• interactions
  • Both types of interactions occur simultaneously in both half-sites of the operator DNA. (nih.gov)
  • The model simulates interactions between the components of the genetic circuit that results in an emergent cellular behavior. (northwestern.edu)
  • Non-coding DNA has been found to be involved in epigenetic activity and complex networks of genetic interactions, and is being explored in evolutionary developmental biology. (wikipedia.org)
  • The crystal structures of (i) TARS complexed with two tRNA(Thr) molecules, and (ii) TARS complexed with two isolated domains 2, have confirmed that TARS recognition is primarily governed by similar base-specific interactions between the anticodon loop of tRNA(Thr) and the loop of the operator domain 2. (wikipedia.org)
  • ligand
  • SPIDR incorporates a genetic algorithm-based, heuristic search procedure, which was used to explore the ligand binding domain of the α 3 β 2 -nAChR isoform using a library consisting of 640,000 α -conotoxin MII peptide analogs. (springer.com)
  • is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNF.alpha. (patentgenius.com)
  • genomic
  • Although SA1665 bound to the mecA promoter region, it had no apparent influence on mecA transcription or translation, suggesting that this predicted DNA-binding protein modulates resistance indirectly, most likely through the control of other genomic factors which contribute to resistance. (uzh.ch)
  • receptor
  • Small-molecule Peptide-Influenced Drug Repurposing (SPIDR) was developed to identify small molecule drugs that target a specific receptor by exploring the conformational binding space of peptide ligands. (springer.com)
  • replication
  • The structure of DNA was studied by Rosalind Franklin and Maurice Wilkins using X-ray crystallography, which led James D. Watson and Francis Crick to publish a model of the double-stranded DNA molecule whose paired nucleotide bases indicated a compelling hypothesis for the mechanism of genetic replication. (wikipedia.org)
  • plasmid
  • Molecular cloning of the plasmid RP4 primase region in a multi-range tacP expression vector," Elsevier Science BV, Amsterdam, Netherlands, Gene, 48: 119-131 (1986). (patentgenius.com)
  • The expression of an engineered T7 RNA polymerase (T7 RNAP) was placed on a separate plasmid containing the genetic sensors/circuits referred to as the controller. (openwetware.org)
  • characterization
  • Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. (naver.com)
  • Synthesis, Characterization, and Immunological Properties in Mice of Conjugates Composed of Detoxified Lipopolysaccharide of Salmonella paratyphi A Bound to Tetanus Toxoid, with Emphasis on the Role of O Acetyls",Infect.Immun. (patentgenius.com)
  • novel
  • Here we searched for novel proteins binding to the mec operator, in an attempt to identify new factor(s) controlling methicillin resistance phenotypes. (uzh.ch)
  • RESULTS: Analysis of proteins binding to a DNA fragment containing the mec operator region identified a novel, putative helix-turn-helix DNA-binding protein, SA1665. (uzh.ch)
  • The Lyme disease spirochete, Borrelia burgdorferi, encodes a novel type of DNA-binding protein named EbfC. (nih.gov)
  • EbfC was shown to bind DNA as a homodimer, and site-directed mutagenesis studies indicated that EbfC and its orthologs appear to bind DNA via a novel alpha-helical 'tweezer'-like structure. (nih.gov)
  • The repressilator is a milestone of synthetic biology which shows that genetic regulatory networks which perform a novel desired function can be designed and implemented. (wikipedia.org)
  • regulation
  • Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation. (nih.gov)
  • The resulting gene cluster is a set of discrete genetic parts free of native regulation [ 2 ]. (openwetware.org)
  • This type of regulation requires the design of genetic sensors and circuits. (openwetware.org)
  • In the aforementioned proof of principle study from the Voigt lab, refactored the nitrogen fixation pathway from Klebsiella oxytoca in order "to reorganize the cluster, simplify its regulation, and assign a concrete function to each genetic part [ 2 ]. (openwetware.org)
  • traits
  • Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life. (wikipedia.org)
  • incorporates
  • The structure of KorA bound to an 18-bp DNA duplex that contains the symmetric operator sequence and incorporates 5-bromo-deoxyuridine nucleosides has been determined by multiple-wavelength anomalous diffraction phasing at 1.96-A resolution. (nih.gov)
  • Biological
  • Though this was not necessarily unexpected due to previous decades of research discovering many functional noncoding regions, some scientists criticized the conclusion for conflating biochemical activity with biological function. (wikipedia.org)
  • evolutionary
  • CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology. (wikipedia.org)
  • species
  • All cyanobacteria are lacking the type II system, which has been widely adapted for genetic engineering purposes across many species. (wikipedia.org)
  • Molecular
  • Deoxyribonucleic acid (DNA) was shown to be the molecular repository of genetic information by experiments in the 1940s to 1950s. (wikipedia.org)