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  • therapeutic
  • Our mechanistic and pharmacokinetic insights are relevant to understanding and developing the role of biguanides in new and existing therapeutic applications, including cancer, diabetes and malaria. (biochemj.org)
  • Drugs used for androgen deprivation in prostate cancer treatment and most PI3K inhibitors provide examples of therapies that induce hyperinsulinemia which may attenuate therapeutic benefit, justifying study of combinations of each of these with biguanides. (springer.com)
  • Recent work is identifying contexts where 'direct' actions of biguanides as inhibitors of OXPHOS may be of particular therapeutic benefit. (springer.com)
  • diabetes
  • To investigate the safety and efficacy of long-term treatment with pioglitazone (Actos tablets) in combination with biguanides (for 12 months after the start of pioglitazone tablets treatment) in patients with type 2 diabetes mellitus. (clinicaltrials.gov)
  • This is a special drug use surveillance with an observation period of 12 months designed to investigate the safety and efficacy of pioglitazone (Actos) in the routine clinical setting in patients with type 2 diabetes mellitus who responded inadequately to treatment with biguanides in addition to diet therapy and exercise therapy (planned sample size, 1000). (clinicaltrials.gov)
  • Biguanides were reintroduced into Type 2 diabetes treatment in the late 1950s. (wikipedia.org)

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  • reduction
  • We report that biguanides inhibit complex I by inhibiting ubiquinone reduction (but not competitively) and, independently, stimulate reactive oxygen species production by the complex I flavin. (biochemj.org)
  • present
  • In the present paper, we describe the effects of five pharmacologically relevant biguanides on oxidative phosphorylation in mammalian mitochondria. (biochemj.org)
  • Biguanides also tend to make the cells of the body more willing to absorb glucose already present in the blood stream, and there again reducing the level of glucose in the plasma. (wikipedia.org)

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