• 촉진자) 서열을 사용해 유전자 군집(즉, 구조유전자(structural gene) 군집)을 단일 mRNA 분자로 전사(transcription)하기 시작합니다. (jove.com)
  • Taken together, the data indicates that gene topology causes NSD1 to deposit H3K36me2 throughout the genome and represses transcription. (epigenie.com)
  • Mutually exclusive transcription of the 60 var genes (encoding PfEMP1) and switching to formerly silenced variants results in antigenic variation and allows the parasite to efficiently evade host immune responses and to establish chronic infection. (unibas.ch)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • The gene transcription burst frequency and intensity combined with RNA-degradation rate form the shape of RNA distribution at the moment of observation and thus whether the gene is bi- or monoallelic. (wikipedia.org)
  • Transcription of the wheat chloroplast gene that encodes the 32 kd polypeptide. (ncsu.edu)
  • One CCGG site 164 base-pairs upstream from the start of transcription is preferentially unmethylated in some genes. (ncsu.edu)
  • It is concluded that cytosine methylation in rDNA is regulated and that the methylation pattern correlates with the transcription potential of an rRNA gene. (ncsu.edu)
  • A five-week graduate survey course concentrating on biochemical mechanisms of gene transcription. (mcb-seattle.edu)
  • The expression, or transcription, of genes controls the identity and function of a cell. (isbscience.org)
  • The general transcription factor TFIIH plays central roles in both processes and is also important to couple gene transcription with DNA repair. (isbscience.org)
  • This study demonstrates that mammalian condensin II functions to organize long-range chromosome contacts and regulate transcription at specific genes. (bepress.com)
  • In a living cell, it is unlikely that the transcription of any gene is resistant to changes in the cell cycle or in the levels of nutrients. (biomedcentral.com)
  • Our network approach leads to the identification of the upstream transcription factors for prognostic signature genes to provide leads to their regulatory mechanisms. (biomedcentral.com)
  • Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
  • one includes structural genes encoding enzymes that directly participate in the formation of anthocyanins and other flavonoids, and the other comprises regulatory genes controlling the transcription of structural genes. (scirp.org)
  • 5) in 1978 put forth a the- on exposed surfaces led to studies that revealed surface-associ- ory of biofilms that explained the mechanisms whereby micro- ated microorganisms (biofilms) exhibited a distinct phenotype organisms adhere to living and nonliving materials and the with respect to gene transcription and growth rate. (cdc.gov)
  • At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • Genetics and Molecular Biology is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. (eolss.net)
  • The Theme on Genetics and Molecular Biology with contributions from distinguished experts in the field deals with genetics and its development and biology at the Molecular level. (eolss.net)
  • In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules. (pharmiweb.com)
  • XCI leads to the transcriptional silencing of one of the X chromosomes in female cells, which results in expression of the genes that located on the other, remaining active X chromosome. (wikipedia.org)
  • In 1987, she became the first to establish p53 as a transcriptional activator of other genes. (mdanderson.org)
  • Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)
  • The best chromosomal gene for normalization in the presence of the transcriptional activators used in this study, cadmium, dexamethasone, forskolin and phorbol-12-myristate 13-acetate was first identified. (biomedcentral.com)
  • The biological variables include the differences in the levels of transcriptional expression of genes between tissues and cell types [ 7 ]. (biomedcentral.com)
  • applied a reverse engineering method for context-specific transcriptional regulatory networks to 176 gene expression profiles from high-grade glioblastoma (HGG) patients. (biomedcentral.com)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • For old rats, a muted transcriptional profile (13 and 2 differentially expressed genes at 6 and 120 h, respectively) coincided with deficiencies in demethylation, muscle remodeling, and torque recovery. (cdc.gov)
  • Here, we examined the lung transcriptional response after inhalation of GMA-SS fume and used gene network-based analysis to compare with previous aspiration data. (cdc.gov)
  • We are continously seeking talented and highly motivated postdocs, graduate students and master students within computational biology and bioinformatics. (lu.se)
  • The Affymetrix software Microarray Suite 4.0 and 5.0 (MAS 4 and MAS 5) estimate expression from the average difference of PM and MM fluorescence. (biomedcentral.com)
  • Individual expression patterns are extraordinarily diverse, but by supplementing qualitative in situ hybridization data with quantitative microarray time-course data using a hybrid clustering strategy, we identify groups of genes with similar expression. (biomedcentral.com)
  • This book focuses on the development and application of the latest advanced data mining, machine learning, and visualization techniques for the identification of interesting, significant, and novel patterns in gene expression microarray data. (firebaseapp.com)
  • Biomedical researchers will find this book invaluable for learning the cutting-edge methods for analyzing gene expression microarray data. (firebaseapp.com)
  • In recent exploratory regional therapy alone or by the addition of systemical studies, markers from microarray gene expression medical therapy with increased side effects and costs. (lu.se)
  • Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
  • PUREE was trained on gene expression data and genomic consensus purity estimates from 7864 solid tumor samples. (nature.com)
  • Overall, PUREE is a highly accurate and versatile method for estimating tumor purity and interrogating tumor heterogeneity from bulk tumor gene expression data, which can complement genomics-based approaches or be used in settings where genomic data is unavailable. (nature.com)
  • Constitutive monoallelic expression occurs from the same specific allele throughout the whole organism or tissue, as a result of genomic imprinting. (wikipedia.org)
  • The reason for this is that passengers frequently take the majority of the signature gene and an accurate discrimination of cancer drivers from passengers becomes a key subject in cancer genomic studies. (biomedcentral.com)
  • This alignment process enables the determination of the origin of each read, allowing us to associate it with specific genes or genomic regions. (pharmiweb.com)
  • This parent-specific gene activation results from a phenomenon called genomic imprinting. (medlineplus.gov)
  • Explores the normal developmental function of genes that have been identified as causal in human developmental disorders such as skeletal dysmorphologies, ciliopathies, autism, and cancer. (mcb-seattle.edu)
  • Within each of these categories, we identified clusters of genes associated with particular cellular and developmental functions. (biomedcentral.com)
  • Within the same functional classes, however, different gene populations were expressed in distinct developmental phases. (biomedcentral.com)
  • Different genes in the same functional clusters are expressed in the different developmental stages, suggesting that cells might change gene expression profiles from differentiation to maturation stages. (biomedcentral.com)
  • Gene expression profiles obtained without artifacts introduced by isolation procedures or gene mutations provide a valuable overview of retina development under natural developmental conditions. (biomedcentral.com)
  • When studying gene expression, researchers often compare gene expression profiles between different biological samples or experimental conditions, such as healthy and diseased tissues, treated and untreated cells, or different developmental stages. (pharmiweb.com)
  • By comparing gene expression patterns during embryogenesis or tissue differentiation, we unravel the molecular events that shape organisms, advancing our understanding of developmental biology. (pharmiweb.com)
  • The findings advance fundamental knowledge of how germline stem cells become egg cells , and could lead to important findings in developmental biology . (bvsalud.org)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • It is believed that this specialised environment at chromosome ends generates a structural framework for the epigenetic control of var gene expression. (unibas.ch)
  • However, we still lack a detailed functional understanding of the underlying molecular mechanisms that regulate Plasmodium chromosome end biology. (unibas.ch)
  • During my PhD thesis, I tackled chromosome end biology from three different angles to improve our understanding of how virulence gene expression is regulated and how genome integrity is preserved. (unibas.ch)
  • Genome-wide mapping by ChIP-Seq experiments not only confirmed that PfTRF indeed binds to all chromosome termini in vivo, but as well revealed an unexpected second binding hotspot at telomere repeat-like sequences found in subtelomeric var gene promoters. (unibas.ch)
  • Diploid organisms bear two homologous copies of each chromosome (one from each parent), a gene can be expressed from both chromosomes (biallelic expression) or from only one (monoallelic expression). (wikipedia.org)
  • The allelic choice of XCI by individual cells takes place randomly in epiblasts of the preimplantation embryo, which leads to mosaic gene expression of the paternal and maternal X chromosome in female tissues. (wikipedia.org)
  • XCI is a chromosome-wide monoallelic expression, that includes expression of all genes that are located on X chromosome, in contrast to autosomal RME (aRME) that relates to single genes that are interspersed over the genome. (wikipedia.org)
  • They also provide a listing of suggested courses for those interested in Gene Expression, Cell Cycle & Chromosome Biology. (mcb-seattle.edu)
  • The MCB Program has a strong focus on understanding various aspects of chromosome biology. (mcb-seattle.edu)
  • Long-range chromosome contacts are disrupted by loss of condensin II loading, which leads to altered expression at bidirectional gene pairs. (bepress.com)
  • An Rb-condensin II complex mediates long-range chromosome interactions and influences expression at divergently paired genes" Molecular and Cellular Biology Vol. 40 Iss. (bepress.com)
  • [ 8 ] The hGR gene is one locus on the long arm of chromosome 5 (q31.3) and consists of 9 exons. (medscape.com)
  • Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • However, some genes on this chromosome, including some of those in the 15q11.2-q13.1 region, are turned on (active) only on the maternal copy. (medlineplus.gov)
  • Data from these define genetic and non-genetic variation, define a measure of heritability for expression of individual genes, and provide the basis for a new method of data reduction for genetical genomics. (biomedcentral.com)
  • Spatio-temporal expression pattern showed that these genes were expressed in many tissues with different levels, and they had distinct expression pattern during adventitious root formation and development. (biomedcentral.com)
  • Nearly 60% of the genes with detectable expression exhibit broad patterns reflecting quantitative rather than qualitative differences between tissues. (biomedcentral.com)
  • Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. (nih.gov)
  • Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
  • Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
  • Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
  • An alternative approach is gene coexpression analysis, which detects groups of genes with similar expression patterns across unrelated sets of transcriptomic data from the same organism. (mdpi.com)
  • However, little information is available on the gene expression profile (GEP) of CMV-CTL clones according to CMV reactivation patterns (and donor CMV serostatus) after allo-HCT. (nature.com)
  • However, the range of gene expression patterns, the extent of the correlation of expression with function, and the classes of genes whose spatial expression are tightly regulated have been unclear due to the lack of an unbiased, genome-wide survey of gene expression patterns. (biomedcentral.com)
  • We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. (biomedcentral.com)
  • Of 4,496 genes with detectable expression in the embryo, 2,549 (57%) fall into 10 clusters representing broad expression patterns. (biomedcentral.com)
  • the expression patterns of over 1,500 of these genes are documented here for the first time. (biomedcentral.com)
  • We have assembled an atlas of gene expression patterns during Drosophila embryogenesis. (biomedcentral.com)
  • We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. (nih.gov)
  • Six individual gene expression clusters were identified based on expression patterns of transcripts through retina development. (biomedcentral.com)
  • Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
  • Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
  • Third, even using currently available comprehensive arrays, tissue-specific genes are still under-represented, including alternatively spliced variants or genes that are only briefly expressed in a tissue-specific pattern. (biomedcentral.com)
  • Biofilm-associated cells can be differentiated from their suspended counterparts by generation of an extracellular polymeric substance (EPS) matrix, reduced growth rates, and the up- and down-regulation of specific genes. (cdc.gov)
  • Yeast-form-specific genes identified in Histoplasma capsulatum function in calcium/calmodulin signaling pathways and sulphur metabolism. (cdc.gov)
  • Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. (ucsd.edu)
  • In this study, we investigated the reproducibility of growth phenotypes and global gene expression states during adaptive evolution. (ucsd.edu)
  • The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
  • We combine genome-wide association studies (GWAS) based on unique sample materials and large sets of phenotypes, including flow cytemetric and gene expression data as well as advanced imaging. (lu.se)
  • Differentially expressed genes (DEGs) may be responsible for phenotypic differences between various biological conditions. (mdpi.com)
  • Gene expression changes initially showed a large number of differentially expressed genes in response to an environmental change followed by a return of most genes to a baseline expression level, leaving a relatively small set of differentially expressed genes at the endpoint that varied between evolved populations. (ucsd.edu)
  • DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. (pharmiweb.com)
  • After identifying Differentially Expressed Genes (DEGs), we delve deeper into their functional significance. (pharmiweb.com)
  • 20 differentially expressed genes at each time point) and was accompanied by robust DNA demethylation, tissue remodeling, and isometric torque recovery. (cdc.gov)
  • For the vast majority of autosomal genes, expression occurs from both alleles simultaneously. (stackexchange.com)
  • DNMT3A is putting down non-CG methylation-mostly at CA (mCA)-and MeCP2 reads these marks to regulate enhancers and genes. (epigenie.com)
  • Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)
  • An individual T-cell has a specific complementarity-determining region 3 (CDR3) of T cell receptor (TCR)-α and -β, which is a result of the recombination of somatic TCR V-(D)-J genes and junction diversity. (nature.com)
  • RME is a broader class of monoallelic expression, which is defined by random allelic choice in somatic cells, so that different cells of the multi-cellular organism express different alleles. (wikipedia.org)
  • Relatively open GSC chromatin is further restricted by Polycomb repression of testis or somatic cell -expressed genes briefly active in early female germ cells . (bvsalud.org)
  • We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. (lu.se)
  • Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. (cambridge.org)
  • The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
  • Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
  • These Unigenes represent a wide range of genes classified according to their characterization and function. (karger.com)
  • introductory biochemistry and cell biology. (mcb-seattle.edu)
  • It is recommended to simultaneously attend the practical module BIO-M-PM-PBE Protein Biochemistry and Enzymology. (uni-regensburg.de)
  • Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology , 2018, 8 edition, Hofmann A and Clokie, S, Cambridge University Press, ISBN 978-1-316-61476-1. (lu.se)
  • Coexpressed genes tend to be involved in similar biological processes. (mdpi.com)
  • The limitations and possibilities associated with expression profiling in intracellular amastigotes and promastigotes were assessed through a series of comparative experiments in which technical and biological parameters were scrutinized. (cambridge.org)
  • On the biological level, we demonstrate that gene expression levels fluctuate during in vitro development of both intracellular amastigotes and promastigotes. (cambridge.org)
  • We chose to use expression-curves rather than single, specific, time-point measurements to capture this biological variation. (cambridge.org)
  • Finally, we validated these analyses by testing two chromosomal genes ( B2M and ActB ) and a co-transfected gene ( Rluc ) under biological conditions. (biomedcentral.com)
  • it significantly reduces the standard deviation within biological experiments as it takes into account the transfection efficiencies and has easily controllable expression levels. (biomedcentral.com)
  • The analysis of gene expression using quantitative real-time polymerase chain reaction (qPCR) has become increasingly important as biological research has focused on developing insights into the complex regulatory networks that exist within cells [ 1 ]. (biomedcentral.com)
  • By subjecting DEGs to gene ontology enrichment analysis, pathway analysis, or functional annotation, we gain insights into the biological processes, molecular functions, and pathways associated with the observed gene expression changes. (pharmiweb.com)
  • We compared the power of gene expression measurements with that of conventional prognostic markers, i.e., clinical, histo- pathological, and cell biological parameters, for predicting distant metastases in breast cancer patients using both established prognostic indices (e.g., the Nottingham Prognostic Index (NPI)) and novel combinations of conventional markers. (lu.se)
  • Epigenetics involves biological processes such as DNA methylation or histone modification that do not change the genome sequence but alter gene expression. (cdc.gov)
  • The bacterial genes encoding chloramphenicol acetyltransferase (CAT) and beta-glucuronidase (GUS) were transiently expressed in leaf discs from the AR1 promoter in TGMV A. The levels of AR1 and GUS RNAs were similar in leaf discs after adjusting for viral DNA copy number, while CAT RNA was less abundant. (ncsu.edu)
  • Although these comparisons favoured the gene expression markers, this was usually in comparison against single factors and the new tech- q Sources of support: Swedish Research Council, Swedish Founda- nology has not been tested against a combined index, tion for Strategic Research, Lund University Medical Faculty and the such as the Nottingham Prognostic Index (NPI). (lu.se)
  • Cytosine methylation in ribosomal DNA and nucleolus organiser expression in wheat. (ncsu.edu)
  • A correlation coefficient analysis of gene expression during retina development between previous SAGE studies and this study was also carried out. (biomedcentral.com)
  • it allows the simultaneous analysis of gene expression in a number of different samples and as a result of the high dynamic range, this technique is suitable even when only a few cells are available. (biomedcentral.com)
  • MAE can be Random monoallelic expression (RME) or Constitutive monoallelic expression (constitutive). (wikipedia.org)
  • Two most studied cases of allelic exclusion are monoallelic expression of immunoglobulins in B and T cells and olfactory receptors in sensory neurons. (wikipedia.org)
  • The high virulence of P. falciparum is mostly attributable to the expression of P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of infected red blood cells. (unibas.ch)
  • In-depth analysis of the expression profile of endogenous PfSIP2 revealed that this protein is only expressed during a very narrow time window of approximately 10hrs in late stage parasites, which coincides with intra-erythrocytic schizogony. (unibas.ch)
  • The AR1 gene, which encodes the TGMV coat protein, was transcribed transiently in leaf discs after agroinoculation of TGMV A DNA. (ncsu.edu)
  • The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. (nih.gov)
  • The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. (nih.gov)
  • There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)
  • We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods. (biomedcentral.com)
  • This can be achieved by counting the number of reads that align to each gene or by estimating transcript abundance using sophisticated algorithms. (pharmiweb.com)
  • This gene was tagged by insertion of the Tc1 transposon, and the wild-type gene was cloned by chromosomal walking 11 kb from ama-1, a cloned gene encoding the large subunit of RNA polymerase II. (ncsu.edu)
  • Including a co-transfected plasmid encoding the Renilla luciferase gene ( Rluc ) in this analysis showed that its calculated stability was not as good as the optimised chromosomal genes, most likely as a result of the lower expression levels and transfection variability. (biomedcentral.com)
  • Surprisingly, however, neither phenotypic changes nor differential gene expression were observed in a conditional PfSIP2-loss-of-function mutant and hence this approach didn't uncover novel insights into the function of this ApiAP2 factor. (unibas.ch)
  • This analysis enables us to pinpoint genes that play pivotal roles in phenotypic variation, disease development, or response to treatments. (pharmiweb.com)
  • In order to identify prognostic master regulators, we took the known 85 prognostic signature genes for colorectal cancer and inferred their upstream TFs. (biomedcentral.com)
  • We demonstrate that our approach could identify upstream biomarkers for a given set of signature genes with markedly smaller size and comparable performances. (biomedcentral.com)
  • The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
  • Existing methods that estimate tumor purity from a tumor gene expression profile adopt different analytical strategies (Supplementary Note 1 , 2 ). (nature.com)
  • Several alternative methods have been proposed to combine multiple probe-specific values into a single expression estimate. (biomedcentral.com)
  • Methods of MAE detection can be divided into single gene or whole genome MAE analysis. (wikipedia.org)
  • Methods for Plant Molecular Biology. (ncsu.edu)
  • Specifically, the coverage includes the following state-of-the-art methods: * Gene-based anal. (firebaseapp.com)
  • Statistical methods are employed to identify genes that exhibit significant changes in expression between experimental conditions. (pharmiweb.com)
  • The latest schedule for the course Methods in Molecular Biology in the schedule software TimeEdit. (lu.se)
  • Methods for gene identification and analysis of gene structure: cloning, PCR, restriction mapping, in situ hybridisation, DNA sequencing. (lu.se)
  • Gene technology: basic and applied molecular genetic methods. (lu.se)
  • Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
  • On the other hand, bulk RNA-sequence analyses reveal that gene expression profiles among patients are different according to the cytomegalovirus reactivation pattern, and are associated with cytokine production or cell division. (nature.com)
  • We investigate the relationship between expression clusters and known molecular and cellular-physiological functions. (biomedcentral.com)
  • Gene features of PUREE were further validated using single-cell RNA-seq data from distinct tumor types. (nature.com)
  • A skewed preference for BV7 genes and sequential "G" amino acids motif is observed in complementarity-determining region-3 of T cell receptor-β. (nature.com)
  • Thus, our data unveiled PfHP1 not only as a master regulator of variegated expression of exported virulence factors, but also as a crucial factor in the regulation of sexual cell differentiation. (unibas.ch)
  • aRME's can be fixed or dynamic, depending whether or not the allele-specific expression is conserved in daughter cells after mitotic cell division. (wikipedia.org)
  • The methylation pattern within a specific multigene locus is influenced by the number and type of rRNA genes in other rDNA loci in the cell. (ncsu.edu)
  • The remaining 1,947 (43%) genes fall into 29 clusters representing restricted expression, 20% patterned as early as blastoderm, with the majority restricted to differentiated cell types, such as epithelia, nervous system, or muscle. (biomedcentral.com)
  • PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway. (nih.gov)
  • M2-polarization-related CNTNAP1 gene might be a novel immunotherapeutic target and biomarker for clear cell renal cell carcinoma. (nih.gov)
  • Among the later increased population, only about 40% genes are correlated with rod photoreceptors, indicating that multiple cell types contributed to gene expression in this phase. (biomedcentral.com)
  • With RNA-seq , we can capture and quantify the abundance of transcripts, revealing the dynamic landscape of gene expression within a cell or tissue. (pharmiweb.com)
  • germline stem cell development illuminate the biology of highly potent stem cells. (bvsalud.org)
  • Further experiments investigated how these changes impact the transition from stem cell to egg cell , revealing that germline stem cells express a wide diversity of genes , including most genes whose transcripts will be stored in the mature egg later on. (bvsalud.org)
  • Another type of cell produced by germline stem cells known as nurse cells , which synthesize most of the contents of the egg , dramatically upregulate genes supporting growth . (bvsalud.org)
  • Heukelekian and genes involved in cell adhesion and biofilm formation. (cdc.gov)
  • The fungal cell cyle is considered with respect to the mechanism of sequential gene expression in Candida albicans, since little is known about the cell cycle in pathogenic molds. (cdc.gov)
  • Genes controlling hyphal development include ones that are upregulated during cell elongation and adherence to epithelia. (cdc.gov)
  • Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. (lu.se)
  • In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)
  • We describe the tissue specificity of gene expression at each stage range using selected terms from a controlled vocabulary (CV) for embryo anatomy [ 18 ]. (biomedcentral.com)
  • This demonstrates that age-related constitutive elevations in stress response gene expression was accompanied by diminished SSC-induced responsiveness in epigenomic regulation and tissue remodeling. (cdc.gov)
  • Molecular approaches to understanding the functional circuitry of the nervous system promise new insights into the relationship between genes, brain and behaviour. (nih.gov)
  • Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. (stackexchange.com)
  • Researchers at the Institute for Systems Biology, in collaboration with the University of California, San Francisco, the University of Colorado Boulder, and the Fred Hutchinson Cancer Research Center, have mapped the architecture of the multi-subunit TFIIH complex. (isbscience.org)
  • By analyzing the expression levels of thousands of genes simultaneously, researchers can identify genes that are upregulated (higher expression) or downregulated (lower expression) in one condition compared to another. (pharmiweb.com)
  • The Graduate Research School of Integrative Biology (IBIO) offers a collaborative, inclusive and interdisciplinary environment for PhD students and researchers. (lu.se)
  • Quantitative real-time PCR analysis revealed that ABA treatment around véraison resulted in the upregulation of genes encoding enzymes responsible for both general flavonoid and anthocyanin biosynthesis. (scirp.org)
  • Thus, increases in the total amount and composition ratios of petunidin- and malvidin-type anthocyanins were mainly caused by ABA-induced upregulation of uridine diphosphate glucose flavonoid glucosyl transferase , glutathione S-transferase 4, O-methyl transferase and flavonoid 3', 5' hydroxylase expression, resulting in the deep coloration of berry of skin. (scirp.org)
  • Age-dependent stress response DNA demethylation and gene upregulation accompany nuclear and skeletal muscle remodeling following acute resistance-type exercise in rats. (cdc.gov)
  • Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns. (cdc.gov)
  • With the exception of a few molecules, differences in gene network signatures are apparent between aspiration and inhalation of GMASS welding fume in B6 mice. (cdc.gov)
  • These annotations are used as experimental factors and the user can analyze differences in gene expression between the annotation type values. (lu.se)
  • Here we developed PUREE, which uses a weakly supervised learning approach to infer tumor purity from a tumor gene expression profile. (nature.com)
  • In our proposed project, you would investigate expression regulation in clinically significant bacterium non-typeable Haemophilus influenzae (NTHi). (lu.se)
  • In our previous research, we have isolated a GolS gene from drought stress cDNA library of Oryza sativa L. Moctuyen (named OsGolS) . (ac.vn)
  • The hGR cDNA was isolated by expression cloning in 1985. (medscape.com)
  • We used agroinoculation of petunia leaf discs with the A component to develop a transient expression system which permits direct examination of viral transcripts by S1 nuclease protection. (ncsu.edu)
  • Among 4,180 transcripts that changed significantly during development, approximately 2/3 of the genes were expressed at high levels up until PN5 and then declined whereas the other 1/3 of the genes increased expression from PN5 and remained at the higher levels until at least PN21. (biomedcentral.com)
  • To uncover the causes of drug interactions, we developed a systematic approach based on precise quantification of the individual and joint effects of antibiotics on growth of genome-wide Escherichia coli gene deletion strains. (embopress.org)
  • Our study lays a foundation for translating mitochondrial biology into clinical applications. (lu.se)
  • Revealing the intrinsic program of gene regulation that accompanies mammalian retinal development is a key step for eventual cure of many human retina diseases and blindness. (biomedcentral.com)
  • We found that inhalation of GMA-SS welding fume was associated with activation of complement (C2, C3, C1QA-C, C4B), type 1 interferon pathways and increased expression of monocyte and lymphocyte chemotactic genes such as CCL2, CCL7 and CCL8. (cdc.gov)
  • Kohji Hasunuma Graduated from Tokyo University, Faculty of Science, Department of Biology (Plant Science) in 1966, and Graduate School of Biology (Plant Science) in 1971. (eolss.net)
  • Dominant, very active loci have a higher proportion of rRNA genes with unmethylated cytosine residues in comparison with recessive and inactive loci. (ncsu.edu)
  • A gene's expression pattern can be defined as a series of differential accumulations of its products in subsets of cells as development progresses. (biomedcentral.com)
  • RNA in situ hybridization has the potential to reveal both spatial and temporal aspects of gene expression during development. (biomedcentral.com)
  • This study provides a complementary genome-wide view of common gene dynamics and a broad molecular classification of mouse retina development. (biomedcentral.com)
  • We propose that large-scale changes in gene regulation during development are necessary for the final maturation and function of the retina. (biomedcentral.com)
  • Sometimes called the 'guardian of the genome,' p53 is a tumor suppressor gene that, when neutralized, plays a critical role in the development of many types of tumors. (mdanderson.org)
  • In silico analysis of available array data showed that a large number of genes traditionally classified as PEP dependent genes are transcribed during early embryo development from the pre-globular stage to the mature-green-stage. (frontiersin.org)
  • In all cases of dup15q syndrome, the duplicated genetic material results in extra copies of certain genes involved in development. (medlineplus.gov)