• Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantation. (wikipedia.org)
  • citation needed] Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. (wikipedia.org)
  • The β-subunit of hCG gonadotropin (beta-hCG) contains 145 amino acids, encoded by six highly homologous genes that are arranged in tandem and inverted pairs on chromosome 19q13.3 - CGB (1, 2, 3, 5, 7, 8). (wikipedia.org)
  • Human chorionic gonadotropin interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum for the maternal recognition of pregnancy at the beginning of pregnancy. (wikipedia.org)
  • citation needed] Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis. (wikipedia.org)
  • Currently, serial ß-human chorionic gonadotropin (ß-hCG) and progesterone are the most commonly used plasma biomarkers for evaluating pregnancy prognosis when ultrasound is inconclusive. (bvsalud.org)
  • Its structure is similar to those of luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). (wikidoc.org)
  • Residual blood samples were assayed for interleukin (IL)-6, IL 1-beta (IL-1ß), tumour necrosis factor alpha (TNF-α), and high sensitivity C-reactive protein (hsCRP). (bvsalud.org)
  • The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. (biomedcentral.com)
  • Abstract 3420: Tgfbm3b is a natural germline genetic variant that modifies anti-tumor responses to anti-PD-1 immunotherapy through its action on the tumor microenvironment. (ucsf.edu)
  • Integrin av�8 on T�cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. (ucsf.edu)
  • It really is known that T cells can handle inducing anti-tumor reactions that are very potent. (techieindex.net)
  • It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and a β (beta) subunit that is unique to hCG. (wikipedia.org)
  • These include regular hCG, hyperglycosylated hCG, and the free beta-subunit of hCG. (wikipedia.org)
  • Degradation products of hCG have also been detected, including nicked hCG, hCG missing the C-terminal peptide from the beta-subunit, and free alpha-subunit, which has no known biological function. (wikipedia.org)
  • FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor . (wikidoc.org)
  • In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3. (wikidoc.org)
  • The gene for the FSH beta subunit is located on chromosome 11p13, and is expressed in gonadotropes of the pituitary cells, controlled by GnRH , inhibited by inhibin , and enhanced by activin . (wikidoc.org)
  • The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
  • We offer high quality native and recombinant antigens, enzymes, and other proteins to be used in a wide range of life science research and diagnostics applications, such as calibrator and control products, serological immunoassays, and biological activity assays. (medixbiochemica.com)
  • Antibodies against tumor-associated epitopes, that are limited by antigens presented for the cell surface area of tumors, have already been exploited and determined against multiple types of malignancies using passive immunization.4 Notable for example rituximab (anti-CD20 for B-cell lymphomas5) and trastuzumab (anti-HER-2/neu for several breast malignancies6). (techieindex.net)
  • This mechanism protects the female fetus from possible virilization in women who develop androgen-secreting tumors of the ovary during pregnancy. (medscape.com)
  • Genetic Markers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • We are presenting a case of giant ovarian leiomyoma in a young lady which was suspected as germ cell tumour on imaging. (ommegaonline.org)
  • Although a number of theories have been proposed, the most accepted one is that the tumour arises from the smooth muscle cells of the ovarian hilar blood vessels [8] . (ommegaonline.org)
  • Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications. (stanford.edu)
  • The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models. (duke.edu)
  • Since the number of ovarian follicles declines with increasing age, AMH levels might be used as a marker for ovarian ageing. (crgw.co.uk)
  • Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. (mdpi.com)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • Description: The 61D3 monoclonal antibody reacts with human CD14, a 53-55 kDa GPI-linked glycoprotein. (thermofisher.com)
  • FSH is a 35.5 kDa glycoprotein heterodimer , consisting of two polypeptide units, alpha and beta. (wikidoc.org)
  • performed a primary comparison from the in vitro level of sensitivity of each technique, using the same anti-cancer scFv fragments, aimed against a tumor-specific glycopeptide epitope Atractylodin for the sialomucin-like transmembrane glycoprotein OTS8, which outcomes type a cancer-specific mutation of Cosmc. (techieindex.net)
  • Restorative antibodies experienced achievement against tumors, eliciting both complement-mediated reactions and antibody-dependent mobile cytotoxicity (ADCC). (techieindex.net)
  • α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas. (ucsf.edu)
  • Dr. Devi's research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer. (duke.edu)
  • The present case illustrates potential clinical challenges in using serum tumor markers, namely CEA, to monitor cancer patients. (degruyter.com)
  • This study reports useful information on the limits of the organotypic culture of neonatal mouse testes, which has been regarded as an experimental strategy that can be extended to humans in the clinical setting for the conservation and subsequent re-use of testicular tissue. (elifesciences.org)
  • Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans , zebrafish, mouse, and human tissue models of genetic-based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients. (agbt.org)
  • Further, methods useful for studying the therapeutic profile of one or more drugs within a cell microenvironment, including but not limited to a tumor, are provided. (justia.com)
  • Following ovulation the neovascularization during the early stages of corpus luteum development has been compared to the rapid angiogenesis observed during tumor formation. (biomedcentral.com)
  • Analogous to events occurring in the corpus luteum, the vascular endothelium of other tissues responds to extracellular signals during the physiologic processes of embryonic development and wound healing, and in the pathologic process of tumor angiogenesis. (biomedcentral.com)
  • Human pregnancy involves considerable endocrine changes. (medscape.com)
  • Large quantities of estrogen are produced during normal human pregnancy, and, after the first 3-4 weeks of gestation, the placenta produces nearly all of the estrogen. (medscape.com)
  • The net transfer of steroids to maternal blood is approximately 10 times that of the net transfer to fetal blood, secondary to the nature of placentation in human pregnancy. (medscape.com)
  • Contrast enhanced computed tomography (CECT) of the abdomen revealed 13 X 13 X 11 cm lobulated mixed (predominantly solid) markedly enhancing soft tissue mass is noted in the right adnexal region with enhancing intralesional and perilesional vessels with peripheral irregular dense calcification suggestive of yolk sac tumour (Figure 1a). (ommegaonline.org)
  • CECT abdomen showing mixed, markedly enhancing soft tissue mass arising in the right adnexal region with enhancing intralesional and perilesional vessels with peripheral irregular dense calcification suggestive of yolk sac tumour. (ommegaonline.org)
  • In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
  • However, natural MSCs in vivo survival and their biological effects on tissue recovery decrease with long-term cultivation called aging and also injected cells demonstrate poor targeted migration [ 21 ]. (biomedcentral.com)
  • As the most abundant biological source is in women who are presently pregnant, some organizations collect urine from pregnant women to extract hCG for use in fertility treatment. (wikipedia.org)
  • Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control PerCP-eFluor® 710 (Product # 46-4714-82) (blue histogram) or Anti-Human CD14 PerCP-eFluor® 710 (purple histogram). (thermofisher.com)
  • Applications Tested: This 61D3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)
  • solid course="kwd-title" Keywords: bispecific T-cell engager (BiTE), chimeric antigen receptors (Vehicles), gene-modified adoptive T-cell transfer, Atractylodin T-cell tumor therapy, tumor-specific epitope Intro Tumor cells communicate different epitopes and proteins on the surface area that differentiate them from healthful cells, either by degrees of manifestation or by uncovering novel epitopes not really seen in regular self. (techieindex.net)
  • Nevertheless, those T cells that could most efficiently react to peptide-MHC epitopes on the top of tumors tend to be put through clonal tolerance or deletion, as much of the epitopes have become identical or just like self epitopes. (techieindex.net)
  • 19 To many effectively funnel the billed power of T cells in the fight tumors, several methods have already been designed that allow T cells to react to traditional antibody epitopes. (techieindex.net)
  • The genes on the chromosomes are responsible for making proteins, which direct our biological development and the activity of about 100 trillion cells in our bodies. (healthywomen.org)
  • citation needed] Naturally, it is produced in the human placenta by the syncytiotrophoblast. (wikipedia.org)
  • Scholarly interests include investigation of molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. (stanford.edu)
  • There is a continuous and expanding need for rapid, highly specific methods of detecting and quantifying chemical, biochemical and biological substances as analytes in research and diagnostic mixtures. (justia.com)
  • Patient underwent tumor resection with adjuvant radiotherapy and maintenance with letrozole until 2017. (degruyter.com)
  • To explore the involvement of enzymes of drug metabolism in bladder cancer, in the present study, we analyzed the gene expression profiles of tumor and normal looking tissues obtained from the same patient by cDNA macroarray. (jak-signaling.com)
  • Corticotropin levels in human fetal blood decline as gestation progresses, but the adrenals continue to grow in late gestation. (medscape.com)
  • Generalised estimating equation models were used to model associations with the outcome of interest-clinically significant depression symptoms (CESD ≥16)-and risk factors: inflammatory marker levels (log transformed), adverse childhood experiences group, and current life stressors group. (bvsalud.org)
  • In view of imaging findings, normal levels of tumour markers, young age and incomplete family, tentative plan of treatment was right salpingo-oophorectomy and decision on chemotherapy based on histopathological report. (ommegaonline.org)
  • Of particular interest is the treatment of urogenital tumors in men and urogynecological diseases. (bookinghealth.com)
  • In this review, we explore the role of biological sex in the development of the brain and analyze its impact on the predisposition toward and the progression of neurodegenerative diseases. (mdpi.com)
  • Three major forms of hCG are produced by humans, with each having distinct physiological roles. (wikipedia.org)
  • Papillary tumor of the pineal region (PTPR) represents a rare and histologically distinct subgroup of tumors originating in the pineal region. (surgicalneurologyint.com)
  • Essential oil increases human erythrocyte membrane fluidity. (ac.rs)
  • and inclusion in the 2007 World Health Organization (WHO) classification of tumors of the nervous system, several pediatric cases of the PTPR were described up to date. (surgicalneurologyint.com)
  • Histopathological examination revealed tumour composed of interlacing bundles of smooth muscles with oedematous intervening stroma suggestive of leiomyoma (Figure 1d). (ommegaonline.org)
  • Anticipated technological breakthroughs will create numerous opportunities for determining genetic predisposition, detecting specific tumors, and monitoring biological response to cancer therapy. (aarkstore.com)
  • Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. (ucsf.edu)
  • Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance. (rush.edu)
  • The ranges denoted By biological stage may be used in closely monitored menstrual cycles in regard to other markers of its biological progression, with the time scale being compressed or stretched to how much faster or slower, respectively, the cycle progresses compared to an average cycle. (wikidoc.org)
  • Recombinant human lactoferrin, also known as lactotransferrin/LTF, antigen is produced by mammalian expression system and the target gene encoding Gly20-Lys710 is expressed with a 6His tag at the C-terminus. (medixbiochemica.com)
  • Recombinant human natriuretic peptide B antigen is produced by E. coli expression system and the target gene encoding His27-His134 is expressed with a 6His tag at the N-terminus. (medixbiochemica.com)
  • Recombinant human S100 calcium binding protein B antigen is produced by E. coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. (medixbiochemica.com)
  • Almost all humans have two copies of each chromosome and therefore have two copies of each gene, one inherited from the mother and the other from the father. (healthywomen.org)
  • The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids , while the beta subunits vary. (wikidoc.org)
  • Concurrent alteration of p16 and PTEN tumor suppressor genes could be considered as potential molecular marker for specific subgroups of NSCLC patients. (ac.rs)
  • This graph shows the total number of publications written about "Biological Markers" by people in UAMS Profiles by year, and whether "Biological Markers" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Biological Markers" by people in Profiles over the past ten years. (uams.edu)
  • T1 contrast-enhanced midsagittal MRI displays a tumor mass located in the pineal region, demonstrating heterogeneous post contrast opacification, signs of hemorrhage, and cystic areas (a and b). (surgicalneurologyint.com)
  • Tumour markers including CA 125, AFP (Alfa feto protein), B-HCG (Beta human chorionic gonadotrophin) and LDH (Lactate Dehydrogenase) were within normal limits. (ommegaonline.org)
  • Marni J. Falk, M.D., received her B.S. in Biology graduating Summa cum Laude and Phi Beta Kappa, as well as M.D. in the Alpha Omega Alpha Medical Honor Society from a combined 7-year program at the George Washington University School of Medicine. (agbt.org)
  • FSH regulates the development, growth, pubertal maturation and reproductive processes of the human body. (wikidoc.org)
  • Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. (lookformedical.com)
  • Substances and Disease Registry or the U.S. Department of Health and Human Services. (cdc.gov)
  • Preferred labels are inexpensive, safe, and capable of being attached efficiently to a wide variety of chemical, biochemical, and biological materials without significantly altering the important binding characteristics of those materials. (justia.com)
  • The presence of a particular analyte can often be determined by binding methods that exploit the high degree of specificity, which characterizes many biochemical and biological systems. (justia.com)
  • Don't confuse DHEA with 7-alpha-hydroxy-DHEA, 7-beta-hydroxy-DHEA, and 7-keto-DHEA. (medlineplus.gov)
  • BETA hCG TEST (BhCG) - A blood test used to detect very early pregnancies and to evaluate the development of the embryo. (crgw.co.uk)
  • Recombinant human coronavirus SARS-CoV-2 nucleocapsid protein with a C-terminal histidine tag. (medixbiochemica.com)
  • Many affected individuals develop malignant tumors, especially SARCOMA. (lookformedical.com)
  • Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor originating in this area. (surgicalneurologyint.com)
  • Due to similar morphological features of PTPR with a number of other papillary-like tumors of the pineal region, immunohistochemical analysis is crucial to its distinction. (surgicalneurologyint.com)