• molecule
  • Small-molecule Peptide-Influenced Drug Repurposing (SPIDR) was developed to identify small molecule drugs that target a specific receptor by exploring the conformational binding space of peptide ligands. (springer.com)
  • an ion or a molecule that binds to another chemical entity to form a larger complex. (bioscreening.net)
  • The structure of DNA was studied by Rosalind Franklin and Maurice Wilkins using X-ray crystallography, which led James D. Watson and Francis Crick to publish a model of the double-stranded DNA molecule whose paired nucleotide bases indicated a compelling hypothesis for the mechanism of genetic replication. (wikipedia.org)
  • interactions
  • Both types of interactions occur simultaneously in both half-sites of the operator DNA. (nih.gov)
  • The model simulates interactions between the components of the genetic circuit that results in an emergent cellular behavior. (northwestern.edu)
  • We present analyses of protein/nucleotide interactions based on information from genetic sequence comparisons, secondary structure prediction, molecular model building, molecular dynamics simulations, X-ray crystallography, NMR and point mutation studies in support of our hypothesis describing the underlying mechanism of site specific protein/nucleotide recognition. (jbsdonline.com)
  • Non-coding DNA has been found to be involved in epigenetic activity and complex networks of genetic interactions, and is being explored in evolutionary developmental biology. (wikipedia.org)
  • The crystal structures of (i) TARS complexed with two tRNA(Thr) molecules, and (ii) TARS complexed with two isolated domains 2, have confirmed that TARS recognition is primarily governed by similar base-specific interactions between the anticodon loop of tRNA(Thr) and the loop of the operator domain 2. (wikipedia.org)
  • algorithm-based
  • SPIDR incorporates a genetic algorithm-based, heuristic search procedure, which was used to explore the ligand binding domain of the α 3 β 2 -nAChR isoform using a library consisting of 640,000 α -conotoxin MII peptide analogs. (springer.com)
  • organisms
  • 1 1 Part 340 regulates, among other things, the introduction of organisms and products altered or produced through genetic engineering which are plant pests or which there is reason to believe are plant pests. (docplayer.net)
  • The genetic modification of organisms by recombinant DNA techniques. (docplayer.net)
  • Therefore we propose that prebiotic, template directed autocatalytic synthesis of mutually cognate peptides and polynucleotides resulted in their amplification and evolutionary conservation in contemporary prokaryotic and eukaryotic organisms as a genetic regulatory apparatus. (jbsdonline.com)
  • novel
  • Here we searched for novel proteins binding to the mec operator, in an attempt to identify new factor(s) controlling methicillin resistance phenotypes. (uzh.ch)
  • RESULTS: Analysis of proteins binding to a DNA fragment containing the mec operator region identified a novel, putative helix-turn-helix DNA-binding protein, SA1665. (uzh.ch)
  • Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. (naver.com)
  • The Lyme disease spirochete, Borrelia burgdorferi, encodes a novel type of DNA-binding protein named EbfC. (nih.gov)
  • EbfC was shown to bind DNA as a homodimer, and site-directed mutagenesis studies indicated that EbfC and its orthologs appear to bind DNA via a novel alpha-helical 'tweezer'-like structure. (nih.gov)
  • The repressilator is a milestone of synthetic biology which shows that genetic regulatory networks which perform a novel desired function can be designed and implemented. (wikipedia.org)
  • specific
  • Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life. (wikipedia.org)
  • regulation
  • This type of regulation requires the design of genetic sensors and circuits. (openwetware.org)
  • In the aforementioned proof of principle study from the Voigt lab, refactored the nitrogen fixation pathway from Klebsiella oxytoca in order "to reorganize the cluster, simplify its regulation, and assign a concrete function to each genetic part [ 2 ]. (openwetware.org)
  • regulate
  • As confirmed by mutagenesis, recognition specificity is based on two KorA side chains forming hydrogen bonds to four bases within each operator half-site.KorA has a unique dimerization module shared by the RP4 proteins TrbA and KlcB.We propose that these proteins cooperate with the global RP4 repressor KorB in a similar manner via this dimerization module and thus regulate RP4 inheritance. (nih.gov)
  • algorithms
  • Calculation of bound states and local-density approximations Chemical kinetics (gas and solid phases) Climatology: Modelling global temperature changes Climatology: Estimation of heat flux between the atmosphere and sea ice Clustering, using genetic algorithms to optimize a wide range of different fit-functions. (wikipedia.org)
  • Satellite communication scheduling for the NASA Deep Space Network was shown to benefit from genetic algorithms. (wikipedia.org)
  • Groundwater monitoring networks Learning robot behavior using genetic algorithms Image processing: Dense pixel matching Learning fuzzy rule base using genetic algorithms Linguistic analysis, including grammar induction and other aspects of Natural language processing (NLP) such as word sense disambiguation. (wikipedia.org)
  • incorporates
  • The structure of KorA bound to an 18-bp DNA duplex that contains the symmetric operator sequence and incorporates 5-bromo-deoxyuridine nucleosides has been determined by multiple-wavelength anomalous diffraction phasing at 1.96-A resolution. (nih.gov)
  • behavior
  • This model shows how biologists can use laboratory techniques to tweak certain aspects of a genetic circuit in order to affect the cell's behavior. (northwestern.edu)