• proliferation
  • Through exogenous expression analyses, we found that PDCD2 and NCoR1 can decrease proliferation, and increase apoptosis and G1 cell cycle arrest, in GIST-derived cells. (cancerindex.org)
  • Through her work with two genera of retroviruses, Quackenbush determined mutations to Gammaretrovirus (feline leukemia virus) makes them less lethal, and Epsilretrovirus (walleye dermal sarcoma virus) contains sequences that encode for cyclin proteins, leading to the proliferation of normal cells and eventually giving a means for cancer cells to become abundant Her most notable work focuses on feline leukemia virus. (wikipedia.org)
  • As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development. (wikipedia.org)
  • Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikipedia.org)
  • It exerts its biological functions through binding to signalling proteins of the MAPKK level of the MAPK pathway, therefore eliciting a regulatory role in the function of this pathway which mediates proliferation, apoptosis and differentiation in cells. (wikipedia.org)
  • Genes
  • Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. (mybiosource.com)
  • The 2002 Nobel Prize in Medicine was awarded to Sydney Brenner, Horvitz and John E. Sulston for their work identifying genes that control apoptosis. (wikipedia.org)
  • The genes were identified by studies in the nematode C. elegans and homologues of these genes function in humans to regulate apoptosis. (wikipedia.org)
  • cellular
  • This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. (uniprot.org)
  • In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. (wikipedia.org)
  • TIGAR transcription is rapidly activated by the p53 tumour suppressor protein in response to low levels of cellular stress, such as that caused by exposure to low doses of UV. (wikipedia.org)
  • Calcium ions are important for cellular signalling, as once they enter the cytosol of the cytoplasm they exert allosteric regulatory effects on many enzymes and proteins. (wikipedia.org)
  • Chromosome
  • Fas-associated protein with death domain (FADD), also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans. (wikipedia.org)
  • antibodies
  • Promising novel therapies directed at specific malfunctioning proteins, including anti-receptor tyrosine kinase antibodies [ 7 ], will no doubt greatly improve treatment outcomes. (biomedcentral.com)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • However, apoptosis was not observed following culture with other anti-CD47 antibodies. (wikipedia.org)
  • apoptotic
  • The prevalence of apoptosis and expression of the pro-apoptotic factor PUMA were significantly reduced in Atm-deficient mice fed the high fat diet when compared with wild type controls. (biomedsearch.com)
  • Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them. (wikipedia.org)
  • initiates
  • The mechanism involves two metal ions binding and activating water, which initiates a nucleophilic attack on the phosphorus atom. (wikipedia.org)
  • cells
  • Acting through ataxia telangiectasia mutated (ATM) and its downstream effectors, T-oligos induced apoptosis and senescence of MCF-7 cells but not NME cells, in which these signaling pathways were induced to a far lesser extent. (biomedcentral.com)
  • It is developed by Pfizer and made in such a way that it protects liver cells from excessive apoptosis. (drugbank.ca)
  • We found that BV inhibited growth of colon cancer cells through induction of apoptosis. (blogspot.co.nz)
  • Between 50 and 70 billion cells die each day due to apoptosis in the average human adult. (wikipedia.org)
  • Increased expression levels of the Ifi202 mRNA and nuclear localization of p202 protein in immune cells are associated with the development of autoimmunity in certain strains of mice. (wikipedia.org)
  • CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells. (wikipedia.org)
  • The activation of CD47 induces rapid apoptosis of T cells. (wikipedia.org)
  • Jurkat cells and peripheral blood mononuclear cells (PBMC) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikipedia.org)
  • Apoptosis Immune system Immune tolerance T-cell Autoimmunity Fas receptor Caspase Zhang J, Xu X, Liu Y. (2004), Activation-Induced Cell Death in T Cells and Autoimmunity. (wikipedia.org)
  • Viral nonstructural proteins are proteins coded for by the genome of the virus and are expressed in infected cells. (wikipedia.org)
  • Once the whole complex is completed the system switches to secreting proteins that are intended to be delivered into host cells. (wikipedia.org)
  • pathway
  • section describes the metabolic pathway(s) associated with a protein. (uniprot.org)
  • This protein is involved in the pathway protein neddylation, which is part of Protein modification. (uniprot.org)
  • View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification . (uniprot.org)
  • The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. (wikipedia.org)
  • Apoptosis induction appears to be regulated by the hypoxia inducible factor 1α (HIF-1α) pathway. (wikipedia.org)
  • Tribbles-1 plays a role in regulating its own expression by binding to its substrate, which not only produces its function on the MAPK pathway, but also works to protect it from degradation whilst binding. (wikipedia.org)
  • FADD
  • FADD is a 23 kDa protein, made up of 280 amino acids. (wikipedia.org)
  • This complex is then internalised, and FADD binds to TRADD via an interaction of the DD's of the two adapter proteins, forming what is known as complex II. (wikipedia.org)
  • FADD can also bind to RIPK1 and RIPK3 directly, however the significance of this interaction is currently unclear. (wikipedia.org)
  • FADD binds to ATG5 in a complex which also contains ATG12, Caspase 8 and RIPK1. (wikipedia.org)
  • regulate
  • p>This subsection of the 'Function' section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction. (uniprot.org)
  • Such condensed structure occludes many DNA regulatory regions, not allowing them to interact with transcriptional machinery proteins and regulate gene expression. (wikipedia.org)
  • mediates
  • Since it is known that p53 mediates the expression of proapoptotic proteins, the increased p202 correlates with increased p53 levels. (wikipedia.org)
  • membrane
  • CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). (wikipedia.org)
  • DAG recruits protein kinase C (PKC), attaching it to the plasma membrane IP3 diffuses to the endoplasmic reticulum, and binds to an IP3 receptor, The IP3 receptor serves as a Ca2+ channel, and releases Ca2+ from the endoplasmic reticulum. (wikipedia.org)
  • Viral membrane fusion proteins act as catalysts to overcome this high energy barrier. (wikipedia.org)
  • Most viral membrane fusion proteins would end up in a hairpin-like conformation after fusion, in which FLs/FPs and the transmembrane domain are all on the same side of the protein. (wikipedia.org)
  • Viral membrane fusion proteins have been grouped into four different classes, and each class is identified by characteristic structural conformations: Class I: Post-fusion conformation has a distinct central coiled-coil structure composed of signature trimer of α-helical hairpins. (wikipedia.org)
  • Class III: Structural conformation is a combination of features from Class I and Class II viral membrane fusion proteins. (wikipedia.org)
  • winged-helix domain
  • APAF1 contains a CARD domain with a Greek key motif composed of six helices, a Rossman fold nucleotide binding domains, a short helical motif and a winged-helix domain. (wikipedia.org)
  • transcription factors
  • Activating Protein 2 (AP-2) is a family of closely related transcription factors which plays a critical role in regulating gene expression during early development. (wikipedia.org)
  • The transcriptional regulation of the genome is controlled primarily at the preinitiation stage by binding of the core transcriptional machinery proteins (namely, RNA polymerase, transcription factors, and activators and repressors) to the core promoter sequence on the coding region of the DNA. (wikipedia.org)
  • Methylation of specific lysine residues in H3 and H4 causes further condensation of DNA around histones, and thereby preventing binding of transcription factors to the DNA leading to gene repression. (wikipedia.org)
  • high affinity
  • In spite of the fact that these noncovalent polynuclear platinum complexes contain no leaving groups, they have been shown to bind to DNA with high affinity. (ibp.cz)
  • One site is found within the first intron, and binds p53 with high affinity. (wikipedia.org)
  • neuronal
  • Immunohistochemistry for IENF was performed on the glabrous skin of the hind-paw foot pad using the pan-neuronal marker, protein gene product 9.5. (blogspot.com.ar)
  • It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. (wikipedia.org)
  • interaction
  • The H1 helix and surrounding L2 loop do not participate directly in DNA interaction but contribute instead to dimer contacts in the DNA-bound tetramer (Supplementary Fig. S4a), as well as other protein-protein interactions (Supplementary Fig. S4b). (nih.gov)
  • Besides, Interleukin 1 Alpha (IL1a) has been identified as an interactor of CASP1, thus a binding ELISA assay was conducted to detect the interaction of recombinant rat CASP1 and recombinant rat IL1a. (uscnk.com)
  • s apoptosis-stimulating activity is inhibited by its interaction with DDX42. (mybiosource.com)
  • Researchers at Howard University showed that Tat protein targets PP1 to the nucleus and the consequent interaction is important for HIV-1 transcription. (wikipedia.org)
  • The critical concept of the histone code hypothesis is that the histone modifications serve to recruit other proteins by specific recognition of the modified histone via protein domains specialized for such purposes, rather than through simply stabilizing or destabilizing the interaction between histone and the underlying DNA. (wikipedia.org)
  • substrates
  • Recent crystal structures show that Tribbles 1 has an unusual 3D structure, containing a 'broken' C-helix region, a binding site for ubiquitinated substrates such as C/EBPalpha and a key regulatory C-tail region. (wikipedia.org)
  • degradation
  • The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (uscnk.com)
  • Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. (uniprot.org)
  • antibody
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)