• gene
  • Unlike what has been reported in T cells and colon cancer cell lines, Lef1ΔN activated gene transcription in the absence of exogenous β-catenin and cooperated with constitutively active β-catenin to further stimulate gene transcription in mesenchymal and osteoblastic cells. (asbmr.org)
  • Together our data indicated that Lef1ΔN binds β-catenin, stimulates gene expression, and promotes terminal osteoblast differentiation. (asbmr.org)
  • mutations
  • According to him, when over-activated by genetic mutations, beta-catenin could drive tumor formation in several tissues, such as the colon, the skin and the kidney. (medindia.net)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • Lef1
  • Here we show that Lef1ΔN retains the ability to physically and functionally interact with β-catenin. (asbmr.org)
  • Residues at the amino-terminus of Lef1ΔN were required for β-catenin binding and the expression of osteoblast differentiation genes. (asbmr.org)
  • domain
  • As sketched above, the ARM domain of beta-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)
  • Located in structurally diverse partners, the β-catenin binding motifs are typically disordered on their own, and typically adopt a rigid structure upon ARM domain engagement - as seen for short linear motifs. (wikipedia.org)
  • targets
  • In contrast, in several important targets, NF-AT and beta-catenin, CKI does not require n − 3 priming but, instead, phosphorylates the first serine in the sequence S-L-S, which is followed by a cluster of acidic residues, albeit less efficiently than the optimal sites. (wikipedia.org)
  • several
  • Maguschak, however, insisted that lithium was an imprecise tool for studying beta-catenin because it affects several enzymes in the brain. (medindia.net)
  • different
  • The first repeat of β-catenin (near the N-terminus) is slightly different from the others - as it has an elongated helix with a kink, formed by the fusion of helices 1 and 2. (wikipedia.org)
  • further
  • They further said that medications that enhance beta-catenin function within the brain might serve as new therapies to treating disorders of memory, such as Alzheimer's disease. (medindia.net)
  • Short
  • However, after the process of moving memories from short-term to long-term is complete, beta-catenin doesn't appear to be necessary anymore," she said. (medindia.net)