The specific objective of this component is to determine the prevalence of iron deficiency anemia using iron and TIBC (transferrin saturation) in conjunction with ferritin and erythrocyte protoporphyrin. (cdc.gov)
The iron variable name is LBXIRN, the TIBC variable name is LBXTIB, and the variable name for transferrin saturation is LBDPCT. (cdc.gov)
Associations between self-reported supplementation and duration of vegan diet with biomarkers of cobalamin (serum cobalamin, holotranscobalamin, homocysteine, folate) and iron status (serum ferritin, iron binding capacity, transferrin and saturation of transferrin) were assessed by cross-sectional analyses of medical data from a clinical nutrition center. (mdpi.com)
An increased transferrin saturation level of more than 45% indicates an early phenotypic marker or lab finding. (proprofs.com)
Transferrin saturation measures the percentage of iron-binding sites on transferrin that are occupied by iron. (proprofs.com)
Values consistent with iron deficiency include a low serum iron level, low transferrin saturation, and a high total iron-binding capacity. (aafp.org)
Transferrin saturation percentage (TS %) is calculated by dividing serum iron by TIBC, then multiplying by 100. (irondisorders.org)
We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). (who.int)
Nous avons examiné des patients yéménites âgés de 12 mois à 30 ans atteints de drépanocytose homozygote afin d'établir leur bilan en fer à l'aide de quatre critères (taux de fer sérique faible, taux de saturation de la transferrine faible, capacité totale de fixation du fer élevée et volume globulaire moyen faible par rapport à l'âge). (who.int)
Biochemical assessment of iron status relies on serum-based indicators, such as serum ferritin (SF), transferrin saturation, and soluble transferrin receptor (sTfR), as well as erythrocyte protoporphyrin. (cdc.gov)
Receptor23
On its own, the IRE-BP binds to the IREs of ferritin and transferrin receptor mRNA. (wikipedia.org)
Transferrin receptor production depends on a similar mechanism. (wikipedia.org)
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). (rcsb.org)
Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. (rcsb.org)
When Tf binds receptor, its N-lobe moves by about 9 A with respect to its C-lobe. (rcsb.org)
The structure of TfR-Tf complex helps account for known differences in the iron-release properties of free and receptor bound Tf. (rcsb.org)
These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. (nih.gov)
Comparison of polypeptides that bind the transferrin receptor for targeting gold nanocarriers. (open.ac.uk)
Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis. (rcsb.org)
Complejo de proteínas que forma un receptor para la TRANSFERRINA en BACTERIAS. (bvsalud.org)
Transferrin receptor testing is used to measure the level of soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia. (medscape.com)
Transferrin receptor levels within the reference range indicate normal physiology. (medscape.com)
[ 2 ] Unlike ferritin, the transferrin receptor level is not affected by infection or inflammation and is therefore useful in distinguishing iron deficiency anemia from anemia of chronic disease. (medscape.com)
Transferrin receptor testing is used in the diagnosis of anemia and in deciding adequate treatment. (medscape.com)
Along with other tests in an anemia panel (iron, ferritin, reticulocyte count, lactate dehydrogenase [LDH], vitamin B-12, folate), the type of anemia can be diagnosed based on the transferrin receptor levels. (medscape.com)
Your healthcare provider will look at your iron level along with the TIBC, transferrin, and possibly other tests to see what the results mean. (rochester.edu)
Total iron binding capacity (TIBC) is a blood test to check for levels of iron in the blood. (medicalnewstoday.com)
Total iron binding capacity (TIBC) is often measured at the same time as serum iron. (irondisorders.org)
When TIBC is at or below the low end of a laboratory range, it is an indication that there is limited capacity for transferrin molecules to accept additional iron. (irondisorders.org)
Ferritin6
Sequences of mRNA called iron-responsive elements (IREs) are contained within the mRNA sequences that code for transferrin receptors and for ferritin. (wikipedia.org)
But, when iron binds to the IRE-BP, the IRE-BP changes shape with the result that the IRE-BPs can no longer bind the ferritin mRNA. (wikipedia.org)
When the cell has obtained more iron than it can bind up with ferritin or heme molecules, more and more iron will bind to the IRE-BPs. (wikipedia.org)
And iron-IRE-BP binding will also start ferritin production. (wikipedia.org)
transferrin A plasma protein (a β- globulin ) that can bind to iron and transport it to the liver for storage (see ferritin ) or to the cells of bone marrow , where it is used for the formation of haemoglobin. (encyclopedia.com)
What causes high ferritin, retic count & iron binding cap? (healthtap.com)
Soluble1
Limiting dilutions of soluble H5 trimers complexed with horseradish peroxidase−conjugated antibodies were used in a fetuin- or transferrin-binding assay. (cdc.gov)
Receptors11
Since iron is tightly bound to transferrin, cells throughout the body have receptors for transferrin-iron complexes on their surfaces. (wikipedia.org)
In low-iron conditions, IRE-BPs allow the cell to keep producing transferrin receptors. (wikipedia.org)
And more transferrin receptors make it easier for the cell to bring in more iron from transferrin-iron complexes circulating outside the cell. (wikipedia.org)
An increase in the number of epidermal growth factor and transferrin receptors (EGFR, TrfR) is induced by Ara-C on these cells. (cnr.it)
Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Receptors, Transferrin" by people in Profiles. (umassmed.edu)
In vitro and in vivo experiments will be conducted to investigate how recombinant transferrin interacts with cellular receptors, regulates iron uptake, and influences cellular proliferation. (prospecbio.com)
Reference intervals of transferrin receptors have not been established for pregnant females, children, or recent or frequent blood donors. (medscape.com)
Proteins6
The iron-responsive element-binding proteins, also known as IRE-BP, IRBP, IRP and IFR , bind to iron-responsive elements (IREs) in the regulation of human iron metabolism. (wikipedia.org)
Examining how much iron is in the transferrin proteins can tell your doctor if you have too much or too little iron in your blood. (healthline.com)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)
In addition, aluminum does not cross dialysis membranes because it is bound to albumin and transferrin plasma proteins. (nih.gov)
Each mAb demonstrates slight differences in epitope specificity, for example, recognition of hydrogenated MDI (HMDI) or different carrier proteins (transferrin, actin) reacted with vapor phase HDI, and is encoded by unique recombination of different germline antibody genes, with distinct complementary determining regions. (cdc.gov)
Transferrins (TFs) belong to a family of iron-binding proteins that play a crucial role in regulation of the iron levels. (lu.se)
They showed that the level of serum iron and the total iron binding capacity were decreased in active CD patients due to impaired oral iron absorption 8 . (nature.com)
If that occurs in combination with a relatively high measure of serum iron, it is likely that the ability of transferrin to safely bind serum iron is impaired. (irondisorders.org)
Glycoprotein3
transferrin ( siderophilin ) (trans- fer -in) n. a glycoprotein, found in the blood plasma, that acts as a carrier for iron in the bloodstream. (encyclopedia.com)
Human recombinant transferrin, a glycoprotein responsible for iron transport in the body, has gained increasing attention in the fields of biomedicine and health sciences. (prospecbio.com)
Transferrin is an iron-binding glycoprotein found in the plasma. (medscape.com)
UIBC2
This is an inverse outcome: greater color development indicates the transferrin is more highly occupied by iron (low UIBC). (cdc.gov)
Lesser color development indicates that the transferrin has more binding capacity available (high UIBC). (cdc.gov)
Ferric1
Human Transferrin has homologous C and N-terminal domains, each of which binds one ion of ferric iron. (prospecbio.com)
Reticulocyte1
The value of hepcidin, non-transferrin-bound iron, and reticulocyte indexes is being explored in research settings. (cdc.gov)
Molecule4
But those IREs have a different effect: When the IRE-BP binds to these sites, the binding not only allows for translation but also stabilizes the mRNA molecule so it can stay intact for longer. (wikipedia.org)
To help define the steps in iron release, we have determined the three-dimensional structure of the iron-free (apo) form of the recombinant N-lobe half-molecule of human serum transferrin (ApoTfN) by X-ray crystallography. (rcsb.org)
Each molecule of transferrin can transport two molecules of iron to areas of the body that need this element. (irondisorders.org)
Unbound1
In an alkaline environment it is converted to Fe3+ as it binds to the unbound endogenous transferrin. (cdc.gov)
Recombinant8
Recombinant Human Transferrin produced in CHO cells is a glycosylated, polypeptide chain containing having a molecular mass of 76 kDa. (prospecbio.com)
This study aims to provide a comprehensive exploration of human recombinant transferrin, shedding light on its various functions and potential applications in health and biomedicine. (prospecbio.com)
The second objective is to assess the clinical relevance of human recombinant transferrin in medical interventions. (prospecbio.com)
Clinical trials and studies involving individuals with iron-related disorders, such as iron-deficiency anemia, will be conducted to evaluate the efficacy and safety of recombinant transferrin supplementation. (prospecbio.com)
These investigations may provide insights into the use of recombinant transferrin as a therapeutic agent in various clinical settings. (prospecbio.com)
The third objective is to explore the broader implications of human recombinant transferrin in biomedicine and research. (prospecbio.com)
Understanding the multifaceted properties of recombinant transferrin may open new avenues for innovative approaches in various medical specialties and scientific research. (prospecbio.com)
By delving into the diverse functions of human recombinant transferrin, this research aims to expand our understanding of its physiological roles and clinical applications. (prospecbio.com)
Albumin1
mAb that bind aliphatic di- and polyisocyanates (conjugated to albumin), but not aromatic toluene or methylene diphenyl diisocyanate (TDI or MDI). (cdc.gov)
Initially, lead is distributed to the blood plasma and soft tissues, but under steady state conditions 99% of the lead in blood is found in the erythrocyte, where much of it is bound to hemoglobin. (cdc.gov)
25-OHD (25-hydroxyvitamin D), the major circulating metabolite of vitamin D, was measured in serum by competitive protein-binding (CPB) assay and radioimmunoassay kit (Nichols, San Juan Capistrano, California). (who.int)
Uptake1
3H]Thymidine uptake is clearly stimulated on KB cells by nanomolar concentrations of EGF and transferrin, whereas in Ara-C-treated cells [3H]thymidine uptake is not increased by EGF and transferrin under conditions where maximal EGFR and TrfR up-regulation occurs. (cnr.it)
Molecules3
Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)
Generally, with minor variances based on blood PH, when 40% or less of transferrin molecules are used, iron is considered safely bound. (irondisorders.org)
Some of the iron will then bind to other molecules not have transferrin's ability to protect its host from iron catalyzed lipid peroxidation and the formation of reactive oxygen species. (irondisorders.org)
Characterization1
Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate. (umassmed.edu)
Complex2
The Roche method of iron measurement is a three-step process using the FerroZine reagent: Fe3+ is liberated from transferrin by acid/detergent, Fe3+ is reduced to Fe2+ by ascorbate, and the reduced iron then reacts with the FerroZine reagent to form a colored complex. (cdc.gov)
Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum. (bvsalud.org)
Blood1
Transferrin is a protein in the blood that transports iron throughout your body. (healthline.com)
A known ferrous iron standard of 105 μmol/L (586 μg/dL) was incubated with serum at a pH of 7.9, which saturates the available binding sites on serum transferrin. (cdc.gov)
Two classes of EGF-binding sites with a Kd of 0.055 nM and 2.3 nM respectively, and one class of transferrin-binding sites with a Kd of about 4 nM are detected on both untreated and Ara-C-treated KB cells. (cnr.it)
Cells2
The enhanced EGF and transferrin binding is paralleled by a twofold increase of in vitro targeting of Ara-C-treated KB and A549 cells with anti-EGFR 108.1 mAb and anti-TrfR OKT9 mAb. (cnr.it)
he binding and release of iron is dependent of several factors, such as pH, ionic strength, and chelators that have an influence on protein stability. (lu.se)
Stability2
The current work focused on stability-structure studies of human serum transferrin using Nano-Differential Scanning Fluorimetry (NanoDSF), Isothermal Chemical Denaturation (ICD), light scattering techniques, and Small Angle X-ray Scattering (SAXS). (lu.se)
The overall stability and behavior of transferrin was investigated at varying pH and ionic strength using nanoDSF and ICD. (lu.se)
Human1
The primary objective of this research is to elucidate the essential role of transferrin in iron homeostasis and its significance for human health. (prospecbio.com)
Body2
When iron levels are low, the body increases the amount of transferrin in the body in an effort to increase the availability of the iron that is there. (medicalnewstoday.com)
Comparison with the holo form (FeTfN) shows that a large rigid-body domain movement of 63 degrees has occurred in ApoTfN, to give an open binding cleft. (rcsb.org)
Levels1
Porphyrin levels can be reduced by direct methods or with medications that bind porphyrins. (medscape.com)