Biological intracellular signaling peptides and proteins. Medical search. Frequent questions

PPIA may also regulate ERK1/2, JNK, p38 kinase, Akt, and IκB signalling pathways through activating the CD147 receptor. (wikipedia.org)
Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
Furthermore, these pathways are essential for cellular dynamics and build a highly regulated cellular signalling network. (mdpi.com)
However, dysregulations of these signalling pathways are also causes for pathophysiological processes and diseases. (mdpi.com)
Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)
However, the prediction of these signaling pathways is primarily based on the structure of Dixdc1. (mcmaster.ca)
Given the role of Dixdc1 in neural development and brain disorders, we hypothesized that Dixdc1 may regulate additional signaling pathways in the brain. (mcmaster.ca)
This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)
In the tumor microenvironment, cell migration and invasion are regulated by many factors such as intracellular signaling pathways, growth factors or onco-proteins [ 2 ]. (oncotarget.com)
We use a number of model systems (pituitary cells, cell lines, transgenic animals) to study signal pathways for a hypothalamic peptide hormone, TRH, which acts via a G protein coupled receptor to increase cytoplasmic calcium and protein kinase C activity. (rochester.edu)

The structural information provides a template for the further dissection of receptor binding specificity of TRAF2 and for the understanding of the complexity of TRAF-mediated signal transduction. (rcsb.org)
M.B. holds a Canada Research Chair in Signal Transduction and Molecular Pharmacology. (acs.org)
Abundant proteins, including membrane trafficking molecules, cytoskeleton molecules, chaperones, signal transduction proteins and cytoplasmic enzymes have been included in secreted exosomes [ 9 ]. (oncotarget.com)
The long-term goal is to understand signal transduction in endocrine cells at a molecular and cellular level. (rochester.edu)

Though small molecules and protein therapeutics are well established agents in current pharmaco-therapeutics, their target range is limited to only one-tenth of the cell membrane surface or hydrophobic protein facade. (amphysiol.com)
Firstly, exploration of entities that promote the active endosomal uptake and release of molecules which are not lipid soluble like polypeptides, proteins and nucleic acids. (amphysiol.com)
Secondly, identification of molecules that enters the cell by passive diffusion, facilitated diffusion or active transport so as to reach the intracellular molecular targets [ 4 ] . (amphysiol.com)
Noteworthy progress has been made in the field of cancer therapeutics with identification/development of molecules capable of generating extra-cellular or intra-cellular death signals which plunges the malignant cells to undergo apoptosis. (amphysiol.com)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
The expression of EMT-related molecules and Jagged-1/Notch signaling pathway was analyzed by Western blot and qPC experiments. (researchsquare.com)
Target cells expressing single viral proteins were then used to identify the molecules recognized by cytotoxic Tlymphocytes (CTLS). (ox.ac.uk)
These and more recent results with nonviral glycoproteins are consistent with the existence of a mechanism for degrading viral (and perhaps host) proteins and exposing them at the cell surface for recognition by cytotoxic T cells in association with class I molecules of the major histocompatibility complex. (ox.ac.uk)
Evolution has developed for this purpose a great variety of membrane proteins, so-called receptors, that receive physical cues from the external environment through encounters with molecules or absorption of photons and send respective signals into the cell. (uiuc.edu)
According to the current view, damage-associated molecules released by infected or injured cells, or secreted by innate immune cells generate danger signals activating an immune response. (frontiersin.org)
PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
red collection: blood vessel) begin to excrete growth factors (step 2 2), cytokines, and additional signaling molecules (green). (lacbiosafety.org)
These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)

The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. (rndsystems.com)
Biological Signals and Receptors 10:399-415. (horseshoecrab.org)
proteins of this type are called G protein coupled receptors (GPCRs). (uiuc.edu)
Background G-protein-coupled receptors (GPCRs) play an essential role in lots of natural processes and represent a significant class of drug targets. (exposed-skin-care.net)
Therefore, we attempt to check whether we'd elicit ligand-dependent behavioural reactions in em C. elegans /em by expressing mammalian GPCRs in the ASH and ADL gustatory neurons, because they are straight exposed to the surroundings allowing gain access to of proteins and peptide ligands towards the heterologous receptors. (exposed-skin-care.net)
The IMune protein family contains 15 known receptor sequences, which are capable of inducing the potent inhibitory action of all fifteen known receptors on the target cell. (highdesertwanderer.com)
Imune has the ability to directly interfere with the communication between the tumor necrosis factor receptor and the tumor cells through the intracellular receptors. (highdesertwanderer.com)
Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
Some G protein- coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, have been identified as HIV coreceptors. (qedbio.com)

Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)
Many members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting TNFR-associated factors (TRAFs) through their cytoplasmic tails. (rcsb.org)
Biochemical and functional evidence suggest that the calcitonin receptor-like receptor (CRLR) interacts with receptor activity-modifying protein-1 (RAMP1) to generate a calcitonin gene-related peptide (CGRP) receptor. (acs.org)
In addition to shed new light on the CRLR−RAMP1 signaling complex, the BRET assays developed herein offer new biosensors for probing CGRP receptor activity. (acs.org)
Furthermore, pre-exposure of GPCR transgenic pets to its ligand prospects to receptor desensitisation and behavioural version to following ligand publicity, providing further proof integration from the mammalian GPCRs in to the em C. elegans /em sensory signalling equipment. (exposed-skin-care.net)
X. Trefoil peptide and EGF receptor/ligand transgenic mice. (embl.de)
This review highlights some of the major findings pertinent to the epidermal growth factor (EGF) receptor and its ligands, particularly the major gut ligand transforming growth factor-alpha, as well as the trefoil peptides. (embl.de)
Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. (embl.de)
The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. (cdc.gov)
Moreover, blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor ( FSHR ) gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding. (nature.com)
In addition, we use biochemical and genetic approaches to identify proteins that interact with the receptor during biosynthesis, signaling and desensitization. (rochester.edu)
siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor. (rochester.edu)
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. (rochester.edu)
Biological Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). (qedbio.com)

Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. (nih.gov)
We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. (nih.gov)
All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. (rndsystems.com)
It is a PROTEIN-SERINE-THREONINE KINASE that is translocated to the CELL NUCLEUS in response to light signals. (bvsalud.org)
Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)

GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
This em in vivo /em program, which imparts book avoidance behavior on em C. elegans /em 1062368-24-4 supplier , therefore provides a basic means of learning and screening conversation of GPCRs with extracellular agonists, antagonists and intracellular binding companions. (exposed-skin-care.net)
Immunogen Peptide corresponding to aa 182- 196 in the second extracellular loop (EL) of human CXCR4. (qedbio.com)
I-FABP) and bovine heart fatty acid-binding pro- tissues and in intracellular as well as extracellular tein (H-FABP). (lu.se)

Molecular targets (MT) are intra-cellular structures, ranging from proteins to DNA and RNA that are potential entities for pharmacological action. (amphysiol.com)
Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology 1596:177-181. (horseshoecrab.org)
Gene ontology functional enrichment analysis revealed twenty eight biological processes and 10 molecular functions associated with cognitive impairment. (ijpsonline.com)
These factors can influence the stromal cells to also create these factors, which transmission Rabbit Polyclonal to OR5B3 (observe visualization and quantification of molecular markers involved in biological/cellular processes [38,39] C can be performed with numerous imaging modalities including, positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), ultrasound (US), and optical imaging (Number 2). (lacbiosafety.org)
Like compounds from biological sources and low-molecular-weight nonoccupational asthma, occupational asthma is probably the chemicals cause occupational asthma after a latent period of result of multiple genetic, environmental, and behavioral exposure. (cdc.gov)

The use of genetically engineered mice with both gain-of-function and loss-of-function mutations has been particularly informative about the normal and pathophysiological actions of a number of regulatory peptides of the gastrointestinal tract. (embl.de)

Conclusions Our data implicate loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. (bmj.com)

As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. (wikipedia.org)
and, regulation of biological processes such as chromosomal folding, protein secretion and intracellular signaling. (berkeley.edu)
The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
Therefore, authors are invited to submit original research and review articles which address the progress and current standing of cellular signalling processes. (mdpi.com)
Prolactin (PRL) and growth hormone (GH) are hormones/cytokines responsible for the coordination of a wide range of biological processes in vertebrates. (biomedcentral.com)
A biomarker panel was selected based on (1) prognostic association in published literature, (2) prognostic association in gene expression data sets, (3) availability of reliable antibodies, and (4) representation of diverse biological processes. (nih.gov)
Here, we review the diverse, and still expanding, collection of stimuli and processes now known to harness the noncanonical autophagy pathway, including engulfment processes, drug treatments, TRPML1 and STING signaling, viral infection, and other pathogenic factors. (babraham.ac.uk)
The different secretory processes are controlled by corresponding Rab proteins including Rab3A/B/C/D, Rab26, Rab27A/B and Rab37. (oncotarget.com)

Other approaches being worked on are intra-cellular antibodies (intrabodies) [ 7 ] and peptide aptamers [ 8 ] . (amphysiol.com)
However, he notes that this method has shown to be effective in identifying subtle biological differences in patients with various types of cancers and furthermore, the antibodies tend to remain active for longer periods of time. (highdesertwanderer.com)
Antibodies can be found on the surface of lymphocytes as an integral part of the cell membrane protein or can be freely circulating in the blood or be part of one of the body's gland secretion. (medscape.com)
Antibodies belong to immunoglobulin family of protein and have 5 isotypes (G, A, M, E, D) with further subclasses of G and A. The classes are differentiated with the characteristics of the Ig heavy chain of the antibody. (medscape.com)

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
As a secretory small GTPase, Rab3D is a vital regulator for protein secretion. (oncotarget.com)

Thirty nine phytoconstituents were identified in Amaranthus tricolor , five of which were predicted to modulate eight potential protein targets involved in cognitive impairment. (ijpsonline.com)
A common virulence strategy of intracellular pathogens is to favorably modulate the intracellular milieu of hosts for their own benefit. (biomedcentral.com)

This network is the main organizational feature that allows the immune system to keep its dynamic equilibrium (homeostasis) through activating and inhibitory signals and, at the same time, to adapt the response to environmental cues. (frontiersin.org)
Both of these peptide families have important local actions in maintaining tissue homeostasis and repair after injury, and when mechanisms governing their regulation are disrupted they may contribute to disease progression. (embl.de)

The five selected proteins (MKI67, EZH2, SLC2A1, CADM1, and NKX2-1 alias TTF1) were analyzed by immunohistochemistry on tissue microarrays including tissue from 326 non-small cell lung cancer patients. (nih.gov)
The combination of a prognostic biomarker panel with clinicopathological parameters did not improve survival prediction in non-small cell lung cancer, questioning the potential of immunohistochemistry-based assessment of protein biomarkers for prognostication in clinical practice. (nih.gov)

Amino acids are building blocks of proteins. (medlineplus.gov)

We expressed a GFP-tagged plasma membrane protein in the yeast deletion library and identified mutants with altered marker localization. (ox.ac.uk)
Other intracellular pathogens, such as Listeria monocytogenes , degrade the phagosomal membrane and escape into the cytoplasm to replicate freely [ 8 ]. (biomedcentral.com)
Experiments with deletion mutants of the nucleoprotein (NP) gene showed that transport of epitopes to the membrane for recognition by CTLS was independent of a definable signal sequence. (ox.ac.uk)
T he question arose as to whether a similar phenomenon would be found with viral proteins which are naturally inserted in the target cell membrane. (ox.ac.uk)
Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)
However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
Rab GTPases, as intracellular transport proteins, are master regulators of exocytic and endocytic membrane trafficking [ 10 ]. (oncotarget.com)
Such a membrane-anchoring strategy has been adopted by a wide range of signaling proteins ( Fivaz and Meyer, 2003 ) with significant variations in the structure of these motifs (see Table S1). (rupress.org)

This screen revealed a requirement of several enzymes regulating the synthesis of sphingolipids and ergosterol in the correct and efficient delivery of the marker protein to the cell surface. (ox.ac.uk)

Moreover, as the word 'coding' refers to the relationship between nucleic acids and proteins, rather than the mere transcription of DNA into RNA, it is logical to call the strand with the mRNA sequence the coding strand, as in the first example. (genomicglossaries.com)

Thus we have discovered a novel protein that links the alpha5beta1 integrin to migration controlled by Rho-family GTPases. (nih.gov)

One approach is development of tumor targeting antibody fragments genetically fused to a cytotoxic protein payload called Targeted Protein Therapeutics (TPTs) [ 6 ] . (amphysiol.com)
Fundamental contrast agent design includes a binding ligand such as a small molecule, peptide, antibody/antibody fragment, or protein to bind to the protein target of interest, as well as a label for readout by the different imaging modalities. (lacbiosafety.org)

In particular, PPIA is predominantly expressed in the nucleus and cytoplasm of the cell, where it partakes in intracellular signaling, protein transport, and transcription regulation. (wikipedia.org)
We monitor intracellular calcium in the cytoplasm and the endoplasmic reticulum using several fluorescence imaging techniques. (rochester.edu)

In terms of mechanism, the functional gain and loss experiments of human LEC show that TLR3 regulates the proliferation, migration, invasion of LEC and EMT induced by TGF-β2 by targeting the Jagged-1/Notch signaling pathway to affect the development of fibrotic cataract. (researchsquare.com)
Whereas the G s /G i -protein-dependent tuning of striatal neurons is fairly well known, the precise impact and underlying mechanism of G q -protein-dependent signals remain poorly understood. (jneurosci.org)
Our data thus define a novel signaling mechanism that differentially regulates KRas and HRas localization and activity in neurons. (rupress.org)

In non-canonical Atg8-family protein lipidation they become conjugated to single membranes. (babraham.ac.uk)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)

Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)

leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). (qedbio.com)

Biochemical fractionation showed that IglA is a soluble cytoplasmic protein and immunoprecipitation experiments demonstrate that it interacts with the downstream-encoded IglB. (biomedcentral.com)
for example, H-FABP makes up 3% of the plasmic intracellular LBPs from three different cytoplasmic protein content in rat heart. (lu.se)

A single amino acid substitution in SP26 was found to be responsible for altering its intracellular localization as well as its function as a post-transcriptional regulator of viral gene expression. (gla.ac.uk)
Gene ontology functional enrichment analysis was performed using search tool for the retrieval of interacting genes/proteins. (ijpsonline.com)
IglA is a 21 kDa protein encoded by a gene that is part of an iglABCD operon located on the Francisella pathogenicity island (FPI). (biomedcentral.com)
These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)

Future applications of transgenic technology to these areas are likely to be productive in furthering our understanding of the biology of these peptides in health and disease. (embl.de)

Radioligand binding and cAMP production assays also confirmed that the fusion proteins retained normal functional properties. (acs.org)
What makes imune a valuable tool in the fight against cancer lies in the medico-functional properties of its peptide sequences. (highdesertwanderer.com)

These results led to the suggestion that the epitopes recognized by class-I-restricted CTLS resulted from degradation of viral proteins. (ox.ac.uk)
Strategies for designing vaccines for severe acute respiratory syndrome (SARS) using A) spike (S) protein and B) fragments containing neutralizing epitopes. (cdc.gov)

These signals are also relevant to the subsequent activation of homeostatic mechanisms that control the immune response in pro- or anti-inflammatory reactions, a feature that allows modulation by therapeutic treatments. (frontiersin.org)
Nowadays, the immune system is thought to be activated by "danger signals" which are relevant not only to the induction of inflammation and immune responses but also to the activation of counter regulatory (anti-inflammatory/modulatory) mechanisms required to shutdown inflammation and allow tissue healing. (frontiersin.org)

Some ERVs, however, have maintained intact open reading frames for some of their genes, and have been co-opted by the host as they fulfil important biological functions. (gla.ac.uk)
We recently described a Francisella pathogenicity island (FPI) harboring several genes necessary for intracellular growth. (biomedcentral.com)
And when we started mapping these active promoter genes, we found that in addition to thousands of signals at sites of known genes, many signals are mapped to different genomic sites where no genes are marked by the reference genome. (vechnayamolodost.ru)
By integrating these chromatin "signals to promoters" data and transcriptomics data (analysis of RNA transcripts of brain cells from many individuals), we have shown the possibility of discovering new genes that have not yet been annotated. (vechnayamolodost.ru)
For the most part, in this way we identified a series of protein-non-coding genes, but also some protein-coding ones. (vechnayamolodost.ru)

These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. (researchsquare.com)
TLR3-Jagged-1/Notch' signal axis may be a therapeutic target for the treatment of fibrotic cataract. (researchsquare.com)
We also used in vitro assays to test a possible link between our exome-derived candidate and Notch signaling. (bmj.com)
Transient suppression or CRISPR/Cas9-mediated deletion of mmp21 in zebrafish embryos induced cardiac looping defects, with concomitant disruption of laterality markers in the lateral plate mesoderm and disrupted notch signalling in vitro and in vivo. (bmj.com)

Journal of Biological Chemistry 276:27166-27170. (horseshoecrab.org)

Its active site is a hydrophobic pocket that binds peptides containing proline. (wikipedia.org)
A mutant haemagglutinin has been produced that lacks a hydrophobic signal sequence. (ox.ac.uk)

with short synthetic peptides. (ox.ac.uk)
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. (google.es)

The protein content of BIO-MPM-1 is therefore less than 30 mg/L, and the medium contains no growth factors or hormones other than insulin. (bioind.com)
In the present review, we describe and discuss the effects of extremely low frequency (ELF)-EMF and pulsed EMF on cell signals and factors relevant to the activation of danger signals and innate immunity cells. (frontiersin.org)
These results illustrate the combined impact of genetic, lifestyle, and environmental factors in modulating immunological responsivity and emphasize the importance of the exposome in shaping biological responses. (cdc.gov)

BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)

Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control. (microbialcell.com)
The formylation of N-terminal Met in bacterial proteins is not strictly essential for either translation or cell viability. (microbialcell.com)
What, then, is the main biological function of this metabolically costly, transient, and not strictly essential modification of N‑terminal Met, and why has Met formylation not been eliminated during bacterial evolution? (microbialcell.com)
We suggest that the faster emergence of nascent proteins from bacterial ribosomes is one mechanistic and evolutionary reason for the pretranslational design of bacterial fMet/N‑degrons, in contrast to the cotranslational design of analogous Ac/N‑degrons in eukaryotes. (microbialcell.com)

As for their wild-type counterparts, fusion proteins linking CRLR and RAMP1 to the energy donor Renilla luciferase ( R luc) and energy acceptor green fluorescent protein (GFP) reach the cell surface only upon coexpression of CRLR and RAMP1. (acs.org)
For example, we can 'tag' signaling proteins with green fluorescent protein (GFP) and then follow their movements in the cell during hormonal stimulation in real time. (rochester.edu)

Facilities include those for protein-sequence analysis, peptide and oligonucleotide synthesis, access to the synchrotron at Lawrence Berkeley National Lab for X-ray crystallography, and NMR spectrometry. (berkeley.edu)
At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. (rndsystems.com)
This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines. (cdc.gov)

5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)

For the proteins associated with cystic fibrosis, mitochondrial disease, cancer and a wide variety of metabolic disorders, physical, biochemical and catalytic studies are carried out to derive a picture of both normal and abnormal structure and function. (utoronto.ca)

2001. Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)

These ATG proteins also perform an important parallel role in 'noncanonical' autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. (babraham.ac.uk)
Pulmonary inflammation was evaluated 24 hrs following MWCNT exposure, in terms of cell and protein quantification of bronchoalveolar lavage fluid (BALF). (cdc.gov)

To analyze this effect anatomically, we manipulated G q -protein-dependent signaling selectively in neurons belonging to the direct or indirect striatal pathway. (jneurosci.org)
Acute G q -protein activation in direct-pathway or indirect-pathway neurons produced an enhancement or a decrease, respectively, of activity-dependent parameters. (jneurosci.org)
In contrast, sustained G q -protein activation impaired the functionality of direct-pathway and indirect-pathway neurons and disrupted the behavioral performance and electroencephalography-related activity tasks controlled by either anatomical framework. (jneurosci.org)
It uses just 11 pairs of amphid chemosensory neurons to identify environmental signals. (exposed-skin-care.net)
Furthermore, the ASH and ADL neurons communicate a large selection of G subunits [3], raising the probability of GPCR-G proteins conversation. (exposed-skin-care.net)

The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)

The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. (rndsystems.com)

Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity- based enrichment. (genomicglossaries.com)

Anatomy10

Organisms11

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Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes71

Disciplines and Occupations5

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Molecules14

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Receptor14

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