• Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). (wikipedia.org)
  • IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. (wikipedia.org)
  • Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. (rcsb.org)
  • Circulating IGF-I and -II are bound to specific insulin-like growth factor (IGF)-binding proteins (IGFBPs), of which IGFBP-3 binds the majority of the IGFs. (nih.gov)
  • The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. (eur.nl)
  • Connective Tissue Growth Factor belongs to the CCN family of proteins. (neuromics.com)
  • The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). (neuromics.com)
  • The full length protein consists of four modulesModule I shares partial identity with the N-terminal part of the Insulin-like Growth Factor Binding Proteins (IGFBPs). (neuromics.com)
  • Proteolysis of the secreted full-length CCN proteins that has been reported in the case of CCN2 and CCN3 might result in the production of CCN-derived peptides with high affinity for ligands that full-length CNN proteins bind only poorly. (neuromics.com)
  • Because IGF-1 exhibits neuroprotective and myelinogenetic effects, it possesses therapeutic potential in treating neurodegenerative demyelinating diseases such as multiple sclerosis (MS). However, IGF actions are largely dependant on high-affinity regulatory IGF binding proteins (IGFBPs), which are likely to interfere with therapeutic attempts at elevating IGF-1 levels in the CNS. (vub.be)
  • Here the possibility that this is accompanied by a corresponding episode of accelerated evolution of IGF1 receptor (IGF1R), insulin receptor (IR) and/or IGF binding proteins (IGFBPs) was investigated. (figshare.com)
  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. (cusabio.com)
  • Influence of estradiol administration mode on plasma insulin-like growth factor-I (IGF-I) and its binding proteins 1 and 3 concentration in postmenopausal women treated with norethisterone acetate]. (druglib.com)
  • Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are key elements in fetal growth. (ox.ac.uk)
  • The predominant IGF-binding proteins (IGFBPs) produced by hFOB/ER9 and by normal trabecular osteoblasts are IGFBP-3 and IGFBP-4, of which IGFBP-4 is consistently inhibitory of IGF action. (elsevierpure.com)
  • Insulin-like growth factor-I (IGF-I) and IGF binding proteins: Potential mediators of the influence of nutrition on ovarian function in the heifer and gilt. (ncsu.edu)
  • The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). (rndsystems.com)
  • Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. (rndsystems.com)
  • Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. (rndsystems.com)
  • Chordin like-1 (CHRDL1) is an antagonist of bone morphogenetic proteins (BMPs) that acts through binding BMPs and blocking their interaction with BMP receptors. (bvsalud.org)
  • The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). (wikipedia.org)
  • IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. (wikipedia.org)
  • Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions" (PDF). (wikipedia.org)
  • Using microarray expression analysis, we recently reported that expression of the insulin-like growth factor binding protein-2 (IGFBP-2) gene is elevated in advanced epithelial ovarian cancers. (rti.org)
  • Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation" by Sahil S Singal, Karen Nygard et al. (uwo.ca)
  • Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. (uwo.ca)
  • We recently reported that hypoxia and/or leucine deprivation triggered hyperphosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) in decidualized human immortalized endometrial stromal cells (HIESCs), resulting in decreased insulin-like growth factor-1 (IGF-1) bioactivity. (uwo.ca)
  • The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. (lu.se)
  • Module IV resembles the CT domain of several extracellular protein including, Von Willebrand's factor and mucins. (neuromics.com)
  • Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. (nih.gov)
  • Insulin-like growth factor binding protein-3 (IGFBP-3) is postulated to be a mediator of growth suppression signals. (nih.gov)
  • Insulin-like growth factor binding protein 2 (IGFBP2) is a protein known to be overexpressed in a majority of glioblastoma multiforme (GBM) tumors. (tmc.edu)
  • Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. (vub.be)
  • Dive into the research topics of 'Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. (vub.be)
  • Insulin is the principal regulator of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) production, mediating the rapid decrease in plasma IGFBP-1 in response to nutritional intake. (utmb.edu)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). (cusabio.com)
  • We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. (cusabio.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in samples from serum, plasma, urine, tissue homogenates or other biological fluids. (novosides.eu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in serum, plasma, urine, tissue homogenates and other biological fluids. (novosides.eu)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Insulin Like Growth Factor Binding Protein 2 (IGFBP2) in samples from serum, plasma, urine, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (novosides.eu)
  • In one of two complementary studies, IARC scientists analysed data from almost 230 000 women using Mendelian randomization to examine genetic variants known to be associated with circulating concentrations of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3), which may modulate the availability of IGF-1. (who.int)
  • Description: A sandwich ELISA kit for detection of Insulin Like Growth Factor Binding Protein 5 from Cattle in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (orbitalbiosciences.com)
  • Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Cattle Insulin Like Growth Factor Binding Protein 4 (IGFBP4) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. (ox.ac.uk)
  • OBJECTIVE: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. (ox.ac.uk)
  • The GH study group of the Korean Endocrine Society aims to establish the Korean reference ranges of serum IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) and assess the relationship between IGF-I and IGFBP-3 and clinical parameters. (e-enm.org)
  • In blood circulation, over 75% of IGF-I is bound to the insulin-like growth factor binding protein-3 (IGFBP-3). (e-enm.org)
  • IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. (westminster.ac.uk)
  • Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (ox.ac.uk)
  • Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. (ox.ac.uk)
  • We now show that, in prostate cancer cells, stimulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein (CREB) activation. (unical.it)
  • Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)
  • Dive into the research topics of 'Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)
  • Effects of dietary protein level on growth and body composition in mice divergently selected for fat content. (ncsu.edu)
  • A study was conducted to examine the effects of dietary protein percentage and selection for divergence in fat content on growth and body composition in mice. (ncsu.edu)
  • Genetic line-by-dietary-protein-level interactions were generally not significant for growth, feed efficiency and body composition traits. (ncsu.edu)
  • ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. (rndsystems.com)
  • Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)
  • Synthesis of insulin-like growth factor binding protein-1 ( IGFBP-1 ) in pregnant cat uteri. (anl.gov)
  • Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis. (uc.edu)
  • Estrogens are important regulators of growth and differentiation in (range, 0 -9 fmol/mg protein, median 0.7). (lu.se)
  • Patients with idiopathic hypogonadotropic hypogonadism and severe obesity secondary to mutations of the leptin receptor gene may have decreased GH secretion, including low insulinlike growth factor I (IGF I) and insulinlike growth factor binding protein 3 (IGFBP 3) levels. (medscape.com)
  • Mechanistic explorations revealed that CHRDL1 is directly bound to insulin-like growth factor binding protein 3 (IGFBP3) and attenuated the degradation of the latter. (bvsalud.org)
  • All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. (wikipedia.org)
  • In humans, IGFBPs are transcribed from the following seven genes: IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Insulin-like growth factor receptor Kalus W, Zweckstetter M, Renner C, et al. (wikipedia.org)
  • IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs. (rcsb.org)
  • Marked accelerated evolution on this branch was also seen for some IGFBPs, but not the mannose 6-phosphate/IGF2 receptor or epidermal growth factor receptor. (figshare.com)
  • Overall the results suggest that adaptive coevolution of IGF1, insulin and their receptors and some IGFBPs occurred during the evolution of NWM. (figshare.com)
  • In IGFBP4, residues 1-38 form a rigid disulphide bond ladder-like structure, and the first five N-terminal residues bind to IGF and partially mask IGF residues responsible for the type 1 IGF receptor binding. (rcsb.org)
  • Although the C-terminal domains do not form stable binary complexes with either IGF1 or the N-terminal domain of IGFBP4, in the ternary complex, the C-terminal domain contacts both and contributes to blocking of the IGF1 receptor-binding region of IGF1. (rcsb.org)
  • Analysis of receptor sequences from a range of primates and some non-primate mammals showed that accelerated evolution did indeed occur on this branch in the case of IGF1R and IR, but not for the similar insulin receptor-related receptor (IRRR) which does not bind insulin or IGF1. (figshare.com)
  • For the most part, the residues that change on this branch could not be associated with specific functional aspects (ligand binding, receptor dimerization, glycosylation) and the physiological significance of this coevolution remains to be established. (figshare.com)
  • Measuring serum IGF-I and IGFBP-3 is essential for diagnosis and monitoring of treatment responses in GH deficiency such as hypopituitarism, growth hormone-releasing hormone (GHRH) receptor mutation, or GH insensitivity [ 8 ] and GH excess such as acromegaly or gigantism [ 9 ]. (e-enm.org)
  • Abstract Insulin-like growth factor-I receptor (IGF-IR) overexpression may play a role in prostate cancer progression. (unical.it)
  • Two color flow cytometric analysis of mononuclear cells stained with mouse monoclonal antibodies specific for the human IGF-I receptor, the human insulin receptor, and monoclonal antibodies directed against specific monocyte and lymphocyte subset cell surface antigens revealed that both IGF-I receptors and insulin receptors were present on nearly all monocytes and B-lymphocytes, but were present on only 2% of T-lymphocytes. (utmb.edu)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
  • Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)
  • Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
  • Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
  • Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
  • Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
  • In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
  • Immunocytochemical ( ICC ) Localization of Transforming Growth Factor- ( TGF- ), Epidermal Growth Factor ( EGF ), and Epidermal Growth Factor Receptor ( EGFR ) in the Cat Endometrium and Placenta. (anl.gov)
  • Furthermore, CHRDL1 and IGFBP3 suppressed the activity of insulin receptor substrate 1 (IRS1)/AKT serine/threonine kinase (AKT)/mechanistic target of rapamycin kinase complex 1 (mTORC1) signaling in progenitor cells undergoing osteogenic differentiation. (bvsalud.org)
  • IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. (wikipedia.org)
  • The structures reveal the mechanisms of IGF signaling regulation via IGFBP binding. (rcsb.org)
  • Age, sex, height, BMI, and pubertal maturation were all important factors in determining the circulating levels of IGFBP-3, whereas IGF-I levels were unaffected by BMI. (nih.gov)
  • IGF-I levels increased to relatively higher levels than IGFBP-3, leading to an increasing molar ratio between IGF-I and IGFBP-3 in puberty, when growth velocity is high. (nih.gov)
  • Here, we examined the methylation status of IGFBP-3 to correlate to clinicopathological factors in human cancers. (nih.gov)
  • In this study, we defined IGFBP-1 regulation by insulin in upper and lower body obesity, conditions associated with insulin resistance and chronic hyperinsulinemia. (utmb.edu)
  • Overnight postabsorptive IGFBP-1 levels in obese and nonobese women showed an inverse, nonlinear relationship with plasma insulin concentrations. (utmb.edu)
  • Maximum suppression of IGFBP-1 was seen at 70-90 pmol/L plasma insulin. (utmb.edu)
  • Both groups of obese women had mean fasting plasma insulin concentrations above this threshold level and, consequently, markedly suppressed IGFBP-1 levels. (utmb.edu)
  • Insulin infusion rapidly decreased plasma IGFBP-1 levels in nonobese subjects (60% decrease in 2 h), but had little or no further suppressive effect in obese subjects. (utmb.edu)
  • Complete insulin withdrawal resulted in a significant rise in plasma IGFBP-1 concentrations in all subjects, but the response was blunted in obese compared to nonobese groups. (utmb.edu)
  • In conclusion, low IGFBP-1 levels in obesity are related to elevated insulin levels which are, in turn, related to body fat distribution and insulin resistance. (utmb.edu)
  • In addition, our findings imply that hepatic insulin sensitivity in terms of IGFBP-1 production is preserved despite peripheral insulin resistance in obesity. (utmb.edu)
  • Higher levels of IGFBP-3 increase the binding capacity of IGF-I, but also decrease the circulating IGF-I bioavailability [ 2 ]. (e-enm.org)
  • IGFBP-1 is elevated in the fetal circulation of human and animal pregnancies complicated by IUGR caused by placental insufficiency and in utero hypoxia and is believed to restrict fetal growth by sequestering IGFs. (ox.ac.uk)
  • Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. (ox.ac.uk)
  • However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes. (ox.ac.uk)
  • Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa matricellular glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. (rndsystems.com)
  • A severe or moderate suppression of serum insulin-like growth factor I (IGF-I) was induced in heifers, beginning at 104 days of age, by active immunization against growth hormone-releasing factor (GRFi) or by chronic feed restriction (RES), respectively. (ncsu.edu)
  • Serum LH and FSH levels cannot reliably distinguish between Kallmann syndrome or idiopathic hypogonadotropic hypogonadism patients and individuals with constitutional delay in growth and development. (medscape.com)
  • Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (IGF-1) and serum zinc. (who.int)
  • Insulin-like growth factors (IGFs) are indispensable peptide hormones for proper development of the central nervous system (CNS). (vub.be)
  • A high-affinity IGF1-binding site is located in a globular structure between residues 39 and 82. (rcsb.org)
  • Previous work has shown that the evolution of both insulin-like growth factor 1 (IGF1) and insulin shows an episode of accelerated change on the branch leading to New World monkeys (NWM). (figshare.com)
  • abstract = "Insulin-like growth factor-I (IGF-I) is a potential modulator of responses to a variety of immunological challenges. (utmb.edu)
  • Our findings provide further support that the insulin-like growth factor pathway plays a significant role in epithelial ovarian cancer pathogenesis. (rti.org)
  • Using a recently developed human osteoblastic cell line (hFOB/ER9) with high levels (approximately 4,000 per nucleus) of estrogen receptors and the characteristic phenotype of the mature osteoblast, we tested the hypothesis that estrogen decreases bone formation by inhibiting the action of the insulin-like growth factor (IGF) paracrine/autocrine system. (elsevierpure.com)
  • We conclude from these data that among human peripheral blood nonactivated mononuclear cells, IGF-I binds to specific type I IGF receptors found predominately on monocytes and B-lymphocytes. (utmb.edu)
  • IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. (wikipedia.org)
  • Insulin-like growth factor-I (IGF-I) plays a pivotal role in the diagnosis and treatment of growth hormone (GH) excess or deficiency. (e-enm.org)
  • The insulin-like growth factor-I (IGF-I) (termed since 1978) with activity similar to insulin was initially reported in 1972 as a sulfation factor secreted by liver, mediating the stimulating effect of growth hormone (GH) [ 1 ]. (e-enm.org)
  • Immunization against growth hormone releasing factor or chronic feed restriction initiated at 3.5 months of age reduces ovarian response to pulsatile administration of gonadotropin-releasing hormone at 6 months of age and delays onset of puberty in heifers. (ncsu.edu)
  • Obesity decreases the sex hormone-binding globulin (SHBG) level and therefore decreases the total testosterone level. (medscape.com)
  • Intrinsic factors include chronically activated proliferative, invasive, and antiapoptotic signaling pathways. (springer.com)
  • Even with these similarities, some characteristics are different: chromosomal location, heparin binding domains, RGD recognition site, preference for binding IGF-I or IGF-II, and glycosylation and phosphorylation differences. (wikipedia.org)
  • Downregulation of CCN2 expression in these cells was associated with a growth arrest at the G1/S transition while over-expression of CCN2 induced a two-fold increase of the number of cells in the G1 phase. (neuromics.com)
  • A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug. (cusabio.com)
  • IGF-I is a major growth promoter in utero. (ox.ac.uk)
  • We also showed that CREB binds to IGF-IR promoter region and identified the relevant CREB-binding site at the 5'-untranslated region fragment of IGF-IR promoter. (unical.it)
  • Sequence similarities to heparin-binding motifs are also found within this domain. (neuromics.com)
  • Intrauterine growth restriction (IUGR) is often caused by placental insufficiency, which is believed to be associated with decreased delivery of oxygen and nutrients to the placental barrier. (uwo.ca)
  • Intrauterine growth restriction (IUGR) can be a consequence of decreased uterine blood flow (uteroplacental insufficiency) and maternal and fetal hypoxia. (ox.ac.uk)
  • IGFBP6 might be an important regulator and prognostic factor for glioma. (cusabio.com)
  • Radioresistance of these tumors can be ascribed to two factors: environmental and intrinsic. (springer.com)
  • Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)
  • The former include hypoxia, high lactate levels or the abundance of growth factors within the cellular microenvironment. (springer.com)
  • The prognostic impact of IGFBP7high depends on host factors and treatment. (lu.se)
  • The exact binding domain on IGFBP2 responsible for its interaction with integrin α5 is also determined, confirming our initial findings and reaffirming that the IGFBP2/integrin α5 interaction is specific. (tmc.edu)
  • Binding of [ 125 I]IGF-I to mononuclear cells was inhibited by both unlabeled IGF-I and insulin, insulin being 200-fold less potent than IGF-I. Covalent affinity labeling with [ 125 I]IGF-I, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography, revealed a specific binding species with an apparent mol wt of 130 kDa. (utmb.edu)
  • Requirements for many minerals are poorly defined but hopefully by early in the 21st century our knowledge of requirements and factors that affect requirements for specific minerals will become more complete, allowing nutritionists to better formulate mineral supplements to meet animal requirements. (ncsu.edu)
  • Furthermore, this resource has allowed the identification of cis -regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. (nature.com)
  • Collectively, these studies suggest that milkborne growth factors may provide important regulatory signals to the neonatal intestine under both normal and pathophysiological states. (ncsu.edu)
  • Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
  • Circulating levels of IGF-I extensively depend on genetic factors and age [ 3 , 4 ] and are also affected by sex, anthropometric indices, physical activity, exogenous sex hormones, smoking, and nutritional status [ 5 - 7 ]. (e-enm.org)
  • Researchers from the International Agency for Research on Cancer (IARC) and partners have published results showing that insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer. (who.int)
  • This review explores the role that milkborne growth factors may play in stimulating functional development of the neonatal intestine, with emphasis on the porcine, bovine, and ovine species. (ncsu.edu)
  • Prostate cancer-secreted CCN3 uses the GSK3β and β-catenin pathways to enhance osteogenic factor levels in osteoblasts. (nih.gov)
  • In contrast, RES may delay puberty by delaying follicular development at two stages: a) decreased IGF-I in follicles ≤ 7 mm may delay predominant follicular growth, and b) decreased LH may delay maturation of the preovulatory follicle. (ncsu.edu)
  • Finally, we verified that ME reduced the growth of three-dimensional (3D) pancreatic cancer spheroids. (bvsalud.org)
  • Module II includes a stretch of 70amino acid residues - which shares sequence identity with the Von Willebrand Factor Type C repeat (VWC). (neuromics.com)
  • Module III contains sequences sharing identity with the Thrombospondin type 1 repeat (TSP1) (WSXCSXXCG), which is thought to be implicated in the binding of sulfated glycoconjugates and to be important for cell adhesion. (neuromics.com)
  • Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum. (nature.com)
  • Then, we confirmed the G1 phase arrest mediated growth inhibitory effect of ME using a cell counting assay and cell cycle analysis. (bvsalud.org)
  • The objectives of this experiment were to determine 1) whether GRFi and RES would alter follicular development and delay onset of puberty through similar mechanisms, and 2) whether GnRH would enhance follicular growth in control, GRFi, and RES heifers at 6 mo of age. (ncsu.edu)
  • Because nutritional insufficiency and diarrhea represent major stressors, an understanding of factors mediating postnatal growth and development of the gastrointestinal tract is essential. (ncsu.edu)
  • [ 7 ] Some data suggest the close resemblance in the pattern of pathophysiological development shared with amalgam tattoos or other external or internal stimulants as reactive-induced lesions, including comorbidities, leaving the location and the rate of presentation as the first clinical differentiating factors. (medscape.com)