• tissue
  • Lack of biological assays to measure many of these contaminants in tissue specimens, the high cost of using these assays in large epidemiologic studies when they were available, and challenges related to the interpretation of the results when exposures were measured after the adverse reproductive event occurred limit the conclusions that can be drawn from these investigations. (thefreedictionary.com)
  • The Canadian team of organic chemists and enzymologists developed drug design motifs, and pursued preparative chemistry, enzymology, molecular biology, and tissue culture studies that were interfaced with biological assays and pharmacokinetic studies carried out in Syntex, Palo Alto, CA. (thefreedictionary.com)
  • In addition to the bovine and porcine tissue from which pharmaceutical-grade heparin is commonly extracted, it has also been extracted and characterised from: Turkey Whale Dromedary camel Mouse Humans Lobster Fresh water mussel Clam Shrimp Mangrove crab Sand dollar Atlantic salmon Zebra fish The biological activity of heparin within species 6-11 is unclear and further supports the idea that the main physiological role of heparin is not anticoagulation. (wikipedia.org)
  • time resolved
  • Terbium and Rhodamine as Labels in a Homogeneous Time-resolved Fluorometric Energy Transfer Assay of the .beta. (patentgenius.com)
  • This data taken together with the long luminescence lifetimes and narrow emission bands associated with lanthanides make this technology an excellent tool for time resolved, low-background, multiplexed assays and biomedical imaging. (umich.edu)
  • Probes
  • The hyperpolarized probes are produced ex situ , introduced into biological systems and detected with high sensitivity and contrast against background signals using high resolution NMR spectroscopy. (mdpi.com)
  • A variety of natural, derivatized and designed hyperpolarized probes has emerged for diverse biological studies including assays of intracellular reaction progression, pathway kinetics, probe uptake and export, pH, redox state, reactive oxygen species, ion concentrations, drug efficacy or oncogenic signaling. (mdpi.com)
  • These probes are readily used directly under natural conditions in biofluids and are often directly developed and optimized for cellular assays, thus leaving little doubt about their specificity and utility under biologically relevant conditions. (mdpi.com)
  • Hyperpolarized molecular probes for biological NMR spectroscopy enable the unbiased detection of complex processes by virtue of the high spectral resolution, structural specificity and quantifiability of NMR signals. (mdpi.com)
  • Here, we provide a survey of strategies used for the selection, design and use of hyperpolarized NMR probes in biological assays, and describe current limitations and developments. (mdpi.com)
  • Lerche, M.H. Hyperpolarized NMR Probes for Biological Assays. (mdpi.com)
  • affinity
  • In this study, we developed a method to label the 5' ends of aptamers with cotinine, which allows formation of a stable complex with anti-cotinine antibodies for the purpose of providing another affinity unit for the application in biological assays using aptamers. (archive.org)
  • To demonstrate the functionality of this affinity unit in biological assays, we utilized two well-known aptamers: AS1411, which binds nucleolin, and pegaptanib, which binds vascular endothelial growth factor. (archive.org)
  • hormone
  • In 1949, he began post-graduate studies at the University of Edinburgh, returning to Sri Lanka in 1952 with a PhD. His doctorate thesis was a study of biological assays of cortical hormone and their application. (wikipedia.org)
  • novel
  • One of the emerging challenges for the NTP and the NIEHS is to use the best science to create, validate, and implement in environmental health research novel, robust, and efficient biological assays that will more effectively predict the risk of human disease and protect the health of our public. (freethesaurus.com)
  • dose
  • 2. The application of a progressively increasing dose method to the biological assay of epinephrine may be an improvement upon the U.S.P.XI procedure. (aspetjournals.org)
  • Indeed, among the biological assays present in the Pharmacopoeia of the United Slates of America, Ninth Decennial Revision, of 1916 (pages 605-606) is a description of the assay used, in which a standard cannabis tincture is defined as producing incoordination in dogs when administered in a dose of 0. (freethesaurus.com)
  • In a direct dilution assay the amount of dose needed to produce a specific (fixed) response is measured, so that the dose is a stochastic variable defining the tolerance distribution. (wikipedia.org)
  • bound
  • Some newer types are called "mix-and-measure" assays because they do not require separation of bound ligands. (wikipedia.org)
  • targets
  • Small-molecule anti-genomic therapeutics, or SMAT, refers to a biodefense technology that targets DNA signatures found in many biological warfare agents. (wikipedia.org)
  • sensor
  • More recently, a smartphone has been used as an optical sensor to read a signal from a capillary channel (for simple biological assays such as cell sorting) or from a lateral-flow assay (a common format for pregnancy tests). (freethesaurus.com)
  • cell
  • Scope of review: This review discusses general aspects on miniaturization of biological assays and in particular summarizes single-cell assays in microwell formats. (diva-portal.org)
  • General significance: In vitro assays offering low volume sampling and rapid analysis in a high-throughput manner are of great interest in a wide range of single-cell applications. (diva-portal.org)
  • responses
  • Vol 3: Comparison of Antibody Responses to Human Papillomavirus Vaccination as Measured by Three Assays. (archive.org)
  • For a mathematical definition of a dilution assay an observation space U {\displaystyle U} is defined and a function f : U → R {\displaystyle f:U\rightarrow \mathbb {R} } so that the responses u ∈ U {\displaystyle u\in U} are mapped to the set of real numbers. (wikipedia.org)
  • standard
  • To eliminate possible interference of DTNB with enzyme hydrolysis, we introduce a modification of the standard Ellman's assay. (sigmaaldrich.com)
  • complex
  • In analogy to digital microelectronics, these basic instructions can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. (wikipedia.org)
  • Development
  • It includes information on all aspects of drug research and development, from drug discovery to biological assays , pharmacokinetics, clinical trials, and post-market surveillance. (thefreedictionary.com)
  • Through the development of RIA technology, researchers have been able to move beyond the use of radioactivity, and instead, use liquid- and solid-phase, competitive, and immunoradiometric assays. (wikipedia.org)
  • specifically
  • Specifically, despite the human body's endogenous receptors, hormones, and other neurotransmitters, pharmacologists utilize assays in order to create drugs that are selective, or mimic, the endogenously found cellular components. (wikipedia.org)
  • range
  • Of notable importance in this respect is the theory of Generalized Linear Models with which a wide range of dilution assays can be modelled. (wikipedia.org)
  • Although
  • Although binding assays are simple, they fail to provide information on whether or not the compound being tested affects the target's function. (wikipedia.org)
  • type
  • New Type Of Biological Food Anti - Oxygen And Antiseptic D-Sodium Erythorbate D-sodium erythorbate, It is a new type of biological food anti - oxygen and antiseptic. (eceurope.com)
  • include
  • Essential aspects of binding assays include, but are not limited to, the concentration level of reactants or products (see radioactive section), maintaining the equilibrium constant of reactants throughout the assay, and the reliability and validity of linked reactions. (wikipedia.org)