• axonal transport
  • Retrograde axonal transport of cellular signals driven by dynein is vital for neuronal survival. (jneurosci.org)
  • The dynein/dynactin complex drives retrograde axonal transport, moving signaling molecules like neurotrophins from cell periphery to cell body. (jneurosci.org)
  • Axonal transport defects have also been suggested to contribute to the pathogenesis of more rapidly progressive neurodegenerative disease such as amyotrophic lateral sclerosis (ALS). (jneurosci.org)
  • Accumulating data from other disease models also suggest that inhibition of axonal transport leads to neurodegeneration ( Chevalier-Larsen and Holzbaur, 2006 ), presumably through inhibition of neurotrophic signaling. (jneurosci.org)
  • Here, we investigate the relative contributions of the slowing of axonal transport and changes in retrograde signaling along the axon to the pathogenesis of neuronal degeneration. (jneurosci.org)
  • Defective axonal transport causes abnormal axonal cargo accumulations and is connected to neurodegenerative diseases, including Alzheimer's disease (AD). (utexas.edu)
  • Glycogen synthase kinase 3 (GSK-3) has been proposed to be a central player in AD and to regulate axonal transport by the MT motor protein kinesin-1. (utexas.edu)
  • Using genetic, biochemical and biophysical approaches in Drosophila melanogaster , we ?nd that endogenous GSK-3 is a required negative regulator of both kinesin-1-mediated and dynein-mediated axonal transport of the amyloid precursor protein (APP), a key contributor to AD pathology. (utexas.edu)
  • dynein
  • Mouse models with defects in the retrograde transport machinery, including the Loa mouse (point mutation in dynein) and the Tg dynamitin mouse (overexpression of dynamitin), exhibit mild neurodegenerative disease. (jneurosci.org)
  • Neurons rely on microtubule (MT) motor proteins such as kinesin-1 and dynein to transport essential cargos between the cell body and axon terminus. (utexas.edu)