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  • interactions
  • Both types of interactions occur simultaneously in both half-sites of the operator DNA. (nih.gov)
  • Non-coding DNA has been found to be involved in epigenetic activity and complex networks of genetic interactions, and is being explored in evolutionary developmental biology. (wikipedia.org)
  • The crystal structures of (i) TARS complexed with two tRNA(Thr) molecules, and (ii) TARS complexed with two isolated domains 2, have confirmed that TARS recognition is primarily governed by similar base-specific interactions between the anticodon loop of tRNA(Thr) and the loop of the operator domain 2. (wikipedia.org)
  • affinity
  • The present work defines the DNA sequence required for high-affinity binding by EbfC to be the 4 bp broken palindrome GTnAC, where 'n' can be any nucleotide. (nih.gov)
  • CI binds O 1 very strongly, then O 2 with slightly less affinity and O 3 quite weakly. (wordpress.com)
  • ligand
  • SPIDR incorporates a genetic algorithm-based, heuristic search procedure, which was used to explore the ligand binding domain of the α 3 β 2 -nAChR isoform using a library consisting of 640,000 α -conotoxin MII peptide analogs. (springer.com)
  • is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNF.alpha. (patentgenius.com)
  • genetics
  • It is quite under-rated but A Genetic Switch by Mark Ptashne is one of my favourite molecular genetics books, a must read for anyone interested in gene regulation. (wordpress.com)
  • molecule
  • Small-molecule Peptide-Influenced Drug Repurposing (SPIDR) was developed to identify small molecule drugs that target a specific receptor by exploring the conformational binding space of peptide ligands. (springer.com)
  • The structure of DNA was studied by Rosalind Franklin and Maurice Wilkins using X-ray crystallography, which led James D. Watson and Francis Crick to publish a model of the double-stranded DNA molecule whose paired nucleotide bases indicated a compelling hypothesis for the mechanism of genetic replication. (wikipedia.org)
  • plasmid
  • Molecular cloning of the plasmid RP4 primase region in a multi-range tacP expression vector," Elsevier Science BV, Amsterdam, Netherlands, Gene, 48: 119-131 (1986). (patentgenius.com)
  • characterization
  • Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. (naver.com)
  • Synthesis, Characterization, and Immunological Properties in Mice of Conjugates Composed of Detoxified Lipopolysaccharide of Salmonella paratyphi A Bound to Tetanus Toxoid, with Emphasis on the Role of O Acetyls",Infect.Immun. (patentgenius.com)
  • silencers
  • Most silencers are constitutively expressed in organisms, only allowing activation of a gene by either inhibiting the silencer or by activating an enhancer region. (wikipedia.org)
  • specific
  • Each of these steps is controlled by specific sequence elements, or regions, within the gene. (wikipedia.org)
  • Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life. (wikipedia.org)
  • regulation
  • Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation. (nih.gov)
  • The resulting gene cluster is a set of discrete genetic parts free of native regulation [ 2 ]. (openwetware.org)
  • This type of regulation requires the design of genetic sensors and circuits. (openwetware.org)
  • In the aforementioned proof of principle study from the Voigt lab, refactored the nitrogen fixation pathway from Klebsiella oxytoca in order "to reorganize the cluster, simplify its regulation, and assign a concrete function to each genetic part [ 2 ]. (openwetware.org)
  • incorporates
  • The structure of KorA bound to an 18-bp DNA duplex that contains the symmetric operator sequence and incorporates 5-bromo-deoxyuridine nucleosides has been determined by multiple-wavelength anomalous diffraction phasing at 1.96-A resolution. (nih.gov)
  • Biological
  • Though this was not necessarily unexpected due to previous decades of research discovering many functional noncoding regions, some scientists criticized the conclusion for conflating biochemical activity with biological function. (wikipedia.org)
  • evolutionary
  • CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology. (wikipedia.org)
  • species
  • All cyanobacteria are lacking the type II system, which has been widely adapted for genetic engineering purposes across many species. (wikipedia.org)
  • hypothesis
  • The structure of DNA was studied by Rosalind Franklin and Maurice Wilkins using X-ray crystallography, which led James D. Watson and Francis Crick to publish a model of the double-stranded DNA molecule whose paired nucleotide bases indicated a compelling hypothesis for the mechanism of genetic replication. (wikipedia.org)
  • bacteria
  • Group II K antigens closely resemble those in gram-positive bacteria and greatly differ in composition and are further subdivided according to their acidic components, generally 20-50% of the CPS chains are bound to phospholipids. (wikipedia.org)
  • material
  • In molecular cloning, a vector is a DNA molecule used as a vehicle to artificially carry foreign genetic material into another cell, where it can be replicated and/or expressed (e.g.- plasmid, cosmid, Lambda phages). (wikipedia.org)
  • Such vectors have bacterial or viral elements which may be transferred to the non-bacterial host organism, however other vectors termed intragenic vectors have also been developed to avoid the transfer of any genetic material from an alien species. (wikipedia.org)
  • specific
  • Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life. (wikipedia.org)
  • host
  • During infection, the phage particle recognizes and binds to its host, E. coli, causing DNA in the head of the phage to be ejected through the tail into the cytoplasm of the bacterial cell. (wikipedia.org)
  • produce
  • It comprises a constant- or variable-size population of individuals, a fitness criterion, and genetically inspired operators that produce the next generation from the current one. (wikipedia.org)
  • process
  • This process of refactoring aims to reduce the overall complexity of genetic systems and allows them to be tailored for a particular purpose. (openwetware.org)