• insulin
  • However, in hyperinsulinemia, biguanides can lower fasting levels of insulin in plasma. (wikipedia.org)
  • As high levels of insulin have been associated with poor prognosis of prostate, breast, and colon cancer and as early retrospective pharmaco-epidemiologic studies suggested reduced cancer burden among diabetics treated with metformin relative to other diabetes treatments, the hypothesis that metformin or other biguanides could be useful in cancer prevention or treatment has received considerable attention. (springer.com)
  • Reduction in HbA1c with basal insulin supplement, sulfonylurea, or biguanide therapy in maturity-onset diabete. (nih.gov)
  • diabetes
  • The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. (biochemj.org)
  • Our mechanistic and pharmacokinetic insights are relevant to understanding and developing the role of biguanides in new and existing therapeutic applications, including cancer, diabetes and malaria. (biochemj.org)
  • To investigate the safety and efficacy of long-term treatment with pioglitazone (Actos tablets) in combination with biguanides (for 12 months after the start of pioglitazone tablets treatment) in patients with type 2 diabetes mellitus. (clinicaltrials.gov)
  • This is a special drug use surveillance with an observation period of 12 months designed to investigate the safety and efficacy of pioglitazone (Actos) in the routine clinical setting in patients with type 2 diabetes mellitus who responded inadequately to treatment with biguanides in addition to diet therapy and exercise therapy (planned sample size, 1000). (clinicaltrials.gov)
  • Biguanides were reintroduced into Type 2 diabetes treatment in the late 1950s. (wikipedia.org)
  • Biguanides ( ATC A10 BA ) form a class of oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment. (chemeurope.com)
  • Although it must be used with caution in patients with impaired liver or kidney function, metformin, a biguanide, has become the most commonly used agent for type 2 diabetes in children and teenagers. (wikipedia.org)

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  • therapeutic
  • Drugs used for androgen deprivation in prostate cancer treatment and most PI3K inhibitors provide examples of therapies that induce hyperinsulinemia which may attenuate therapeutic benefit, justifying study of combinations of each of these with biguanides. (springer.com)
  • Recent work is identifying contexts where 'direct' actions of biguanides as inhibitors of OXPHOS may be of particular therapeutic benefit. (springer.com)
  • pharmaceutical
  • The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions. (google.co.uk)
  • More specifically, the invention is directed to use of the subject biguanide/quaternary ammonium compounds in compositions and methods for disinfecting contact lenses, and to the use of these compounds to preserve various types of pharmaceutical compositions from microbial contamination, particularly ophthalmic, otic and nasal pharmaceutical compositions. (google.co.uk)

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  • reduction
  • We report that biguanides inhibit complex I by inhibiting ubiquinone reduction (but not competitively) and, independently, stimulate reactive oxygen species production by the complex I flavin. (biochemj.org)

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  • properties
  • Therefore, studies of maximally tolerated doses of biguanides with more favourable pharmacokinetic properties than metformin may be necessary if the "direct action" hypothesis is to be clinically tested. (springer.com)

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  • cancer
  • The separate hypothesis that biguanides can directly influence cancer cell metabolism is attractive, as this mechanism has been shown to operate in many laboratory models - yet there is uncertainty if metformin administered at conventional anti diabetic doses achieves sufficient concentrations in extra-hepatic tissues or cancers to perturb their cellular energy metabolism. (springer.com)

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