• CYP1A1
  • The mechanism of action of benzo[a]pyrene-related DNA modification has been investigated extensively and relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1). (wikipedia.org)
  • Seemingly, the high activity of CYP1A1 in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene from entering portal blood and systemic circulation. (wikipedia.org)
  • In the first step, a cytochrome P450 1A1 (CYP1A1) catalysed oxidation produces several products including (+)-benzo[a]pyrene-7,8-epoxide. (wikipedia.org)
  • Induction of CYP1A1 by benzo[a]pyrene occurs via binding to the aryl hydrocarbon receptor in the cytosol, leading the transformed receptor to translocate to the nucleus where it dimerises with aryl hydrocarbon receptor nuclear translocator and then binds xenobiotic response elements in DNA located upstream of certain genes. (wikipedia.org)
  • Seemingly, CYP1A1 activity in the intestinal mucosa prevents major amounts of ingested benzo[a]pyrene to enter portal blood and systemic circulation. (wikipedia.org)
  • ubiquitous
  • Land developers and remediators in Pennsylvania and New Jersey may soon have an easier time addressing soils containing benzo[a]pyrene, one of the most ubiquitous urban contaminants, thanks to updated information that was just released by U.S. Environmental Protection Agency (EPA). (lexology.com)
  • The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. (mdpi.com)
  • Benzo[a]pyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 °C (572 °F) and 600 °C (1,112 °F). The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. (wikipedia.org)
  • enzyme
  • We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs). (sigmaaldrich.com)
  • levels
  • The revised toxicity criteria form the basis for the New Jersey Soil Remediation Standards and the Pennsylvania Statewide Health Standards, which define the acceptable default levels of benzo[a]pyrene that can be present in soil. (lexology.com)
  • form
  • On reduction of this ketone using lithium aluminium hydride the alcohol 3,4-dihydro-5H-benzo[cd]pyren-5-ol was obtained, the 3,4-dihydro-5H-benzo[cd]pyren-5-ol was treated with an acid in the form of ion exchange resin to furnish the product. (wikipedia.org)
  • production
  • The production of 3- OH-benzo(a)pyrene (13345216) and 9-OH-benzo(a)pyrene (17573216) was used to evaluate the effects of dimethyl-sulfoxide (DMSO), acetone, methanol, ethanol, and ethyl-acetate on BP-hydroxylase activity. (cdc.gov)
  • include
  • Natural sources of benzo[a]pyrene include forest fires and volcanoes, and anthropogenic sources include stoves/furnaces burning fossil fuels (especially wood and coal), motor vehicle exhaust, and various industrial combustion processes. (epa.gov)