• proteins
  • Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. (wikipedia.org)
  • The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. (wikipedia.org)
  • Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. (wikipedia.org)
  • SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids. (wikipedia.org)
  • In this study, we investigate whether a cascade of events (including death receptor activation, alteration in the ratio of proapoptosis- and antiapoptosis-regulating proteins in mitochondria, altered mitochondrial activity and location, cytochrome c accumulation, and cleavage of caspases into active subunits) leads to apoptotic neurodegeneration in the thalamus after neonatal hypoxia-ischemia. (jneurosci.org)
  • These studies demonstrated that many different types of proteins are acetylated, such as transcription factors, nuclear receptors, cytoskeletal proteins, and enzymes involved in metabolism. (frontiersin.org)
  • The similarity between Toll-like receptors (TLRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. (wikipedia.org)
  • It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements. (wikipedia.org)
  • soluble
  • Expression of IL-13Rα2 transcripts are restricted to spleen and brain and in contrast to IL-13Rα1, a soluble form of this receptor has been detected in mouse serum ( 13 ). (rupress.org)
  • Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. (wikipedia.org)
  • mAbs can be targeted against many soluble or membrane-bound targets, thus these compounds may act by a variety of mechanisms to achieve their pharmacological effect. (springer.com)
  • mAbs targeting soluble antigen generally exhibit linear elimination, whereas those targeting membrane-bound antigen often exhibit non-linear elimination, mainly due to target-mediated drug disposition (TMDD). (springer.com)
  • The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide. (springer.com)
  • 1996
  • To transmit the apoptotic signal ( Schlottmann and Coggeshall, 1996 ), CD95 associates via its death domain with the Fas-associating protein with death domain (FADD/MORT1), which binds FADD-like ICE (interleukin 1-converting enzyme) (FLICE/caspase 8/MACH-1). (aspetjournals.org)
  • 1998
  • Sharp BM, Roy S, Bidlack JM (1998) Evidence for opioid receptors on cells involved in host defense and the immune system. (springer.com)
  • interact
  • Although scaffolds are not strictly defined in function, they are known to interact and/or bind with multiple members of a signalling pathway, tethering them into complexes. (wikipedia.org)
  • IRAK
  • Some special/significant features of each IRAK family member: There is some evidence that IRAK-1 functions in regulating other signaling cascades leading to NF-kB activation. (wikipedia.org)
  • One signaling pathway in particular nerve growth factor (NGF) may be dependent on the function of IRAK-1 in its signaling pathway for its activation and cell survival. (wikipedia.org)
  • IRAK-M negatively regulates TLR signaling by inhibiting the IRAK-4/IRAK-1 complex The newest described IRAK family member, IRAK-4, has been found to be critical for the recruitment of IRAK-1 and for its activation/degradation. (wikipedia.org)
  • 2002
  • It is estimated that in the year 2002 alone, 205,000 new patients (including 1,500 male) were diagnosed in the United States and about 40,000 patients died from this disease ( 1 ). (aacrjournals.org)
  • human
  • When psychologically stressed, the human body produces stress hormones like cortisol, which are able to trigger interleukin-6 release into the circulation. (wikipedia.org)
  • Detects Recombinant Human IL-18 R alpha /IL-1 R5 in direct ELISAs. (novusbio.com)
  • In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 RII, rhIL-1 R3, rhIL-1 R4, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, rhIL-1 R9, rhSIGIRR or recombinant mouse IL-18 R alpha is observed. (novusbio.com)
  • 1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
  • Numerous in vitro studies performed in recent years have shown that most types of drug-induced cytotoxicity in human tumor cell lines are associated with the induction of apoptosis. (aspetjournals.org)
  • Wybran J, Appelboom T, Famaey J, Govaerts A (1979) Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T-lymphocytes. (springer.com)
  • Chuang LF, Chuang TK, Killiam KF, et al (1995) Expression of kappa opioid receptors in human and monkey lymphocytes. (springer.com)
  • Welters ID, Mezenbach A, Goumon Y, et al (2000) Morphine inhibits NF-xb nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism. (springer.com)
  • SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. (wikipedia.org)
  • Feng Y, Klein BK, McWherter CA, Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3. (wikipedia.org)
  • Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. (springer.com)
  • Mizutani H, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase . (proteopedia.org)
  • 5. The antibody or antigen-binding fragment of claim 1, wherein said antibody or antigen-binding fragment is selected from the group consisting of a monoclonal antibody, a human antibody, a humanized antibody, a chimeric antibody, and an antigen-binding fragment of any of the foregoing. (patentsencyclopedia.com)
  • expression
  • IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. (wikipedia.org)
  • Expression and release of SFRP4 from islets is enhanced by interleukin-1β. (wikipedia.org)
  • One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. (wikipedia.org)
  • Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. (springer.com)
  • Fas death receptor protein expression increased rapidly after neonatal hypoxia-ischemia, in concert with cleavage of procaspase 8 to its active form. (jneurosci.org)
  • We hypothesized, therefore, that the effect of IL-16 on HIV-1 replication might occur at the level of virus expression. (umassmed.edu)
  • Sequence
  • Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. (ebi.ac.uk)
  • Rønnestad and colleagues recently detected five isoforms of the leptin receptor (lepr) that have differences in 3'-end of the mRNA sequence. (wikipedia.org)
  • Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). (wikipedia.org)
  • Drug, bio-affecting and body treating compositions immunoglobulin, antiserum, antibody, or antibody fragment, except conjugate or complex of the same with nonimmunoglobulin material binds antigen or epitope whose amino acid sequence is disclosed in whole or in part (e.g., binds specifically-identified amino acid sequence, etc. (patentsencyclopedia.com)
  • enzyme
  • IL-1β precursor(31KDa) need to be activated by protease (convertase or IL-1β converting enzyme) to form IL-1 active species(17KDa). (proteopedia.org)
  • membrane
  • It lacks the DNA binding region of CUTL1, but instead contains a trans-membrane domain that allows it to insert into lipid bilayers. (wikipedia.org)
  • Consequently, the plasma membrane receptors for IL-13 (IL-13R) have been vigorously studied ( 8 -12 ). (aacrjournals.org)
  • IL-1β is yellow, with site A residues in green and site B residues in red.The structure is oriented so that the carboxy terminus of s-IL 1R and the cell membrane are at the bottom of the picture. (proteopedia.org)
  • responses
  • These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Rα2 in regulating immune responses in wild-type mice. (rupress.org)
  • molecule
  • The complex has approximate dimensions of 97Å×52 Å ×35 Å with one s-IL1R molecule wrapping around the IL-1β molecule with 1:1 ratio. (proteopedia.org)