. (pubmedcentralcanada.ca)
  • After the treatment period, isoprenaline (11 mg/100 g body weight) was intraperitoneally administered to rats at intervals of 24 h for 2 days. (pubmedcentralcanada.ca)
  • Wistar rats were treated with Ang II (200 ng·kg −1 ·min −1 , 42 days) and or losartan (10 mg·kg −1 ·day −1 , 14 days). (springer.com)
  • Hoof was administered orally (0.12 g/kg) for 3 days and the rats were mated on day 10 after the last administration. (alliedacademies.org)