• proteins
  • Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. (wikipedia.org)
  • The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. (wikipedia.org)
  • Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. (wikipedia.org)
  • SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids. (wikipedia.org)
  • We find that PU.1 inhibits the erythroid program by binding to GATA‐1 on its target genes and organizing a complex of proteins that creates a repressive chromatin structure containing lysine‐9 methylated H3 histones and heterochromatin protein 1. (embopress.org)
  • PU.1 and GATA‐1 are two sequence‐specific DNA binding proteins that play central roles in the lineage commitment decisions of common myelo‐erythroid progenitors (CMPs) to become myeloid progenitors or megakaryocytic‐erythroid progenitors, respectively ( Graf, 2002 ). (embopress.org)
  • In addition to their roles as sequence‐specific DNA binding proteins, PU.1 and GATA‐1 also physically interact. (embopress.org)
  • The similarity between Toll-like receptors (TLRs) and IL-1R is not restricted to sequence homology since these proteins also share a similar signaling pathway. (wikipedia.org)
  • It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal elements. (wikipedia.org)
  • IL-1 Receptor Accessory Protein (also IL-1 R3) is a ubiquitous 70-90 kDa member of the interleukin-1 receptor family of proteins (1-5). (rndsystems.com)
  • In this study, we investigate whether a cascade of events (including death receptor activation, alteration in the ratio of proapoptosis- and antiapoptosis-regulating proteins in mitochondria, altered mitochondrial activity and location, cytochrome c accumulation, and cleavage of caspases into active subunits) leads to apoptotic neurodegeneration in the thalamus after neonatal hypoxia-ischemia. (jneurosci.org)
  • These studies demonstrated that many different types of proteins are acetylated, such as transcription factors, nuclear receptors, cytoskeletal proteins, and enzymes involved in metabolism. (frontiersin.org)
  • 1996
  • To transmit the apoptotic signal ( Schlottmann and Coggeshall, 1996 ), CD95 associates via its death domain with the Fas-associating protein with death domain (FADD/MORT1), which binds FADD-like ICE (interleukin 1-converting enzyme) (FLICE/caspase 8/MACH-1). (aspetjournals.org)
  • soluble
  • Expression of IL-13Rα2 transcripts are restricted to spleen and brain and in contrast to IL-13Rα1, a soluble form of this receptor has been detected in mouse serum ( 13 ). (rupress.org)
  • Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. (wikipedia.org)
  • The soluble receptor isoforms appear to be inhibitory to IL-1 signaling. (rndsystems.com)
  • When present with soluble IL-1 RII, soluble IL-1 RAcP increases the IL-1 binding affinity of IL-1 RII more than 100-fold, thus neutralizing the effects of IL-1 (14). (rndsystems.com)
  • mAbs can be targeted against many soluble or membrane-bound targets, thus these compounds may act by a variety of mechanisms to achieve their pharmacological effect. (springer.com)
  • mAbs targeting soluble antigen generally exhibit linear elimination, whereas those targeting membrane-bound antigen often exhibit non-linear elimination, mainly due to target-mediated drug disposition (TMDD). (springer.com)
  • The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide. (springer.com)
  • Molecular
  • Encyclopedia of Molecular Pharmacology, Vol. 1 (2nd ed. (wikipedia.org)
  • Thus, an insight into the molecular basis of the mutual antagonism between PU.1 and GATA‐1 is important for understanding control processes in normal hematopoiesis and how these processes are disrupted in leukemia. (embopress.org)
  • interact
  • Although scaffolds are not strictly defined in function, they are known to interact and/or bind with multiple members of a signalling pathway, tethering them into complexes. (wikipedia.org)
  • PU.1 and GATA‐1 are two critical hematopoietic transcription factors that physically interact and mutually antagonize each other's transcriptional activity and ability to promote myeloid and erythroid differentiation, respectively. (embopress.org)
  • genes
  • Cux1 DNA binding is stimulated by activation of the PAR2/F2RL1 cell-surface G-protein-coupled receptor in fibroblasts and breast-cancer epithelial cells to regulate Matrix metalloproteinase 10, Interleukin1-alpha, and Cyclo-oxygenase 2 (COX2) genes. (wikipedia.org)
  • At least 2 leptin genes (lepa and lepb) exist in the crown-clade (Fig. 1). (wikipedia.org)
  • Numerous genes that are directly activated by PU.1 or GATA‐1 have been identified in myeloid or erythroid cells, respectively. (embopress.org)
  • extracellular
  • The extracellular region shows three C2-type Ig-like domains, the most membrane proximal of which is suggested to be responsible for dimerization with IL-1 RI (10). (rndsystems.com)
  • In murine systems, IL-13Rα2 chain is shown to function as a decoy receptor because its extracellular domain is cleaved and the protein is detected in serum and urine ( 31 ). (aacrjournals.org)
  • IRAK
  • Some special/significant features of each IRAK family member: There is some evidence that IRAK-1 functions in regulating other signaling cascades leading to NF-kB activation. (wikipedia.org)
  • One signaling pathway in particular nerve growth factor (NGF) may be dependent on the function of IRAK-1 in its signaling pathway for its activation and cell survival. (wikipedia.org)
  • IRAK-M negatively regulates TLR signaling by inhibiting the IRAK-4/IRAK-1 complex The newest described IRAK family member, IRAK-4, has been found to be critical for the recruitment of IRAK-1 and for its activation/degradation. (wikipedia.org)
  • 1998
  • Sharp BM, Roy S, Bidlack JM (1998) Evidence for opioid receptors on cells involved in host defense and the immune system. (springer.com)
  • subunits
  • The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). (novusbio.com)
  • human
  • When psychologically stressed, the human body produces stress hormones like cortisol, which are able to trigger interleukin-6 release into the circulation. (wikipedia.org)
  • Detects Recombinant Human IL-18 R alpha /IL-1 R5 in direct ELISAs. (novusbio.com)
  • In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 RII, rhIL-1 R3, rhIL-1 R4, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, rhIL-1 R9, rhSIGIRR or recombinant mouse IL-18 R alpha is observed. (novusbio.com)
  • Numerous in vitro studies performed in recent years have shown that most types of drug-induced cytotoxicity in human tumor cell lines are associated with the induction of apoptosis. (aspetjournals.org)
  • SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. (wikipedia.org)
  • Detects human IL-1RAcP/IL-1 R3 in direct ELISAs. (rndsystems.com)
  • Detection of IL‑1 RAcP/IL‑1 R3 in Human Blood Monocytes by Flow Cytometry. (rndsystems.com)
  • Human peripheral blood monocytes were stained with Mouse Anti-Human IL‑1 RAcP/IL‑1 R3 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB676G, filled histogram) or isotype control antibody (Catalog # IC002G , open histogram). (rndsystems.com)
  • Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. (springer.com)
  • Wybran J, Appelboom T, Famaey J, Govaerts A (1979) Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T-lymphocytes. (springer.com)
  • Chuang LF, Chuang TK, Killiam KF, et al (1995) Expression of kappa opioid receptors in human and monkey lymphocytes. (springer.com)
  • Welters ID, Mezenbach A, Goumon Y, et al (2000) Morphine inhibits NF-xb nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism. (springer.com)
  • Mizutani H, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase . (proteopedia.org)
  • membrane
  • It lacks the DNA binding region of CUTL1, but instead contains a trans-membrane domain that allows it to insert into lipid bilayers. (wikipedia.org)
  • Consequently, the plasma membrane receptors for IL-13 (IL-13R) have been vigorously studied ( 8 -12 ). (aacrjournals.org)
  • IL-1β is yellow, with site A residues in green and site B residues in red.The structure is oriented so that the carboxy terminus of s-IL 1R and the cell membrane are at the bottom of the picture. (proteopedia.org)
  • expression
  • IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. (wikipedia.org)
  • Expression and release of SFRP4 from islets is enhanced by interleukin-1β. (wikipedia.org)
  • One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. (wikipedia.org)
  • Although these features are thought to be stable aspects of repressed chromatin, we find that silencing of PU.1 expression leads to removal of the repression complex, loss of the repressive chromatin marks and reactivation of the erythroid program. (embopress.org)
  • Repression of one transcription factor bound to DNA by another transcription factor not on the DNA represents a new mechanism for downregulating an alternative gene expression program during lineage commitment of multipotential hematopoietic progenitors. (embopress.org)
  • Fas death receptor protein expression increased rapidly after neonatal hypoxia-ischemia, in concert with cleavage of procaspase 8 to its active form. (jneurosci.org)
  • Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. (springer.com)
  • 2002
  • It is estimated that in the year 2002 alone, 205,000 new patients (including 1,500 male) were diagnosed in the United States and about 40,000 patients died from this disease ( 1 ). (aacrjournals.org)
  • enzyme
  • IL-1β precursor(31KDa) need to be activated by protease (convertase or IL-1β converting enzyme) to form IL-1 active species(17KDa). (proteopedia.org)
  • isoforms
  • Rønnestad and colleagues recently detected five isoforms of the leptin receptor (lepr) that have differences in 3'-end of the mRNA sequence. (wikipedia.org)
  • Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. (wikipedia.org)
  • 1995
  • Stefano GB, Hartman A, Bilfinger TV, et al (1995) Presence of the µ3 opiate receptor in endothelial cells: coupling to nitric oxide production and vasodilation. (springer.com)
  • molecule
  • IL-13 and IL-4 carry out a number of functions and both regulate a number of functions related to the allergic phenotype, such as isotype class switching to IgE in B-cells, activation of mast cells and eosinophils, up-regulation of vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells, and production of chemokines such as eotaxins, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC). (allindianpatents.com)
  • The complex has approximate dimensions of 97Å×52 Å ×35 Å with one s-IL1R molecule wrapping around the IL-1β molecule with 1:1 ratio. (proteopedia.org)