AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
S100 Calcium Binding Protein GCalciumCalcium-Binding ProteinsCalbindinsCalbindin 1Calbindin 2ParvalbuminsCalcium SignalingMolecular Sequence DataS100 ProteinsProtein BindingAmino Acid SequenceBinding SitesEF Hand MotifsCalmodulinCalsequestrinRecoverinCalgranulin BCalcium ChannelsCalgranulin ABase SequenceSalamandraCalcium, DietaryFluorescamineProtein Structure, TertiaryCalcium RadioisotopesModels, MolecularCollodionEntamoeba histolyticaEgtazic AcidCell LineCalcium IsotopesDNA-Binding ProteinsCalcium CarbonateProtein ConformationCalcium ChlorideRabbitsLigandsCalcium PhosphatesSarcoplasmic ReticulumMusclesSpectrometry, FluorescenceSequence Homology, Amino AcidRNA, MessengerTranscription FactorsKineticsPoly(A)-Binding ProteinsPromoter Regions, GeneticCattleTroponin CCalcitriolCarrier ProteinsMolecular WeightCalcium Channels, L-TypeCloning, MolecularS100 Calcium Binding Protein beta SubunitImmunohistochemistryCalcium OxalateChickensNeuronsNerve Tissue ProteinsGene Expression RegulationCalcium GluconateMagnesiumRats, Sprague-DawleySequence Homology, Nucleic AcidCells, CulturedTerbiumRecombinant ProteinsTroponinChelating AgentsMutationCalcium CompoundsCalcium Channels, N-TypeTacrolimus Binding ProteinsHydrogen-Ion ConcentrationLanthanumCalcium Channel AgonistsCytosolTime FactorsPoly(A)-Binding Protein IHippocalcinCations, DivalentSignal TransductionRecombinant Fusion ProteinsRNA-Binding ProteinsModels, BiologicalDose-Response Relationship, DrugMembrane PotentialsCalcimycinCircular DichroismElectrophoresis, Polyacrylamide GelRyanodine Receptor Calcium Release ChannelInsulin-Like Growth Factor Binding ProteinsProtein Structure, SecondaryMicrofilament ProteinsAdenosine TriphosphateCalcium HydroxidePhosphorusMyocardium
Similar proteinsCalmodulin proteinsIonsReceptorVariantsMediateAffinityEncodesAnnexinRegulatesTissuesEnzymesMotifsGenesCaMKIISuperfamilyIntracellularMechanismSecretionVitaminBiologicalReceptorsAlbuminWestern blotRolesFamilyInteractionPhysiologicInitialMolecularPopulationsZincPromoterSynapticCentrinExpressionConsistsMechanismsCellularATSDRHypothesisBoneRegulationSuggestsExposureFoundExperimentalAnalysis
Similar proteins2
  • S100A1 and S100B binding to ions was also compared and differences between ion binding sites within the two highly similar proteins were determined. (umaryland.edu)
  • The biochemical properties of CaBPs from different parasites have been investigated, and despite the considerable resemblance between structural models of all family members, differences exist in the dimerization, ion-binding and drug-binding characteristics of these apparently similar proteins [ 14 ]. (biomedcentral.com)
Calmodulin proteins1
  • This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
Ions4
Receptor5
  • By western blot, this antibody detects a 46kDa protein corresponding to mouse Endothelin Receptor A. (thermofisher.com)
  • This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. (thermofisher.com)
  • The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)
  • As to CB1, CBD is considered to be a negative allosteric modulator, which means, it modifies this receptor in such a way that the binding of classical agonists such as anandamide (AEA), THC, or nabilone is dramatically reduced. (genengnews.com)
  • Both the CAPS and UNC-13 docking pathways converge on syntaxin, a component of the SNARE (soluble N -ethyl-maleimide-sensitive fusion protein attachment receptor) complex. (rupress.org)
Variants6
  • Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. (nih.gov)
  • Alternative splicing results in multiple transcript variants. (thermofisher.com)
  • Multiple alternatively spliced transcript variants have been observed at this gene. (nih.gov)
  • Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. (arigobio.com)
  • Alternative splicing results in many transcript variants encoding different proteins. (thermofisher.com)
Mediate1
  • The liver fluke Fasciola gigantica secretes excretory-secretory proteins during infection to mediate its interaction with the host. (biomedcentral.com)
Affinity4
  • Another study revealed an allosteric mechanism in which a peptide termed BP2, derived from the STRA6 vitamin A transporter, increased the Ca2+-binding affinity of CaM upon binding. (umaryland.edu)
  • The rFg-CaBP4 protein was induced and purified by affinity chromatography. (biomedcentral.com)
  • Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. (nih.gov)
Encodes2
  • This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. (nih.gov)
  • CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. (thermofisher.com)
Annexin2
  • S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. (gzsys.org.cn)
  • Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)
Regulates4
  • Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
  • Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred calmodulin binding proteins. (biomedcentral.com)
  • The Calcium Hypothesis was thus extended as the Calmodulin Hypothesis since CaM not only binds to and regulates CaMBPs critical to learning and memory but also proteins involved in the formation of amyloid plaques and tangles, hallmarks of AD [ 41 ]. (biomedcentral.com)
  • Vitamin D-binding protein (VDBP), encoded by the GC gene, binds to 85% to 90% circulating 25(OH)D and thereby regulates the vitamin D bioavailability. (medscape.com)
Tissues3
  • The expression levels of VGLL3 mRNA and protein were analyzed in the freshly resected tumor and normal gastric tissues from GC patients by quantitative RT-PCR and Western blot, respectively. (researchgate.net)
  • In the blood, absorbed lead is bound to erythrocytes and then is distributed initially to multiple soft tissues and eventually into bone. (cdc.gov)
  • Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. (gzsys.org.cn)
Enzymes3
  • Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. (nih.gov)
  • Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. (nih.gov)
  • The toxic effects of lead result from its interference with the physiologic actions of calcium, zinc, and iron, through the inhibition of certain enzymes, and through binding to ion channels and regulatory proteins. (cdc.gov)
Motifs2
  • Tegumental proteins (TegPs) belong to a family of calcium-binding proteins (CaBPs), which contain two EF-hand motifs at the N-terminal domain and a C-terminal dynein light chain-like domain [ 7 ]. (biomedcentral.com)
  • This analysis revealed the presence of at least one binding domain within which visual scanning demonstrated the presence of valid binding motifs. (biomedcentral.com)
Genes4
  • The various forms of Waardenburg syndrome (WS), a neurocristopathy, arise from mutations in multiple genes. (medscape.com)
  • CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
  • There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. (thermofisher.com)
  • Mutations in multiple genes cause the various forms of Waardenburg syndrome (WS). (medscape.com)
CaMKII1
  • Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. (nih.gov)
Superfamily1
  • Centrin is a calcium binding protein (CaBP) belonging to the EF-hand superfamily. (rcsb.org)
Intracellular3
  • EF-hand Ca2+-binding proteins (CBPs), such as calmodulin (CaM) or those belonging to the S100 protein family (S100s) undergo conformational changes upon increasing intracellular Ca2+, facilitating interactions with protein targets and inducing important biological responses. (umaryland.edu)
  • Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
  • The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
Mechanism2
  • Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). (nih.gov)
  • Absorption of strontium from the gastrointestinal tract shares a common mechanism with absorption of calcium. (cdc.gov)
Secretion1
  • We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
Vitamin3
Biological2
  • As with other proteins within this family, centrin is a calcium sensor with multiple biological target proteins. (rcsb.org)
  • Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
Receptors2
  • CBD shows insufficient binding to the cannabinoid receptors, particularly to CB1, which is involved in psychotomimetic effects. (genengnews.com)
  • Cannabidiol (CBD), a major cannabinoid of hemp, does not bind to CB1 receptors and is therefore devoid of psychotomimetic properties. (genengnews.com)
Albumin1
  • Diagnosis involves measurement of serum calcium with adjustment for serum albumin concentration. (msdmanuals.com)
Western blot1
  • The isopropyl-ß- D -thiogalactopyranoside-induced rFg-CaBP4 protein reacted with rat sera containing anti-rFg-CaBP4 polyclonal antibodies in a western blot analysis. (biomedcentral.com)
Roles2
  • These findings provide additional evidence that calcium-binding EF-hand proteins play roles in host-parasite interaction. (biomedcentral.com)
  • The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)
Family1
  • Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. (nih.gov)
Interaction1
  • Finally, the protein interaction network analysis revealed that VGLL3 is likely involved in the Hippo signaling pathway. (researchgate.net)
Physiologic1
  • Calcium absorption is higher in physiologic states in which there is an increased demand for calcium, such as pregnancy and lactation, suggesting that strontium absorption may also be higher as well. (cdc.gov)
Initial1
  • The molecular implications of these results are: (1) the recognition of hydrophobic contacts as requirements for initial binding, (2) minimum electrostatic interactions within the C-terminal end of the peptide, and (3) van der Waals interactions within MLTs N-terminal end are required for complex formation. (rcsb.org)
Molecular2
  • First, molecular fragments were used to differentiate between two highly similar S100 proteins, S100B and S100A1, with the goal of designing S100-specific inhibitors to block these elevated S100 proteins in various disease states. (umaryland.edu)
  • By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
Populations1
  • CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
Zinc2
  • Lead absorption is augmented when iron, zinc, and/or calcium deficiency is also present. (medscape.com)
  • Lead absorption is augmented in the presence of iron, zinc, and calcium deficiency. (medscape.com)
Promoter1
  • By analyzing the chromatin immunoprecipitation sequencing data of MYC-associated X-factor (MAX) based on lung cancer cell lines, we found that the transcriptional regulator MAX is able to bind to the promoter region of the PD-L1 gene. (bvsalud.org)
Synaptic1
  • Therefore, the discovery of markers specific to PSCs is necessary to advance our understanding of PSCs, and synaptic glia in general, on multiple fronts. (elifesciences.org)
Centrin1
  • Also, discussed is the first structure of a CaBP-MLT complex by X-ray crystallography, which shows that MLT has a different binding orientation than previously characterized centrin-bound peptides. (rcsb.org)
Expression3
  • This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • The expression of the major histocompatibility complex (MHC) class-II molecule (MHC-II) in response to rFg-CaBP4 protein was analyzed using Flow cytometry. (biomedcentral.com)
  • Although various studies have assessed OPN protein levels in several tumor types, a broad survey of OPN expression in human neoplasia under the same experimental conditions has not been carried out. (aacrjournals.org)
Consists1
  • The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. (thermofisher.com)
Mechanisms1
  • This research seeks to elucidate both the mechanisms of allostery and the basis of ligand- and target- specificity for S100 proteins and CaM. (umaryland.edu)
Cellular1
  • Osteopontin (OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions (1) . (aacrjournals.org)
ATSDR1
  • 2000). Many animal studies have established the multiple neurotoxic effects of lead (ATSDR, 2007). (cdc.gov)
Hypothesis3
  • Calcium dysregulation ("Calcium Hypothesis") is an early and critical event in Alzheimer's and other neurodegenerative diseases. (biomedcentral.com)
  • Early and continued research first revealed the importance of dysregulated calcium levels in the events of AD leading to the Calcium Hypothesis [ 31 , 32 , 48 ]. (biomedcentral.com)
  • The intimate role of CaMBPs in AD was recently reviewed reinforcing the role of CaM in binding to and regulating multiple key proteins adding further support for the Calmodulin Hypothesis of O'Day and Myre [ 41 , 47 ]. (biomedcentral.com)
Bone1
  • This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. (nih.gov)
Regulation1
  • Activity of this protein is important in the regulation of the cell cycle and cytokinesis. (nih.gov)
Suggests1
  • The strong correlation between pathological stage and OPN across multiple tumor types suggests a role for OPN in tumor progression. (aacrjournals.org)
Exposure1
  • Diisocyanates bind select- diisocyanate exposure (Chiung et al. (cdc.gov)
Found1
  • Overall, 477 proteins were found interacting with at least one of four distinct sGAGs. (degruyter.com)
Experimental1
  • Osteopontin (OPN) is an integrin-binding protein overexpressed in various experimental models of malignancy and appears to be involved in tumorigenesis and metastasis. (aacrjournals.org)
Analysis1
  • Classes for this protein according to Protein ANalysis THrough Evolutionary Relationships (PANTHER) Classification System. (nih.gov)