• Here, a Bmal1 conditional knockout mouse line and a novel Cre transgenic mouse line were used to examine the role of myometrial Bmal1 in parturition. (tamu.edu)
  • Protein structure predictions, patient mutations, in vitro binding studies and transgenic and knockout mice suggest that dystrophin plays a mechanical role in skeletal muscle, linking the subsarcolemmal cytoskeleton with the extracellular matrix through its direct interaction with the dystrophin-associated protein complex (DAPC). (ox.ac.uk)
  • Although tumor immunosurveillance was first hypothesized more than four decades ago, the observed absence of spontaneous tumors in several immune-compromised mouse strains initially dampened enthusiasm for this idea. (silverchair.com)
  • Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains. (sciencedaily.com)
  • Neuroscientists around the world can now download these extremely accurate anatomical templates and use them to map other data -- such as which parts of the brain are metabolically active and where particular genes are expressed -- and for making quantitative anatomical comparisons with other, genetically engineered mouse strains," said project leader Helene Benveniste, who is a researcher in Brookhaven's medical department and a professor of anesthesiology at Stony Brook University. (sciencedaily.com)
  • MTB integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, emphasizing data on tumors that develop characteristically in different genetically defined strains of mice. (tigm.org)
  • The International Mouse Strain Resource (IMSR) is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice. (tigm.org)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. (nih.gov)
  • The North American Conditional Mouse Mutagenesis project (NorCOMM) is a large-scale research initiative focused on developing and distributing a library of mouse embryonic stem (ES) cell lines carrying single conditional knockout mutations across the mouse genome. (tigm.org)
  • We infected LMP7(-/-) and C57BL/6 mice with MCMV or with newly-generated recombinant vaccinia viruses (rVVs) encoding the immunodominant MCMV protein M45 in either full-length or epitope-only minigene form. (ox.ac.uk)
  • The use of recombinant inbred lines allows an estimate of the heritability of expression measured by individual probes. (biomedcentral.com)
  • Genetical genomics is further enhanced by using recombinant inbred lines as a mapping population. (biomedcentral.com)
  • In addition, recombinant inbred lines can provide both replicates from genetically identical individuals and samples from different segregants. (biomedcentral.com)
  • Rabbits and mice vaccinated with the live recombinant virus produced antibodies that recognized 48K, 57K and 61K mol. (microbiologyresearch.org)
  • Therefore, to gain insight into how the CrT is regulated, we studied two mouse models of severely altered myocardial creatine levels. (ox.ac.uk)
  • This important part of their business includes research animal models such as inbred, outbred, disease and immunodeficiency models, including mice, rats, hamsters, guinea pigs and rabbits to name a few examples. (citeab.com)
  • CiteAb's recently launched experimental models data covers nearly 200,000 biological products, with over 187,000 citations from 91 suppliers . (citeab.com)
  • C57BL/6J is an inbred strain, commonly used as a genetic background when genetically modified mice are utilised as models for human disease. (citeab.com)
  • High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
  • Insect larvae such as tobacco hornworm can accelerate and economize preclinical research by complementing classic laboratory animals such as rats and mice. (uni-giessen.de)
  • Small mammals like mice or rats are indispensable for preclinical research. (uni-giessen.de)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
  • To identify potential non-mechanical roles of dystrophin, we tested the ability of various truncated dystrophin transgenes to prevent any of the skeletal muscle abnormalities associated with the double knockout mouse deficient for both dystrophin and the dystrophin-related protein utrophin. (ox.ac.uk)
  • In addition, these mice provide unique insights into skeletal muscle fiber type composition. (ox.ac.uk)
  • Plasma and liver from compound-treated mice (n = 5 per time point) were individually harvested at 0.5, 1, 3, 6, 12, 24, and 48 h post-drug administration. (beingmedicos.com)
  • The Mouse Genome Informatics (MGI) Database at the Jackson Laboratory provides integrated access to data on the genetics, genomics and biology of the laboratory mouse. (tigm.org)
  • Male C57Bl/6JolaH mice on a normal or vitamin D-deficient diet were exposed to CS or room air for 18 wk. (ljmu.ac.uk)
  • The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, and contains data on 20 segmented structures, including variability of brain structures across the strain, and downloadable visualization tools. (sciencedaily.com)
  • Murine adenocarcinoma lung cancer 344SQ cells (0.5 × 10 5 cells) were injected subcutaneously into male 129/Sv mice (Charles River Laboratories, Wilmington, MA). (beingmedicos.com)
  • In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)
  • Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)
  • 2000. Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)
  • The lister mouse uncovers a pathway involved in neurodegeneration and may serves as a model for understanding the molecular mechanisms underlying human neurodegenerative disorders. (nih.gov)
  • The visceral endoderm (VE) is a simple epithelium that forms the outer layer of the egg-cylinder stage mouse embryo. (ox.ac.uk)
  • Genome-edited mice were also obtained using frozen-warmed pronuclear embryos with clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) nucleases introduced using the technique for animal knockout system by electroporation (TAKE) method, which were transferred to females with pseudopregnancy induced on the day of embryo transfer. (nature.com)
  • The increase in plantaris muscle fiber cross-sectional area in response to overload was attenuated in vitamin D-deficient CS-exposed mice (smoking × diet interaction for hypertrophy, P = 0.03). (ljmu.ac.uk)
  • The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
  • The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
  • psychosocial and biological treatments to improve social functioning. (upenn.edu)
  • Acetylcholinesterase activity also increased for both treatments in 3xTgAD mice. (stanford.edu)
  • The work was done in parallel with an international collaboration, the Mouse Phenome Database (MPD) project, which was created to establish a collection of baseline phenotypic data from commonly used inbred mice. (sciencedaily.com)
  • PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive therapeutic target for immune modulation. (cam.ac.uk)
  • METHODOLOGY/PRINCIPAL FINDINGS: In the present study we assessed static adhesion, cell spreading, granule secretion, integrin alpha(IIb)beta(3) activation and platelet aggregation in washed mouse platelets lacking PKCtheta. (cam.ac.uk)
  • AIM OF THE STUDY: To reveal the potential mechanisms of JQZF inhibiting B cell proliferation and activation in MRL/lpr mice. (bvsalud.org)
  • Far-infrared (FIR) radiation has been found to induce promyelocytic leukemia zinc finger protein (PLZF) activation to protect the vascular endothelium in diabetic mice. (tmu.edu.tw)
  • We imaged axons in layer (L) 1 of the mouse barrel cortex in vivo. (cshl.edu)
  • RESULTS: Sorafenib reduced blood glucose levels in both control and diabetic mice, particularly in the latter. (bvsalud.org)
  • The diabetic mice exhibited improved glucose and insulin tolerance after sorafenib treatment. (bvsalud.org)
  • CONCLUSION: Sorafenib reduces blood glucose levels through downregulating gluconeogenic genes, especially in diabetic mice, suggesting the patients with T2DM when treated with sorafenib need more emphasis in monitoring blood glucose to avoid unnecessary hypoglycemia. (bvsalud.org)
  • It is worth noting that The Jackson Laboratory and Charles River have a cooperative agreement concerning local supplies of JAX™ Mice, including the ApoE knockout mice. (citeab.com)
  • The Jackson Laboratory , offers a fully integrated suite of services to provide efficient and cost-effective solutions to cryopreserve, expand, breed and characterize your mice following recovery from the TIGM library. (tigm.org)
  • Inbred 8-12 weeks old female C57BL/6J mice (The Jackson Laboratory, Bar Harbor, ME) were housed in ventilated cages on a regular 12 h light/dark cycle with ad libitum access to food and water. (beingmedicos.com)
  • To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. (bath.ac.uk)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • This study examined the application of sonic vibration to induce pseudopregnancy in mice. (nature.com)
  • The members of the International Knockout Mouse Consortium are working together to mutate all protein-coding genes in the mouse using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells. (tigm.org)
  • Sprouting angiogenesis is a core biological process critical to vascular development. (ibecbarcelona.eu)
  • Obstruction of flow in biological or prosthetic vascular grafts. (lookformedical.com)
  • In the present study, we investigated the biological effects of FIR (8-10 μm) on both survival and insulin secretion function of β-cells. (tmu.edu.tw)
  • FIR reduced pancreatic islets loss and increased insulin secretion in nicotinamide-streptozotocin-induced DM mice, but only promoted insulin secretion in DM PLZF − / − mice. (tmu.edu.tw)
  • In summary, FIR-enhanced mitochondrial function prevents β-cell apoptosis and enhances insulin secretion in DM mice through the Sirt1 pathway. (tmu.edu.tw)
  • MATERIALS AND METHODS: MRL/lpr mice were treated with low-dose, high-dose JQZF and normal saline for 6 weeks. (bvsalud.org)
  • METHODS: We established a mouse model of type 2 diabetes by a high-fat diet combined with a low-dose of streptozotocin (STZ), to identify the hypoglycemic effect of sorafenib in different mice. (bvsalud.org)
  • More research is needed to determine the biochemical mechanisms and treatment efficacy of this technique.OBJECTIVE: We aimed to determine if forebrain repetitive transcranial magnetic stimulation can improve cortical BDNF gene expression and cholinergic signaling in the 3xTgAD mouse model of AD.METHODS: Both B6 wild type mice and 3xTgAD mice aged 12 months were given daily treatment sessions for 14 days or twice weekly for 6 weeks. (stanford.edu)
  • Transmission to mice occurred from each sample tested, and data were similar between non-UK and UK cases, with the exception of the ranking of mean clinical incubation times of mouse lines. (cdc.gov)
  • The similarity between BSE and vCJD was shown by experimental transmission of the 2 diseases into standard panels of inbred wild-type mouse lines (RIII, C57BL, and VM [ 1 , 2 ]) and into FVB mice ( 3 ). (cdc.gov)
  • Glucose tolerance, insulin tolerance and pyruvate tolerance tests were done after daily gavage with sorafenib to diabetic and control mice. (bvsalud.org)
  • In marked contrast, a dystrophin protein lacking the cysteine-rich domain, which is unable to prevent dystrophy in the mdx mouse, is able to ameliorate these abnormalities in utrophin/dystrophin-deficient mice. (ox.ac.uk)
  • Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. (silverchair.com)
  • A significant incidence of late onset adenocarcinoma observed in both IFN-γ- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance. (silverchair.com)
  • references 5 , 14 , and 16 ), key molecules of both the innate and adaptive immune systems, contribute to tumor prevention in mice treated with the chemical carcinogen, methylcholanthrene (MCA), or in mice deficient for p53 expression. (silverchair.com)
  • These effects persisted in RBP4-deficient mice and were independent of changes in intestinal ß-carotene absorption, suggesting that fenretinide inhibits vitamin A synthesis in mice. (bvsalud.org)
  • He began his undergraduate education at the University of Southern California in Los Angeles and, in 1971, finished his Bachelor of Science degree in biological sciences at the University of California, Irvine. (wikipedia.org)
  • Our results show that wild-type mice treated with fenretinide for ten days had a reduction in tissue vitamin A stores accompanied by a two-fold increase in ß-carotene in plasma (P (bvsalud.org)
  • To test this hypothesis, we inoculated strain-typing panels of wild-type mice with brain material from human vCJD case-patients from France, the Netherlands, Italy, and the United States. (cdc.gov)
  • The effect of JQZF on disease improvement in MRL/lpr mice was studied using enzyme-linked immunosorbent assay (ELISA), histopathological staining, serum biochemical parameters and urinary protein levels. (bvsalud.org)
  • We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
  • The strain properties of vCJD and BSE have been extensively characterized in these sets of mice by using a combination of the order in which each strain of mouse dies of disease (incubation period rankings), distribution of brain vacuolation at the terminal stage of disease (lesion profiles), distribution pattern of abnormal prion protein (PrP Sc ) in the brain, and glycosylation pattern of PrP Sc as assessed by Western blot analysis. (cdc.gov)
  • Our laboratory is interested in the neurobiological and genetic mechanisms of social behavior development, as well as biological mechanisms underlying social motivation, social learning, and social skill acquisition and generalization. (upenn.edu)
  • Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. (nih.gov)
  • Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513 (p.R250W) or Kif3c (p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. (nature.com)
  • BSE and vCJD produce highly reproducible and similar incubation period rankings and neuropathology, which indicates that they are the same strain in the RIII, C57BL, and VM mice, whereas in the FVB mice, both diseases exhibit the same pattern of PrP Sc deposition ( 3 - 5 ). (cdc.gov)
  • The functional effects of APC (adenomatous polyposis coli gene) germ-line mutations on crypt fission and cell proliferation were investigated in the normal intestine of human familial adenomatous polyposis (FAP) and multiple intestinal neoplasia (MIN) mice. (ox.ac.uk)
  • 1974. In: Biological handbooks: Biology data book. (cdc.gov)
  • Using Bco1-/- and Bco2-/- mice we also show that fenretinide regulates intestinal carotenoid and vitamin E uptake by activating vitamin A signaling during short-term vitamin A deficiency. (bvsalud.org)
  • The goal of this study was to determine if the inhibition of BCO1 by fenretinide affects vitamin A formation in mice fed ß-carotene. (bvsalud.org)
  • Fourteen house mice (Mus musculus) were trained to estimate a 10 s interval using a modified peak procedure, and then underwent electrolytic lesions. (ox.ac.uk)
  • GXD integrates different types of gene expression information from the mouse and provides a searchable index of published experiments on endogenous gene expression during development. (tigm.org)
  • The inbred mice were at least 8 weeks old and had at least a one-week acclimation period before experiments began. (beingmedicos.com)
  • It was the first mouse strain to have its genome sequenced, back in 2003. (citeab.com)
  • The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium . (tigm.org)
  • Cardiac creatine uptake levels were measured in isolated hearts from creatine-free guanidinoacetate-N-methyl transferase knock out (GAMT(-/-)) mice and from mice overexpressing the myocardial CrT (CrT-OE) using (14)C-radiolabeled creatine. (ox.ac.uk)
  • Cardiac creatine uptake levels in CrT-OE mice were increased on average 2.7-fold, showing a considerable variation, in line with a similar variation in creatine content. (ox.ac.uk)
  • To augment cardiac fumarate levels and to assess fumarate's cardioprotective properties, we generated fumarate hydratase (Fh1) cardiac knockout (KO) mice. (ox.ac.uk)
  • Researchers at the US Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse. (sciencedaily.com)
  • Researchers at the U.S. Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse (see http://www.bnl.gov/CTN/mouse/ ). (sciencedaily.com)
  • Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells. (ox.ac.uk)
  • It has been proposed that the biological clock underlying the limited division potential of eukaryotic cells is telomere length. (nih.gov)
  • The transformed cells are, however, all oncogenic in the host animal and in immunocompetent mice. (microbiologyresearch.org)
  • Murine colon adenocarcinoma MC38/gp100 cells (5 × 10 5 ) or melanoma BP cells (5 × 10 5 ) were injected into C57BL/6 mice (Charles River Laboratories, Wilmington, MA) subcutaneously. (beingmedicos.com)
  • ED1SQ4 cells (0.5 × 10 5 cells) were injected into FVB/N or athymic mice (Charles River Laboratories, Wilmington, MA). (beingmedicos.com)
  • We have obtained preliminary data consistent with this hypothesis in mouse model of asthma where chronic treatment with ß2AR inverse agonists significantly reduces the effects of a bronchoconstrictor. (americanasthmafoundation.org)
  • Researchers can search and browse the IGTC database for cell lines of interest using accession numbers or IDs, keywords, sequence data, tissue expression profiles and biological pathways. (tigm.org)
  • However, differences in incubation times require further subpassage in mice to establish any true differences in strain properties between cases. (cdc.gov)
  • Hearts from GAMT(-/-) mice showed a 7-fold increase in V(max) of creatine uptake and a 1.4-fold increase in CrT mRNA levels. (ox.ac.uk)
  • The increase in Cr uptake and in CrT mRNA levels, however, was almost completely prevented when mice were fed a creatine supplemented diet, indicating that creatine uptake is subject to negative feedback regulation. (ox.ac.uk)
  • Interval timing in mice does not rely upon the circadian pacemaker. (ox.ac.uk)
  • Following treatment, brain tissue was extracted for immunological stains for plaque load, as well as biochemical analysis for BDNF gene expression and cholinergic signaling via acetylcholinesterase and choline acetyltransferase ELISA assays.RESULTS: For the 3xTgAD mice, both 14 days and 6 weeks treatment regimens resulted in an increase in BDNF gene expression relative to sham treatment, with a larger increase in the 6-week group. (stanford.edu)
  • Schwartz serves as the editor-in-chief of the Journal of Biological Rhythms from 2014-present, and was previously elected as the Chair of the Gordon Research Conference on Chronobiology (1993) and President of the Society for Research on Biological Rhythms (2004-2006). (wikipedia.org)
  • The development of the web-browser and database was supported by both NIBIB and the Office of Biological and Environmental Research within the U.S. Department of Energy's Office of Science. (sciencedaily.com)
  • The goal of the IMSR is to assist the international scientific community in locating and obtaining mouse resources for research. (tigm.org)
  • Murine lung adenocarcinoma cell lines (344SQ and 393P) were obtained from Dr. Jonathan Kurie at MD Anderson Cancer Center (Houston, TX) and were originally derived from K-ras LA1/ + p53 R172HΔg/ + engineered mice 24 . (beingmedicos.com)
  • Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. (silverchair.com)
  • Production of gene-targeted mice for specific effector molecules has greatly aided this endeavor ( 4 - 14 ). (silverchair.com)
  • The B6 mice only had an increase in BDNF gene expression for the 6-week group.CONCLUSION: Brain stimulation is a possible non-invasive and nonpharmaceutical treatment option for AD as it improves both plasticity markers and cholinergic signaling in an AD mouse model. (stanford.edu)
  • Each mouse was observed for lack of respiration and faded eye color, which was followed by continued CO 2 flow for a minimum of 1 min after respiration ceased. (beingmedicos.com)
  • In this study, we investigated the effect of sorafenib on blood glucose levels in diabetic and normal mice and explored the possible mechanism. (bvsalud.org)
  • Our results show that the formation of multi-cellular rosettes in the mouse VE is dependent on normal PCP signalling. (ox.ac.uk)