• Many functionally important motions occur on the microsecond and low millisecond time scale and can be characterized by nuclear magnetic resonance relaxation experiments. (rcsb.org)
  • We show that one of the apo conformations and one of the holo conformations are identical, whereas the two remaining conformations are only detectable by nuclear magnetic resonance spectroscopy in either the apo or holo form. (rcsb.org)
  • In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about structural heterogeneity contained in a parameter that is exquisitely sensitive to molecular shape called residual dipolar coupling measured in steric alignment. (europa.eu)
  • To complement the structural information obtained by nuclear magnetic resonance and, especially, measure the rate of information transfer across the androgen receptor we will carry out in a collaborative fashion high precision single molecule Förster resonance energy transfer and fluorescence correlation spectroscopy experiments on AR constructs labelled with fluorescent dyes. (europa.eu)
  • Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies. (nih.gov)
  • Our studies rely on nuclear magnetic resonance (NMR) spectroscopy, a research approach that relies on the magnetic properties of the nucleus of certain atoms to determine physical and chemical properties of the molecules in which they are contained. (nih.gov)
  • In my research group we primarily use nuclear magnetic resonance (NMR) spectroscopy to study protein dynamics over a wide range of time scales, from picoseconds to seconds. (lu.se)
  • In order to better understand the complex formation of GAP-43 and BASP1, nuclear magnetic resonance (NMR) spectroscopy in combination with other biophysical methods are employed for this work. (univie.ac.at)
  • An overview of the metabolic differences between Bradyrhizobium japonicum 110 bacteria and differentiated bacteroids from soybean (Glycine max) root nodules : an in vitro C- and P-nuclear magnetic resonance spectroscopy study. (ibs.fr)
  • Hydrogen-deuterium exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy. (jnu.ac.in)
  • My group exploits the complementary nature and distance dependence of nuclear magnetic resonance (NMR) and single molecule fluorescence, in particular single molecule Förster Resonance Energy Transfer (FRET), to study the conformational landscape and dynamics of IDPs at molecular resolution. (fu-berlin.de)
  • The Columbus lab seeks to determine the structure and conformational changes of membrane proteins involved in bacterial infection using a combination of site-directed spin labeling (SDSL), nuclear magnetic resonance (NMR) spectroscopy, and X-ray crystallography, and also to develop tools to accelerate membrane protein structure determination by these methods. (case.edu)
  • Our principal experimental tool is nuclear magnetic resonance (NMR), in particular nuclear spin relaxation measurements. (lu.se)
  • To gain fundamental insights, we combine nuclear magnetic resonance (NMR) and broadband dielectric spectroscopy (BDS) with molecular dynamics (MD) simulations. (uni-halle.de)
  • Nuclear Magnetic Resonance ( NMR ) spectroscopy is a powerful tool for the study of structural biology, structure/activity relationships and macromolecule and small-molecule analysis. (irbm.com)
  • The obtained colloids were characterized by scanning electron microscopy, dynamic and electrophoretic light scattering, Fourier transform infrared and nuclear magnetic resonance spectroscopy. (degruyter.com)
  • In particular, they are and nuclear magnetic resonance (NMR) refinement. (lu.se)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • Experimental methods of multi-dimensional NMR spectroscopy, dynamics and theoretical description of spin system evolution, multiple resonance NMR technique for structural studies of proteins and nucleic acids by NMR spectroscopy, contemporary methods of structural biology, studies of complex biomolecular systems. (muni.cz)
  • Quasielastic incoherent neutron scattering (QENS) is a well-suited experimental method to study protein dynamics from the picosecond to several nanoseconds and in the Ångström length-scale. (lu.se)
  • In my presentation, I will summarize recent QENS and NSE results on the dynamics of the intrinsically disordered myelin basic protein (MBP) and the chemically denatured bovine serum albumin (BSA) (1,2,3). (lu.se)
  • Protein dynamics plays an important role in protein function. (rcsb.org)
  • The purpose of my lab's research is to understand the interrelationship between the structure, dynamics, and function of proteins. (nih.gov)
  • Our lab is developing new tools and techniques that facilitate the study of the structure and dynamics of proteins and protein complexes, functional units that include one or more proteins. (nih.gov)
  • I am interested in how protein dynamics contribute to biological function. (lu.se)
  • We address specific questions regarding the role of protein dynamics in various types of function and dysfunction, for example: ligand binding and allostery, enzyme catalysis, and protein misfolding and aggregation. (lu.se)
  • Change of dynamics of raft-model membrane induced by amyloid-beta protein binding. (ibs.fr)
  • The ecology of protein dynamics. (ibs.fr)
  • This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
  • Quantitative studies of biomolecular interactions, dynamics and structure at the molecular level establish the necessary foundation for analyzing higher levels of biological complexity. (lu.se)
  • He pioneered high pressure NMR to study protein folding and protein dynamics. (uni-halle.de)
  • For metal- powerful methods to obtain and compare reaction and activation loproteins, a third method to obtain local information about the energies for suggested enzyme mechanisms and they can also provide atomic details about the protein dynamics. (lu.se)
  • A particular focus is the study of rare, highly transient, "excited" states of proteins and their complexes that play a key role of molecular recognition. (nih.gov)
  • Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly. (nih.gov)
  • See also David Thirumalai's Emerging Ideas on the Molecular Basis of Protein and Peptide Aggregation ' (.pdf). (alzforum.org)
  • Structural biology is a powerful method to derive an understanding of the molecular basis of biological phenomena by visualizing the involved biomacromolecules at atomic resolution. (helmholtz-hzi.de)
  • Since RNA-binding proteins (RBPs) are key players in the post-transcriptional regulation of gene expression precise knowledge of their binding sites is critical for determining their molecular function and for understanding their roles in cell development and disease. (biosyn.com)
  • Single Molecular Force Spectroscopy (SMFS) techniques, e.g. optical tweezers, magnetic tweezers and atomic force microscopy, have emerged as powerful tools to investigate these interactions. (uni-halle.de)
  • These experiments have provided various insights and understanding of biological processes at the molecular level. (uni-halle.de)
  • First, molecular fragments were used to differentiate between two highly similar S100 proteins, S100B and S100A1, with the goal of designing S100-specific inhibitors to block these elevated S100 proteins in various disease states. (umaryland.edu)
  • at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)
  • Protein structures are invaluable for biochemical studies and for mechanical or molecular mechanics calculations have become the understanding of how proteins work. (lu.se)
  • Protein complexes, which are formed as a result of these interactions, consist of two or more components that associate along specific pathways - protein association pathways. (lu.se)
  • As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
  • Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)
  • Exploration of the supramolecular interactions involving tris-dipicolinate lanthanide complexes in protein crystals by a combined biostructural, computational and NMR study. (ibs.fr)
  • Qualitative and quantitative approaches are undertaken to effectively integrate parameters from both techniques to shed new light onto how IDPs and their interactions with folded proteins regulate and enable various biological processes. (fu-berlin.de)
  • The characterization of RNA and RNA interactions is closely related to transcription, for example, gene expression levels are investigated within a biological context. (biosyn.com)
  • Over the last decades, a variety of RNA methods have been developed for the study of RNA-DNA, RNA-RNA, and RNA-protein interactions including RNA complexes with ligand molecules. (biosyn.com)
  • The mapping of RNA-protein or RNA-RNA interactions by protein pull-down or affinity pull-down methods allow studying RNA structures, as well as RNA-protein, and RNA-RNA interactions. (biosyn.com)
  • The membrane proteins that mediate interactions between bacterial pathogens and hosts are of particular interest to the Columbus laboratory. (case.edu)
  • Although these bacteria have diverse mechanisms of cellular invasion, all of the pathways rely upon interactions between host and bacterial membrane proteins. (case.edu)
  • EF-hand Ca2+-binding proteins (CBPs), such as calmodulin (CaM) or those belonging to the S100 protein family (S100s) undergo conformational changes upon increasing intracellular Ca2+, facilitating interactions with protein targets and inducing important biological responses. (umaryland.edu)
  • Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin-spin interactions. (muni.cz)
  • To support our discovery programs we can use CD spectroscopy for different applications for the study of secondary structure content of peptides and proteins, monitoring conformational transitions , and the study of the thermodynamics of unfolding and protein-ligand interactions . (irbm.com)
  • The fast and real time analysis of the kinetic and thermodynamic binding parameters of small molecules , peptides , antibodies , or other protein-protein interactions, are crucial information for target characterization, hit identification, lead optimization or characterization of the binding properties of a molecule to its target. (irbm.com)
  • Due to its great flexibility, it allows us to detect, quantify and determine the kinetics of biomolecule interactions even in different types of complex biological matrixes. (irbm.com)
  • The intrinsic disorder and flexibility of IDPs grant them a number of advantages with respect to ordered proteins, such as conformational plasticity to bind several targets, a large interaction surface, involvement in high specificity/low affinity interactions, enhanced binding kinetics. (edu.pl)
  • Theoretically a radical pair could be described though the Hamilton operator that includes interactions between unpaired electrons and nuclei, the so-called hyperfine interactions, as well as the Zeeman interaction between the magnetic field and the electrons. (nature.com)
  • Due to those interactions, the magnetic field influences the total spin character of the radical pair, continuously altering it between the triplet and the singlet states. (nature.com)
  • In the case of biological macromolecules such as proteins, the advantage of SAXS over crystallography is that a crystalline sample is not needed. (wikipedia.org)
  • The Department Structure and Function of Proteins uses protein crystallography to investigate proteins that play a role in infectious disease, e.g. by controlling the production of toxic molecules or by acting as toxins themselves. (helmholtz-hzi.de)
  • They might first use NMR or surface plasmon resonance to screen and then X-ray crystallography to determine the structure of the fragment-protein complex. (the-scientist.com)
  • The most common strong alternative and complement to experimental methods to methods to obtain protein structures are X-ray crystallography obtain insight in biochemical processes. (lu.se)
  • The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
  • Bioinformatic algorithms allowing predicting of biomolecular folding for proteins, peptides, and RNAs, even though sometimes successful, have all their limitations. (biosyn.com)
  • RNA molecules in solution may adopt secondary structures that are only partially determined by thermodynamics since RNA molecules can undergo conformational changes during interaction with other RNAs, RNA binding proteins or RNA binding peptides. (biosyn.com)
  • We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins. (nih.gov)
  • The many proteins and protein complexes we describe are resulting in new insights into fundamental cell operations. (nih.gov)
  • The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
  • During protein synthesis, ribosomes become stalled on polyproline-containing sequences, unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and in bacteria by the homologous protein EF-P. While a structure of EF-P bound to the 70S ribosome exists, structural insight into eIF-5A on the 80S ribosome has been lacking. (cipsm.de)
  • A general property of disordered proteins is their structural expansion that results in a high macromolecular flexibility. (lu.se)
  • Another key result is the critical role of rare, transient, high-energy conformations in biological function: proteins spontaneously undergo transitions between multiple structural states that are either active or inactive. (lu.se)
  • Some functions are performed by disordered protein structural parts. (alzforum.org)
  • Some light is thus shed on the binding of intrinsically disordered proteins to membrane systems and on the accompanying structural changes. (univie.ac.at)
  • Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex. (ibs.fr)
  • 74] V. Chevelkov, K. Giller, S. Becker, and A. Lange, Measurement of backbone hydrogen-deuterium exchange in the type III secretion system needle protein PrgI by solid-state NMR, Journal of Magnetic Resonance , 283 (2017), pp. 110-116. (leibniz-fmp.de)
  • Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)
  • Since the rather recent discovery of their crucial role in protein interaction networks intrinsically disordered proteins (IDPs) are subject to intense investigations. (univie.ac.at)
  • Many intrinsically disordered proteins have the potential to interact simultaneously or sequentially with a range of different partner molecules. (univie.ac.at)
  • This work focuses on two neuronal human intrinsically disordered proteins, the Growth Associated Protein 43 (GAP-43) and the Brain Acid Soluble Protein 1 (BASP1). (univie.ac.at)
  • Therefore, these two proteins are models of choice to understand the complex formation of structurally different but functionally related intrinsically disordered proteins. (univie.ac.at)
  • Intrinsically disordered proteins (IDPs) lack clearly defined three-dimensional structure and sample many different conformations on a sub-microsecond time scale. (fu-berlin.de)
  • In the last few years intrinsically disordered proteins (IDPs) have received great attention from the scientific community as they participate in several important biological processes and diseases. (edu.pl)
  • Furthermore, the properties of SAXS allow investigation of conformational diversity in these molecules. (wikipedia.org)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • RNA molecules are functionally diverse and involved in many cellular processes such as catalysis, ligand binding, and protein recognition. (biosyn.com)
  • Water in confinements of nanoscopic size and in mixtures with various molecules, ranging from alcohols to proteins, is of great relevance in many fields, from biology to geology. (uni-halle.de)
  • This provided insight into the specificity of S100A1 versus S100B for small molecules and will enable improved S100 protein-based drug design efforts. (umaryland.edu)
  • However, the ability to crystallize or solve an NMR structure of your protein once fragments are bound to it makes it far easier to understand how those molecules bind to a target of interest and to begin to develop those fragments into larger molecules. (the-scientist.com)
  • These amyloid plaques are immunoreactive with antibodies to the prion protein and do not immunoreact with antibodies to other amyloidogenic proteins, such as the amyloid-beta (which is deposited in Alzheimer disease). (medscape.com)
  • In summary we will develop a method that will make it possible to describe some of the most fascinating biological phenomena, such as allostery and signal transduction, and will, in the long term, be an instrument for the discovery of drugs to treat castration resistant prostate cancer, a late stage of prostate cancer that is incurable and kills ca. 70.000 European men every year. (europa.eu)
  • Our research has resulted in unique insights showing how conformational entropy can contribute significantly to ligand binding and allostery, which has future applications in the field of drug design. (lu.se)
  • This research seeks to elucidate both the mechanisms of allostery and the basis of ligand- and target- specificity for S100 proteins and CaM. (umaryland.edu)
  • The effect of CaM on multiple full-length target proteins was then discussed to further describe CaM allostery. (umaryland.edu)
  • When we're taught biochemistry, we see proteins in their physiologically active forms. (alzforum.org)
  • Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. (europa.eu)
  • In QENS experiments of protein solutions hydrogens act as reporters for the motions of methyl groups or amino acids to which they are bound. (lu.se)
  • Biostatistics areas of interest include development of advanced statistical techniques and methodologies for design of biological experiments, collection and analysis of the data from those experiments and interpretation of, and inference from, the results. (nih.gov)
  • Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
  • They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
  • Institute of Biophysical Chemistry, Centre for Biomolecular Magnetic Resonance (BMRZ), J.W. Goethe University of Frankfurt, Marie-Curie-Strasse, D-60439 Frankfurt/Main, Germany. (rcsb.org)
  • Biological Chemistry (2007). (jnu.ac.in)
  • Her research group uses interdisciplinary approaches in chemistry, engineering, and biophysics to study complex biological systems and to develop new tools for basic science and biomedical applications. (stanford.edu)
  • Dr. Cochran obtained her Ph.D. in Biological Chemistry from the Massachusetts Institute of Technology, where she also completed a postdoctoral fellowship in Biological Engineering. (stanford.edu)
  • The Cochran laboratory uses interdisciplinary approaches in chemistry, engineering, and biophysics to study complex biological systems. (stanford.edu)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • The association pathway from monomer to oligomer is critical in a range of biological processes and thus it is of a vital importance to elucidate both atomic-resolution structures of intermediates along the pathway as well as the structure of the final state. (lu.se)
  • These extremely dynamic proteins are highly flexible and easily adaptable to different binding partners, making them important players in many biological processes, often with vital regulatory functions. (fu-berlin.de)
  • The ultimate aim is to understand biological systems and processes in terms of the underlying physical and chemical laws. (lu.se)
  • For a long while this shut academic labs out of such searches, but a related technique, fragment-based drug discovery (also called fragment-based lead discovery), offers another way to develop small-molecule drugs and chemical probes for investigating biological processes. (the-scientist.com)
  • He is interested in the structure and conformational fluctuations of biopolymers. (uni-halle.de)
  • 76] M. Zinke, P. Fricke, S. Lange, S. Zinn-Justin, and A. Lange, Protein-protein interfaces probed by methyl-labeling and proton-detected solid-state NMR spectroscopy, ChemPhysChem , 19 (2018), pp. 2457-2460. (leibniz-fmp.de)
  • For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)
  • Their membrane interaction properties are influenced by acylation of the proteins' N-termini. (univie.ac.at)
  • Small angle neutron scattering for the study of solubilised membrane proteins. (ibs.fr)
  • Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of alldrug targets. (case.edu)
  • The shift of the absorption band at 1,161 cm−1 at higher wave numbers up to 1,172 cm−1 is assigned to vC-O-C bonds due to membrane, protein, and DNA glycosylation. (cancerdiagnosisprognosis.org)
  • These types of transitions can mediate allosteric signaling within proteins via distinct pathways that we have detected using NMR spectroscopy. (lu.se)
  • Efficient refolding of aggregation prone Citrate Synthase by polyol osmolytes: How well are protein folding and stability aspects coupled? (jnu.ac.in)
  • We further demonstrate that this conformational diversity is an essential prerequisite for the directed movement of the 4'-PP cofactor and its interaction with externally acting proteins such as thioesterases and 4'-PP transferase. (rcsb.org)
  • Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
  • Of interest are development of computational and mathematical algorithms and tools, modeling techniques and approaches for understanding the complexity of biological systems, and utilization of big datasets and data science methods for model construction. (nih.gov)
  • We are also active in analytical and computational modeling of biological and colloidal systems. (lu.se)
  • High-resolution electron paramagnetic resonance (EPR) spectroscopy has reached a level of sophistication that allows for a multitude of small hyperfine and quadrupole couplings to be experimentally determined. (mpg.de)
  • The resulting better understanding of the physics behind the magnetic fingerprint of the spin systems will lead to optimized sample preparation and, by this, to increased experimental sensitivity. (mpg.de)
  • The possible mechanism to explain the biophysics of this compass sense involves electron transfers within the photoreceptive protein cryptochrome. (nature.com)
  • The similar problem is faced when resolving conformational ensembles from small angle scattering data. (lu.se)
  • 1 Jack H. Skirball Center for Chemical Biology and Proteomics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. (nih.gov)
  • Chemical chaperone mediated protein folding: Stabilization of P22 tailspike folding intermediates by glycerol. (jnu.ac.in)
  • To investigate the reaction catalysed by IdmH, 88% of the backbone NMR resonances were assigned, and using chemical shift perturbation of [ 15 N]-labelled IdmH it was demonstrated that indanomycin binds in the active-site pocket. (iucr.org)
  • Fourier transform infrared spectroscopy does not require any preparation, such as fixation and histological stains. (cancerdiagnosisprognosis.org)
  • CD spectra in the far UV range report for secondary structures while in the near UV they are characteristics of the tertiary structure of proteins. (irbm.com)
  • Neutron Spin-Echo spectroscopy (NSE) on the other hand, offers the highest energy resolution in the field of neutron spectroscopy and allows the study of slow collective motions in proteins up to several hundred nanoseconds and in the nanometer length-scale. (lu.se)
  • Combining small-angle neutron and X-ray scattering for studying protein denaturation. (ibs.fr)
  • Circular dichroism (CD) spectroscopy is a measurement of the difference in absorbance of right and left-circularly polarized light. (irbm.com)
  • An auto-catalytic surface for conformational replication of amyloid fibrils- Genesis of an amyloid world? (jnu.ac.in)
  • The latter represents a conformationally modified form of a normal cellular PrP C , which is a normal host protein found on the surface of many cells, in particular neurons. (medscape.com)
  • The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
  • The polymer complex consists of ISCA1 protein monomers with internally bound iron sulphur clusters and simultaneously binds ten cryptochromes. (nature.com)
  • This would fundamentally change our conventional thinking about protein structure-function relationship, no? (alzforum.org)
  • I do not think there is a contradiction to the conventional thinking of protein structure-function relation. (alzforum.org)
  • It is unknown how the structure and, effectively, the function of these proteins are directly impacted by UV-C exposure. (bvsalud.org)
  • Here, we present the effect of UV-C irradiation on the structure and function of pro-apoptotic Bid-FL and anti-apoptotic Bcl-xlΔC proteins. (bvsalud.org)
  • Both problems need to be thoroughly addressed in order for EPR spectroscopy to develop into an even more powerful structure determination tool than it is today. (mpg.de)
  • The replication of prions involves the recruitment of the normally expressed prion protein, which has mainly an alpha-helical structure, into a disease-specific conformation that is rich in beta-sheet. (medscape.com)
  • They are known to bind Calmodulin (by very distinct modes), are substrates of Protein Kinase C and co- localize with phosphatidylinositol-4,5-bisphosphate. (univie.ac.at)
  • STEP BY STEP: This plan illustrates one set of steps by which researchers can screen for fragments that bind to a protein target of interest. (the-scientist.com)
  • In his talk he will discuss spectroscopic applications under high pressure to explore the energy landscape of proteins including examples from the fields of amyloid and prion proteins, deep-sea biology and food science. (uni-halle.de)
  • The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein. (medscape.com)
  • Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I. Proc Natl Acad Sci U S A. 2020;117(11):5844-5852. (nih.gov)
  • shown in red), a poorly characterized protein implicated in oxidative stress response. (upstate.edu)
  • Further, our NMR studies reveal that these compounds interact with the N-terminal region of αSyn which is unstructured even in the fibrillar form of the protein and is known as the "fuzzy coat" of fibrils. (bvsalud.org)
  • The degree of conformational order in the prefibrillar aggregates is not yet known, I don't think. (alzforum.org)
  • The accumulation of the intrinsically disordered protein alpha-synuclein (αSyn) in the form of insoluble fibrillar aggregates in the central nervous system is linked to a variety of neurodegenerative disorders such as Parkinson's disease, Lewy body dementia, and multiple system atrophy. (bvsalud.org)