Biochemical antigens tumor associated carbohydrate. Medical search. Frequent questions

As a result, she contributed and edited several books on techniques for analysis of carbohydrate modifications on proteins and lipids. (wikipedia.org)
These proteins called tumour-associated antigens may be present in higher than usual concentrations in other tissues serum urine or body fluids of patients with cancer. (scienceexhibitions.org)
Insulin levels affect the production and storage of carbohydrates, fats and proteins in the body. (myhealth.gov.my)
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
Rapid and comprehensive analysis of putative proteinous allergens ( allergenome ) by applying such a proteomic strategy … With allergenomics, we can not only detect and assign the putative allergens (proteins specifically interacting with IgE antibodies in a patient's blood) in a short time, but also analyze the quantitative and qualitative change of the antigens, depending on the surroundings and environmental conditions of an allergenic causative. (genomicglossaries.com)

Overexpression and biochemical characterization of b-1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus influenzae strain Rd. Biochem Biophy Res Comm , 2002 , 295, 1. (glycoenzymes.org)

Renal function indexes, serum inflammatory factors, and tumor markers were evaluated. (biomedcentral.com)
Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). (biomedcentral.com)
Currently CA 15-3 the circulating form of CACNG4 DF3 antigen is one of the most widely used WIKI4 serum biochemical markers in breast cancer. (scienceexhibitions.org)
Currently there is a lack of scientific documentation regarding the application of serum tumour markers in the canine mammary oncology WIKI4 field and only one preliminary report describing the possible use of serum CA 15-3 in dogs has been published [15]. (scienceexhibitions.org)
Our clinical biochemistry Unit at the Pathology department provides routine and specialized biochemical tests such as tumor markers, therapeutic drug monitoring, and hormone assays. (yashodahealthcare.com)

We also investigated serum CA 15-3 activity to establish whether its expression could be assigned WIKI4 to several tumour characteristics to evaluate its potential use as a serum tumour marker in the canine mammary oncology field. (scienceexhibitions.org)
0.0019) between serum CA 15-3 levels and the degree of tumour proliferation and differentiation was shown which indicates that the values of this serum marker increase as the tumour stage progresses. (scienceexhibitions.org)
Conclusions The results of this study reveal that CA 15-3 is expressed in both canine mammary tumour cell lines and tissues and that serum levels significantly correlate with the histological grade of the malignancy. (scienceexhibitions.org)
Several histopathological variables such as tumour size lymph node status lymphatic or vascular invasion and the tumour grade of differentiation form have been widely used parameters in prognostic evaluations [2 3 In human breast cancer and other malignancies serum tumour markers play an important role in patient management [4 5 Tumour cells display protein molecules on their surfaces. (scienceexhibitions.org)
This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)

Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)
Future studies will aim at the identification of these anti-invasive M6P-modified protein(s) followed by a comprehensive assessment of their involvement in tumour invasion and metastasis. (boku.ac.at)
In our search for potentially tumour-suppressive M6P/IGF2R interaction partners, we identified an essentially uncharacterized M6P-modified protein previously named Cellular Repressor of E1A-stimulated Genes (CREG). (boku.ac.at)
We're talking about things such as diet (too much protein and too many simple carbohydrates stored as triglycerides in the liver), overeating, toxins, heavy metals, and pesticides to name a few. (jonbarron.org)

Switchable targeting of solid tumors by BsCAR T cells. (yale.edu)

An elevated tumor marker level needs to be interpreted within the context of the patient's history, physical examination, diagnostic imaging, and laboratory work-up findings. (medscape.com)
Carbohydrate antigen-125 (CA-125) is a tumor marker that has been used for differential diagnosis of peritoneal malignancies. (go.jp)
Carbohydrate antigen 19-9 - tumor marker: Past, present, and future World J Gastrointest Surg. (moleculardepot.com)

ISBN 978-0-89603-355-9 T Feizi, HC Gooi, RA Childs, JK Picard, K Uemura, LM Loomes, SJ Thorpe and EF Hounsell (1984) Tumor-associated and differentiation antigens on the carbohydrate moieties of mucin-type glycoproteins. (wikipedia.org)
Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor. (gicancerindia.com)

Anti-idiotypic antibody mimicking a T-antigen-specific lectin inhibits human epithelial tumor cell proliferation. (conicet.gov.ar)
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is a multifunctional tumour suppressor which binds a variety of factors that impinge on the proliferation, migration and invasiveness of cancer cells. (boku.ac.at)
Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
Molecular mechanisms exhibit alterations in the expression of multiple genes usually involve: (proto) oncogenes, tumour suppressor genes, and DNA repair genes that contribute to the development of cancer genotype and phenotype with a state of cell proliferation dysregulation events. (lifepronow.com)

With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)

Cachexia is thought to be caused by bioactive molecules produced by the tumor, such as alpha-lymphotoxin (tumor necrosis factor [TNF] alpha), peptides, and nucleotides, which are able to affect metabolism. (medscape.com)
The non-polymorphic class Ib molecule, human leukocyte antigen (HLA)-E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. (diamond.ac.uk)
Although peptides of pathogenic origin can also be presented by HLA-E to T cells, the molecular basis underpinning their role in antigen surveillance is largely unknown. (diamond.ac.uk)

However, the impact of M6P/IGF2R on tumour invasion and metastasis is so far only poorly understood. (boku.ac.at)

When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
[ 9 ] For example, antibodies or T cells directed against the tumor may mistakenly attack normal nerve cells. (medscape.com)
It used to measure concentration of antigens by use of antibodies. (myhealth.gov.my)
Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
Antibodies reactive with HIV ANTIGENS . (lookformedical.com)
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)

Cancer antigen 19-9 (CA 19-9) is used to help differentiate between cancer of the pancreas and other conditions, as well as to monitor treatment response and recurrence. (medscape.com)
At laparoscopy there was a large (approximately 9 x 7cm) multiloculated exophytic tumor in the body and tail region of pancreas that was adherent to the mesocolon and left branch of the middle colic artery (Figure D). She had an uncomplicated postoperative period and was discharged on 8th day following surgery. (gicancerindia.com)
Serous Cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. (gicancerindia.com)
MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients. (gicancerindia.com)

Carbohydrate xenoantigens and xenoantibody epitope-specificity, the removal of xenoantibodies by plasmapheresis, and antibody neutralization using soluble saccharides, were all explored. (gu.se)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)

Biochemical Society Transactions 12 (4) 591-596 E F Hounsell and T Feizi (1982) Gastrointestinal mucins - structures and antigenicities of their carbohydrate chains in health and disease. (wikipedia.org)

Before their final diagnoses were made, each of these nine primary tumor patients had undergone imageological examination and hematological and blood biochemical determinations to preclude other primary tumor diseases. (biomedcentral.com)
Her other hematological & biochemical parameters were within prescribed normal range. (gicancerindia.com)

During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. (cambridge.org)

More rarely, the tumor may interfere with normal metabolic pathways or steroid metabolism. (medscape.com)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

Though the majority of the primary tumors are hepatocellular carcinoma (HCC), some rare diseases also could not be ignored by the reason of their characteristics. (biomedcentral.com)

Fever may also be related to necrotic-inflammatory phenomena of the tumor and/or to alterations in liver function and consequent disorders of steroidogenesis. (medscape.com)

Carbohydrates, such as fructose and sucrose, are not only stimulate de novo lipogenesis but also induce hepatic oxidative stress and inflammation [ 2 ]. (biomedcentral.com)

The technical success rate, clinical success rate, complications, biochemical and tumor indexes at 8 weeks after operation [total bilirubin (TB), direct bilirubin (DB), alanine transaminase (ALT), aspartate transaminase (AST), carbohydrate antigen 19-9 (CA19-9)], stent patency time (SP), median progression-free survival time (mPFS) and median survival time (mOS) were analyzed. (bvsalud.org)

Biochemical Society Transactions, December 2014, Portland Press Ltd. (growkudos.com)

These tumor components presented more malignant biological behavior, and that may be the common reason for the poor prognosis of the both [ 11 ]. (biomedcentral.com)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)

The D- threo isomer has been shown to be the active glucosylceramide synthase inhibitor.2 Due to PDMP's ability to inhibit the joining of ceramides with carbohydrates there can be an accumulation of ceramide in the cells and this can lead to apoptosis. (matreya.com)
Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. (yale.edu)
low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromafﬁn-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)
Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. (lookformedical.com)
NK cells are themselves adaptive: remembering their encounters and mounting pattern-sensitive (antigen-aware) secondary responses. (ishinobu.com)
Cancer biomarkers (CB) are biomolecules produced in response to the tumour by either the tumour cells or other cells within the body. (lifepronow.com)
Cancer biomarkers (CB) are biomolecules formed in response to the tumour by either the tumour cells or other cells in the body, and CB may be used as a screening / early warning method for cancer, diagnosis , prognosis, or indicator of a patient's overall outcome. (lifepronow.com)

He has published more than 150 scientific articles in the fields of carbohydrate biochemistry, glycobiology, allo- and xeno-transplantation, and regeneratvie medicine. (gu.se)

An immunoassay is a biochemical test that measures the presence or concentration of a macromolecule in a solution through the use of an antibody or immunoglobulin. (myhealth.gov.my)

Due to the prevalence of hepatitis and some other reasons, the morbidity of primary liver tumor is high in Asia, especially in China [ 1 ]. (biomedcentral.com)
Primary hepatic ASC was defined as a liver tumor containing definite components of both adenocarcinoma and squamous cell carcinoma, and sometimes it was considered as a variant of cholangiocarcinoma [ 9 ]. (biomedcentral.com)
A total of 75 liver tumor patients, who had received liver resection (LR) during the period from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital, were picked out and included in this study. (biomedcentral.com)

and Ph.D. degrees, Elizabeth Fay Hounsell worked with the synthetic and analytical chemistry of carbohydrates at the (then) Imperial Cancer Research Fund and UK Medical Research Council Clinical Research Centre, Harrow, London from 1977 to 1994. (wikipedia.org)

The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. (lookformedical.com)

Finally, CA 19-9 levels can be used to monitor tumor response to active treatment with surgery, with or without chemotherapy, radiation therapy, and/or other targeted or biological therapies. (medscape.com)

This patient series included those who underwent primary tumor resection, a bypass or a proctostomy and those who underwent the simultaneous resection of metastases with curative intent. (scirp.org)

After his PhD examination, his biochemical studies relating to ABO-incompatible organ transplantation continued in the Department of Surgery. (gu.se)

The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. (thermofisher.com)

The treatment for renal parenchymal tumors has changed over time, and this trend continues today as a result of technological progress made with clinical research and improved diagnostic and therapeutic tools. (biomedcentral.com)

Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)

Many studies have confirmed the role of high trans fatty acids, high sugars, and high cholesterol in NASH models, but few studies have involved the simultaneous use of high-trans fat, high-carbohydrate, high-cholesterol, high-cholate (HFHCCC) models to induce NASH. (biomedcentral.com)

After a meal, carbohydrates usually are broken down into glucose and other simple sugars. (myhealth.gov.my)

On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. (biomedcentral.com)

In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself. (medscape.com)

The causes of hypertrophic osteoarthropathy remain unknown, although several hypotheses have been developed (eg, estrogen or growth hormone [GH] production by the tumor, vagal hyperactivity). (medscape.com)

This sialylated Lewis A blood group antigen is identified by a radioimmunometric assay. (medscape.com)
Michael Breimer started his research in the Department of Medical and Physiological Chemistry isolating and structurally characterising blood group AB(O)H and related carbohydrate antigens. (gu.se)
Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. (gu.se)
Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. (gu.se)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)

Anatomy16

Organisms12

Diseases34

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science4

Health Care4

Proteins9

Characterization1

Markers6

Serum5

Protein4

Solid tumors1

Marker3

Differentiation2

Proliferation4

Malignancies3

Peptides3

Metastasis1

Antibodies6

Pancreas4

Specificity2

Gastrointestinal1

Hematological2

Tissues2

Metabolism1

Nucleotide1

Hepatocellular1

Phenomena1

Sucrose1

Complications1

Society Transactions1

Malignant2

Cells7

Biochemistry1

Concentration1

Liver3

Cancer1

Cell1

Biological1

Underwent1

Examination1

Collagen1

Therapeutic1

Mice1

Fatty1

Glucose1

Rarely1

Symptoms1

Hormone1

Blood4

Growth1