• PMID
  • The two tandemly repeated domains of BLIP have an alpha(2)-beta(4) structure, the beta-hairpin loop from domain 1 inserting into the active site of beta-lactamase [ PMID: 8605632 ]. (ebi.ac.uk)
  • active
  • In typical circumstances, they derive from genes for TEM-1, TEM-2, or SHV-1 by mutations that alter the amino acid configuration around the active site of these β-lactamases. (wikipedia.org)
  • found
  • NDM-1 β-lactamase was also found in an K. pneumoniae isolate from Croatia, and the patient arrived from Bosnia and Herzegovina. (wikipedia.org)
  • Catalyitic triads are most commonly found in hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). (wikipedia.org)
  • express
  • Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin. (wikipedia.org)