• Fleming operates its own Animal House, which can house more than 20,000 mice. (wikipedia.org)
  • Its main activity is the reproduction and maintenance of mice stocks either of inbred strains or genetically engineered mice, such as transgenic and knockout mouse lines, as well as chemically induced mutants developed by Fleming researchers. (wikipedia.org)
  • The Animal House has 6 different Facilities-Units of SPF status and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
  • Animal models, specifically mice models, usually receive a large portion of research investment. (reportsanddata.com)
  • Mice have been used as models of human biology and diseases, due to their phylogenetic and physiological similarities to humans, ease with which they can be maintained and bred in the laboratory, and existence of various inbred strains. (reportsanddata.com)
  • The global mice model market is expected to be primarily driven by use of mice models in cancer research. (reportsanddata.com)
  • Complying with required legislation for use of animal models can be time-consuming and inconvenient, and could restrain growth of the global mice model market. (reportsanddata.com)
  • The inbred mice segment accounted for the largest share in 2020. (reportsanddata.com)
  • The growth of the segment can be attributed to rising use of inbred mice in research of pharmacology and cardiovascular diseases, and to study responses of monoclonal antibodies. (reportsanddata.com)
  • These type of mice are being considered as an important tool in genetics studies of complex diseases, owing to which there is high demand for inbred mice. (reportsanddata.com)
  • Initially sought as pets, the Granby mice become important in research. (jax.org)
  • Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
  • The work was done in parallel with an international collaboration, the Mouse Phenome Database (MPD) project, which was created to establish a collection of baseline phenotypic data from commonly used inbred mice. (sciencedaily.com)
  • The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, and contains data on 20 segmented structures, including variability of brain structures across the strain, and downloadable visualization tools. (sciencedaily.com)
  • Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
  • Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
  • [4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
  • With these webinar opportunities, Cyagen's expert team will comprehensively explain the cutting-edge technology, academic hotspots, and application limitations of animal models - such as genetically modified, humanized, and immunodeficient mice - from various perspectives, as we aim to exchange and share valuable experiences with you and your team. (cyagen.com)
  • Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation. (tno.nl)
  • [3] I think the vast majority of the animals used in research are rodents, but it's hard to know for sure given the U.S.'s exclusion of rats and mice from reporting requirements. (erichgrunewald.com)
  • In 2004 JAX Professor Gary Churchill, together with JAX Professor Elissa Chesler when she was at Oak Ridge National Laboratory and dozens of other leading laboratory mouse experts around the world (known collectively as the Complex Traits Consortium), devised the Collaborative Cross: a mouse population established with eight different founder strains, including standard inbred strains but also some wild-type mice. (jax.org)
  • Crossing these animals shuffles the genetic deck to yield populations of mice with greater genetic diversity than is present in the entire human race. (jax.org)
  • The 2003 EC proposal for the In the USA, laboratory animal use is federally reg- Registration, Evaluation and Authorisation of ulated by the Animal Welfare Act 1966 (amended in Chemicals (REACH), similarly aims to assess the 1985), which excludes laboratory-bred mice and toxicity of chemicals produced or imported in high rats, as well as non-mammals, from consideration quantities (15-20). (drugstorepdfsearch.com)
  • Up to date, there are 16 strains of laboratory rats and mice, including outbreed stocks, inbreed strains, and immunedeficient models have been breeding. (contractresearchmap.com)
  • Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
  • Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)
  • To further dissect these relationships, we established a panel of 21 recombinant inbred lines that showed a broad range of aggregation phenotypes, independent of differences in expression levels. (biomedcentral.com)
  • We now have been utilizing the Inbred Lengthy- and Quick-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to research the genetic underpinnings of acute ethanol tolerance which is taken into account to be a threat issue for alcohol use issues (AUDs). (eumorphia.org)
  • Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains. (sciencedaily.com)
  • Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains," said project leader Helene Benveniste, who is a researcher in Brookhaven's medical department and a professor of anesthesiology at Stony Brook University. (sciencedaily.com)
  • Animal modeling has a played a prominent role in traditional scientific research for hundreds of years, and more recently, inbred strains have been developed to support genetically modified models for applications in biomedical and health research. (cyagen.com)
  • Dr. Steve Yu has more than 20 years of experience in the field of genetically modified animal models from both R&D and management roles. (cyagen.com)
  • As an internationally renowned expert in model animals and cell biology, Dr. Yu successively served in Yale School of Medicine and NYU Grossman School of Medicine, inGenious Targeting Laboratory (iTL), Applied StemCell (ASC) and other institutions in the field of genetically modified animal models. (cyagen.com)
  • Currently, Dr. Yu is working for Cyagen as Senior Vice President and Senior Scientist, primarily responsible for the technical development of genetically modified animal model platforms. (cyagen.com)
  • Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)
  • Sequencing the DNA of each animal allows the researchers to peg physiological and behavioral characteristics (phenotypes, in the vernacular) to specific genetic variants. (jax.org)
  • Biomedical scientists have linked obesity in humans to higher risk of cardiovascular disease, as well as greater cancer risk and in some cases impaired immune systems . (the-scientist.com)
  • Monkeys are one of the main types of lab animals used in such experiments, because they are biologically similar to humans. (sixthtone.com)
  • If you are like me, when you think about ending animal testing, the first thing you think about is all the knowledge we humans would be giving up along with it. (erichgrunewald.com)
  • There are seven major areas of medicine and biology, where animals are used, but majority of animal models is used to study the cause, nature and cure of diseases affecting both humans and animals. (ommegaonline.org)
  • When the use of laboratory animal is obligatory, the most appropriate specie, breed, and strain with the closest homology to humans must be chosen. (ommegaonline.org)
  • It is upon the researcher to ensure that research involving animals will contribute significantly to the health and welfare of either humans or animals. (ommegaonline.org)
  • Humans have been using animals as models of their anatomy and physiology since the dawn of medicine. (ommegaonline.org)
  • Ancient Greek physicians dissected animals for anatomical studies because of the taboos regarding the dissection of humans[1]. (ommegaonline.org)
  • results from animal experimentations are applied to humans. (ommegaonline.org)
  • Most of these dogs are raised and live in intraspecific groups, and their interaction with humans is mostly limited to feeding, cleaning their enclosure, and research procedures. (frontiersin.org)
  • This review will assist basic researchers, clinical investigators, as well as epidemiologists, population, and social scientists by providing an annotated bibliography of currently available resource tools on how to consider sex and gender as independent variables in research design and methodology. (biomedcentral.com)
  • The authors defined a resource as a broadly based tool that can be used to guide both novice and experienced researchers to consider the impact of sex and gender differences within research design and methodology. (biomedcentral.com)
  • The research team included seven academic researchers, both basic science and clinical science, from US universities. (biomedcentral.com)
  • You may have heard of the scandal where researchers from the University of Minnesota Twin Cities (UMN) intentionally tried to introduce bugs into the Linux kernel codebase as part of a research project. (erichgrunewald.com)
  • Using animals in scientific experiments seems like a clear case of using those animals as a mere means, just as the UMN researchers used those Linux kernel maintainers to further their own ends. (erichgrunewald.com)
  • The turning of the century saw the development and use of animal models for infectious diseases and screening and the evaluation of new antibacterial drugs based upon the work of these three researchers. (ommegaonline.org)
  • Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)
  • Lawson HA , Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides. (wustl.edu)
  • Cheverud JM, Lawson HA , Funk R, Zhou J, Blakenhorn EP, Heber-Katz E, Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses. (wustl.edu)
  • Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. (genenetwork.org)
  • In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
  • Additionally, gene-edited animal models are widely adopted by drug R&D companies, scientific research institutions, and laboratories worldwide in analyzing the function of disease-related genes, studying signaling pathways, identifying drug targets, screening new drugs, and more. (cyagen.com)
  • Consequently, conservation of farm animal breeds had been for several reasons, for example, to retain potentially useful genes and gene combinations such as the Booroola fecundity gene in sheep [10], the exploitation of heterosis, and to overcome selection plateaus, in addition to cultural motivations, research, and food security. (scirp.org)
  • Using H99-derivative strains with natural genetic differences, we showed that titan cell formation was dependent on LMP1 and SGF29 genes. (broadinstitute.org)
  • Furthermore, careful re-introduction of biological variation, be that through outbred populations, environmental diversity or including animals of both sexes, can ensure that results are more broadly applicable and are less impacted by particular traits of homogeneous experimental populations. (biologists.com)
  • Model organisms such as yeast, fruit flies, and worms have advanced the study of genomics, eukaryotic biology, and evolution. (cshlpress.org)
  • To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxico- logical utility of animal experiments. (drugstorepdfsearch.com)
  • JAX changed science 90 years ago with the advent of inbred laboratory mouse models and a genetic theory of cancer. (jax.org)
  • Undoubtedly, animal experimentation has played a central role in biomedical research throughout history, where animals were first used as models of anatomy and physiology. (ommegaonline.org)
  • Since, new animal models are continually being characterized, identifying and selecting the most appropriate animal model is the single most essential element in animal-based research. (ommegaonline.org)
  • It became the first published book to advocate creating "induced animal models" for biomedical research, by proposing the use of chemical and physical induction of disease in animals. (ommegaonline.org)
  • Systematic Reviews of Animal Experiments DemonstratePoor Human Clinical and Toxicological Utility Animal Consultants International, London, UK Summary - The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. (drugstorepdfsearch.com)
  • In 20 reviews in which clinical utility was examined, the authors con- cluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one of which was contentious. (drugstorepdfsearch.com)
  • Non-animal models are generally required to pass formal scientific validation prior to their regulatory acceptance. (drugstorepdfsearch.com)
  • In contrast, animal models are simply assumed to be predictive of human outcomes. (drugstorepdfsearch.com)
  • The consistent application of formal validation studies to all test models is clearly warranted, regardless of their animal, non-animal, historical, contem- porary or possible future status. (drugstorepdfsearch.com)
  • Likely benefits would include, the greater selection of models truly pre- dictive of human outcomes, increased safety of people exposed to chemicals that have passed toxicity tests, increased efficiency during the development of human pharmaceuticals and other therapeutic interven- tions, and decreased wastage of animal, personnel and financial resources. (drugstorepdfsearch.com)
  • The poor human clinical and toxicological utility of most animal models for which data exists, in conjunction with their generally sub- stantial animal welfare and economic costs, justify a ban on animal models lacking scientific data clearly establishing their human predictivity or utility. (drugstorepdfsearch.com)
  • Here, we report on the clinical impact of a novel NiV-derived nonspreading replicon particle lacking the fusion (F) protein gene (NiVF) as a vaccine in three small animal models of disease. (cdc.gov)
  • Thus, careful characterisation and judicious use of an array of mouse models provides an opportunity to address some of the issues surrounding both the reproducibility and translatability crises often referenced in pre-clinical cancer research. (biologists.com)
  • Chief Resident in Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, 1995-1995. (upenn.edu)
  • Jacques Derrida has explored the fundamental question of the "limit" that identifies and differentiates the human animal from the nonhuman animal. (erudit.org)
  • The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
  • Despite its importance, the fundamental biology of these social processes is not well understood, and currently available treatments for these social behavior domains are inadequate. (upenn.edu)
  • They can answer fundamental research questions that research on rodents has failed to address. (sixthtone.com)
  • A good example would be the brain, since there is still a lot we do not know about how it works and if we are to find answers to these important questions, fundamental research must continue.The information acquired by fundamental research often provides new insights into more applied medical research that ultimately leads to the developmentof new medicines. (ommegaonline.org)
  • In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
  • The scientific world originally embraced C.C. Little's inbred mouse because it was a way to reduce the daunting complexity of biology and focus on a single genetic trait, such as coat color or cancer susceptibility. (jax.org)
  • Today the Collaborative Cross concept (as well as a further refinement, Diversity Outbred mouse populations) is a big idea in the research community, with more than 1,400 citations in the scientific literature. (jax.org)
  • characterise several novel Rag1 −/− mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. (biologists.com)
  • T. muris is an established laboratory mouse model for human trichuriasis and shares with T. trichiura many aspects of its biology, including the specialized niche within the host. (nature.com)
  • Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)
  • Noah Lucas Weisleder, PhD is a professor in the Department of Physiology and Cell Biology at Ohio State University Wexner Medical Center. (jain-foundation.org)
  • The research that makes up this database was published as a cover article in the October 2005 issue of the journal Neuroscience. (sciencedaily.com)
  • A survey of ten different disciplines including neuroscience, physiology, pharmacology, endocrinology, zoology, and behavioral science demonstrated that the majority of studies published in 2009 were conducted in male animals [ 2 ]. (biomedcentral.com)
  • Pam does research in Neuroscience, Physiology and Molecular Biology. (jain-foundation.org)
  • Dr. Lemckert is a senior research officer at The Children's Hospital at Westmead & The Children's Medical Research Institute, Kid's Neuroscience Centre. (jain-foundation.org)
  • Mathematical Biology is the application of mathematical modelling to solve problems in biology and physiology. (gla.ac.uk)
  • Monkeys are also used for basic research into areas such as viruses, diseases, and neurology, as well as cutting-edge biology research into areas like stem cells and gene editing. (sixthtone.com)
  • United States alone, that many millions of animalsare used worldwide, and that certain trends areresulting in an increase in laboratory animal use. (drugstorepdfsearch.com)
  • Standards for the reporting of laboratory animal usevary internationally, with many countries failing to European Commission (EC) statistics on laboratory record or publicise statistics on animal use at all. (drugstorepdfsearch.com)
  • In 2007, BioLASCO Taiwan Yi-Lan Breeding center has been awarded the Full Accreditation of AAALAC International, as the first one commercial laboratory animal breeding facility which is accredited by AAALAC International in Asia. (contractresearchmap.com)
  • Dive into critical research updates from pioneers in the field with keynotes including: Carolyn Bertozzi, Ph.D. from Stanford University, Hans de Haard, Ph.D. from Argenx, Douglas Lauffenburger, Ph.D. from Massachusetts Institute of Technology, and Hanneke Schuitemaker, Ph.D. from Janssen Vaccines & Prevention. (cshlpress.com)
  • Trade restrictions and an increase in biomedical research, including into COVID-19 vaccines, have driven the price of animals used in experiments to new heights. (sixthtone.com)
  • At present, animals in research are essential not only in areas of neurological, infectious, digestive, genetic and chronic diseases, but also play a crucial role in the development of antibiotics, vaccines as well as in proper understanding of various diagnostics and prognostic tests. (ommegaonline.org)
  • We found no significant difference between the populations in their genetic diversity (i.e., heterozygosity, level of inbreeding), nor any evidence that the family and kenneled populations originated from different genetic pools. (frontiersin.org)
  • Selecting for such animals could strongly improve the welfare of kenneled dog populations. (frontiersin.org)
  • A high-fat diet induced changes to the animals' vaginal microbiomes that boosted survival after exposure to the virus. (the-scientist.com)
  • In 2020, the veterinary segment accounted for the largest revenue share, due to rising prevalence of several animal disorders such as seizures and severe infectious diseases, resulting in increasing R&D to develop veterinary medicines. (reportsanddata.com)
  • December 17, 2020 - New research from the University of Oxford shows that plant mutation rates accelerate with increasing environmental temperatures. (cshlpress.com)
  • On the other hand, dogs bred and kept solely for breeding or research purposes ("kenneled dogs") are kept and handled under standardized conditions, and are usually of the same breed, thus the effects of environmental and breed-specific genetic variability on their individual behavioral variability is small. (frontiersin.org)
  • Dhawan,V. Animals in Research: Contemplating the Need (2019) J Vet Sci Ani Wel 3(1): 5012. (ommegaonline.org)
  • These cells are found in a wide range of animals including amphibians , fish , reptiles , crustaceans and cephalopods . (wikipedia.org)
  • Here we show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces T1 immunity to dietary antigen. (broadinstitute.org)
  • The Biomedical Sciences Research Center "Alexander Fleming" is a non-profit research organisation based in Vari, Athens, Greece. (wikipedia.org)
  • Since the beginning of its operations in 1998, the Center develops basic as well as translational and applied research programs in biomedical sciences. (wikipedia.org)
  • One of the ten national laboratories overseen and primarily funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven National Laboratory conducts research in the physical, biomedical, and environmental sciences, as well as in energy technologies and national security. (sciencedaily.com)
  • 3 Department of Animal and Avian Sciences, University of Maryland, College Park, USA . (scirp.org)
  • Open Journal of Animal Sciences , 11 , 304-332. (scirp.org)
  • Dr Bradley Launikonis heads the muscle research lab at the School of Biomedical Sciences at the University of Queensland. (jain-foundation.org)
  • In recent years, allostery has seen sustained growth and wide-ranging applications in life sciences, from basic research to new therapeutics development, while also elucidating emerging obstacles across allosteric research stages. (bvsalud.org)
  • Located in the center of Taichung City, CMU includes 7 colleges where western medicine, Chinese medicine, pharmacy (including Chinese herbs), health care (including nursing), life sciences, management, and public health educational, research and practice programs are provided. (contractresearchmap.com)
  • Crown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) providing discovery, preclinical and translational platforms to advance oncology, immuno-oncology, and immune-mediated inflammatory diseases. (contractresearchmap.com)
  • In the past, animal research played a vital role in discoveries such as how the kidneys work, or how hormones control different parts of the body. (ommegaonline.org)
  • L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
  • L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
  • Eight employees and $50,000, 'For research in cancer and the effects of radiation. (jax.org)
  • Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. (tno.nl)
  • More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research. (broadinstitute.org)
  • Automatic detection and segmentation of biological objects in 2D and 3D image data is central for countless biomedical research questions to be answered. (mpi-cbg.de)
  • The development of the web-browser and database was supported by both NIBIB and the Office of Biological and Environmental Research within the U.S. Department of Energy's Office of Science. (sciencedaily.com)
  • Animals may have both biological pigments and structural colours, for example, some butterflies with white wings. (wikipedia.org)
  • These resources will assist investigators applying for funding from the National Institutes of Health since all grant applicants will be required (as of January 25, 2016) to address the role of sex as a biological variable in vertebrate animal and human studies. (biomedcentral.com)
  • To address the underrepresentation of females in biomedical research, the National Institutes of Health (NIH) released a notice on June 9, 2015 entitled, Consideration of Sex as a Biological Variable in NIH-funded Biomedical Research that focuses on the "expectation that scientists will account for the possible role of sex as a biological variable in vertebrate animal and human studies" [ 5 ]. (biomedcentral.com)
  • I got some (legitimate) pushback on this, stating essentially that while rodents aren't covered by the Animal Welfare Act, their use is now regulated by the NIH . (erichgrunewald.com)
  • Students have an opportunity to integrate training in bioinformatics with chemistry and biology. (ucsd.edu)
  • In other words, explanations of the operation of the mind, soul or intellect ----including problems of consciousness, thought, learning and memory----cannot, according to Descartes, be reduced to the laws governing biology, chemistry & physic, which clearly have dominion over the body and its parts. (typepad.com)
  • Priya Rajasethupathy recalls a youthful fondness for chemistry and biology. (rockefeller.edu)
  • The NIH has launched a research initiative focusing on the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), which currently has $1.15 billion in funding. (nature.com)
  • One understands a philosopher only by heeding closely what he means to demonstrate, and in reality fails to demonstrate, concerning the limit between human and animal. (erudit.org)
  • One lab animal is generally used for only one experiment. (sixthtone.com)
  • Similarly, even if animals being tested upon could consent to it, which they cannot, it seems highly unlikely that they would choose to do so, if for no other reason than that they are often euthanised after the experiment is over. (erichgrunewald.com)
  • Additionally, improved reporting of thedetailsmaximizes the availability andutility of the information gained fromevery animal experiment, also preventing the unnecessary animal use in thefuture. (ommegaonline.org)
  • Nearly one-third of this sum is used for modeling lab monkeys - breeding animals with desirable traits for particular experiments. (sixthtone.com)
  • BioLASCO is applying the most advance technology and the well -designed facility to monitor and maintain the animal genetic, microbiological, environmental, and growth/ physiological traits to ensure animal quality to meet the international standards. (contractresearchmap.com)
  • Right here, we've got used RNA-seq to look at the transcriptome of complete mind in 40 of the LXS strains eight hours after a saline or ethanol "pretreatment" as in earlier behavioral research. (eumorphia.org)
  • Oct. 2 Presentation by Brody Holohan, PhD, CIBM postdoctoral fellow (Center for Human Genetics, Marshfield Clinic Research Inst. (wisc.edu)
  • Viral diseases have long been studied, but COVID-19 is a "new disease" that pushes the research community and the world more generally into "uncharted territories," says Casanova. (nature.com)
  • There is a growing appreciation by the biomedical community that studying the impact of sex and gender on health, aging, and disease will lead to improvements in human health. (biomedcentral.com)
  • The project allowed her to take full advantage of her early training in computer science, and it marked a turning point in her life: Though she still spent her free time doing community service and exploring the clinical side of neuropsychiatric disease, she found her attention turning ever more toward research. (rockefeller.edu)
  • While sex and gender differences in the etiology, age of disease onset, symptomology, diagnostics, response to treatment, and outcomes have long been known to exist for key health outcomes in medicine, insufficient biomedical research and reporting on the impact of sex and gender in health and disease still exists. (biomedcentral.com)
  • Possible causes include interspecies differences, the distortion of outcomes arising from experimental environments and protocols, and the poor methodological quality of many animal experiments, which was evident in at least 11 reviews. (drugstorepdfsearch.com)
  • Sex- and gender-based comparisons can inform research on disease mechanisms and the development of new therapeutics as well as enhance scientific rigor and reproducibility. (biomedcentral.com)
  • 2014. Strategies for combating and eradicating important infectious diseases of animals with particular reference to India: Present and future perspectives. (scialert.net)
  • Basic research requires around 5,000 monkeys annually, but the largest demand is for use in preclinical trials of new drugs, with approximately 25,000 monkeys - mainly crab-eating macaques - needed each year. (sixthtone.com)
  • 7/F, 107 Ren Ai Road Sec, 4, Da An District , Taipei City, 10689 Taiwan BioDuro-Sundia, an Advent International portfolio company is a trusted, leading contract research development, manufacturing organization (CRDMO) for over 27 years. (contractresearchmap.com)
  • Bioethics tends to be dominated by discourses concerned with the ethical dimension of medical practice, the organization of medical care, and the integrity of biomedical research involving human subjects and animal testing. (erudit.org)
  • To pursue this question, however, means that our movement in language should be more radical than what has been undertaken to date, in which case we may well have to rectify our language by eschewing the very concepts "human" and "nonhuman," as well as the more basic concept "animal," which has its provenance in the Latin renditions of classical Greek philosophical nomenclature. (erudit.org)
  • Regulations state that every lab monkey must have detailed genetic and health records, and that only second-generation human-reared monkeys and their offspring can be used for experiments and research. (sixthtone.com)
  • Human biology is very much similar to that of many other animals. (ommegaonline.org)
  • Most laboratory animals have the same set of organs - heart, lungs, liver, and so on which work in the same way as they do in human. (ommegaonline.org)
  • The continuous increase in the human population coupled with rising incomes and urbanization necessitates the need to conserve the genetic potential of animals to avoid or lower the consequences of biodiversity loss. (scirp.org)
  • Nutritional and healthical aspects of Spirulina (arthrospira) for poultry, animals and human. (scialert.net)
  • This review focuses on sex and gender as independent variables, as the first step in identifying their impact in medical research and health outcomes. (biomedcentral.com)
  • 2015. Effect of immunomodulation and immunomodulatory agents on health with some bioactive principles, Modes of action and potent biomedical applications. (scialert.net)
  • The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa. (broadinstitute.org)