Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition. (ucdavis.edu)
Oxidative stress2
Group responses were compared using standard plasma biochemistry and antioxidant/oxidative stress parameters in tissues. (nel.edu)
In HRSdx cells, less sensitive to DNA damage and oxidative stress, the efflux drug transporters MDR1 and MRP1 were not up-regulated, and doxorubicin accumulated in cytoplasm rather than in nucleus. (preprints.org)
Toxicology1
The word is most commonly used in this context in biochemistry and toxicology: interference in the physiological action of a chemical substance by another having a similar structure. (wikipedia.org)
The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
These nanocapsules are made of a PLGA-polymer matrix coated with Fe/FeO core-shell nanocrystals and co-loaded with chemotherapy drug and photothermal agent. (nature.com)
Cellular assays and combination studies were conducted using arctigenin and anti-ccRCC drugs. (bvsalud.org)
The combination of arctigenin with clinical anti-RCC drugs completely inhibits tumor growth without tumor progression even for an extended time period. (bvsalud.org)
The data suggest that inhibitors of the Fd/FNR redox system should be avoided as ART partner drugs in ART combination therapy for treating malaria. (biorxiv.org)
Diseases2
The search for new active drugs that can alleviate or cure different diseases is a constant challenge to researchers in the biological area and to the pharmaceutical industry. (scielo.br)
Now, a report by University of Pennsylvania School of Dental Medicine scientists in the journal Biomaterials suggests a new approach for delivering a protein drug to treat and prevent oral diseases, including dental caries, commonly known as cavities. (upenn.edu)
Bacteria1
Bringing our research together led to this new concept of a topical protein drug made in plants that can both kill bacteria and break down the oral biofilm. (upenn.edu)
Therapy2
Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. (nature.com)
Classical Hodgkin lymphoma (cHL) is a highly curable disease (70-80%), even though long-term toxicities, drug resistance, and predicting clinical responses to therapy are major challenges in cHL treatment. (preprints.org)
Department1
The work arose from a partnership between Koo and co-corresponding author Henry Daniell , director of translational research and professor in Penn Dental Medicine's Department of Biochemistry . (upenn.edu)
Biological1
Protein drugs, which derive from biological sources, represent some of the most important and effective biopharmaceuticals on the market. (upenn.edu)
Resistance7
This low survival may result from the metastasis of cancer cells and arising resistance to drugs. (oncotarget.com)
Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
nonetheless, mutations of Fd gene ( fd ) may modulate ART resistance and Fd would be an important target for antimalarial drugs. (biorxiv.org)
Due to various factors including socioeconomic factors, compliance is poor to anti-tuberculosis drugs, leading to resistance. (preprints.org)
Conclusion Multi-drug resistance tuberculosis is very prevalent in Pakistan, which may increase burden on health care system and may lead to various complications of tuberculosis. (preprints.org)
Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. (preprints.org)
Both HDLM-2 and HDLM-2dx cells had an intrinsic resistance to BV but not to the drug MMAE. (preprints.org)
Redox1
2019. Targeting redox heterogeneity to counteract drug tolerance in replicating . . (ncbs.res.in)
Tumor1
On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)
Efficacy1
These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models. (researchgate.net)
20201
Se realizó un estudio transversal de enero a febrero de 2020 en los teléfonos móviles de 100 trabajadores de laboratorio, que fueron seleccionados al azar mediante hisopos estériles humedecidos. (jppres.com)
Clinical1
The frequently altered clinical presentation of urea cycle disorders later in life develops from intrinsic differences in physiology based on age, as well as molecular aspects of the underlying biochemistry. (medscape.com)
Pharmaceutical2
The search for new drugs presents such great importance in medicine that pharmaceutical industries have invested significant resources in this field. (scielo.br)
We investigated the usefulness of openly available RDF/OWL tools and datasets to find evidence for pharmaceutical compounds from Chinese medicine that may treat depressive disorders or serve as lead compounds for the future pharmaceutical drug development. (biomedcentral.com)
Effects1
The effects of ions and antischistosomal drugs on adenosine- triphosphatase (ATPase) activity in Schistosoma-mansoni were investigated. (cdc.gov)
Compounds1
It is possible to use traditional medicines to identify the source of pharmacological compounds that may otherwise be missed by modern rational drug design. (biomedcentral.com)
Institute1
School of Biology, Chemistry and Biochemistry and the Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA. (sphingolipidclub.com)
Development3
Therefore, Src has been considered a target molecule for drug development. (oncotarget.com)
These findings will assist the development of anti-tumour drugs to treat lung cancer. (oncotarget.com)
Advances in nanotechnology resulted in the development of targeted and multifunctional nanoscale drug constructs. (preprints.org)
Agents1
Moreover, according to the requirements of US Food and Drug Administration (FDA), theranostic agents should be completely cleared from the body within a reasonable period of time. (nature.com)
Cancer1
Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. (nature.com)
Models1
Furthermore, venoms and their toxins have been considered good tools for prospecting for new active drugs or models for new therapeutic drugs. (scielo.br)
Modern1
The first Chinese herb book (or herbal), dating from about 2700 B.C., lists 365 medicinal plants and their uses - including ma-Huang , the shrub that introduced the drug ephedrine to modern medicine. (wikidoc.org)
Found2
A new generation of drugs is likely to emerge from peptides, including those found in animal venoms. (scielo.br)
Multi-drug resistant was found in 29.4% participants. (preprints.org)
Complex1
The metabolic biochemistry of folate biosynthesis and utilisation has evolved into a complex network of reactions. (nih.gov)
High1
Yet the field of dental medicine has very few such drugs due to their high costs, and the ones that are used are delivered invasively, often through surgical procedures, to gum tissues. (upenn.edu)