Component of surfactantLung surfactantMannose-bindinLipidsProtein A AntibodyDefense against respiratory pathogensPulmonary surfactantInnate immunityAlveolarPathogensLectinsHomeostasisMicroorganismsSerumRespiratoryAntimicrobialAntibodiesLungsBacteriaCollagenousExtracellularIntracellularRoleFamilyStructuralInfectionsHumanCellsTargetFoundAbilitySurfaceFunctionStructureDiseasePlasma
Component of surfactant2
- The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. (wikipedia.org)
- 4 SP-D is most commonly identified as a component of surfactant in the lungs, but it is not exclusive to the lungs and is significantly expressed in non-pulmonary tissues, such as skin, eye, ear, nasal compartment, epithelia of the urinary, glandular, circulatory system, gastrointestinal and reproductive tracts. (org.pk)
Lung surfactant3
- SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. (lsbio.com)
- SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. (labome.cn)
- It is also the only surface active component of lung surfactant capable of lowering surface tension to near zero levels. (absoluteastronomy.com)
Mannose-bindin7
- [ 5 ] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)
- Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)
- We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. (cdc.gov)
- We focused on 8 single-nucleotide polymorphisms (SNPs) in 2 candidate genes important in the innate immune response to influenza infection and for which national prevalence estimates were available: the gene for tumor necrosis factor superfamily, member 2 (official symbol TNF ) and the mannose-binding lectin gene (official symbol MBL2 ). (cdc.gov)
- Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. (springeropen.com)
- Mannose binding lectin gene 2 ( MBL2 ) polymorphisms are reported to be associated with various diseases. (springeropen.com)
- Mannose binding lectin (MBL) is a liver derived acute phase protein. (springeropen.com)
Lipids4
- The protein encoded by this gene (SP-A2) is primarily synthesized in lung alveolar type II cells, as part of a complex of lipids and proteins known as pulmonary surfactant. (wikipedia.org)
- The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. (lsbio.com)
- In preterm infants, surfactant replacement therapies that include lipids and the hydrophobic surfactant proteins are highly efficacious in improving lung function. (fz-borstel.de)
- SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. (labome.cn)
Protein A Antibody1
- Surfactant Protein A antibody LS-C699595 is a Cy3-conjugated rabbit polyclonal antibody to Surfactant Protein A (SFTPA1) (aa21-248) from mouse. (lsbio.com)
Defense against respiratory pathogens2
- SP-A2 binds to the carbohydrates found in the surface of several microorganisms and helps in the defense against respiratory pathogens. (wikipedia.org)
- This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. (lsbio.com)
Pulmonary surfactant4
- Surfactant protein A2 (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2) is a protein that in humans is encoded by the SFTPA2 gene. (wikipedia.org)
- Together with (surfactant protein A1 ) SP-A1, they are the most abundant proteins of pulmonary surfactant. (wikipedia.org)
- An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. (nih.gov)
- Dipalmitoylphosphatidylcholine is a phospholipid consisting of two palmitic acids and is the major constituent of pulmonary surfactant. (absoluteastronomy.com)
Innate immunity3
- Binding of pathogens, allergens, and other molecules Increasing phagocytosis and chemotaxis of alveolar macrophages Induction of proliferation of immune cells Stimulation of proinflammatory cytokine production Modulation of the generation of reactive oxygen species Serving as a hormone in parturition Maintaining the structure of tubular myelin (an extracellular form of surfactant) The role of SFTPA2 in innate immunity has been extensively studied. (wikipedia.org)
- Surfactants and MBL play an important role in innate immunity. (medscape.com)
- Hemagglutinin with reduced glycan occupancy required a higher concentration of surfactant protein D (an important innate immunity respiratory tract collectin) for inhibition compared to that with normal glycan occupancy. (cdc.gov)
Alveolar1
- Using specific monoclonal antibodies for Surfactant protein A, the protein can be detected in lung alveolar type II pneumocytes, Club cells, and alveolar macrophages, but no extrapulmonary SP-A immunoreactivity was observed. (wikipedia.org)
Pathogens2
- SP-A-deficient mice have an enhanced susceptibility to infection to pulmonary infection with bacterial and fungal pathogens and collectin replacement in these animals corrects defects in dysregulated cellular functions and microbial clearance. (fz-borstel.de)
- It binds to carbohydrates on the surface of mannose-rich pathogens and mediates clearing by phagocytosis or complement activation (Nepomuceno et al. (springeropen.com)
Lectins3
- SP-A2 is a member of a subfamily of C-type lectins called collectins. (wikipedia.org)
- At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
- When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)
Homeostasis1
- Surfactant homeostasis is critical for breathing (and thus survival) in the prematurely born infant, but also for maintaining lung health, and normal lung function throughout life. (wikipedia.org)
Microorganisms2
- The C-terminal carbohydrate recognition domain (CRD) allows binding to various types of microorganisms and molecules. (wikipedia.org)
- Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. (labome.cn)
Serum7
- Extra pulmonary infections, body mass index and random blood glucose levels were noted and serum surfactant protein-D was analysed using enzynme-linked immunosorbent assay. (org.pk)
- Serum surfactant protein-D was found to have negative association with extra-pulmonary infections. (org.pk)
- Collectins are surfactant proteins that are present in serum, lung secretions, and mucosal surfaces. (brmi.online)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Surfactant Associated Protein D (SPD) in serum, plasma, lung lavage fluid and other biological fluids. (2sars.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Surfactant Associated Protein D (SPD) in samples from serum, plasma, lung lavage fluid and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
- Description: A sandwich ELISA kit for detection of Surfactant Associated Protein D from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Surfactant Associated Protein D (SPD) in samples from serum, plasma, tissue homogenates, cell lysates, lung lavage fluid, cell culture supernates or other biological fluids. (2sars.com)
Respiratory1
- Quantitative and/or qualitative alterations in surfactant composition and/or function are associated with respiratory diseases. (wikipedia.org)
Antimicrobial1
- It is currently discussed that adult and infant patients suffering from diseases associated with lung infection may benefit from the anti-inflammatory and antimicrobial properties of the pulmonary collectins. (fz-borstel.de)
Antibodies1
- These differences in HA ADCC antibodies were not reflected in differences in HA binding antibodies. (cdc.gov)
Lungs1
Bacteria1
- SP-A has the ability to bind and agglutinate bacteria, fungi, viruses, and other non-biological antigens. (wikipedia.org)
Collagenous1
- It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
Extracellular1
- Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Intracellular1
- The data on the role of lung collectins in immunomodulation are compelling, but the intracellular events by which they exert anti-inflammatory effects on activated immune cells are only partially understood. (fz-borstel.de)
Role2
- Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
- Out of these, 4 SNPs from 3′ UTR were found to play role in miRNA binding, 7 SNPs from 5′ near and intronic region were predicted to involve in transcription factor binding and expression of MBL2 gene. (springeropen.com)
Family2
Structural1
- Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke. (lsbio.com)
Infections2
Human1
- Deficiencies and inactivation of surfactant have been associated with a variety of human lung diseases in both infants and adults. (fz-borstel.de)
Cells5
- C3b and C4b bind to CR1, which is present on various phagocytes and also on erythrocytes and B cells. (medscape.com)
- CR2 binds C3dg, and C3d is present on B cells and dendritic cells (see the Table 1). (medscape.com)
- Evidence suggests that C1q binds a receptor present on phagocytic cells, termed C1qRP. (medscape.com)
- Our group is investigating the functions and mechanisms of immune cells that are involved in the specific ability of pulmonary collectins to carry out immunomodulations that are important for preventing infection and inflammation. (fz-borstel.de)
- Interferon(s), which include(s) a group of proteins that are produced by virally infected cells, can bind to noninfected cells and produce a generalized antiviral state. (brmi.online)
Target1
- Upon activation and cleavage of C3, C3b is formed as a major fragment that covalently binds to its target (see Table 1). (medscape.com)
Found1
- A negative association between random blood glucose and surfactant protein-D was found, but it was not significant (p=0.15). (org.pk)
Ability1
- Carbohydrate binding ability may have evolved independently and sporadically in numerous unrelated families, where each evolved a structure that was conserved to fulfil some other activity and function. (embl.de)
Surface2
- Surfactants are compounds that lower the surface tension of a liquid, the interfacial tension between two liquids, or that between a liquid and a solid. (absoluteastronomy.com)
- Higher selectivity of binding is achieved by extending binding sites through additional direct and water-mediated contacts between oligosaccharides and the protein surface. (embl.de)
Function1
- Many of these domains function as calcium-dependent carbohydrate binding modules. (embl.de)
Structure1
- There are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. (embl.de)
Disease1
- A better understanding of collectin-mediated lung immunity will contribute to the identification of disease states in which the therapeutic administration of pulmonary collectins may be beneficial. (fz-borstel.de)
Plasma1
- The constant management constitutively required to bind down the methylmalonic of aberrant plasma. (evakoch.com)