• mutations
  • Grigoryan T, Wend P, Klaus A, Birchmeier W. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. (springer.com)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). (wikipedia.org)
  • nucleus
  • This study also showed that signaling via the insulin/Insulin-like growth factor 1 receptor led to increased levels of HDAC7 in the cytosol than the nucleus and increased levels of active β-catenin, indicating that HDAC7 associates with β-catenin. (wikipedia.org)
  • modulation
  • Another study supported the conclusion that HDAC7 and β-catenin associate together by demonstrating that HDAC7 controls endothelial cell growth through modulation of β-catenin. (wikipedia.org)
  • peptide
  • Synthetic phospho-peptide corresponding to amino acid residues surrounding tyrosine 489 of Human beta Catenin. (abcam.com)
  • synthetic peptide corresponding to the C-terminal region (amino acids 768-781) of human/mouse β-catenin, conjugated with gluteraldehyde to KLH. (genetex.com)
  • Western Blot of Catenin, beta (p120) in human brain 1) absence and 2) presence of immunizing peptide and 3) mouse brain lysate using Catenin, beta (p120) PAb. (genetex.com)
  • human
  • Over the past two decades, interdisciplinary research has tremendously advanced our knowledge of β-catenin function and its involvement in human disorders (Takemaru et al. (springer.com)
  • membrane
  • Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. (wikipedia.org)