• Most E2F have a pocket protein binding domain. (wikipedia.org)
  • In repressors E2F4 and E2F5, pocket protein binding (more often p107 and p130 than pRB) mediates recruitment of repression complexes to silence target genes. (wikipedia.org)
  • E2F6, E2F7, and E2F8 do not have pocket protein binding sites and their mechanism for gene silencing is unclear. (wikipedia.org)
  • The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. (wikipedia.org)
  • E2F targets genes that encode proteins involved in DNA replication (for example DNA polymerase, thymidine kinase, dihydrofolate reductase and cdc6), and chromosomal replication (replication origin-binding protein HsOrc1 and MCM5). (wikipedia.org)
  • The activation of E2F-3a genes follows upon the growth factor stimulation and the subsequent phosphorylation of the E2F inhibitor retinoblastoma protein, pRB. (wikipedia.org)
  • amyloid beta precursor protein bind. (gsea-msigdb.org)
  • E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence. (wikipedia.org)
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
  • The E2F family is generally split by function into two groups: transcription activators and repressors. (wikipedia.org)
  • In activators, E2F binding with pRB has been shown to mask the transactivation domain responsible for transcription activation. (wikipedia.org)
  • When cells are not proliferating, E2F DNA binding sites contribute to transcriptional repression. (wikipedia.org)
  • In vivo footprinting experiments obtained on Cdc2 and B-myb promoters demonstrated E2F DNA binding site occupation during G0 and early G1, when E2F is in transcriptional repressive complexes with the pocket proteins. (wikipedia.org)
  • E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F. (wikipedia.org)
  • Pocket proteins such as pRB and related proteins p107 and p130, can bind to E2F when hypophosphorylated. (wikipedia.org)
  • This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
  • Long non-coding RNAs (lncRNAs) is an important member of non-coding RNAs (ncRNAs) comprising a transcription length of more than 200 nucleotides but not coding proteins [2,3]. (researchsquare.com)
  • In the absence of pRb, E2F1 (along with its binding partner DP1) mediates the trans-activation of E2F1 target genes that facilitate the G1/S transition and S-phase. (wikipedia.org)
  • When bound to E2F-3a, pRb can directly repress E2F-3a target genes by recruiting chromatin remodeling complexes and histone modifying activities (e.g. histone deacetylase, HDAC) to the promoter. (wikipedia.org)
  • Genes having at least one occurrence of the highly conserved motif M53 RYTGCNNRGNAAC in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb]. (gsea-msigdb.org)
  • LncRNA small nucleolar RNA host gene 16 (SNHG6), also known as U87HG, locates in human chromosome 8q13.1. (researchsquare.com)
  • Binding with DP1,2 provides a second DNA binding site, increasing E2F binding stability. (wikipedia.org)
  • This matches the MIF [GeneSymbol=MIF] transcription factor binding site V$MIF1_01 (v7.4 TRANSFAC). (gsea-msigdb.org)
  • In repressors E2F4 and E2F5, pocket protein binding (more often p107 and p130 than pRB) mediates recruitment of repression complexes to silence target genes. (wikipedia.org)
  • The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. (wikipedia.org)
  • While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ng/ml) or left without activation. (gsea-msigdb.org)
  • AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • It is related in sequence and structure to ACTIN and binds ATP. (nih.gov)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • Moreover, transcriptional variants resulted from alternative transcription start sites or alternative polyadenylation sites were found in Ras and genes encoding adhesion or cytoskeleton proteins such as integrin, β-catenin, α-catenin, and actin. (biomedcentral.com)
  • E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F. (wikipedia.org)
  • In the absence of pRb, E2F1 (along with its binding partner DP1) mediates the trans-activation of E2F1 target genes that facilitate the G1/S transition and S-phase. (wikipedia.org)
  • E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target promoter sequence. (wikipedia.org)
  • COLEC10 overexpression potentiated ER stress in HCC cells, as demonstrated by elevated expression levels of phosphorylated protein kinase RNA-like ER kinase, phosphorylated inositol-requiring protein 1α, activating transcription factor 4, DNA damage-inducible transcript 3, and X-box-binding protein 1s. (bvsalud.org)
  • Specifically, E2F5 is only expressed in terminally differentiated cells in mice. (wikipedia.org)