ProteinAntibodyAntibodiesMoleculeEndothelialTransgenic miceCD31ProteinsPeptideInhibitorTumor cellsAffinityComplexesLigandSusceptibilityMembrane-boundInteractionImmunologyDifferentiationInteractsImmuneChemokineInducesTyrosineExpressionInhibitsComplement systemPeripheral bloodPhenotypeDendritic cellsSurfaceViralCD21EpithelialCellsToleranceDeficiencyUbiquitousDensitySubfamilyActivateLectinClinicalActivationGammaIdentificationFoundStronglyVirus
Protein9
- Recently we found that direct contact of the MV glycoproteins hemagglutinin (H) and fusion protein (F) with the cell surface of lymphocytes or lymphoid cell lines induces a dominant negative signal in the contacted cells leading to this proliferative inhibition (33 44 It is likely that this unfavorable signal is usually transduced by a receptor present on the surface of lymphoid cells. (careersfromscience.org)
- Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
- it occurs when mannose-binding lectin (MBL), a serum protein, binds to mannose, fucose, or N -acetylglucosamine groups on bacterial cell walls, yeast walls, or viruses. (msdmanuals.com)
- Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
- The H protein targets the cellular receptors of the CD46 and CD150. (bestessaywriters.com)
- In this case, these two drugs bind and block PD-1, an immune checkpoint protein. (ucsf.edu)
- Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
- The protein includes a diphtheria toxin (DT) without a receptor binding domain and the C1, C2, C3 (3C) domains of Streptococcus protein G, that is DT3C. (cusabio.com)
- amyloid beta precursor protein binding. (gsea-msigdb.org)
Antibody8
- To identify this receptor we selected a monoclonal antibody (MAb) directed to the surface of B95a cells which inhibits MV binding and contamination and identified the acknowledged molecule as SLAM (CD150). (careersfromscience.org)
- Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. (acrobiosystems.com)
- The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
- For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
- 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
- Antibody-based therapies utilize antibodies that are designed to bind to specific molecules in the body. (ucsf.edu)
- DX5 is a monoclonal antibody which binds to CD49b. (wikidoc.org)
- Whether an antibody can be internalized is mainly determined by the target, and the efficiency of antibody internalization is closely related to the antigen density, antibody affinity, and antibody and antigen-binding epitopes. (cusabio.com)
Antibodies3
- Although anti-SLAM and/or anti-CD46 antibodies stop virus binding they don't hinder the contact-mediated proliferation inhibition. (careersfromscience.org)
- The T-cells and antibodies will then recognize, attack, and continually "remember" how to identify tumor cells based on the tumor-specific antigens in the vaccine. (ucsf.edu)
- Monoclonal antibodies (mAbs) are localized to the surface of tumor cells via the specificity and targeting of tumor cell-associated antigens. (cusabio.com)
Molecule1
- The virus CD46 molecule is the cellular receptor. (bestessaywriters.com)
Endothelial3
- The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
- P-selectin glycoprotein ligand-1 ( PSGL-1 ) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet ), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). (wikidoc.org)
- 00:03:11.16 And what those can do, if you do a transplant from a pig to an old-world primate, 00:03:18.28 is they can immediately bind to the endothelial cells at the graft, fix complement, and cause 00:03:25.15 hyperacute rejection, or a more delayed form of rejection called delayed xenograft rejection. (ibiology.org)
Transgenic mice1
- To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
CD311
- Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
Proteins6
- Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
- Integrins are membrane-bound proteins that are key inflammatory proteins. (goconqr.com)
- The affected patients' genetic backgrounds revealed significant genetic heterogeneity in several genes involved in complement regulation, including the complement factor H, complement factor H-related proteins, complement factor I, complement factor B, complement component 3, and CD46 genes in the alternative complement pathway. (ekjt.org)
Peptide1
- extended and triggered with SIINFEKL peptide antigen pulsed tumor cells as focuses on. (grandlacs-med-journal.com)
Inhibitor1
- Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
Tumor cells2
- On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
- In bursting, the tumor cell releases molecules called tumor antigens, which allows the immune system to recognize and target remaining tumor cells. (ucsf.edu)
Affinity3
- The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
- SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)
- PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin. (wikidoc.org)
Complexes3
- Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
- They tend to enhance the effects of complement and are highly important in the binding of opsonized immune complexes on B cells. (medscape.com)
- Opsonized immune complexes (coated by C3b and C4b) bind to CR1, mostly on red blood cells, and are cleared through the liver where they can be transferred to CR3-bearing phagocytes and endocytosed. (medscape.com)
Ligand2
- The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
- IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
Susceptibility1
- During and weeks after acute measles delayed-type hypersensitivity skin test responses to recall antigens are suppressed and there is an increased susceptibility to opportunistic infections which aggravates the course of the disease. (careersfromscience.org)
Membrane-bound1
- A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Interaction1
- Our results indicate that an Arg279Glu substitution is sufficient to convert the Ad11p receptor-interaction phenotype to that of Ad7p and abolish sB2AR and CD46 interaction. (grandlacs-med-journal.com)
Immunology1
- Her study in Immunology concentrates on Complement, Inflammation, Complement receptor, Classical complement pathway and Complement membrane attack complex. (research.com)
Differentiation1
- Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)
Interacts1
- Measles trojan (MV) interacts with cellular receptors on the top of peripheral bloodstream lymphocytes (PBL) which mediate trojan binding and uptake. (careersfromscience.org)
Immune4
- The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
- CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
- This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
- Her Innate immune system research focuses on Classical complement pathway and how it connects with T cell, Complement receptor and Acquired immune system. (research.com)
Chemokine1
- Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
Induces2
- Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
- Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Tyrosine1
- discoidin domain receptor tyrosine kin. (gsea-msigdb.org)
Expression1
- Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Inhibits1
- A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
Complement system3
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
- Her Complement system research integrates issues from Proteases, Biochemistry, Binding site and Cell biology. (research.com)
- The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors. (uams.edu)
Peripheral blood1
- One aspect of the viral immunosuppression is the proliferation inhibition in response to mitogens T-cell receptor cross-linking or recall antigens of IDH-C227 peripheral blood mononuclear cells (PBMC) isolated from patients (ex vivo) and in vitro. (careersfromscience.org)
Phenotype1
- These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
Dendritic cells1
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Surface2
- Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
- In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
Viral1
- Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
CD211
- CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)
Epithelial1
- Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
Cells6
- Figure 3: Characteristics of CD3/CD46-activated, sorted CD3 + CD4 + CD45RA + CD45RO + T cells. (nature.com)
- Figure 4: Suppressive and proliferative properties of CD3/CD46-activated CD4 + T cells. (nature.com)
- Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
- Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. (cardiff.ac.uk)
- Upon binding to antigen, ADC-antigen complex enters cells through endocytosis (also called internalization). (cusabio.com)
- Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
Tolerance1
- These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
Deficiency1
- Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)
Ubiquitous1
- 00:01:59.26 However, pigs, and most mammalian species, and also non-mammalian species, in fact, 00:02:07.05 express an antigen that is quite ubiquitous and that causes. (ibiology.org)
Density1
- The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
Subfamily1
- ATP binding cassette subfamily C membe. (gsea-msigdb.org)
Activate1
- These variants encoded truncated GP130 receptors, with intact extracellular and transmembrane domains, but lacking the intracellular recycling motif and the four STAT3-binding residues, resulting in an inability to recycle and activate STAT3. (bvsalud.org)
Lectin1
- MBL = mannose-binding lectin. (msdmanuals.com)
Clinical1
- Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy. (cardiff.ac.uk)
Activation2
- [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
- CR1 also regulates complement activation by acting as a cofactor for factor I in the cleavage and degradation of bound C3b and C4b to its inactive forms. (medscape.com)
Gamma2
- Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
- The human interferon-gamma receptor. (wikidoc.org)
Identification1
- Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications. (cardiff.ac.uk)
Found1
- Thus it is identical to the MV receptor recently found by Tatsuo et al. (careersfromscience.org)
Strongly1
- In conjunction with earlier results, our findings Cytochalasin H also strongly suggest that sB2AR is equivalent to CD46. (grandlacs-med-journal.com)
Virus2
- The info suggest that proliferation inhibition induced by MV get in touch with is in addition to the existence or absence of the virus-binding receptors SLAM and CD46. (careersfromscience.org)
- This result is comparable to Cytochalasin H another non-coxsackie-adenovirus receptor binding Ad (Ad37p), where substitution of one amino acid abolishes virus-cell connection. (grandlacs-med-journal.com)