Loading...
  • apoptosis
  • Our previous work (5) and other studies (4) suggest that RASSF1A may indeed have multiple functions, which affect tumorigenesis ranging from inhibiting cell cycle progression to influencing other important variables of tumorigenesis, including cell adhesion, cell migration, angiogenesis, transcription, and apoptosis. (aacrjournals.org)
  • Most prominently, factors reported to be engaged in early stages of acute viral infection were affected, e.g. entry, integration and provirus transcription and other cellular responses such as apoptosis and proliferation were modulated. (biomedcentral.com)
  • histone
  • In a previous study, we provided the first in vivo evidence that a specific fragment of ER-α promoter is bound by pRb2/p130-E2F4/5-histone deacetylase 1 (HDAC1)-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNA methyltransferase 1 (DNMT1) complexes in ER-α-positive and ER-α-negative breast cancer cells, respectively ( 14 ). (aacrjournals.org)
  • p130
  • Here, we showed that the presence of a specific pRb2/p130 multimolecular complex on the ER-α promoter strongly correlates with the methylation status of this gene. (aacrjournals.org)
  • viral
  • There have, however, been many reports of difficulties in establishing functioning stable cell lines due to the cytotoxic effects of expressing high levels of the tetracycline transactivator, tTA, from a strong viral promoter. (biomedcentral.com)
  • pathway
  • For example, factors of the Ikaros family specifically favor differentiation down the lymphoid pathway ( 3 ), whereas other factors, such as GATA-1 and C/EBPα, favor differentiation down the myeloid pathway ( 4 , 5 ). (jimmunol.org)
  • Smads were first discovered in Drosophila, in which they are known as mothers against dpp (Mad), through a genetic screen for dominant enhancers of decapentaplegic (dpp), the Drosophila version of TGF-B. Studies found that Mad null mutants showed similar phenotypes to dpp mutants, suggesting that Mad played an important role in some aspect of the dpp signaling pathway. (wikipedia.org)
  • In particular, we show that FLP represses the expression of the mitosis-inducing factor CDKB1;1 , which, along with CDKB1;2 , is specifically required both for the last division in the stomatal pathway and for cell overproliferation in flp mutants. (plantcell.org)
  • whereas
  • Overexpression of E2F4 promotes terminal differentiation of cells in vitro ( 16 ), whereas E2F4-deficient animals show reduced neonatal viability, with very few animals surviving to adulthood ( 15 , 17 ). (jimmunol.org)
  • However, electrophoretic mobility shift assays indicate that knockdown of endogenous RASSF1A in HB2 and HeLa cells leads to a reduction in the binding capacity of p120 E4F to the cyclin A2 promoter, whereas in the A549 clone stably expressing RASSF1A the binding capacity is increased. (aacrjournals.org)
  • contrast
  • In contrast to cells produced using the CMV and PGK promoters, those produced using the EF1α and TRE promoters expressed high levels of β-galactosidase in a tetracycline-dependent manner. (biomedcentral.com)
  • modulate
  • FLP recognizes a distinct cis -regulatory element that overlaps with that of the cell cycle activator E2F-DP in the CDKB1;1 promoter, suggesting that these MYBs may also modulate E2F-DP pathways. (plantcell.org)
  • found
  • We analyzed the impact of E2F4 deficiency on early steps in mouse hematopoietic development, and found defects in early hematopoietic progenitor cells that were propagated through common lymphoid precursors to the B and T lineages. (jimmunol.org)
  • We found a highly significant enrichment for several transcription factor binding sites (TFBS) leading to the prediction that corresponding transcription factors, such as Sp1, Tcfap2, E2f, Myc and Egr, are regulated by Rage signaling. (beds.ac.uk)
  • nucleus
  • R/Co-Smads are primarily located in the cytoplasm, but accumulate in the nucleus following TGF-B signaling, where they can bind to DNA and regulate transcription. (wikipedia.org)
  • genetic
  • The pathogenesis of breast cancer is poorly understood, but epidemiologic, molecular, and clinical genetic studies have implicated factors and defined molecular markers that are associated with an increased risk of developing breast cancer ( 15 , 16 ). (aacrjournals.org)
  • The MS etiology is still complex and mostly unclear, with genetic and environmental factors possibly influencing the susceptibility and/or the outcomes of the disease. (pubmedcentralcanada.ca)
  • molecular
  • Consistently, at the molecular level, activation of growth factor signaling pathways by EGFR / ERBB / AKT and a switch from phospho-Ser118 (pS118)- to pS167-ER α were observed during MCF7-LTED adaptation. (nature.com)
  • unclear
  • It is still unclear how environmental signals ( 1 ) and lineage-specific transcription factors work together to control the frequency with which dividing HSC either undergo self-renewal or commit to one or the other lineage. (jimmunol.org)
  • complex
  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. (cancerindex.org)
  • several
  • It is one of several major transcripts that are produced by alternative promoter selection and alternative messenger (mRNA) splicing. (aacrjournals.org)
  • Several variables associated with latitude, e.g., the daily vitamin D intake, have been investigated as possible influencing factors [ 1 ]. (pubmedcentralcanada.ca)
  • signaling pathway
  • Smads were first discovered in Drosophila, in which they are known as mothers against dpp (Mad), through a genetic screen for dominant enhancers of decapentaplegic (dpp), the Drosophila version of TGF-B. Studies found that Mad null mutants showed similar phenotypes to dpp mutants, suggesting that Mad played an important role in some aspect of the dpp signaling pathway. (wikipedia.org)
  • Enhancer
  • We are striving to understand how enhancers are activated in response to developmental stimuli, how they communicate with target promoters, what is the dynamics of this process in living cells, and what is the role of chromatin context in priming or restricting enhancer activity. (stanford.edu)
  • sequences
  • Central to the cell type-specific transcriptional regulation are distal cis-regulatory elements called enhancers, canonically defined as short noncoding DNA sequences that act to drive transcription independent of their relative distance, location or orientation to their cognate promoter. (stanford.edu)
  • Many studies have focused on the mechanisms of how TFs respond to specific signals, bind specific DNA sequences and recruit molecular machines on a right base pair where transcription should start. (bmbreports.org)
  • pathways
  • These instant metabolic changes bypass the signaling pathways which are required for activating the TFs, but instead, they just alter the catalytic activities of the JMJDs, which are already assigned to specific histones through their interactions with the DNA-binding TFs. (bmbreports.org)
  • regulation
  • Appears to have a similar effect on MLLT7/ FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). (rcsb.org)
  • family
  • However, the generalization that only the Rho family of small GTPases induce cytoskeletal rearrangement may be simplistic, as the Ras subfamily GTPase Ral has been reported to act downstream of Cdc42 in the formation of filopodia by binding to the actin filament cross-linking protein filamin ( 5 ). (jimmunol.org)
  • Activation
  • Overexpression of DOCK 180 induces activation of Rac, and DOCK 180 binds to Rac1, but not RhoA or Cdc42 ( 15 ). (jimmunol.org)
  • activity
  • GO annotations related to this gene include carbohydrate binding and low-density lipoprotein receptor activity . (genecards.org)
  • GO annotations related to this gene include nucleotide binding and ligase activity, forming aminoacyl-tRNA and related compounds . (genecards.org)
  • HUMAN
  • We integrated six PPI data (BIND, DIP, MINT, HPRD, IntAct, and GNP_Y2H), and predicted human protein complexes by finding densely connected regions in the PPI networks. (biomedcentral.com)
  • cell
  • In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. (genecards.org)
  • Deacetylates 'Lys-382' of p53/ TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491). (rcsb.org)
  • adhesion
  • p130Cas and HEF1 are a structurally related pair of such docking molecules that localize to the focal adhesion complex, assembling members of adhesion and growth factor-related signaling cascades ( 10 , 11 ). (jimmunol.org)
  • release
  • The ratio of GTPases in these two conformations is regulated by GDP exchange factors (GEFs), enzymes that catalyze release of GDP, allowing the more abundant intracellular GTP to bind and activate the GTPase. (jimmunol.org)