Biological processes nucleic base sequence. Medical search. Frequent questions

Some DNA- or RNA-binding enzymes can recognize specific base pairing patterns that identify particular regulatory regions of genes. (wikipedia.org)
These mechanical features are reflected by the use of sequences such as TATAA at the start of many genes to assist RNA polymerase in melting the DNA for transcription. (wikipedia.org)
Learn to identify homologs of known genes of interest in your newly sequenced genome. (slideshare.net)
Frameshifts and indel errors - Split genes across scaffolds - Highly repetitive sequences To face these challenges, we train annotators in recovering coding sequences in agreement with all available biological evidence. (slideshare.net)
DNA sequencing allows the researchers to determine the DNA sequences in genes and helps a researcher to create a repository of entire genomes. (thebusinessresearchcompany.com)
have analyzed the tef-1α sequences of F. equiseti , as well as the toxin-related genes PKS13 , PKS4, and TRI5 [26], and Kari has successfully cloned a protease gene [27]. (researchsquare.com)
Functionally active DNA sequences are genes having a role in making proteins. (geneticeducation.co.in)
In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response, and several cancer types. (researchgate.net)
These letters contain instructions or genes that control all of the fundamental biological processes of life. (researchsquare.com)
Discovery of the cancer specific altered genes via the MBD-seq based methylomic and RNA-seq based expression profiling, 2. (selectbiosciences.com)
Genes are passed from parents to offspring and contain the information needed to specify physical and biological traits. (biotechdelnorte.com)
Markers can reflect random sequences, genomic variants, or genes. (biotechdelnorte.com)
Recently, we have implemented and successfully applied a method based on genotype imputation of rare variation, on a set of genes detected by exome sequencing as possible candidates for association to systemic lupus erythematosus (SLE) by mutation in members of Icelandic SLE-multicase families ( 15 ). (frontiersin.org)
Whole genome sequencing can also provide insights into the specific genes or mutations that may be linked to antibiotic resistance. (folkhalsomyndigheten.se)

In this study, the Illumina HiSeq 4000 and PacBio platforms were used to sequence and assemble the whole genome of Fusarium equiseti D25-1. (researchsquare.com)
F. equiseti was most closely related to Fusarium pseudograminearum based on a phylogenetic analysis at the whole-genome level. (researchsquare.com)
Our comprehensive analysis of the whole genome of F. equiseti provides basic data for studies of gene expression, regulatory and functional mechanisms, evolutionary processes, as well as disease prevention and control. (researchsquare.com)
Advances in whole-genome sequencing technologies have enabled numerous key discoveries. (researchsquare.com)
Whole genome sequencing analysis for 100~ liver cancers reveals whole genome landscape of various phenotypes of liver cancers with multiple etiological backgrounds (virus and non-virus) for point mutations, CNVs, SVs, and virus integrations. (selectbiosciences.com)
6 ). In-depth whole-genome sequencing is the most comprehensive approach for measuring rare and common variation in both coding and non-coding regions. (frontiersin.org)
For contact tracing or inquiries related to antibiotic resistance, whole genome sequencing (WGS) of bacterial isolates is offered. (folkhalsomyndigheten.se)
It is a platform and database for the automated analysis of whole genome sequencing data. (folkhalsomyndigheten.se)

Providing comprehensive coverage from international published patent applications containing nucleic acid and protein sequences from the World Intellectual Property Organization (WIPO), the European Patent Office (EPO), the Japanese Patent Office (JPO), and the Korean Intellectual Property office (KIPO). (clarivate.com)

Many biological processes are controlled by light , which acts mostly on photoresponsive proteins. (chemistryviews.org)
AxisPharm provides comprehensive metabolomics and proteomics analysis, which involves profiling and quantification of metabolites or proteins in biological samples using techniques such as LC-MS, GC-MS, and mass spectrometry-based omics analysis. (axispharm.com)
Our concept is to develop a new targeted therapy for the inflamed gut based on using siRNA (the next generation of biological drugs after antibodies) to target and inhibit expression of proteins involved in inflammation cascades (janus kinases) and on a delivery system capable of supplying these nucleic acids to the immune cells at the colon level. (cea.fr)
The biological function of macromolecules such as proteins and nucleic acids relies on their dynamic structural nature and their ability to interact with many different partners. (polytechnique.fr)
Mass spectrometry based proteomic analyses identified 25 proteins (having at least two peptide sequences detected) in the scaffolds generated with an enzymatic approach, 143 with the detergent approach, and 102 with the solvent approach, as compared to 155 detected in unprocessed native human fat. (psu.edu)
It is the process by which the information encoded in a gene is used to either make RNA molecules that code for proteins or to make non-coding RNA molecules that serve other functions. (biotechdelnorte.com)

The nucleic acid double helix is a spiral polymer, usually right-handed, containing two nucleotide strands which base pair together. (wikipedia.org)
A trusted resource for life-science intellectual property professionals, providing unrivalled searchable access to all available peptide and nucleotide sequences from the published applications and issued patents of the United States Patent and Trademark Office (USPTO). (clarivate.com)
DNA is a double stranded that consists of four nucleotide bases: Adenine (A), Guanine (G), Thymine (T) and Cytosine(C). While RNA is a single stranded that contains: Guanine, Uracil (instead of Thymine), Adenine, and Cytosine, denoted by the letters G, U, A, and C respectively. (researchsquare.com)

Nucleic Acids Res. (iit.it)
The research group has established rigorous methods for benchmarking methods for motif discovery (BMC Bioinformatics 2007, 2008) and ChIP-seq data analysis (Nucleic Acids Res 2011). (ntnu.edu)

In molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen bonds are called a base pair (often abbreviated bp). (wikipedia.org)
Immunoassays such as ELISAs or molecular methods such as quantitative PCR can be used to quantify biological materials, but these assays are subject to inherent variability between test instances and different laboratories, and require the use of reference preparations to generate a quantitative output ( 2 ). (cdc.gov)
Molecular computing using programmable nucleic acids has been attracting attention for use in autonomous sensing systems and information processing systems by interacting with a biological environment. (snu.ac.kr)
Here, we introduce a rule-based in vitro molecular classification system that can classify disease patterns using several microRNA (miRNA) markers via the assembly of programmed DNA strands. (snu.ac.kr)
Our results demonstrate the utility of in vitro molecular classification by illustrating one of the ways in which molecular computing can be used in future biological and medical applications. (snu.ac.kr)
Therapeutic molecules will be specific siRNAs allowing a specific, sensitive inhibition of new molecular targets (targeted medicine) and thesenovel bio-therapeutics vulnerable to enzymatic degradation in biological environment will be delivered to the inflamed gut through smartly designed lipid nanoparticles offering protection and transport across biological barriers (barriers). (cea.fr)
Our ultimate goal is to provide software tools and platform elements, to formulate and test hypotheses for the sequence/structure/function relationship in molecular biology. (polytechnique.fr)
With the recent development of computational methods aiming to integrate different levels of information, protein and nucleic acid assemblies studies should provide a better understanding on the molecular processes and machinery occurring in the cell and our research extends to several related issues in comparative genomics. (polytechnique.fr)
Recent advancements in high-throughput sequencing and molecular profiling technologies have provided an unprecedented opportunity for complex disease studies. (zhang-lab.org)
All biological molecular activities occur inside the confines of a cell, which protects them from degradation by the environment. (icr.org)
Putting these basic molecules together via naturalistic processes into larger chains and structures containing the vital molecular information needed for life is also impossible! (icr.org)
Biological sequence analysis has many goals for example: Search of similarity between sequences of different organisms, Identification of intrinsic features of a sequence, Determination of sequence differences, Identification of molecular structure. (researchsquare.com)
In molecular biology and genetics, transactivation is an increased rate of gene expression triggered either by biological processes or by artificial means. (absoluteastronomy.com)
Currently, with the application of molecular biology resources in human identification, it became possible to identify a person even without physical ante-mortem data or with deteriorated biological material in negligible amounts, which are actually relatively common conditions in forensic analyses 7,12,16,19 . (bvsalud.org)

In the years, I have obtained wide experience in using high-throughput experimental and -omics approaches, including total RNA sequencing, small RNA sequencing and, more recently, single-cell RNA sequencing and Nanopore direct RNA sequencing. (iit.it)
The DNA is directly sequenced using nanopore technology with the output expected to be composed of nascent - BrdU containing molecules - as well as parental template and un-replicated DNA. (mskcc.org)
BrdU containing reads which represent nascent molecules are identified by informatically due to current shifts during nanopore sequencing. (mskcc.org)
Nanopore sequencing of replicons proceeds from the 5' end of the lagging strand through to the 3' end of the leading strand of the sister replisome. (mskcc.org)

Use of IRPs also ensures consistency of production and quality of biological medicinal products and is essential for establishment of appropriate clinical dosing. (cdc.gov)
Since 1947, the provision of WHO reference materials has played a vital role in the translation of laboratory science into worldwide clinical practice and has been delivered through the WHO Expert Committee on Biological Standardization, WHO collaborating centers, and various state and nonstate partners. (cdc.gov)
The center also benefits with the close ties with European Institute of Oncology (IEO-hospital, in Milano), one of the largest cancer hospitals, which hosts our lab spaces and provide complementary infrastructure as well access to clinical data and biological samples for cancer studies. (iit.it)
C. The Genome Center maintains an ISO15189 certified medical platform/laboratory for nucleic acid sequencing and analysis to support large-scale genetics and genomics research as well as clinical-grade diagnostic nucleic acid sequencing. (health2030genome.ch)
When appropriate, confirming the acceptance criteria to qualify for ISO 15189 clinical grade sequencing ( iso.org ) are appropriately described and met for each sample (e.g. concentration and amount of material, nucleic acid degradation metrics, etc. (health2030genome.ch)
Processing of samples that do not meet the quality criteria for clinical-grade sequencing and other processing and data governance activities requested by the Customer are specified and priced in Appendix 1. (health2030genome.ch)
Decellularized human adipose tissue has potential clinical utility as a processed biological scaffold for soft tissue cosmesis, grafting, and reconstruction. (psu.edu)
The long-term goal of our research is to develop computational and statistical approaches that help translate multidimensional omics data into biological and clinical insights. (zhang-lab.org)
First, to address a clinically important question of predicting recurrence risk in colon cancer patients, we identified a network-based gene expression signature with both biological and clinical relevance (Shi, et al. (zhang-lab.org)
Next generation sequencing (NGS) promises much to clinical diagnostics with its digital output, speed, and depth and breadth of coverage. (selectbiosciences.com)
All nucleic acid in the clinical sample is sequenced and the resulting data is analysed by experienced bioinformaticians. (folkhalsomyndigheten.se)
Metagenomic sequencing engables a thorough mapping of the genetic material in the clinical sample, providing a broader understanding of the microbiological profile. (folkhalsomyndigheten.se)
The result of of metagenomic sequencing is the outcome of a collaborative effort between bioinformaticians and clinical microbiologists, where the clinical interpretation confirms and complements the technical analysis. (folkhalsomyndigheten.se)
16S sequencing is performed to determine which bacterial species are present in a clinical sample or isolate. (folkhalsomyndigheten.se)
The basis of the GENSAM project is the joint national management of clinical microbial sequencing data. (folkhalsomyndigheten.se)
This document is intended for laboratory personnel responsible for CLIA regulated processing and testing of clinical specimens for C. auris, using the ABI 7500 Fast Real-Time PCR System. (cdc.gov)
Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

Helicases unwind the strands to facilitate the advance of sequence-reading enzymes such as DNA polymerase. (wikipedia.org)
These two candidates were incorporated by solid-phase synthesis into DNA carrying the sequence of a promoter for an RNA polymerase enzyme. (chemistryviews.org)
Prokaryotes and eukaryotes have a similar mechanism of nucleic acid synthesis, involving polymerase as a key enzyme. (geneticeducation.co.in)
The in vivo process of copying or synthesizing the DNA using the DNA polymerase is known as replication. (geneticeducation.co.in)
PCR (polymerase chain reaction) technique has achieved increased importance for post-mortem DNA analysis in forensic cases 8 because of the millions of copies amplified from one specific sequence of DNA. (bvsalud.org)

WALNUT CREEK, CA-Researchers are closer now to thwarting two related plant pathogens, one causing "Sudden Oak Death" (SOD) and another responsible for a devastating soybean disease, thanks to the DNA sequence produced by the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), in collaboration with the Virginia Bioinformatics Institute (VBI). (doe.gov)
This was gradually expanded into various methods in bioinformatics, in particular for sequence analysis and protein structure prediction. (ntnu.edu)
Biological sequence analysis, a subfield of bioinformatics and computational biology, aims at computationally process and decode the information stored in genomes. (researchsquare.com)
Bioinformatics is a multidisciplinary science that uses technology and computational tools in genetics to organize, store, interpret, visualize, and disseminate biological data. (varsomics.com)
The term bioinformatics was first used by Paulien Hogeweg and Ben Hesper in 1970 as "The study of informatics processes in biotic systems. (varsomics.com)
During this time, bioinformatics became even more well-known, and there was an increase in investment to develop new algorithms capable of analyzing more complex and voluminous sequences. (varsomics.com)
Therefore, it was also necessary to develop new bioinformatics tools to quickly and effectively process the enormous volumes of generated data. (varsomics.com)

The DNA is a double-helix structure with a phosphate backbone, sugar and nitrogenous bases, and is known as deoxyribonucleic acid. (geneticeducation.co.in)
The two main classes of nucleic acids are deoxyribonucleic acid commonly named as (DNA) and ribonucleic acid known by the acronym (RNA). (researchsquare.com)

Whole-exome sequencing is a cost-effective alternative, however one of its obvious drawback is the absence of variants in non-coding regions, which may be especially relevant in the context of complex disease genetics. (frontiersin.org)

According to the Human Genome Research Institute, in 2021,, costs per genome sequenced have decreased from $3 billion to approximately $300 million over the past 17 years and are projected to be gradually lowered by 10 times over the next five years. (thebusinessresearchcompany.com)
The first living organism to have its genome sequenced was the bacterium Haemophilus influenzae, in a work published in 1995. (varsomics.com)

Starting from the genomic sequences and NGS data, we currently concentrate our efforts on structures, interactions, evolution and design, trying to meet the growing needs for a rational synthetic biology. (polytechnique.fr)
To study this phenomenon, information on the intron-exon arrangement of a gene is essential, usually obtained by aligning mRNA/EST sequences to their cognate genomic sequences. (edu.au)

The secondary structures of biological DNAs and RNAs tend to be different: biological DNA mostly exists as fully base paired double helices, while biological RNA is single stranded and often forms complex and intricate base-pairing interactions due to its increased ability to form hydrogen bonds stemming from the extra hydroxyl group in the ribose sugar. (wikipedia.org)
In a non-biological context, secondary structure is a vital consideration in the nucleic acid design of nucleic acid structures for DNA nanotechnology and DNA computing, since the pattern of basepairing ultimately determines the overall structure of the molecules. (wikipedia.org)
In RNA, thymine is replaced by uracil (U). Alternate hydrogen bonding patterns, such as the wobble base pair and Hoogsteen base pair, also occur-particularly in RNA-giving rise to complex and functional tertiary structures. (wikipedia.org)
G-rich sequences have a propensity for forming highly stable quadruplex structures in both RNA and DNA termed G-quadruplexes. (nature.com)
Guanine (G)-quadruplexes are highly stable nucleic acid secondary structures formed from short tracts of G-rich sequence associating together. (nature.com)
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. (absoluteastronomy.com)
She was a pioneer in developing computers capable of determining peptide sequences, programs to display three-dimensional protein structures, and computational methods for sequence comparison. (varsomics.com)

GENESEQ™ is a proprietary database used to easily search and identify biological sequences (DNA, RNA and protein sequences) covered in patents from 56 issuing authorities. (clarivate.com)
In 1965, Dr. Dayhoff participated in the creation of the "Atlas of Protein Sequence and Structure," the first computerized public database of protein sequences. (varsomics.com)

Synthetic biology involves researches on micro-organism to perform the desired function or produce a biological desired substance. (thebusinessresearchcompany.com)
The process of DNA replication is best explained using the E Coli model organism for both prokaryotes and eukaryotes. (geneticeducation.co.in)
Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. (absoluteastronomy.com)
It is a change in the DNA sequence of an organism. (biotechdelnorte.com)

AxisPharm bioanalytical services encompass a wide range of scientific and analytical services focused on the characterization, measurement, and analysis of biological molecules and compounds. (axispharm.com)
Bioanalytical quantitative analysis involves the accurate determination of the concentration or amount of a specific analyte in biological samples. (axispharm.com)
They provide valuable insights into the biochemical processes, functional pathways, and disease mechanisms in biological systems.Metabolomics and proteomics in bioanalysis inlcudes Sample Preparation, Analytical Techniques, Data Analysis, and Applications. (axispharm.com)
Search, analysis, and reporting tools designed specifically for sequence searching. (clarivate.com)
We use a combination of methods to map, via quantitative content analysis of CRISPR papers, the research funding profile of major government agencies and philanthropic organizations and the networks involved in supporting key stages of high-influence research, namely, basic biological research and technological development. (mit.edu)
The results of the content analysis show how the research supported by the main U.S. government agencies focuses both on the study of CRISPR as a biological phenomenon and on its technological development and use as a biomedical research tool. (mit.edu)
The analysis of nucleic acids by high-throughput sequencing has dominated biological research for more than a decade. (mskcc.org)
Nanoscale imaging enables the analysis of biological systems, such as cells and tissues, at the fundamental length scales of biomolecules and biomolecular interactions, but classically has required expensive equipment and advanced skillsets to perform, e . g ., via super-resolution microscopy [ 1 ]. (plos.org)
The server also permits the alignment to be saved in several forms, both graphical and text, suitable for further processing and analysis by other programs. (edu.au)
Subsequent in vivo analysis of the predominantly enzymatic- and detergent-based decellularized scaffolds following subcutaneous implantation in GFP + transgenic mice demonstrated that the matrices generated with both approaches supported the ingrowth of host-derived adipocyte progenitors and vasculature in a time dependent manner. (psu.edu)
These evidences are often based on the derivation of standard measures of association, linking (epi-)genetic markers to gene expression combined with gene expression analysis (Wagner, Busche, Ge, Kwan, & Pastinen, 2014). (researchgate.net)
This paper falls within the scope of biological sequence analysis and has as a goal to search the origin(s) and the inter-host(s) of each genome of SARS-CoV-2 by comparing it with all members of Coronaviridae family. (researchsquare.com)
PerkinElmer, Inc. has acquired Geospiza, Inc., a developer of software systems for the management of genetic analysis and laboratory workflows delivered through a Web-based secure cloud computing environment. (rdworldonline.com)
The acquisition of Geospiza supports PerkinElmer's offerings in Next Generation DNA Sequencing and Analysis Services, which enable researchers to explore the genomic origins of disease, and help address customers' need to manage knowledge and drive scientific productivity. (rdworldonline.com)
The addition of Geospiza to PerkinElmer's sequencing and analysis services will deliver an end-to-end solution that provides scientists access to sequencing services and robust analysis and visualization software, offered through significant capability around cloud computing, the company says. (rdworldonline.com)
Geospiza's current informatics offerings include GeneSifter Analysis Edition, a cloud-based data analysis product for microarray and next generation sequencing data and GeneSifter Lab Edition, a software platform supporting laboratory workflows. (rdworldonline.com)
In this talk, I will introduce Chromatin Interaction Analysis with Paired-End Tag sequencing (ChIA-PET), a next-generation sequencing-based method for identifying chromatin interactions between transcription factor binding sites on a genome-wide scale which was part of the ENCODE consortium. (selectbiosciences.com)
It is the stated quantity of a body fluid, exhalation (breath), hair, tissue, or process derived from the examination, study, or analysis of one or more representative properties of a whole. (biotechdelnorte.com)
Process efficiency of buccal samples is improved due to immediate DNA capture on the FTA card thereby enabling direct amplification for STR analysis. (qiagen.com)
FTA Elute Indicating cards are designed for room temperature collection, shipment, preservation and purification of nucleic acids from biological samples for PCR analysis. (qiagen.com)
Eluted DNA can be used for STR analysis (standard amplification), sequencing and real-time PCR applications. (qiagen.com)
Sequence variations between different bacteria provide a unique identity, and the analysis of these sequence enables taxonomic placement. (folkhalsomyndigheten.se)
At our microscopy platform in Lund, you meet personnel with expertise and long experience working with biological material and microscopy, imaging, and analysis. (lu.se)
In our laboratories, you can use both standard microscope techniques, like scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), as well as infra-red based analysis techniques and micro-computed tomography (micro-CT). (lu.se)
This roadmap is based on the draft roadmap and baseline analysis XXX, the research roadmap for DRC, the xxxxxxx. (who.int)

The inadequate availability of biological reference materials for these pathogens poses a genuine obstacle in pursuit of these objectives, and the lack of a comprehensive and equitable framework for developing reference materials is a weakness. (cdc.gov)
We outline the need for internationally standardized biological materials for high-threat pathogens as a core element of global health security. (cdc.gov)
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. (absoluteastronomy.com)
In contrast to metagenomic detection of unknown pathogens which sequences all available genetic material, 16S sequencing specifically targets the small ribosomal subunit. (folkhalsomyndigheten.se)

It can be represented as a list of bases which are paired in a nucleic acid molecule. (wikipedia.org)
Replication is an enzyme governed process, in which new DNA molecule is formed by the process of semi-conservative DNA replication. (geneticeducation.co.in)
A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. (biotechdelnorte.com)

Strand separation by gentle heating, as used in PCR, is simple providing the molecules have fewer than about 10,000 base pairs (10 kilobase pairs, or 10 kbp). (wikipedia.org)
The double helix is an important tertiary structure in nucleic acid molecules which is intimately connected with the molecule's secondary structure. (wikipedia.org)
Before the evolutionary process of building the first cell could begin, a diverse array of key molecules would have to be magically generated in some primordial matrix or soup. (icr.org)
In 1952, Stanley Miller performed one of the first experiments claiming to show that naturalistic processes could produce basic molecules needed for life. (icr.org)

Integration of gene expression and methylation to unravel biological networks in glioblastoma patients: Gadaleta et al. (researchgate.net)

Accreditation number SMTS 0050 granted by the Swiss Accreditation Society on 03.05.2021 (https://www.health2030genome.ch/accredited-sequencing-services). (health2030genome.ch)

It's time for the annual blog about the annual Nucleic Acids Research (NAR) database issue. (scienceblogs.com)
The research activity is based on the integration of Experimental models with Computational methodologies, pointing out the reciprocal regulation of coding and non-coding RNAs. (iit.it)
With Derwent SequenceBase, biological scientists can spend less time searching for sequence data and more time on research and development, and IP professionals can be sure they don't miss any potential infringements or competitor activities. (clarivate.com)
For each event instance, all participants ( arguments ) in the same sentence are identified and assigned a semantic role from a rich set of 13 roles tailored to biomedical research articles, together with a biological concept type linked to the Gene Regulation Ontology. (biomedcentral.com)
Nucleic Acids Research , 31 (13), 3533-3536. (edu.au)
Focus of my research for the last 10 years has been on gene regulation, initially based on transcription factors, promoters and enhancers, but increasingly also including epigenetics, in particular histone modifications. (ntnu.edu)
The advancement of computer technology resulted in increased processing power and memory capacity, which are essential for analyzing the vast amount of data generated in research. (varsomics.com)
This provides a stable base financial base for the planning of research activities for the years to come. (lu.se)
We offer the courses Common Microscopy Methods in Biological Research (external website) and Microscopy - Bioimaging (external website) for PhD and Master students. (lu.se)

Nucleic acid secondary structure is the basepairing interactions within a single nucleic acid polymer or between two polymers. (wikipedia.org)
Nucleic acid secondary structure is generally divided into helices (contiguous base pairs), and various kinds of loops (unpaired nucleotides surrounded by helices). (wikipedia.org)

A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks Researchers combed through more than 5,000 data sets of RNA sequences generated from diverse environmental samples around the world, resulting in a five-fold increase of RNA virus diversity. (doe.gov)
Instead it is an assembly of consensus sequences that are designed to deal with variation in the human population and uncertainty in the data. (scienceblogs.com)
The classification rules were derived by analyzing large-scale miRNA expression data obtained from a public database, and the identified rules were converted into DNA sequences. (snu.ac.kr)
Intuitively built to efficiently search and analyze sequences, users can search with confidence with access to the most comprehensive set of patent sequence data. (clarivate.com)
Manually annotated to highlight IP context and biological significance, GENESEQ™ allows IP professionals and biologic scientists to spend less time searching and understanding sequence data and easily assess patentability, identify potential infringing patents and track competitor activities. (clarivate.com)
A. The Customer is and remains the owner and the controller of the provided biological samples and the produced data. (health2030genome.ch)
D. The Customer wishes to benefit from the Services of the Genome Center as described in this Agreement to perform nucleic acid sequencing and/or data processing. (health2030genome.ch)
2011). More recently, we proposed to derive sample-specific protein sequence databases from RNA-Seq data and have demonstrated that customized databases significantly increase the sensitivity in peptide identification, reduce ambiguity in protein assembly, and enable the detection of known and novel peptide variants (Wang, et al. (zhang-lab.org)
Present technology and computer power allow building and processing large collections of these data types. (researchgate.net)
Making sense of the unprecedented volumes of data generated by next generation sequencing and other biological measurements is critical to improve the disease diagnosis process and drug discovery," said Richard Begley, PhD, president, Emerging Technologies, PerkinElmer. (rdworldonline.com)
As a result, the list of complete genomes and the volume of biological data began to increase dramatically. (varsomics.com)
The bioinformaticians at the Public Health Agency play a central role within the Department of Microbiology by analysing extensive biological data and developing sophisticated software. (folkhalsomyndigheten.se)
Pipelines are series-connected data processes that utilise software tools to structure, process, and interpret genetic information. (folkhalsomyndigheten.se)
The purpose of an Interaction Profile is to evaluate data on the toxicology of the "whole" priority mixture (if available) and on the joint toxic action of the chemicals in the mixture in order to recommend approaches for the exposure-based assessment of the potential hazard to public health. (cdc.gov)
By offering empowerment and control, companies convince consumers to sequence their genome by granting the company access to their genetic data in exchange to results that are not always accurate. (bvsalud.org)

One typically aims at designing new specialized algorithms and methods to efficiently compute properties of real biological objects. (polytechnique.fr)
During this time, the first algorithms for genome assembly, i.e., defining the sequence of nucleotides in the genetic material, began to be developed. (varsomics.com)

Then, in 1977, Sanger used this system to deduce the DNA sequence of the bacteriophage Phi X 174 (ΦX174), the first complete genome to be sequenced with about 5,000 nucleotides. (varsomics.com)

These WHO IRPs, composed of international reference standards and other reference materials ( Table 1 ), provide a common set of reagents that are used to ensure the quality of biological assays and medicines globally. (cdc.gov)

Synthetic biology is a field of biological science that involve engineering principles to redesign organisms to give them new abilities. (thebusinessresearchcompany.com)
The main product types of synthetic biology are oligonucleotides, enzymes, cloning and assembly kits, xeno-nucleic acids (XNA), and chassis organisms. (thebusinessresearchcompany.com)
Such processes possess health risks such as illness, and allergies in humans as well as environmental risks such as toxicity and risk of new micro-organisms affecting living creatures in the ecosystem. (thebusinessresearchcompany.com)
Nucleic acids are the biopolymers that carry all genetic information of living organisms. (researchsquare.com)

The laboratory procedure is based on amplifying and sequencing four variable regions of the 16S rRNA gene with two amplicons. (folkhalsomyndigheten.se)

Computational estimates suggest that the inherent proximity of the ends is a universal property of most mRNA and lncRNA sequences. (nih.gov)
While the biological implications remain to be explored, short end-to-end distances could facilitate the binding of protein factors that regulate translation initiation by bridging mRNA 5' and 3' ends. (nih.gov)
MGAlign is a novel, rapid, memory efficient and practical method for aligning mRNA/EST and genome sequences. (edu.au)

Researchers from 18 countries collaborated to map the human genome, which has about 3 billion base pairs. (varsomics.com)

The process of synthesis of DNA. (geneticeducation.co.in)
Trained in organic chemistry at University of Bergen (MSc 1983), including using computer-based expert system (SECS) and computational methods for strategies in organic synthesis. (ntnu.edu)

Conventional and biological therapies using anti-inflammatory drugs and/or specific antibodies targeting TNF still leave a significant number of IBD patients insufficiently treated. (cea.fr)

FTA cards are a suitable device for SARS-CoV-2 sample collection due to high RNA recovery, RNA stability for 7 days at 20°C and 30°C, sensitive PCR detection of viral RNA compared to direct saliva processing, and the potential for virus inactivation through sample lysis. (qiagen.com)

The Expert Committee on Biological Standardization meets annually to establish detailed recommendations and guidelines for manufacturing, licensing, and control of complex biological materials, including blood products, vaccines, and related in vitro diagnostic tests, and to maintain a catalog of IRPs to be distributed globally as required. (cdc.gov)
CEA-BIG has designed siRNA sequences targeting human JAK1, human JAK3, murine JAK1 and murine JAK3 and has validated their specific characteristics based on in vitro models. (cea.fr)

The company was founded in 2019 and is based in Cambridge, Massachusetts. (cbinsights.com)

Immediate stabilization and protection of nucleic acids is achieved for long-term archiving of samples at room temperature. (qiagen.com)

In the canonical Watson-Crick base pairing, adenine (A) forms a base pair with thymine (T) and guanine (G) forms one with cytosine (C) in DNA. (wikipedia.org)

Several different NGS-based analyses are offered within the Agency's specialised diagnostics. (folkhalsomyndigheten.se)
Dentists, properly supported by Laws 6 and Resolutions 5 in Brazil, may perform analyses involving biological materials from the human body in various conditions (sliced, dilacerated, charred, macerated, decayed, in skeletonization and skeletonized), aiming to establish human identification 18 . (bvsalud.org)

To examine the hypothesis that distinct decellularization processes may yield scaffolds with differing compositions, the current study employed mass spectrometry to compare the proteomes of human adipose-derived matrices generated through three independent methods combining enzymatic-, detergent-, and/or solvent-based steps. (psu.edu)

Melting is the process by which the interactions between the strands of the double helix are broken, separating the two nucleic acid strands. (wikipedia.org)
Unravel the complex strands of biological sequences. (clarivate.com)

Epigenetic processes are deregulated in cancer. (selectbiosciences.com)

The new technological advances in the field of DNA sequencing has enabled the researchers to use DNA to store non-genetic information. (thebusinessresearchcompany.com)
By sequencing the entire genome, a comprehensive understanding of the genetic composition is obtained. (folkhalsomyndigheten.se)
In epidemiological contact tracing, this technology enables the mapping of infection spread and identification of sources of infection through the comparison of genetic sequences. (folkhalsomyndigheten.se)

When students first look at an amino acid sequence, a long string of confusing letters, they often think those letters are part of a chain like an uncooked spaghetti noodle. (scienceblogs.com)

Such limitations have significantly hampered our ability to understand how the replication machinery progresses through chromatin and how replication forks are processed when they are stalled by impediments such as DNA damage. (mskcc.org)

Towards that goal, we develop methodological approaches, based on abstract models that are computationally tractable and biologically relevant. (polytechnique.fr)

The total repetitive sequence length was 1,713,918 bp, accounting for 4.2033% of the genome. (researchsquare.com)

Splicing is a biological phenomenon that removes the non-coding sequence from the transcripts to produce a mature transcript suitable for translation. (edu.au)

Hybridization is the process of complementary base pairs binding to form a double helix. (wikipedia.org)
The classification results were reported as a binary output pattern according to their hybridization to the rule sequences, which can be conveniently visualized using gold nanoparticle aggregation. (snu.ac.kr)

These processes involve optimizing analytical methods and assessing their performance to meet regulatory requirements and scientific standards.The key steps involved in bioanalysis method development and validation are: Method Development, Method Validation, Documentation, Regulatory Compliance. (axispharm.com)
In this study, we report the organisation process, detailed technical methods used, and results of this citywide nucleic acid screening. (nature.com)
As a whole, a common toolkit of computational methods is developed within the group.The trade-off between the biological accuracy of the model and the computational tractability or efficiency is to be addressed in a close partnership with experimental biology groups. (polytechnique.fr)
Adipose tissue decellularization has been accomplished using enzymatic-, detergent-, and/or solvent-based methods. (psu.edu)
In 1970, Fred Sanger and Walter Gilbert developed the first DNA sequencing methods. (varsomics.com)
Metagenomic sequencing is offered in cases where infection is suspected but other methods have failed to identify a pathogen. (folkhalsomyndigheten.se)

Ubiquitous sequencing will allow for the near real-time characterization of pathogen biology, including determinations of virulence, transmissibility, sensitivity or resistance to medicines or vaccines. (slideshare.net)

Recently, expansion microscopy (ExM), which physically magnifies biological specimens through a chemical process, thus enabling nanoimaging on conventional microscopes [ 2 - 4 ]. (plos.org)
In addition to protein content, bioscaffolds were evaluated for deoxyribose nucleic acid depletion, extracellular matrix composition, and physical structure using optical density, histochemical staining, and scanning electron microscopy. (psu.edu)

The method uses an internal control sequence (spike) which is amplified and sequenced simultaneously with the sample to facilitate the assessment of the bacterial content and to detect amplification-inhibiting factors in the sample that may lead to a negative result. (folkhalsomyndigheten.se)
Provision of broad, method-based PT schemes, such as DNA sequencing, would allow assessment of a large number of tests for which formal PT is not currently available. (cdc.gov)

In the project "Systems approach to the biological basis of colon cancer metastases" funded by the National Institute of Health (NIH), we apply the above network-based approaches to colon cancer studies. (zhang-lab.org)

Simplify the complexity of biological sequences. (clarivate.com)
Only guanosine-depleted RNA sequences with low sequence complexity are unstructured and exhibit end-to-end distances expected for the random coil conformation of RNA. (nih.gov)

DNA sequencing is important in the development of the synthetic biology in many ways. (thebusinessresearchcompany.com)
DNA sequencing finds its use in many synthetic biology applications, therefore the availability of the DNA sequencing technique at low cost drives the production of products based on the applications of synthetic biology. (thebusinessresearchcompany.com)

A double helix is formed by regions of many consecutive base pairs. (wikipedia.org)

The Public Health Agency's Next Generation Sequencing (NGS) platform performs massive parallel sequencing of DNA and RNA. (folkhalsomyndigheten.se)

The curation of genomic variants requires collecting evidence not only in variant knowledge bases but also in the literature. (hes-so.ch)
The individual variants may be short or include thousands of bases. (biotechdelnorte.com)

Anatomy10

Organisms15

Diseases3

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes93

Disciplines and Occupations12

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science22

Health Care7

Genes14

Whole-genome8

Containing nucleic acid1

Proteins6

Nucleotide3

Acids Res2

Molecular14

Nanopore4

Clinical18

Polymerase5

Bioinformatics7

Deoxyribonucleic acid2

Exome1

Genome sequenced2

Genomic sequences2

Structures7

Protein sequences2

Organism4

Analysis25

Pathogens4

Molecule3

Molecules4

Gene expression1

Accreditation1

Research9

Acid secondary2

Data15

Algorithms2

5,0001

Assays1

Organisms4

Laboratory1

MRNA3

Human genome1

Synthesis2

Antibodies1

Detection1

Vitro2

20191

Stabilization1

Guanine1

Analyses2

Scaffolds1

Strands2

Epigenetic1

Genetic3

Amino1

Chromatin1

Abstract1

Repetitive1

Transcripts1

Hybridization2

Methods6

Vaccines1

Microscopy2

Assessment2

Approaches1

Complexity2

Synthetic2

Pairs1

Next-generation1

Variants2