• Gene
  • Inactivation of the beta-catenin gene within DP of fully developed hair follicles results in dramatically reduced proliferation of the progenitors and their progeny that generate the hair shaft, and, subsequently, premature induction of the destructive phase of the hair cycle. (nih.gov)
  • Gene expression analysis reveals that beta-catenin activity in the DP regulates signaling pathways, including FGF and IGF, that can mediate the DP's inductive effects. (nih.gov)
  • Regulation
  • Transgenic mice that over-expressed mutant presenilin-1 show an increase of beta-amyloid-42(43) in the brain, which suggest presenilin-1 plays an important role in beta-amyloid regulation and can be highly related to Alzheimer's disease. (wikipedia.org)
  • nucleus
  • This study also showed that signaling via the insulin/Insulin-like growth factor 1 receptor led to increased levels of HDAC7 in the cytosol than the nucleus and increased levels of active β-catenin, indicating that HDAC7 associates with β-catenin. (wikipedia.org)
  • overexpression
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • modulation
  • Another study supported the conclusion that HDAC7 and β-catenin associate together by demonstrating that HDAC7 controls endothelial cell growth through modulation of β-catenin. (wikipedia.org)
  • interacts
  • Overall, this study demonstrated that HDAC7 once again interacts with β-catenin to keep endothelial cells in a low proliferation stage. (wikipedia.org)
  • Mutations
  • These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). (wikipedia.org)
  • expression
  • Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. (wikipedia.org)
  • cells
  • This study reveals a signaling loop that employs Wnt/beta-catenin signaling in both epithelial progenitor cells and their mesenchymal niche to govern and coordinate the interactions between these compartments to guide hair morphogenesis. (nih.gov)
  • activity
  • One study showed that HDAC7 suppresses proliferation and β-catenin activity in chondrocytes. (wikipedia.org)
  • During chondrogenesis, HDAC7 is translocated to the cytosol to be degraded, indicating that generally HDAC7 represses β-catenin activity in chondrocytes. (wikipedia.org)
  • different
  • The first repeat of β-catenin (near the N-terminus) is slightly different from the others - as it has an elongated helix with a kink, formed by the fusion of helices 1 and 2. (wikipedia.org)
  • domain
  • As sketched above, the ARM domain of beta-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)
  • Located in structurally diverse partners, the β-catenin binding motifs are typically disordered on their own, and typically adopt a rigid structure upon ARM domain engagement - as seen for short linear motifs. (wikipedia.org)