• Paucity of local protein-protein contacts suggests that cooperative occupancy of the enhancer comes from both binding-induced changes in DNA conformation and interactions with additional components such as CBP. (rcsb.org)
  • Conclusions Our results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription. (elsevierpure.com)
  • Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. (nih.gov)
  • A murine cDNA which encodes an ICS binding protein has been reported (M-ICSBP). (johnshopkins.edu)
  • This study finds that in Multiple Myeloma (MM), AATF/Che-1 (Che-1), an RNA-binding protein fundamental to transcription regulation, interacts with paraspeckles via the lncRNA NEAT1_2 (NEAT1) and directly localizes on R-loops. (uni-koeln.de)
  • These extracellular vesicles were loaded with mRNA encoding interferon-gamma, an immune signaling protein. (mdanderson.org)
  • GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. (thermofisher.com)
  • Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients. (acs.org)
  • A multiple sclerosis drug that slows progression of the disease reduces the binding of a protein, a peptide and a mineral to patients' red blood cells, thereby lessening nerve damage. (acs.org)
  • Saphnelo, a human monoclonal antibody, is a type 1 interferon (INF) receptor antagonist that inhibits a key protein in the immune system called the IFNAR receptor. (lupus.org)
  • This protein acts like a transmitter, amplifying signals from tiny messengers called type I interferons. (lupus.org)
  • Saphnelo binds to the main receptor (a protein called the IFNAR receptor) that transmits the signals from type I interferons throughout the body. (lupus.org)
  • The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (origene.com)
  • So, the spike protein binds to the ACE2 receptor once it's produced by the human cell … but it's a modified version of the spike protein. (fromthetrenchesworldreport.com)
  • Finally, NSP8 and NSP9 bind to the 7SL RNA in the Signal Recognition Particle and interfere with protein trafficking to the cell membrane upon infection. (cdc.gov)
  • These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. (rcsb.org)
  • Association of eight proteins with the enhancer creates a continuous surface for recognizing a composite DNA-binding element. (rcsb.org)
  • Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. (nih.gov)
  • S100P is a member of large family of multifunctional Ca2+-binding proteins with cytokine-like activities. (usf.edu)
  • Among the thirteen S100 proteins studied S100A1, S100A4, and S100A6 proteins exhibit strictly Ca2+-dependent binding to IFN-β with equilibrium dissociation constants, Kd, of 0.04-1.5 µM for their Ca2+-bound homodimeric forms. (usf.edu)
  • Interferon-α is unable of binding to the S100 proteins studied. (usf.edu)
  • The promoter regions of many interferon-inducible genes share a short DNA sequence motif, termed the interferon consensus sequence (ICS) to which several regulatory proteins bind. (johnshopkins.edu)
  • Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses , parasites and tumor cells. (wikidoc.org)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)
  • It binds on the DNA, exerting an effect on DNA to regulate the synthesis of proteins regulated by DNA. (cdc.gov)
  • The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
  • ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. (nih.gov)
  • In order to directly target a generally conserved feature, elevated trimethyl-lysine 27 on histone H3 (H3K27me3), we developed the Polycomb-based Transcription Factor (PcTF), a fusion activator that targets methyl-histone marks via its N-terminal H3K27me3-binding motif, and co-regulates sets of silenced genes. (elsevierpure.com)
  • These genes are associated with the interferon response pathway. (elsevierpure.com)
  • Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. (lu.se)
  • All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. (wikipedia.org)
  • Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. (pasteur.fr)
  • Further, we found that the cytokine interferon-β (IFN-β) can induce miR-1 expression in mammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges. (elifesciences.org)
  • Interferon-β (IFN-β) is a pleiotropic cytokine used for therapy of multiple sclerosis, which is also effective in suppression of viral and bacterial infections and cancer. (usf.edu)
  • The gene that codes for this cytokine is switched on in an infected cell, and the interferon synthesized and secreted to surrounding cells. (wikidoc.org)
  • This gene encodes a soluble cytokine that is a member of the type II interferon class. (origene.com)
  • Interferons bind to interferon receptors. (wikipedia.org)
  • It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2 (PGE2). (wikipedia.org)
  • When the vesicles bind to receptors on tumor cells, they are internalized and release the mRNA. (mdanderson.org)
  • These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. (embl.de)
  • Two receptors bind one interferon-gamma dimer. (lu.se)
  • The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. (wikipedia.org)
  • Interferons belong to the large class of glycoproteins known as cytokines . (wikidoc.org)
  • GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. (thermofisher.com)
  • miRNAs predominantly interact with mRNA targets through imperfect binding to motifs in target mRNA 3′-untranslated regions (3′UTRs) ( Bartel, 2009 ). (elifesciences.org)
  • The nature of imperfect binding specificity means that a single miRNA can regulate a large number of mRNA targets involved in complex cellular processes, thereby tightly controlling genetic networks during development and in response to stress ( Pocock, 2011 ). (elifesciences.org)
  • NSP16 binds to the mRNA recognition domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. (cdc.gov)
  • NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. (cdc.gov)
  • The recombinant type is interferon alfacon-1. (wikipedia.org)
  • Recombinant feline interferon omega is a form of cat IFN-α (not ω) for veterinary use. (wikipedia.org)
  • The dsRNA acts like a trigger for the production of interferon (via Toll Like Receptor 3 ( TLR 3 ) a pattern recognition receptor of the innate immune system which leads to activation of the transcription factor IRF3 and late phase NF kappa Beta). (wikidoc.org)
  • Mechanistically, OGG1 bound to 8-oxoGua in proximity to interferon response elements, which inhibits the IRF3/IRF7 and NF-κB/RelA DNA occupancy, while promoting the suppressor NF-κB1/p50-p50 homodimer binding to the IFN-λ2/3 promoter. (lu.se)
  • Interferons assist the immune response by inhibiting viral replication within host cells, activating natural killer cells, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. (wikidoc.org)
  • Interferons are there for a good purpose, which is to signal the immune system to be activated when an infection is detected. (lupus.org)
  • A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer. (pasteur.fr)
  • We provide evidence that such failure to resolve R-loops causes sustained activation of a systemic inflammatory response characterized by an interferon (IFN) gene expression signature. (uni-koeln.de)
  • Moreover, increased interferon gene expression signature in patients is associated with markedly poor prognosis. (uni-koeln.de)
  • This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. (powells.com)
  • Interferons are produced by a wide variety of cells in response to the presence of double-stranded RNA , a key indicator of viral infection. (wikidoc.org)
  • Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection. (cdc.gov)
  • As the second messenger, cGAMP activates STING and induces the following cascade to produce type I interferon (IFN-I) to protect against infections. (frontiersin.org)
  • We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA. (rcsb.org)
  • The minor allele of rs12553564 disrupts a conserved C/EBP-β binding motif, prevents binding of C/EBP-β, and abolishes the activation-induced enhancer activity of E5. (pasteur.fr)
  • Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. (rcsb.org)
  • Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). (abcam.com)
  • Saphnelo dampens the excessive type I interferon signature that is found in many lupus patients. (lupus.org)
  • Saphnelo is the only available treatment for lupus that targets the type I interferon receptor IFNAR and inhibits signals from all the different type I interferons. (lupus.org)
  • Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
  • In both mice and human, negative regulation of type I interferon signaling is known to be important. (wikipedia.org)
  • Also, despite the induction of HLA-DR on cultured human fibroblasts, no increased binding of PBMLs after IFN-γ treatment was observed. (elsevierpure.com)
  • Altogether, these results establish a link between a genetic variant preventing binding of a transcription factor and a higher order phenotype, and suggest that the frequent minor allele (around 30% worldwide) might be associated with phenotypes regulated by IFN-β expression in myeloid cells. (pasteur.fr)
  • Since the KCs are Class II histocompatibility antigen (HLA-DR) positive in these diseases (indicating local production of gamma interferon, IFN-γ, by activated T-cells), we sought to determine whether IFN-γ treatment of KCs would influence the ability of allogeneic peripheral blood mononuclear leukocytes (PBMLs) to adhere to cultured KCs in vitro. (elsevierpure.com)
  • Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
  • The heavy chain consists of 2 peptide-binding domains, an immunoglobulin (Ig)-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
  • each chain has a peptide-binding domain, an Ig-like domain, and a transmembrane region with a cytoplasmic tail. (msdmanuals.com)
  • Activation of type I interferon signaling in the context of ADAR1 deficiency can induce cell lethality in non-ADAR1-dependent cell lines. (nih.gov)
  • Aicardi-Goutières syndrome (AGS), a hereditary autoimmune disease, clinically and biochemically overlaps with systemic lupus erythematosus (SLE) and, like SLE, is characterized by spontaneous type I interferon (IFN) production. (nih.gov)
  • Various studies have found that between 50% and 80% of adults with lupus, and up to 90% of children with the disease, have evidence of elevated type I interferon stimulation which is measured by a test called the interferon signature. (lupus.org)
  • Like many aspects of lupus, there is nothing intrinsically bad about type I interferon signals. (lupus.org)
  • Effects of ozone upon macrophage-interferon interactions. (cdc.gov)
  • The effects of ozone (10028156) upon macrophage/interferon interactions were examined. (cdc.gov)
  • Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression. (nih.gov)
  • Translocation and structure switch of STING provides the prerequisite for TANK-binding kinase 1 (TBK1) recruitment and auto-phosphorylation. (frontiersin.org)
  • In summary, hepatitis C promotes insulin resistance and insulin resistance induces steatosis, fibrosis, and interferon resistance. (isciii.es)
  • So, you just injected the envelope of HIV … a syncytin gammaretrovirus envelope, and a SARS S2 receptor binding domain. (fromthetrenchesworldreport.com)
  • Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus. (johnshopkins.edu)
  • Normally it would bind to the ACE2 receptor and then it would reshape and go straight into the membrane like a spear. (fromthetrenchesworldreport.com)
  • Interferon regulatory factor 1 binding to p300 stimulates DN. (pubpeer.com)
  • However, these cells have received interferon, which essentially warns these other cells that there's a wolf in the pack of sheep. (wikidoc.org)
  • But researchers now report in ACS Chemical Neuroscience that the molecule reduces the binding of three components - zinc, C-peptide and albumin - to red blood cells. (acs.org)
  • In lab tests, the researchers found that red blood cells from MS patients bound more zinc, C-peptide and albumin than cells from control subjects. (acs.org)
  • Albumin boosted zinc and C-peptide binding to MS red blood cells, and this effect went away with interferon beta treatment. (acs.org)
  • From these data, the researchers conclude that it's likely the drug is inhibiting albumin binding, keeping it from delivering its cargo of C-peptide and zinc to red blood cells so that NO can be made. (acs.org)
  • most nucleated cells can be induced to express class II MHC molecules by interferon (IFN)-gamma. (msdmanuals.com)
  • T3 binds to the nuclear receptor (TR) and combines with another receptor (RXR) then combines with a receptor element on DNA. (cdc.gov)
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. (abcam.com)