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  • cholangiocarcinoma
  • The most common types are hepatocellular carcinoma (HCC), which makes up 80% of cases, and cholangiocarcinoma. (wikipedia.org)
  • Cancer of the bile duct (cholangiocarcinoma and cholangiocellular cystadenocarcinoma) account for approximately 6% of primary liver cancers. (wikipedia.org)
  • Cholangiocarcinoma, also known as bile duct cancer, is a form of cancer that is composed of mutated epithelial cells (or cells showing characteristics of epithelial differentiation) that originate in the bile ducts which drain bile from the liver into the small intestine. (wikipedia.org)
  • Cholangiocarcinoma is a relatively rare neoplasm that is classified as an adenocarcinoma (a cancer that forms glands or secretes significant amounts of mucins). (wikipedia.org)
  • Known risk factors for cholangiocarcinoma include primary sclerosing cholangitis (an inflammatory disease of the bile ducts), infection with the parasitic liver flukes Opisthorchis viverrini or Clonorchis sinensis, some congenital liver malformations, and exposure to Thorotrast (thorium dioxide), a chemical formerly used in medical imaging. (wikipedia.org)
  • The most common physical indications of cholangiocarcinoma are abnormal liver function tests, jaundice (yellowing of the eyes and skin occurring when bile ducts are blocked by tumor), abdominal pain (30%-50%), generalized itching (66%), weight loss (30%-50%), fever (up to 20%), and changes in the color of stool or urine. (wikipedia.org)
  • tumor
  • Neoplasm is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor. (wikipedia.org)
  • Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy. (wikipedia.org)
  • Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • cancer
  • Cancer which has spread from elsewhere to the liver, known as liver metastasis, is more common than that which starts in the liver. (wikipedia.org)
  • Higher rates of liver cancer occur where hepatitis B and C are common, including Asia and sub-Saharan Africa. (wikipedia.org)
  • Liver cancer can also form from other structures within the liver such as the bile duct, blood vessels and immune cells. (wikipedia.org)
  • The most common, pancreatic adenocarcinoma, accounts for about 85% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. (wikipedia.org)
  • Signs and symptoms of the most common form of pancreatic cancer may include yellow skin, abdominal or back pain, unexplained weight loss, light-colored stools, dark urine and loss of appetite. (wikipedia.org)
  • Pancreatic cancer is the fifth most common cause of death from cancer in the United Kingdom, and the fourth most common in the United States. (wikipedia.org)
  • By contrast, patients with painless jaundice (an abnormal yellowing of the skin and eyes often caused by blockage of the bile ducts) are more likely to have a pancreatic cancer. (wikipedia.org)
  • For example, the most common type of breast cancer is called ductal carcinoma of the breast. (wikipedia.org)
  • Here, the adjective ductal refers to the appearance of the cancer under the microscope, which suggests that it has originated in the milk ducts. (wikipedia.org)
  • urinary bladder
  • Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal rhabdomyosarcoma, that can be observed in the walls of hollow, mucosa lined structures such as the nasopharynx, common bile duct, urinary bladder of infants and young children or the vagina in females, typically younger than age 8. (wikipedia.org)
  • Clonal
  • It is tempting to define neoplasms as clonal cellular proliferations but the demonstration of clonality is not always possible. (wikipedia.org)
  • IPMNs
  • The treatment of choice for main-duct IPMNs is resection due to approximately 50% chance of malignancy. (wikipedia.org)
  • disease
  • Acetaminophen (in the US and Japan), paracetamol (INN), also known by the brand name Tylenol and Panadol, is usually well tolerated in prescribed dose, but overdose is the most common cause of drug-induced liver disease and acute liver failure worldwide. (wikipedia.org)
  • In the Western world, the most common of these is primary sclerosing cholangitis (PSC), an inflammatory disease of the bile ducts which is closely associated with ulcerative colitis (UC). (wikipedia.org)
  • Hyperthyroidism occurs when the gland produces excessive amounts of thyroid hormones, the most common cause being Graves' disease - an autoimmune disorder. (wikipedia.org)
  • In iodine-sufficient regions, the most common cause of hypothyroidism is Hashimoto's thyroiditis-also an autoimmune disease. (wikipedia.org)
  • Adenocarcinoma
  • For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed adenocarcinoma in pathology literature. (wikipedia.org)
  • epigenetic
  • Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal cells. (wikipedia.org)
  • While many of the genetic and epigenetic abnormalities in neoplasms are probably neutral evolution, many have been shown to increase the proliferation of the mutant cells, or decrease their rate of death (apoptosis). (wikipedia.org)
  • lesions
  • Furubo S, Sato Y, Harada K, Nakanuma Y. Roles of myofibroblasts and Notch and Hedgehog signaling pathways in formation of intrahepatic bile duct lesions of the polycystic kidney rat. (kanazawa-u.ac.jp)
  • Okamura A, Harada K, Nio M, Nakanuma Y. Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia. (kanazawa-u.ac.jp)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia, clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • occur
  • Both groups occur mainly (but not exclusively) in people over 40, and are slightly more common in men, but some rare sub-types mainly occur in women or children. (wikipedia.org)
  • acute
  • Finally, several imaging examples review the most common and some unusual complications such as pancreatic fistula, bile leaks, abscesses, intraluminal and extraluminal haemorrhage, and acute pancreatitis. (springer.com)
  • Advances in cytogenetics facilitated discovery of chromosome abnormalities in neoplasms, including the Philadelphia chromosome in chronic myelogenous leukemia and translocations in acute myeloblastic leukemia. (wikipedia.org)
  • symptoms
  • D. Because most vascular sur-gery patients are helpful and may be positive for viagra herbal natural immune thrombocytopenic purpura ttp neurologic symptoms headache, altered mental status examina-tion, stop rt-pa if still present at birth because the most common solid neoplasm outside the cell. (pmhccares.org)
  • In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms. (wikipedia.org)
  • secondary
  • Endstage renal failure secondary to chronic lymphocytic thyroiditis is most difficultdelirium may appear normal and seldom metastasize, although they can be distinguished from ebv infection are less common. (pmhccares.org)