Binds 1993 hsp70 heat shock proteins. Medical search. Frequent questions

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (broadinstitute.org)
HSPs (Heat shock proteins) are highly conserved ubiquitous proteins among species which are involved in maintaining appropriate folding and conformation of other proteins and are thus referred to as molecular chaperones. (biomedcentral.com)

Molecular chaperones are a diverse family of proteins that function to protect proteins from irreversible aggregation during synthesis and in times of cellular stress. (wikipedia.org)
Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate-bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle. (wikipedia.org)
Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. (encyclopedia.pub)
Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases. (encyclopedia.pub)
The Hsp70 family of molecular chaperones is ubiquitously expressed and particularly relevant in the early stages of nascent polypeptide folding [ 1 ] [ 2 ] . (encyclopedia.pub)
Hsp70 and Hsp90 chaperones are tightly regulated by co-chaperones. (encyclopedia.pub)
Hsp40/DNAJ proteins interact differently with Hsp70 chaperones [ 13 ] . (encyclopedia.pub)
DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. (elifesciences.org)
If there are too few chaperones in the cell, then newly-made proteins may fold incorrectly and interrupt other processes. (elifesciences.org)
On the other hand, if too many chaperones are present they may slow down the protein folding process. (elifesciences.org)
Hsp70 chaperones are one family of chaperone proteins. (elifesciences.org)
Heat-shock proteins of the 70 kDa family (Hsp70s) are essential chaperones required for key cellular functions. (biomedcentral.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
Hsp90 (Heat-shock protein 90 kDa) is one of a group of molecular chaperones responsible for managing protein folding and quality control in cell environment. (biomedcentral.com)
These co-chaperones bind and leave the complex at various stages to regulate the chaperoning process. (biomedcentral.com)

Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
59/99 for heat), and overall GWAS candidates were more likely to be differentially expressed than other genes. (frontiersin.org)
Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)
In the current study, genes encoding two related proteins, PnMas1 and PnMas3, were identified in the genome of P. parasitica . (springer.com)
It provides a very informative, albeit preliminary, glimpse into the expression of genes encoding functionally relevant proteins as potential targets for chemotherapy, and evidence for the presence of a relict plastid. (biomedcentral.com)
Eleven putative hsp70 genes could be detected in P. caudatum comprising homologs of three major Hsp70-subfamilies. (biomedcentral.com)
All other groups showed comparatively high basal expression levels and moderate heat-inducibility, signifying constitutively expressed genes. (biomedcentral.com)
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. (harvard.edu)
The hsp70 , dnaJb4 , and bag3 genes were among the highest upregulated genes and were predicted to interact in an HSP70 chaperone system. (biomedcentral.com)
The upregulation of HSP70 chaperone genes was verified and their expression confirmed in BS vasculature cells previously identified as stem and progenitor cells. (biomedcentral.com)
The chaperone system genes hsp70 , dnaJb4 , and bag3 are significantly upregulated in the branchial sac vasculature following distal injury, defining a stress response that is essential for regeneration. (biomedcentral.com)
Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)

In contrast, DnaJ has been shown to bind both L- and D-peptides and is assumed to interact only with the side chains of the substrate. (wikipedia.org)
Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found. (wikipedia.org)
They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)

HSPs, which ameliorate oxidative stress, calpains, which help in regulating synaptic plasticity, and calmodulin-like skin protein (CLSP) with its neuroprotective role are few promising future targets for developing anti-AD therapies. (benthamscience.com)
The most significantly upregulated process was the response to heat stress (mainly heat shock proteins, HSPs). (frontiersin.org)
The plants pre-treated with diethyl ether, and thus with induced HSPs, had increased tolerance of photosystem II to subsequent heat stress through the process known as cross-tolerance or priming. (frontiersin.org)
Heat shock proteins (HSPs) play a role in tumor antigenicity. (biomedcentral.com)
Another approach in predicting prognosis in cancer is expression of heat shock proteins (HSPs). (biomedcentral.com)
Usually, HSPs are expressed at low levels, and under normal physiological conditions, many members of the HSP family are involved in protein synthesis. (biomedcentral.com)
Because they were first described in Drosophila melanogaster larvae that were accidentally exposed to elevated temperatures [ 2 ], these stress-related proteins were called heat-shock proteins (Hsps). (biomedcentral.com)
Extensive research on Hsps revealed also a constitutive expression of some members of these proteins, suggesting that they are also essential in maintaining the cellular functions under normal physiological conditions. (biomedcentral.com)
Some of the most important and well investigated Hsps are the members of the 70 kDa heat-shock protein family (Hsp70s). (biomedcentral.com)

Therefore, we have characterised the Hsp70 gene family of Paramecium caudatum to gain insight into the evolution and differential heat stress response of the distinct family members in protists and to investigate the diversification of eukaryotic hsp70 s focusing on the evolution of heat-inducibility. (biomedcentral.com)
This result indicates convergent evolution during hsp70 subfunctionalization and implies that heat-inducibility evolved several times during the course of eukaryotic evolution. (biomedcentral.com)
Prokaryotic Hsp70 (DnaK) proteins share about 50% amino acid identity with eukaryotic Hsp70s. (biomedcentral.com)
It is one of the most abundant proteins in the eukaryotic cells comprising 1-2% of total proteins under non-stress conditions [ 3 ]. (biomedcentral.com)

The co-opted host proteins likely affect several steps in viral RNA replication, including the assembly of the replicase complex and/or viral RNA synthesis. (prolekarniky.cz)
Insect hormones such as ecdysteroids and juvenoids play a key role in accessory gland development and protein synthesis but little is known about underlying molecular players and their mechanism of action. (sdbonline.org)
5 Since changes in de novo protein synthesis are the basis for glucocorticoid effectiveness, the lack of a modulatory effect on platelet functions is not surprising given that these cells have been regarded as incapable of synthetic activity. (ashpublications.org)
The environmental stress response in all organisms as diverse as pro- and eukaryotes is generally coupled with a remarkable change in gene expression patterns and an enhanced synthesis of several 'stress proteins' [ 1 ]. (biomedcentral.com)
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. (neurotree.org)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)

The bacterial molecular chaperone DnaK is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolyzing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. (wikipedia.org)
Thus, DnaK and DnaJ may bind to one and the same polypeptide chain to form a ternary complex. (wikipedia.org)

Among the identified host proteins are RNA-binding proteins, such as translation factors, ribosomal proteins and RNA-modifying enzymes [1] . (prolekarniky.cz)
Some sequences are similar to those proven to be targets for effective intervention in other protozoan parasites, and include not only proteases, antioxidant enzymes, and heat shock proteins, but also those associated with relict plastids, such as acetyl-CoA carboxylase and methyl erythrithol phosphate pathway components, and those involved in glycan assembly, protein folding/secretion, and parasite-host interactions. (biomedcentral.com)
These ions also act as cofactors or structural components of proteins or enzymes that regulate several physiological processes such as mitochondrial respiration, energy metabolism, and antioxidants [ 3 , 4 ]. (ijbs.com)
Furthermore, the transcriptional responses of B5 at different temperature by using rice straw as sole carbon sources were also analyzed, based on which the mechanism of lignocellulose degradation at high temperature was revealed that B5 could resist the heat by up-regulating the heat shock proteins (HSP) and then secrete various Carbohydrate-Active enzymes (CAZymes) to realize energy balance. (researchsquare.com)

This study aimed to investigate the expression and prognostic significance of highly stress-inducible HSP70 in OSCC. (biomedcentral.com)
These treatments induced exceptionally high mRNA up-regulations in one cytosolic group with a low basal expression, indicative for the major heat inducible hsp70 s. (biomedcentral.com)
Our analyses suggest an independent evolution of the heat-inducible cytosol-type hsp70 s in Paramecium and in its close relative Tetrahymena , as well as within higher eukaryotes. (biomedcentral.com)
Using a heat shock inducible transgene that remains silent unless activated, we have established a stable line of transgenic Xenopus (strain N1 ) in which the BMP inhibitor Noggin can be over-expressed at any time during development. (biomedcentral.com)
We have developed a heat shock inducible transgenic line ( N1 ) of Xenopus in which the BMP antagonist Noggin can be induced at a specific time during either development or regeneration, repressing BMP signalling [ 10 , 12 ]. (biomedcentral.com)

A constitutively expressed subfamily of the HSP70 heat-shock proteins. (lookformedical.com)

P59 [also known as FK506 binding protein 59 (FKBP59) or heat shock protein 56 (hsp56)] and heat shock proteins 90 and 70 (hsp90 and hsp70) associate with steroid receptors and are believed to maintain the receptors in an inactive state. (broadinstitute.org)
A FKBP59 homologue complexed with hsp90-hsp70 was also detected in yeast, which suggests that the immunophilin-heat shock protein association has been evolutionarily conserved. (broadinstitute.org)
Hop (Hsp-organizing protein) promotes the transfer of the substrate from the Hsp70 machinery to Hsp90. (encyclopedia.pub)
Hsp90 coexists in several conformations, from an extended, apo conformation [ 6 ] to a closed, nucleotide bound conformation, where the nucleotide-binding domains (NTD) would rotate to promote ATP hydrolysis [ 7 ] . (encyclopedia.pub)
Phosphorylation of Hsp70 and Hsp90 C-terminal tails dictate the binding of CHIP, promoting substrate degradation [ 10 ] . (encyclopedia.pub)
Results from the molecular dynamics simulations in water show that the trajectories of the protein complexed with ligand WA are stable over a considerably long time period of 4 ns, with the energies of the complex being lowered in comparison to the un-docked association complex, suggesting the thermodynamic stability of WA complexed Hsp90/Cdc37. (biomedcentral.com)
The large value of binding energy involved in binding of WA to the active Hsp90/Cdc37 complex consolidates the thermodynamic stability of the binding. (biomedcentral.com)

Cells carefully regulate the levels of chaperone proteins. (elifesciences.org)

Human Hsp70 presents a variety of highly identical isoforms that coexist in cellular compartments, yet show functional specificity [ 3 ] . (encyclopedia.pub)
After translation of their mRNA-sense genomic RNA(s), the viral RNA and the viral replication proteins are recruited to the site of viral replication in membranous compartments. (prolekarniky.cz)
Immunocytochemistry and GFP-tagging document the occurrence of all three PnMas proteins within the specialised compartments of the ER during mastigoneme formation, but only PnMas1 and PnMas2 occur in mature mastigonemes on the flagellar surface. (springer.com)
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments. (umassmed.edu)

In molecular biology, chaperone DnaJ, also known as Hsp40 (heat shock protein 40 kDa), is a molecular chaperone protein. (wikipedia.org)
It is hoped that the pathogenic correlation of spirochaetal virulence to temperature and heat shock proteins (HSP) might encourage a new direction of research in molecular epidemiology. (biomedcentral.com)
Anti-PnMas1 and anti-PnMas2 antibodies co-labelled two high-molecular-weight (~400 kDa) protein complexes in native gels but anti-PnMas3 antibodies labelled a 65 kDa protein complex. (springer.com)
Several studies have identified oxidative stress, glutamate excitotoxicity, apoptosis, neurofilament dysfunction, protein misfolding and aggregation, impairment of RNA processing, disrupted axonal transport, endosomal trafficking dysfunction, inflammation, and mitochondrial impairment as the molecular pathways which lead to the disease and indicate ALS pathogenesis. (encyclopedia.pub)
Due to this high conservation, Hsp70 has been widely used as a suitable phylogenetic marker in molecular evolution. (biomedcentral.com)
However, there are disadvantages: clinical evidence for efficacy is often weak, absorption may be poor due to low lipophilicity, high molecular weight and binding to other ingredients, and prices can be quite high. (bvsalud.org)

Here, we reviewed the physiological/pathological roles and therapeutic significance of nearly all the proteins associated with AD that addresses putative as well as probable targets for developing effective anti-AD therapies. (benthamscience.com)
To separate the role of Ded1p in viral protein translation from its putative replication function, we utilized a cell-free TBSV replication assay and recombinant Ded1p. (prolekarniky.cz)

Sequences that Confer Response to a Particular Stimulus Consensus Sequences CTNGAATNTT CTAGA Response to Heat Protein Factor Heat-shock transcription Gene Containing Sequences hsp70, hsp83, has a ring of glutamates near the inner entryway of the channel (Brelidze et al. (forextipsnow.com)
Phylogenetic analyses revealed five evolutionarily distinct Hsp70-groups, each with a closer relationship to orthologous sequences of Paramecium tetraurelia than to another P. caudatum Hsp70-group. (biomedcentral.com)
Use of synthetic signal sequences to explore the protein export machinery. (umassmed.edu)

This family of proteins contain a 70 amino acid consensus sequence known as the J domain. (wikipedia.org)
Proteins are composed of long chains of amino acids that fold on themselves to form three-dimensional structures. (elifesciences.org)
The C9 binding domain of Ts -Pmy was identified within 14 amino acid residues at the C-terminus of Ts -Pmy. (biomedcentral.com)

In 1993, the first causative gene ( SOD1 ) of fALS was identified. (encyclopedia.pub)
Information about the hsp70 copy number and diversity in microbial eukaryotes is, however, scarce, and detailed knowledge about the differential gene expression in most protists is lacking. (biomedcentral.com)
Comparative EST analyses for P. tetraurelia hsp70 s unveiled a corresponding expression pattern, which supports a functionally conserved evolution of the Hsp70 gene family in Paramecium . (biomedcentral.com)
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. (neurotree.org)
siRNA-mediated gene knockdown showed that hsp70 and dnaJb4, but not bag3, are required for progenitor cell targeting and distal regeneration. (biomedcentral.com)

Hsp40 regulates the substrate folding and ATP hydrolysis by Hsp70 (Hsp40 J domain is included in PDB 5nro in the blue ribbon representation). (encyclopedia.pub)

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis / trans isomerisation of a prolyl bond. (biomedcentral.com)
The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is traditionally comprised of three distinct protein families, the cyclophilins (cyclosporin A binding proteins), FKBPs (FK506 binding proteins) and parvulins, that are linked by their shared ability to catalyse the bond preceding a proline residue between its cis and trans forms. (biomedcentral.com)

In addition, we found that the FKBP59-hsp complexes are more complicated than previously thought, involving other proteins such as actin and a 63-kDa protein, p63. (broadinstitute.org)
After the assembly of the membrane-bound viral replicase complexes (VRC), the viral replicase uses the viral RNA as a template to produce complementary (−)RNA. (prolekarniky.cz)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)

Interestingly, these variable regions determine the differential effects of Hsp70 isoforms on the aggregation or degradation of the Alzheimer's-disease-related protein tau [ 16 ] . (encyclopedia.pub)
Abnormal accumulation of the protein α-synuclein and its aggregation into oligomers and fibril-containing inclusions, termed Lewy bodies, are also defining features. (biomedcentral.com)

The J domain of DnaJ interacts with Hsp70 heat shock proteins. (wikipedia.org)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

DnaJ heat-shock proteins play a role in regulating the ATPase activity of Hsp70 heat-shock proteins. (wikipedia.org)

They belong to the highest conserved proteins and are present in almost all species, except for some archaea. (biomedcentral.com)

A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)

Recently, we showed that p59 purified from human lymphocytes is an immunophilin (FKBP59) which binds both FK506 and rapamycin. (broadinstitute.org)
Here we provide evidence that rabbit uterine p59 also binds FK506 and rapamycin and that p59 or its homologue is associated with nontransformed progesterone receptors of rabbit uterus and chicken oviduct. (broadinstitute.org)

Lumenal ER calcium depletion caused rapid oligomerization of mammalian BiP and a coincidental diminution in substrate binding, pointing to the relative inertness of the oligomers. (elifesciences.org)

This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)

Disturbed expression of these proteins results in synaptic dysfunction, cognitive impairment, memory loss, and neuronal degradation. (benthamscience.com)
And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)

Hsp70 undergoes large allosteric changes upon ATP hydrolysis and substrate binding, from an extended, ADP-bound conformation with the substrate-binding domain (SBD) closed by the lid (PDB code 2kho) [ 4 ] to a collapsed, ATP-bound conformation with the SBD opened, favoring substrate release (PDB code 5nro) [ 5 ] . (encyclopedia.pub)
These were found to consist of adjacent protomers engaging the interdomain linker of one molecule in the substrate binding site of another, attenuating the chaperone function of oligomeric BiP. (elifesciences.org)

We found a previously undescribed motor phenotype in transgenic α-synuclein C. elegans that correlates with mutant or wild-type α-synuclein protein levels and results from dopaminergic neuron dysfunction, but precedes neuronal loss. (biomedcentral.com)

The presence of an additional Hsp70-binding site, which is not present in the class A Hsp40s, releases the Gly-Phe inhibition upon binding to the C-terminal IEEVD tail of Hsp70 [ 13 ] . (encyclopedia.pub)
Thus specific inhibition of individual proteins or signalling pathways holds a great potential for subversion of this genetic plasticity of cancers. (biomedcentral.com)

An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)

Multiple lines of evidence support the idea that Pol II and nucleosomes compete for promoter binding and suggest that a crucial role of paused Pol II involves maintenance of accessible promoter chromatin architecture. (nature.com)
However it is also involved in the maturation and stabilization of a wide range of oncogenic client proteins which are crucial for oncogenesis and malignant progression. (biomedcentral.com)

Many proteins are made in a compartment within the cell called the endoplasmic reticulum and 'chaperone' proteins help them fold correctly. (elifesciences.org)
This leads to an increase in the number of unfolded proteins in the endoplasmic reticulum and so the cell increases the levels of chaperone proteins to cope with this. (elifesciences.org)
These proteins can be present in a cell as single molecules (monomers) or as a group of several chaperone molecules (oligomers). (elifesciences.org)
Previous research has suggested that the chaperone proteins in oligomers are inactive, but the oligomers may be rapidly broken down into monomers when the cell needs to fold more proteins. (elifesciences.org)
A region within the Hsp70 called the 'interdomain linker' is important for regulating the chaperone activity, but it is not clear if this is connected to the formation of oligomers. (elifesciences.org)

Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)

This suggests that the immunophilin-heat shock protein-steroid receptor interaction is ubiquitous and not limited to immune systems. (broadinstitute.org)

All these data indicate that diethyl ether anesthesia may partially mimic heat stress in plants through the effect on plasma membrane. (frontiersin.org)
Specifically, populations from higher latitudes often are more tolerant of low temperatures than populations from lower latitudes, and the same pattern is also seen for heat stress, where populations that extend to lower latitudes often have improved survival at high temperatures (e.g. (frontiersin.org)
Cuproptosis causes proteotoxic stress and ultimately results in cell death by the binding of Cu ions to lipid-acylated proteins during the tricarboxylic acid cycle of mitochondrial respiration. (ijbs.com)
However, neither hsp70 nor dnaJb4 were strongly expressed in the branchial sac vasculature of distal fragments, implying the absence of a stress response. (biomedcentral.com)
Heat shock treatment of distal body fragments activated hsp70 and dnaJb4 expression indicative of a stress response, induced cell proliferation in branchial sac vasculature cells, and promoted distal regeneration. (biomedcentral.com)
The stress response is absent from distal fragments, but can be induced by a heat shock, which activates cell division in the branchial sac vasculature and promotes distal regeneration. (biomedcentral.com)

Theoretically, the possibilities include (1) a primary T-cell mediated autoimmune response causing muscle damage, (2) a primary degenerative process involving abnormal protein processing leading to a secondary inflammatory response, and (3) separate and independent immune and degenerative processes caused by an external trigger. (medscape.com)
The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)

A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)

The apparently anomalous binding data were clarified by the fact that washed platelets (1) contained mineralocorticoid receptor and that (2) it was associated with GR. Taken together, our data suggest that platelet GR forms a heterodimeric complex with the mineralocorticoid receptor that is susceptible to differential activation by specific receptor ligands. (ashpublications.org)

Natural and synthetic glucocorticoids bind to GR, producing major conformational changes that result in nuclear translocation or transrepression of transcription factors, including nuclear factor κB. (ashpublications.org)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Mandon EC, Trueman SF, Gilmore R. Protein translocation across the rough endoplasmic reticulum. (umassmed.edu)
Trueman SF, Mandon EC, Gilmore R. Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. (umassmed.edu)
Jiang Y, Cheng Z, Mandon EC, Gilmore R. An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. (umassmed.edu)

Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. (neurotree.org)

On the protein level, out of 5,150 proteins identified, 393 were significantly upregulated and 227 were significantly downregulated. (frontiersin.org)

The last few decades were concentrated over identifying and studying protein targets of AD. (benthamscience.com)
The production of a monoclonal antibody that specifically targets the C9 binding site is necessary for further studies of Ts -Pmy function and may be used as a therapeutic agent for T. spiralis infection. (biomedcentral.com)

used biochemical techniques to study how an Hsp70 protein in the endoplasmic reticulum called BiP forms oligomers. (elifesciences.org)

A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)

Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)

Recent work in our laboratory suggested that pleasant human contact may alter ability to tolerate various stressors through enhanced heat shock protein (hsp) 70 expression. (biomedcentral.com)
Light microscopy and analysis 3.1 ® (Soft Imaging System, Münster, Germany), an image processing and analysis program, were used for evaluating HSP70 expression. (biomedcentral.com)
Positive immunoreactivity of tumor cells could be detected in 17 of 28 patients with T2 tumors (60.7%) Prognostic significance of HSP70 expression in tumor cells was detected in patients with T2 tumors (p = 0.009). (biomedcentral.com)
The survival of patients suffering from T2 tumors with positive HSP70 expression was 8 times higher than that for patients with negative HSP70 expression, suggesting that T1-T2 tumors of OSCC with low expression of HSP70 require more radical treatment. (biomedcentral.com)
By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)

Further experiments challenged cells with chemicals that caused the number of unfolded proteins in the cells to increase. (elifesciences.org)

RNA metabolism and protein metabolism have been indicated as commonly proposed ALS pathogenic mechanisms [ 11 ] . (encyclopedia.pub)

Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)

Proteins in this family consist of three domains. (wikipedia.org)
A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size. (lookformedical.com)
A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
Trichinella spiralis expresses paramyosin ( Ts -Pmy) not only as a structural protein but also as an immunomodulator that inhibits host complement as a survival strategy. (biomedcentral.com)

Anatomy19

Organisms19

Diseases11

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes67

Disciplines and Occupations2

Information Science4

Health Care4

Highly conserved2

Chaperones15

Genes12

Peptides3

HSPs9

Eukaryotic4

Synthesis7

DnaK2

Enzymes4

Inducible5

Constitutively expressed1

Hsp907

Regulate1

Compartments6

Molecular6

Putative2

Sequences3

Amino3

Gene6

Hsp401

Class of proteins3

Complexes3

Aggregation2

Interacts2

DnaJ1

Archaea1

Functional1

FK5062

Mammalian1

Ribosomal1

Degradation2

Substrate2

Transgenic1

Inhibition2

Adaptor protein3

Crucial2

Chaperone5

Tightly1

Ubiquitous1

Stress6

Processes2

MRNA1

Differential1

Translocation5

Drosophila2

Significantly1

Targets2

Biochemical1

Cofactors1

Dysfunction1

Expression5

Chemicals1

Metabolism1

Pathway1

Family4

Structural2