Biology leukemia experimental. Medical search. Frequent questions

She is a Scholar of the Leukemia & Lymphoma Society, and past recipient of the Janet Rowley Award from the International Society for Experimental Hematology, the V Foundation V Scholar Award, American Society of Hematology Scholar Award, and the Ellison Medical Foundation New Scholar Award in Aging. (lls.org)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (lls.org)
This talk will survey the use of mass cytometry for systems level characterization of cells in healthy human tissues, including blood, bone marrow, and tonsillar tissue, as well as diseases including melanoma, glioblastoma, lymphoma, leukemia, bone marrow failure and myelodysplastic syndromes, and graft vs. host disease. (uib.no)

Experimental hematology. (nottingham.ac.uk)
Elaine S. Jaffe, M.D. , NIH Distinguished Investigator in the Laboratory of Pathology , received the Lifetime Achievement Award from the Federation of American Societies for Experimental Biology (FASEB) for her pioneering work in the fields of hematology and hematopathology. (cancer.gov)
2021 , '3101 - MIR-10A AS A THERAPEUTIC TARGET AND PREDICTIVE BIOMARKER FOR MDM2 INHIBITION IN ACUTE MYELOID LEUKEMIA' , Experimental Hematology , 100 , pp. (edu.au)
Understanding how HSPCs are regulated is of central importance for several areas in clinical hematology, including stem cell transplantation and the treatment of leukemias. (lu.se)

The Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology. (unige.ch)
It is understood that the Master Thesis (TFM) of Immunology must give great importance to the student's training in the field of laboratory techniques to learn, to know how to apply the experimental design, to know how to use and benefit for the results. (ub.edu)
The state of the art in single cell tumor immunology will be discussed, including tissue collection, technical and biological quality controls, analysis of cell signaling (phospho-flow), computational analysis, and integration of different experimental and clinical data types 3 . (uib.no)

At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)

Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
cyclin-dependent kinase inhibitors in experimental therapy of lymphomas. (cuni.cz)
A clinical trial led by Christopher Kanakry, M.D. , Lasker Clinical Research Scholar in the Center for Immuno-Oncology , is researching blood stem cell transplants for blood cancers such as leukemias or lymphomas. (cancer.gov)
Lasker Clinical Research Scholar in the Pediatric Oncology Branch , is researching CAR T-cell therapy for leukemias and lymphomas. (cancer.gov)

Expanding access to new agents for children with refractory cancers: the experimental therapeutics program at Children's Hospital of Colorado. (alexslemonade.org)

Thus, it is crucial to improve analytical methods of investigation of co-cultured cells, to study their interactions and so to understand biology of leukemia in order to understand molecular mechanisms and offer novel therapeutic strategies. (intechopen.com)
We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. (stanford.edu)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The foundations of modern molecular biology and genetics are based upon studies conducted with bacterial viruses, and continue to provide critical clues to foundational knowledge of molecular and cellular processes. (umn.edu)
In collaboration with Novartis, his laboratory performed pre-clinical studies that were instrumental to the development of Gleevec (imatinib), a drug that targets the molecular defect in chronic myeloid leukemia (CML). (cml-foundation.org)
Methods in molecular biology 1346 , 99-113, doi:10.1007/978-1-4939-2987-0_8 (2015). (uib.no)
Molecular biology as a tool for the treatment of cancer. (cdc.gov)
7.2 Data from molecular biology. (who.int)

To identify and study the impact of pancreatic cancer cell plasticity, the team established an experimental approach to isolate and characterize single cell clones called "escapers" that spontaneously acquire malignant features. (mdanderson.org)
image: From left: Samuel Brady, Ph.D., and Jinghui Zhang, Ph.D., chair, both of Computational Biology, contributed to research that provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy. (sciencecodex.com)
The research provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy and are not always present at diagnosis. (sciencecodex.com)
Dr Eaves' research has focused on leukemia and breast cancer, where she has applied cutting-edge technology and elegant experimental design to the most pertinent problems in stem cell biology and cancer research, constantly contributing to the ongoing pursuit of cures. (scienceworld.ca)
This blog is designed to provide updates in developments in cancer biology and engage in discussions about new findings in the field. (shu.edu)
Cancer cells, including leukemia cells, reside in a complex microenvironment, which influences biology and activity of the cells. (intechopen.com)
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Dr. Druker is director of the OHSU Knight Cancer Institute, JELD-WEN Chair of Leukemia Research at Oregon Health & Science University, and investigator of the Howard Hughes Medical Institute. (cml-foundation.org)
Dr. Jung leads the Department of Cancer Biology, the Infection Biology Program, and the newly-established Global Center for Pathogen & Human Health Research, which is focused on understanding of viral pathogens and the human immune responses toward preparing and protecting future public health threats. (ccf.org)
Leukemia is a blood cancer that develops in the hematopoietic system and presents in the bone marrow with or without peripheral blood cell involvement[ 1 , 2 ]. (ijpsonline.com)
In cancer biology, controlling leukemia remains a big challenge. (ijpsonline.com)
Biology-based clinical trials for children with cancer. (alexslemonade.org)
3 Irish, J. M. & Doxie, D. B. High-dimensional single-cell cancer biology. (uib.no)
Patients who survive cancer treatment with alkylating agents, with or without radiotherapy, have a high risk of developing MDS or secondary acute leukemia 5-7 years after the exposure. (medscape.com)
It seems that cancer cells may increase the number of aquaporins to enhance their own survival and increase their spreading ability, says Karin Lindkvist, professor of cell biology at Lund University and structural biology researcher. (lu.se)

Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers. (sciencecodex.com)
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)

It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
The minimal residual disease state during first remission may be the optimal setting to study novel LSC-targeted therapies, since they may have limited activity against the bulk leukemia and will be utilized at lowest tumor burden as well as least tumor heterogeneity. (johnshopkins.edu)

Next, we used methylation-specific polymerase chain reaction (MSP) technology for detecting the methylation of GRHL2 in clinical samples with acute leukemia and cell lines. (hindawi.com)
Beside basic research questions in biology (e.g. clonal competition at the level of stem cells, stem cell - niche interactions or cell migration), we specifically address topics with an explicit clinical relation (e.g. disease and treatment models of different leukemia types and other malignancies). (tu-dresden.de)
This research area focuses on the development and application of innovative data analysis methods, including the fields of experimental and clinical trial design . (tu-dresden.de)
These clinical cell biology insights have paralleled advances in single cell technology and sparked intense study of the cellular mechanisms driving therapy response and resistance 1 . (uib.no)
Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia. (cdc.gov)
Recommendations from a Portuguese Expert Group for Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Patients in Clinical Practice. (cdc.gov)
Chronic Myeloid Leukemia, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology. (cdc.gov)
The Nilsson lab brings together individuals with diverse scientific backgrounds (clinical, experimental and computational). (lu.se)

Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
expressing high-risk chronic lymphocytic leukemia. (bvsalud.org)
Mutation-specific CAR T cells as precision therapy for IGLV3-21 R110 expressing high-risk chronic lymphocytic leukemia. (bvsalud.org)
Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor- risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor ( CAR ) T cells . (bvsalud.org)
His main scientific interest is the study of chronic myeloid leukemia (CML) and the Ph-negative chronic myeloproliferative neoplasms (MPNs), mainly their natural history, prognosis, biology, and treatment. (cml-foundation.org)
In this study, anticancer properties of heterocyclic salicylaldimines and their Cu(II) complexes on K562 human chronic myelogenous leukemia cell line were investigated. (ijpsonline.com)
Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfunctional immune response leading to life-threatening infections in patients. (biomedcentral.com)
The progression of chronic lymphocytic leukemia (CLL) is strongly associated with the modification of diverse immune cell populations to create a niche appropriate for the proliferation and survival of leukemic B cells. (biomedcentral.com)
Mutational landscape of chronic myeloid leukemia: more than a single oncogene leukemia. (cdc.gov)
Identification of Prognostic and Susceptibility Markers in Chronic Myeloid Leukemia Using Next Generation Sequencing. (cdc.gov)
Pharmacogenetics and the treatment of chronic myeloid leukemia: how relevant clinically? (cdc.gov)
Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: a systematic review and meta-analysis. (cdc.gov)
TP53 codon 72 polymorphism predicts chronic myeloid leukemia susceptibility and treatment outcome. (cdc.gov)
Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents. (cdc.gov)
Balanced translocation abnormalities lead to the generation of fusion oncogenes such as Bcr-Abl in chronic myelogenous leukemia (CML) and PML-Rar alpha in acute promyelocytic leukemia (APL). (medscape.com)

Importantly, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia. (lu.se)
Lund University researchers find that individual blood stem cells (depicted as snowflakes in this image) express stress-related transcripts when subjected to experimental procedures involving cell incubation at elevated temperatures. (lu.se)

The present chapter outlines the importance of modern, multiparameter flow cytometry methods, which allow to analyze interactions between different types of cells within the leukemia microenvironment. (intechopen.com)
To investigate the interrelation between Treg and neutrophils in the leukemia microenvironment, we performed experiments using TCL1-injected DEREG mice with Treg depletion or RAG2KO mice with adoptively transferred TCL1 cells alone or together with Treg. (biomedcentral.com)
Additionally, we show that Treg depletion and IL-10 neutralization induce changes in the leukemia microenvironment, partially restoring the "healthy" phenotype of neutrophils. (biomedcentral.com)

The failure of complete remissions to reliably translate into cures in acute myeloid leukemia (AML) can be explained by the leukemia stem cell (LSC) paradigm, which hypothesizes that rare leukemia cells with stem cell features, including self-renewal capacity and drug resistance, are primarily responsible for both disease maintenance and relapses. (johnshopkins.edu)
Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy. (nottingham.ac.uk)
Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells ONCOTARGET. (nottingham.ac.uk)
In a subgroup of patients, the acquisition of additional genetic abnormalities results in the transformation of MDS into acute myeloid leukemia (AML). (medscape.com)

The findings offer a paradigm shift in understanding how drug resistance develops," said Jinghui Zhang, Ph.D., Department of Computational Biology chair at St. Jude Children's Research Hospital. (sciencecodex.com)
Co-first author Samuel Brady, Ph.D., of St. Jude Computational Biology, identified a mutational signature that helped decipher the process. (sciencecodex.com)

Indeed, neutrophils are able to support leukemia progression through mechanisms that mimic the cooperation of neutrophils with healthy regulatory B cells [ 6 ]. (biomedcentral.com)

The research focus of the Roeder Lab comprises topics from the areas: systems biology / medicine (in particular mathematical modelling and computer simulation), medical biometry / statistics, as well as data integration and study design. (tu-dresden.de)

Development of a childhood leukemia translational research program. (alexslemonade.org)

For patient education information, see Myelodysplastic or Myeloproliferative Neoplasms (Leukemia Types). (medscape.com)

This study indicates that the LTRNL-infected human leukemia cells exhibit inducible susceptibility to GCV. (elsevierpure.com)

2023 Nature Cell Biology 25:92. (ccf.org)

Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
Remodeling of stroma cell functions by leukemia cells is also well documented. (intechopen.com)
Importantly, the proposed experimental setups can be easily transformed to study different cell types and different biological systems. (intechopen.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. (concordia.ca)
Only those rare AML cells characterized by a hematopoietic stem cell (HSC) CD34 + CD38 − phenotype were believed capable of generating leukemia in immunocompromised mice, but more recently, significant heterogeneity in the phenotypes of engrafting AML cells has been demonstrated. (johnshopkins.edu)
However, eradication of the leukaemia repopulating cell or stem cell whilst retaining normal HSCs remains a challenge with current experimental therapies. (nottingham.ac.uk)
Cells of the human leukemia lines (K562, MEG-01) were infected with this vector and two transduced cell lines (K562/LTRNL, MEG-01/LTRNL) were established. (elsevierpure.com)
Cellular activity is confirmed by a viability assay in a leukemia cell line. (uzh.ch)
We have discovered novel insights into the biology of human T cell exhaustion and developed approaches to prevent and reverse this phenomenon. (stanford.edu)
Increasing evidence emphasize that a substantial variance of protein expression is conveyed at the levels of protein synthesis and degradation, and that post-transcriptional control of gene expression plays a critical role in multiple aspects of cell biology, including coordination of cellular processes and rapid alteration of cellular phenotype. (lu.se)
Frontiers in cell and developmental biology. (lu.se)

In Advances in Experimental Medicine and Biology (pp. 153-169). (johnshopkins.edu)
Advances in Experimental Medicine and Biology, vol. 1139, Springer New York LLC, pp. 153-169. (johnshopkins.edu)

The research provided the first direct genomic and experimental evidence of chemotherapy-induced drug resistance mutations. (sciencecodex.com)

Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
In short-term liquid cultures of leukemic blood cells from 60 untreated patients with acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) the 3 H-thymidine incorporation was measured. (karger.com)
CRISPR/Cas9 Genome Editing of the Human Topoisomerase II Intron 19 5' Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells. (osu.edu)
hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase II in Human Leukemia K562 Cells with Acquired Resistance to Etoposide. (osu.edu)
Leukemia cells in patients are intrinsically resistant to standard chemotherapy, and resistance development in leukemia cells toward drugs results in treatment failure[ 4 , 5 ]. (ijpsonline.com)
As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
Suspecting that experimental procedures used during gene expression analysis might be influencing the results, they examined how stress-related genes behaved in cells collected under different conditions. (lu.se)
RUNX1-positive leukemia cells in preclinical models. (lu.se)
Now, a research group at Lund University has succeeded in finding a drug candidate that binds to the protein, something that has been shown to affect the growth capability of leukemia cells. (lu.se)
They have also shown that the drug affects the growth capability of leukemia cells by inactivating aquaporins. (lu.se)

PML was poorly understood until described in the findings of Grignani et al in their 1996 study of patients with acute promyelocytic leukemia (APL). (wikipedia.org)
Our present research is aimed at studying the abnormal expression of GRHL2 and the association of methylation in patients with acute leukemia and its relationship with prognosis. (hindawi.com)
We used quantitative real-time polymerase chain reaction (qRT-PCR) for detecting the aberrant expression level of GRHL2 in 60 patients with acute leukemia and 60 normal controls. (hindawi.com)
We analyzed the significant correlation between the expression level of GRHL2 with clinicopathological features and patients' prognosis in acute leukemia using the corresponding statistical methods. (hindawi.com)
At the same time, the expression level of GRHL2 in patients with acute leukemia was significantly correlated with leukocyte count, platelet count, and cytogenetic risk grouping. (hindawi.com)
In addition, the lower GRHL2 expression group showed a significantly lower overall survival rate in acute leukemia patients than that of patients with a higher GRHL2 expression group. (hindawi.com)
Univariate and multivariate analyses revealed that the expression of GRHL2 is an independent risk factor in acute leukemia patients. (hindawi.com)
Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia. (hindawi.com)
Bone marrow transplants are used to treat leukemia in tens of thousands of patients every year. (scholarsresearchlibrary.com)

We analyzed both the phenotype and activity of neutrophils isolated from the spleens of TCL1 leukemia-bearing mice. (biomedcentral.com)

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia. (wustl.edu)

The Journal of Experimental Medicine, 200(5), 659-69. (concordia.ca)
Brazilian Journal of Biology = Revista Brasileira de Biologia, vol. 82, pp. e264356. (scielo.br)

Sponsored by the Department of Biology, Seton Hall University. (shu.edu)

Chemotherapy is one of the most important treatment options in the treatment of all types of leukemia, but multi-drug resistance often precludes the success of this treatment. (ijpsonline.com)

Epigenetic manipulation of leukemia. (alexslemonade.org)

Anatomy23

Organisms20

Diseases55

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes49

Disciplines and Occupations8

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Acute leukemia cells1

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Cancer15

Cancers2

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Chronic15

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Microenvironment3

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20231

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