• He has done pioneering work in understanding protein structure and synthesis, the enzymatic functions of methane monooxygenase (MMO), and the mechanisms of cisplatin anticancer drugs. (wikipedia.org)
  • Lippard focuses on understanding the physical and structural properties of metal complexes, their synthesis and reactions, and the involvement of metal ions in biological systems. (wikipedia.org)
  • The interesting activities of a subset of 4-hydoxy-2-pyridones provided the impetus for synthesis of additional chemotypes with this core ( Figure 1 ) and their evaluation for effectiveness against additional pathogenic strains including Ng and N. meningitidis (Nm ). (elifesciences.org)
  • Title: FeCl3⋅6H2O-catalyzed intermolecular-cascade cyclization of acetoacetanilide: aldehyde-tuned synthesis to valuable 2-pyridone analogues. (aablocks.com)
  • Title: Mononuclear Ru(III) Schiff base complexes: synthesis, spectral, redox, catalytic and biological activity studies. (aablocks.com)
  • Amr A. E., Elsayed E. A., Al-Sayady A. I.: Synthesis and Antimicrobial Activity of Novel N3,N5-Bis[1-({1-[2-((E)-benzylidene)hydrazinyl]-1-oxo-3-phenylpropan-2-yl}amino)-3-methyl-1-oxobutan-2-yl]pyridine-3,5-dicarboxamides. (cas.cz)
  • Abdel Salam Osama I., Khalifa Nagy M., Said Said A., Amr Abd El-Galil E.: Synthesis and antimicrobial activities of some newly 2,4,6-tri-substituted pyridine derivatives. (cas.cz)
  • Khayyat Suzan, Amr Abd: Synthesis and Biological Activities of Some New (Nα-Dinicotinoyl)- bis-L-Leucyl Linear and Macrocyclic Peptides. (cas.cz)
  • My teaching activities cover all aspects of organic chemistry from basic structure and bonding in organic molecules, to complex organic synthesis. (exeter.ac.uk)
  • Bhat MA (2014) Synthesis and anti-mycobacterial activity of new 4-thiazolidinone and 1,3,4-oxadiazole derivatives of isoniazid. (dntb.gov.ua)
  • Kunzler A, Neuenfeldt PD, das Neves AM, Pereira CM, Marques GH, Nascente PS et al (2013) Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl) ethyl) thiazolidinones. (dntb.gov.ua)
  • Krzywik J, Mozga W, Aminpour M, Janczak J, Maj E, Wietrzyk J et al (2020) Synthesis, antiproliferative activity and molecular docking studies of novel doubly modified colchicine amides and sulfonamides as anticancer agents. (dntb.gov.ua)
  • El-Sayed NS, El-Bendary ER, El-Ashry SM, El-Kerdawy MM (2011) Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo [3, 2-a] pyrimidines. (dntb.gov.ua)
  • In-silico analysis of the dereplicated metabolites led to highlighting the compounds responsible for the antimicrobial activity of Aspergillus sp. (biomedcentral.com)
  • Salmonella typhi , Proteus vulgaris and antifungal activity against Aspergillus niger, Aspergillus fumigates, Rhizopus and Candida albicans carried out by disc diffusion method displayed significant antimicrobial activity. (ijpsr.com)
  • All the synthesised compounds were screened for their in vitro antimalarial activities against chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7) and antimicrobial activity against Gram positive bacteria i.e. (biomedcentral.com)
  • Absorption ability and tautomeric structure of synthesized disazo pyrazole disperse dyes substituted with electron-withdrawing and electron-donating groups at their o, m- and p-positions were also examined in detail. (idexlab.com)
  • Pyrazoles have been studied because of their wide range biological and pharmacological activities. (ijpsr.com)
  • The selection of the two principles in the dual drug is usually based on their observed synergistic pharmacological activities to enable the identification of highly active novel chemical entities. (biomedcentral.com)
  • Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. (ijpsr.com)
  • In metalloneurochemistry, he studies the molecular activity of metal ions in the brain and develops optical and MRI sensors for binding, tracking, and measuring metal ions as they interact with neurotransmitters and other biological signaling agents. (wikipedia.org)
  • The molecular structures were characterized by NMR and HRMS and confirmed by X-ray diffraction. (idexlab.com)
  • Spark's molecular comparisons using ligand similarity are based on their molecular fields, not on their structure. (nodepit.com)
  • He is considered one of the founders of bioinorganic chemistry, studying the interactions of nonliving substances such as metals with biological systems. (wikipedia.org)
  • Lippard's research activities are at the interface of biology and inorganic chemistry. (wikipedia.org)
  • I am a member of the Biological Chemistry research group . (exeter.ac.uk)
  • Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
  • Heterocyclic compounds are well known for their different biological activities. (ijpsr.com)
  • Al-Mohizea Abdullah M., Al-Omar Mohamed A., Abdalla Mohamed M., Amr Abdel-Galil E.: 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives. (cas.cz)
  • Biochemical, biophysical, and biological data support the efficacy of these molecules both in vitro and in mouse models. (elifesciences.org)
  • EVALUATION FOR ACCEPTABLE INTAKE BIOLOGICAL DATA Biochemical aspects Absorption, distribution and excretion The absorption, distribution, and excretion of paraquat in experimental animals have been reviewed by WHO (1984). (inchem.org)
  • in vitro and in vivo therapeutic activity of parthenium hysterophorus against trypanosoma evansi. (liverpool.ac.uk)
  • The seven isolated endophytic strains revealed selective noticeable activity against Escherichia coli (ATCC25922) with varied IC 50s ranging from 1.19 to 10 µg /mL, in which Aspergillus sp. (biomedcentral.com)
  • Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)
  • Since their alpha-pyridone moieties are responsible for their key interactions with the active site via hydrogen bonding, and possibly via C-H.pi interactions, all three maintain similar positions and orientations with respect to it. (proteopedia.org)
  • A unique section is devoted Inhalation toxicology in order to doped NCs, highlighting each synthetic elements as well as structure-property interactions. (nutlin-3antagonist.com)
  • Lippard attempts to better understand the role of metal complexes in the physiology and pathology of existing biological systems, and to identify possible applications of metal ions in medical treatment. (wikipedia.org)
  • All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
  • Abo-Ghalia Mohamed H., Moustafa Gaber O., Amr Abd El-Galil E., Naglah Ahmed M., Elsayed Elsayed A., Bakheit Ahmed H.: Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates. (cas.cz)
  • The protein is not used in a pharmacophoric sense: however, result molecules that clash with the protein structure will be penalised. (nodepit.com)
  • Another area of interest is the structure and function of methane and enzymes that consume greenhouse gas hydrocarbons. (wikipedia.org)
  • This process is mediated by various enzymes modifying chromatin structures to achieve the diversity of epigenetic space and the intricacy in gene expression files. (frontiersin.org)
  • Aptamers are single-stranded RNA or DNA oligonucleotides that fold up into a distinctive 3D structure capable of binding with high affinity and specificity to small molecules up to entire organisms, with nanomolar range dissociation constants. (encyclopedia.pub)
  • Accordingly, using these properties to describe molecules is a powerful tool for the medicinal chemist as it concentrates on the aspects of the molecules that are important for biological activity. (nodepit.com)
  • Using the fields gives a 'protein's view' of how the molecules would line up in the active site, generating ideas on how molecules with different structures could interact with the same protein. (nodepit.com)
  • span title="Soil structure describes the arrangement of the solid parts of the soil and of the pore space located between them. (mn.us)
  • Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. (umassmed.edu)
  • The standard Watson-Crick DNA model justifies the size-complementarity and the hydrogen bonding patterns responsible for the crystal structure which is necessary for the amplification of genetic information and specificity to the formation of base pairs [6]. (fortuneonline.org)
  • The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
  • To address this notion, known natural Epoxide compounds, Cerulenin and Fosfomycin were examined for QSI activity for the agr and fsr systems in addition to in silico and SAR studies. (springeropen.com)
  • The remarkable results on yield, process, development of DHPs, anti‐proliferative activity, structure determination and single crystal study of DHPs discussed in this article. (researchgate.net)
  • Nayak SG, Poojary B (2019) A review on the preparation of 1,3,4-oxadiazoles from the dehydration of hydrazines and study of their biological roles. (dntb.gov.ua)
  • Centre for Imaging & Structure of Materials' and 'Centre for Materials Design & Technology' are important CICECO structures. (ua.pt)
  • Even so, there have been many essential aspects of common ground: very important so you can get a normal donor, the significance of matching the donor towards the non-biological lover, and the amount of thought that went into choosing donor. (ly3295668inhibitor.com)
  • 3 ] Osteoporosis is an age-related disorder that is characterized by bone loss and deterioration of the bone structure, particularly affecting postmenopausal women. (e-jbm.org)
  • 5 ] Typical bone diseases, such as osteoporosis, Paget's disease, and rheumatoid arthritis, have the symptoms of decreased bone mass because of the increased number and activity of osteoclasts. (e-jbm.org)
  • Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
  • Aptamers are short single-stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind to a large variety of targets ranging from small ions to an entire organism. (encyclopedia.pub)
  • For a guided tour on the structure components use FirstGlance . (proteopedia.org)
  • Knowing the components through which the actual ANS influences CBF inside cerebrovascular event people reconstructive medicine may provide the foundation with regard to book therapeutic strategies to enhance well-designed final results throughout cerebrovascular event sex as a biological variable sufferers. (nutlin-3antagonist.com)
  • This specific paper accounts selleck the results of a review associated with non-biological parents. (ly3295668inhibitor.com)
  • International Journal of Biological Macromolecules 2012 , 50 , 171. (cas.cz)
  • International Journal of Biological Macromolecules 2012 , 51 , 56. (cas.cz)
  • As a result, most of investigated Epoxide containing antibiotics correlatively interfere with QSI activity for the agr and fsr systems under sublethal concentrations. (springeropen.com)
  • Superior conversation of benefits involving vaccination to these groups should be used.Your COVID-19 crisis has resulted in elevated use of phone and also movie Cycloheximide mw activities from the Experienced persons Wellness Supervision and many other healthcare systems. (nutlin-3antagonist.com)
  • Lastly, a crucial research latest high tech regarding ZnO colloidal NCs is introduced together with current issues and also long term instructions for your discipline.A new chiral NHC-catalyzed [3 + 3] cycloaddition effect is produced for your successful combination involving pyrazolo[3,4-b]pyridones throughout generally outstanding makes along with eye purities. (nutlin-3antagonist.com)
  • All the compounds had shown good to excellent antimicrobial and antifungal activities. (biomedcentral.com)
  • The proposed method is reproducible and may be used for samples containing many other substances, such as biological fluids. (go.jp)
  • X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. (proteopedia.org)