• vitro assays
  • General significance: In vitro assays offering low volume sampling and rapid analysis in a high-throughput manner are of great interest in a wide range of single-cell applications. (diva-portal.org)
  • In vitro assays with rat mesenchymal stem cells (rMSCs) and rat endothelial progenitor cells (rEPCs) also showed that rMSCs attached and proliferated on the materials influenced by the calcium content in the environment. (rsc.org)
  • Probes
  • The hyperpolarized probes are produced ex situ , introduced into biological systems and detected with high sensitivity and contrast against background signals using high resolution NMR spectroscopy. (mdpi.com)
  • A variety of natural, derivatized and designed hyperpolarized probes has emerged for diverse biological studies including assays of intracellular reaction progression, pathway kinetics, probe uptake and export, pH, redox state, reactive oxygen species, ion concentrations, drug efficacy or oncogenic signaling. (mdpi.com)
  • These probes are readily used directly under natural conditions in biofluids and are often directly developed and optimized for cellular assays, thus leaving little doubt about their specificity and utility under biologically relevant conditions. (mdpi.com)
  • Hyperpolarized molecular probes for biological NMR spectroscopy enable the unbiased detection of complex processes by virtue of the high spectral resolution, structural specificity and quantifiability of NMR signals. (mdpi.com)
  • Here, we provide a survey of strategies used for the selection, design and use of hyperpolarized NMR probes in biological assays, and describe current limitations and developments. (mdpi.com)
  • Lerche, M.H. Hyperpolarized NMR Probes for Biological Assays. (mdpi.com)
  • potency
  • In the quantitative assay, the dose-response (colour production linked to beta-galactosidase production) of a compound is plotted, with the slope of the initial linear region used as a universal parameter, the SOS-inducing potency (SOSIP), which reflects the ability of a compound to induce the SOS response (measured indirectly through production of beta-galactosidase and the breakdown of a lactose analog). (wikipedia.org)
  • specimens
  • Lack of biological assays to measure many of these contaminants in tissue specimens, the high cost of using these assays in large epidemiologic studies when they were available, and challenges related to the interpretation of the results when exposures were measured after the adverse reproductive event occurred limit the conclusions that can be drawn from these investigations. (thefreedictionary.com)
  • affinity
  • In this study, we developed a method to label the 5' ends of aptamers with cotinine, which allows formation of a stable complex with anti-cotinine antibodies for the purpose of providing another affinity unit for the application in biological assays using aptamers. (archive.org)
  • To demonstrate the functionality of this affinity unit in biological assays, we utilized two well-known aptamers: AS1411, which binds nucleolin, and pegaptanib, which binds vascular endothelial growth factor. (archive.org)
  • compound
  • The test serves as a quick and convenient assay to estimate the carcinogenic potential of a compound because standard carcinogen assays on mice and rats are time-consuming (taking two to three years to complete) and expensive. (wikipedia.org)
  • hormone
  • In 1949, he began post-graduate studies at the University of Edinburgh, returning to Sri Lanka in 1952 with a PhD. His doctorate thesis was a study of biological assays of cortical hormone and their application. (wikipedia.org)
  • novel
  • One of the emerging challenges for the NTP and the NIEHS is to use the best science to create, validate, and implement in environmental health research novel, robust, and efficient biological assays that will more effectively predict the risk of human disease and protect the health of our public. (freethesaurus.com)
  • observation
  • This assay provides both a qualitative (visible observation of colour gradient) for screening purposes, or quantitative measurement (spectrophotometry) for calculation of commonly accepted metrics. (wikipedia.org)
  • dose
  • 2. The application of a progressively increasing dose method to the biological assay of epinephrine may be an improvement upon the U.S.P.XI procedure. (aspetjournals.org)
  • Indeed, among the biological assays present in the Pharmacopoeia of the United Slates of America, Ninth Decennial Revision, of 1916 (pages 605-606) is a description of the assay used, in which a standard cannabis tincture is defined as producing incoordination in dogs when administered in a dose of 0. (freethesaurus.com)
  • standard
  • To eliminate possible interference of DTNB with enzyme hydrolysis, we introduce a modification of the standard Ellman's assay. (sigmaaldrich.com)
  • suitable
  • 10 The suitable biological performance of these scaffolds was mainly attributed to their stiffness and the ions released from the glass, in particular calcium ions, as well as the intrinsic surface properties of the materials. (rsc.org)
  • cells
  • Since the chemical tested may inhibit protein synthesis at higher concentrations, which would lead to an underestimation of B-galactosidase induction, alkaline phosphatase is assayed simultaneously with β-galactosidase in order to scale the data to survivability of the cells. (wikipedia.org)
  • chemical
  • PubChem is a database of chemical molecules and their activities against biological assays. (wikipedia.org)
  • In analogy to digital microelectronics, these basic instructions can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. (wikipedia.org)
  • volume
  • Such a cartridge is especially useful with fixed volume assays which permit low centrifugal accelerations to move the fluids within the cartridge. (google.fr)
  • background
  • This data taken together with the long luminescence lifetimes and narrow emission bands associated with lanthanides make this technology an excellent tool for time resolved, low-background, multiplexed assays and biomedical imaging. (umich.edu)
  • Journal
  • The isolation from wheat germ oil of an alcohol, a-tocopherol, having the properties of vitamin E". Journal of Biological Chemistry. (wikipedia.org)
  • wide
  • Many parallel biochemical assays rely on thin aqueous films to spread a reactant solution over a wide area decorated with multiple distinct substrates. (cornell.edu)
  • blood
  • In vivo assays showed that hybrid composite PLA-ORMOGLASS fibers were able to promote the formation of blood vessels. (rsc.org)
  • expression
  • The test is a colorimetric assay which measures the expression of genes induced by genotoxic agents in Escherichia coli, by means of a fusion with the structural gene for β-galactosidase. (wikipedia.org)
  • One of the simplest assays consists of monitoring the expression of an SOS gene by means of fusion with lacZ, the structural gene for E. coli β-galactosidase. (wikipedia.org)
  • response
  • The biological response may be quantal (e.g. positive/negative) or quantitative (e.g. growth). (wikipedia.org)
  • The biological response u {\displaystyle u} is in this case the zone of inhibition and the diameter of this zone f ( u ) {\displaystyle f(u)} can be used as the measurable response. (wikipedia.org)