• Most thyroid nodules are benign hyperplastic lesions, but 5-20% of thyroid nodules are true neoplasms. (medscape.com)
  • We evaluated the semiquantitative expression of ALDH1 using a score based on positive cells rate and staining density in benign lesions. (omicsonline.org)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • CONCLUSIONS: Vesiculopustular lesions are common in congenital/neonatal LCH, but the morphologic characteristics of lesions are not helpful in predicting the extent of disease. (thedoctorsdoctor.com)
  • These polyps may then progress to benign adenomas, and ultimately to invasive cancer lesions. (biomedcentral.com)
  • therefore, the long-term prognosis for untreated lesions involving the weightbearing surface of the joint, though unreported, is one of a progression toward pain and arthrosis. (medscape.com)
  • The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene has been associated with the transformation of benign lesions to malignancy, disease progression, poor prognosis, reduced survival, and development of resistance to radiation and chemotherapy in many types of cancer. (nih.gov)
  • To address this problem, Widemann put together a study of 259 participants to chart the growth of their tumors, creating a baseline for the progression of the disease. (servicetoamericamedals.org)
  • Widemann and her team regularly examined these children with benign tumors for 10 years and detailed how each child's tumors changed. (servicetoamericamedals.org)
  • In addition to her success with NF1 benign tumors, Widemann and her team followed atypical tumors to see why and how they turned cancerous. (servicetoamericamedals.org)
  • My laboratory seeks greater understanding of the mechanisms driving tumorigenesis and disease progression in malignant brain tumors. (stanford.edu)
  • This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
  • Purpose: Infantile hemangiomas (IHs) are commonly observed benign tumors that can cause serious complications. (bvsalud.org)
  • Furthermore, the histologic criteria used to distinguish benign from malignant neoplasms can be subtle. (medscape.com)
  • Dr. Li's research interests focus on all aspects of breast diseases from benign to malignant neoplasms, particularly biomarker development and studying the mechanisms underlying tumor initiation, progression and metastasis. (emory.edu)
  • POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)
  • The underlying pathology in over 98 % of cases is benign adenomatous hyperplasia (adenoma) and as such the disease carries a favourable prognosis with effective therapy. (vin.com)
  • The prognosis is dependent on the stage of the disease and extent of metastases. (hindawi.com)
  • Tumour development, histology and grade of breast cancers: prognosis and progression. (who.int)
  • CRC develops in a progressive fashion during which normal colon epithelial cells transform to form benign growths such as polyps. (biomedcentral.com)
  • Iraq have demonstrated that most patients with benign epithelial mam- 100 lens for counting the positive cells. (who.int)
  • Secondly, bowel cancer typically is a slow-growing cancer, taking years to develop from benign polyps to a malignant tumour. (sjog.org.au)
  • However CRC is a heterogeneous disease with various patient-related confounding factors such as the anatomic location of the tumour, race/ethnicity of the patient, and genetic and dietary interactions influencing the development of the disease [ 3 ]. (biomedcentral.com)
  • Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
  • In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)
  • The positive expression of ALDH1 may play a role during the evolution of disease from ADH to breast cancer, as ALDH1 has a predicted value in outcome of breast cancer. (omicsonline.org)
  • Lycopene as a dietary supplement is a potent antioxidant used to help prevent cancer, heart disease, and macular degeneration. (cancernetwork.com)
  • Predict progression in prostate cancer, where slow-growing prostate cancer is difficult to differentiate from more aggressive forms. (clickpress.com)
  • Likewise, prostatitis has been linked to prostate cancer development and progression. (purdue.edu)
  • Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that expand during benign and cancer-associated inflammation. (purdue.edu)
  • Bowel cancer screening plays a vital role in identifying the disease in its early stages, offering a higher chance of successful treatment which improves survival. (sjog.org.au)
  • These children now have a chance for a better life because of Dr. Brigitte Widemann, a pediatric oncologist at the National Cancer Institute who developed the first successful therapy to treat this debilitating disease after nearly two decades of study. (servicetoamericamedals.org)
  • The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups. (biomedcentral.com)
  • We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups. (biomedcentral.com)
  • The progression of the cancer has also been associated with sequential genetic changes in genes such as K-RAS, APC, DCC, and P53 [ 2 ]. (biomedcentral.com)
  • Age appeared as an independent effect modifier that will be further investigated.A total of 547 men, with a suspicion of prostate cancer that had undergone multiple biopsies, and whose biopsies had benign histology were later compared with the background population to evaluate whether they were a group at risk of developing prostate cancer. (kb.se)
  • It is generally believed that the high mortality rate of lung cancer cases may be a result of the aggressiveness and invasive and metastatic potential of the disease and the fact that it is not easily detectable until it reaches advanced stages [ 2 ]. (hindawi.com)
  • Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
  • The aim of the study is to assess whether alterations in the phenotype and function of NK cells induced by the presence of prostate cancer can be detected in the periphery and be used as parameters for aiding diagnosis and assessing disease progression. (ntu.ac.uk)
  • Our bedside-to-bench-to-bedside research model builds on a foundation of generously donated patient samples, where we test mechanisms of brain cancer growth, develop novel pre-clinical models that reliably recapitulate the human disease, and facilitate clinical trials of new treatments for patients with brain cancer. (stanford.edu)
  • Prostate cancer is a disease we tend to see in older age groups (over-50s), but there are exceptions, as with any form of cancer," said Dr Sanjay Mehta, GP at The London General Practice . (inyourarea.co.uk)
  • This age grouping permits age-specific inputs for patterns of sexual activity and cervical cancer screening and allows for age- specific outputs such as rates of cervical human papillomavirus (HPV) disease among girls and women, and genital warts among both males and females. (cdc.gov)
  • The epidemiologic model simulates HPV infection and occurrence of HPV disease (cervical intraepithelial neoplasia [CIN], cervical cancer, and genital warts) in the population. (cdc.gov)
  • To simulate the occurrence of CIN, genital warts, and cervical cancer among those infected with HPV, we divided the population into distinct epidemiologic categories, according to the population's susceptibility to infection or the population's status with respect to infection, disease, screening, and treatment. (cdc.gov)
  • Breast cancer is a common and frequently fatal disease, and the second ranking cause of cancer death in the Eastern Mediterranean Region. (who.int)
  • This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • The histology is typically well-differentiated and may appear entirely in situ (Bowen disease). (logicalimages.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Provide pneumococcal vaccine and annual influenza vaccines as recommended by Centers for Disease Control and Prevention. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • This Funding Opportunity Announcement (FOA) invites applications for investigator-initiated clinical trials within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to be conducted at no more than two clinical research centers. (nih.gov)
  • Applications for clinical trials submitted under this FOA should be hypothesis driven, have clearly described aims and objectives, and have a high likelihood that the trial findings will improve understanding, diagnosis, prevention or treatment of the diseases studied and have the potential to impact clinical practice and/or public health. (nih.gov)
  • The clinical course of the condition is generally benign regardless of age. (medifocus.com)
  • 7 After progression into the clinical phase of the disease, women had better Unified Parkinson's Disease Rating Scale (UPDRS) motor scores 8 but a greater prevalence of dyskinesias 8, 9 compared with men (at a disease duration of more than 5 years). (bmj.com)
  • Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. (prospecbio.com)
  • the importance of the present case is the rare concomitant occurrence of both conditions, with special concern towards the malignancy potential related to both diseases. (bvsalud.org)
  • The differential diagnosis of solitary thyroid nodule can be broadly classified into benign and malignant. (medscape.com)
  • Presented by Shona Stewart, Ph.D., senior scientist at ChemImage, 'Advancing Raman Molecular Imaging for Disease Diagnosis' will discuss application of RMI in histopatholgy settings. (clickpress.com)
  • The results of a multiorgan workup performed at the time of diagnosis were predictive of which patients in this cohort manifested multisystem disease. (thedoctorsdoctor.com)
  • See also the American Association for the Study of Liver Diseases [AASLD] 2018 practice guidance on the diagnosis and management of MASLD. (merckmanuals.com)
  • This suggests that these markers may only have potential for use as biomarkers of progression, not diagnosis. (ntu.ac.uk)
  • The appearance of people with the disease is depicted in: Carvings of Queen of Punt (Egypt), as noted above The Italian statue The Warrior of Capestrano, as noted above Donna Leon's crime novel, Beastly Things (2012), wherein the protagonist investigates the murder of a man who had the condition, which Brunetti learns has a high incidence in Italy Lipomatosis List of skin conditions Madelung's deformity Rapini, Ronald P. (wikipedia.org)
  • Thyroid adenomas are benign neoplasms and are usually classified as follicular or papillary. (medscape.com)
  • Abnormal fluid-filled sacs or benign/malignant tissue growths on canines may necessitate extraction. (cdhp.org)
  • Discriminate between two challenging kidney disease diagnoses: oncocytoma, a benign condition and chromophobe renal cell carcinoma, a malignant one. (clickpress.com)
  • LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. (prospecbio.com)
  • Taken together, these findings suggest a more benign phenotype in women with PD. (bmj.com)
  • A diagnostic biopsy is often delayed due to the slow progression of disease, patient reluctance to undergo biopsy, technical difficulties, or prolonged treatment of a suspected benign condition. (logicalimages.com)
  • After a mean follow-up time of 6.2 years the first analyses, according to intention-to-treat, showed that radical prostatectomy reduced disease specific mortality, risk of metastases and risk of local progression but did not statistically significantly reduce overall mortality. (kb.se)
  • Solitary thyroid nodule may represent a multitude of thyroid disorders, and a thorough knowledge of the epidemiology of thyroid disease is of paramount importance. (medscape.com)
  • Statistically significant associations included the following: infections in the neonatal period (MS-LCH, odds ratio (OR) = 2.2), solvent exposure (SS-LCH, OR = 54.9), childhood vaccinations (MS-LCH and SS-LCH, OR = 0.4), thyroid disease in the proband (MS-LCH and SS-LCH, OR = 21.6), and family history of thyroid disease (MS-LCH and SS-LCH, OR = 1.4). (thedoctorsdoctor.com)
  • The association with thyroid disease in the proband was explained partially by the involvement of the pituitary, with the relative risk decreasing when patients with diabetes insipidus and thyroid involvement were excluded from analysis. (thedoctorsdoctor.com)
  • In fact, palpable nodular disease is 6 times more common in adolescent females compared to males of the same age. (medscape.com)
  • Do patients with a benign form of MS require therapy or are they exposed unnecessarily to adverse effects of our currently available medications? (nih.gov)
  • 2. Schwarz S, Obermuller-Jevic UC, Hellmis E, et al: Lycopene inhibits disease progression in patients with benign prostate hyperplasia. (cancernetwork.com)
  • This disease seriously affects the quality of life of patients and can even trigger a mental illness. (hindawi.com)
  • Jill Sisco is President of Acromegaly Community, Inc., a patient organization that helps educate patients and loved ones regarding this rare disease and provides guidance on how to cope with their difficult illness. (biospace.com)
  • One third of patients had disease limited to the skin and/or mucous membranes. (thedoctorsdoctor.com)
  • Twelve of the 19 patients had multisystem disease, and 2 died of disease. (thedoctorsdoctor.com)
  • The majority of patients have sporadic disease.6 Although the true Mendelian forms of PD are rare (occuring in 30% of familial and 3-5% of sporadic PD) 5 there is a positive family history in 10% of patients with apparently sporadic PD. (acnr.co.uk)
  • Patients infected with both viruses had slower disease progression than those infected with HIV-1 only. (medscape.com)
  • The natural history of HIV-2 infection tends to be more benign than that of HIV-1, and most patients infected solely with HIV-2 do not progress to AIDS. (medscape.com)
  • For instance, the five-year survival rate for patients with (stage IA) after surgical resection is close to 70% but the five-year survival rate for patients with stage IV (metastatic disease) is as low as 2% [ 4 ]. (hindawi.com)
  • These patients could not be phenotypically distinguished from patients with benign disease. (ntu.ac.uk)
  • Limited investigations into the ability of NK cells from patients to be primed only found phenotypic differences between healthy volunteers and patients in general (regardless of the presence of disease). (ntu.ac.uk)
  • We studied 253 consecutive PD patients who were not receiving levodopa or dopamine agonists (disease duration ⩽10 years). (bmj.com)
  • Patients who are symptomatic may need documentation of impairments caused by asbestos-associated disease for the purpose of filing for workers compensation, social security disability, or other claims. (cdc.gov)
  • Patients with advanced disease and hypoxemia at rest, during exercise, or during sleep may benefit from continuous home oxygen therapy, which can prevent or attenuate cor pulmonale. (cdc.gov)
  • Also, people with diabetes who eat more lycopene don't seem to have a lower risk of dying from heart disease. (medlineplus.gov)
  • She said: "Our results give an early indication that MRI could offer a more reliable method of detecting potentially serious cancers early, with the added benefit that less than 1 per cent of participants were 'over-diagnosed' with low-risk disease. (inyourarea.co.uk)
  • Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)
  • Identification of mechanisms underlying MDSC activities can enable the development of strategies to modify MDSC function in disease. (purdue.edu)
  • Steatotic liver disease develops for many reasons, involves many different biochemical mechanisms, and causes different types of liver damage. (merckmanuals.com)
  • The focus of the scientific community has thus shifted to exploring the identification of non-invasive biomarkers of disease from bio-fluids such as saliva, urine, and blood. (biomedcentral.com)
  • In addition, alpha cell dysfunction is recognised as a prominent feature of the disease [ 3 ]. (springer.com)
  • Failure to institute therapy leads to progression of thyrotoxicosis, emaciation and severe cardiac and metabolic dysfunction and eventual death. (vin.com)
  • Metabolic dysfunction-associated liver disease (MASLD) includes simple fatty infiltration (a benign condition called steatotic liver disease), whereas metabolic dysfunction-associated steatohepatitis (MASH) is defined as the presence of fat leading to lipotoxicity and inflammatory damage to hepatocytes. (merckmanuals.com)
  • MASLD includes simple fatty infiltration (a benign condition called steatotic liver disease) and metabolic dysfunction-associated steatohepatitis (MASH), a less common but more important variant. (merckmanuals.com)
  • The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity and is now the most common chronic liver disease in developed countries. (oregonstate.edu)
  • The early appearance may mimic that of more benign conditions such as verruca , chronic paronychia , or infection. (logicalimages.com)
  • Chronic disseminated: with low-grade intermittent fever, weight loss, weakness, hepatosplenomegaly, mild hematological abnormalities and focal manifestations of disease. (cdc.gov)
  • Another disease that affects the lower lip is Actinic Cheilitis (AC), which is more common than CG, and has chronic sun exposure as its main cause, leading to alterations of the epithelium and of the collagen and elastic fibers. (bvsalud.org)
  • Dysplasia epiphysealis hemimelica (DEH), or Trevor disease, is a rare developmental disorder affecting the epiphyses in young children. (medscape.com)
  • DEH is a benign disorder, and no cases of malignant transformation have been reported. (medscape.com)
  • Hyperthyroidism is considered to be the most common endocrine disorder of cats and a disease frequently encountered in small animal practice. (vin.com)
  • Parkinson's disease (PD) is a heterogeneous, neurodegenerative disorder affecting 6.3 million people worldwide and 1.2 million in Europe. (acnr.co.uk)
  • Our studies have focused on the impact of diet on the onset and progression of NASH. (oregonstate.edu)
  • In addition, heterozygote mutations in certain 'recessive' genes have been associated with late onset disease, possibly because of partial expression of the corresponding protein. (acnr.co.uk)
  • We investigated the influence of gender and oestrogen status on: (1) age at onset, (2) presenting symptom, (3) severity and progression of motor symptoms (Unified Parkinson's Disease Rating Scale III (UPDRS-III) scores) and (4) amount and progression of nigrostriatal degeneration ([ 123 I]FP-CIT single photon emission computed tomography measurements). (bmj.com)
  • Mean UPDRS-III scores at disease onset were equal for both genders, as was the rate of deterioration. (bmj.com)
  • In line with the ageing population, the prevalence of coronary artery disease (CAD), lower extremity peripheral arterial disease (PAD), supra-aortic arterial disease (SAD) and renal stenosis (RAS) is increasing. (who.int)
  • Previous research suggests that HIV-2 infection protects against subsequent HIV-1 infection and, in cases of dual infection, slows the rate of HIV-1 disease progression. (medscape.com)
  • The acquisition of infection and progression from infection to disease follow a similar natural history structure, as assumed in previous models for HPV 16 and 18 ( 7 ). (cdc.gov)
  • Serologic test-immunodiffusion test: A rise in complement fixation titers in paired sera may occur early in acute infection and is suggestive evidence of active disease. (cdc.gov)
  • This study demonstrates that HIV-1 disease progression is inhibited by concomitant HIV-2 infection. (lu.se)
  • Benign symmetric lipomatosis is a skin condition characterized by extensive symmetric fat deposits in the head, neck, and shoulder girdle area. (wikipedia.org)
  • Recent studies suggest that moderate AS is not a benign condition and is associated with increased mortality and morbidity especially when LV function is already reduced. (edwards.com)
  • However, as long-standing Bowen disease frequently shows evidence of microinvasion on serial histologic cuts, it is typically treated as aggressively as invasive SCC. (logicalimages.com)
  • The pattern of inheritance may be elusive at times e.g. reduced penetrance associated with autosomal dominant inheritance may mimic recessive disease. (acnr.co.uk)
  • On the contrary, tangential RT to the left breast without regional lymph node irradiation yielded coronary artery max doses of approximately 50 Gray to distal LAD, probably not safe concerning late radiation vascular effects.To conclude, we found cardiovascular side effects in women irradiated for BC, resulting in stroke and coronary artery disease, and showed an association between the targets for RT and the anatomical location of these vascular events. (kb.se)
  • Acute benign respiratory - mild respiratory illness with general malaise, fever, chills, headache, myalgia, chest pains, nonproductive cough and scattered small calcifications of the lung. (cdc.gov)
  • For example, the single-autoantibody-positive stage generally has a significantly lower of risk of progression [ 12 ] and as such is not considered as the earliest stage of type 1 diabetes. (springer.com)
  • Furthermore, their HIV-1 viruses exhibited significantly less genetic diversity over time, which also suggests an attenuating effect of HIV-2 on HIV-1 disease progression. (medscape.com)
  • Now, a new research has revealed that using MRI scans could significantly decrease fatalities caused by this disease. (inyourarea.co.uk)
  • Immunohistopathological studies of pancreases from individuals with type 1 diabetes are generally compatible with these observations made in mice (see references below) but have exposed additional phenomena peculiar to the natural history of the disease in humans. (springer.com)
  • Pleural plaques are generally benign, but can occasionally result in pulmonary impairment. (cdc.gov)
  • His areas of interest include Parkinson's disease, atypical dementias and the genetics of neurological disorders. (acnr.co.uk)
  • Slip progression after skeletal maturity is usually related to disk degeneration secondary to osteoarthritis at the slip level. (medifocus.com)
  • To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD). (bmj.com)
  • Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)
  • While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. (frontiersin.org)
  • While these conventional drugs have been found to be efficacious in the treatment of BPH, the adverse effects associated with them, ranging from impotence and gynaecomastia to orthostatic hypotension, abnormal ejaculation amongst others, have led to increased search for alternative means of managing this disease. (frontiersin.org)
  • How do we identify disease progression and treatment failures? (nih.gov)
  • In affected cats, treatment of the underlying cardiac disease is required together with antithyroid medication. (vin.com)
  • In many cases, on-going treatment of the cardiac disease is required even when euthyroidism is induced suggesting either irreversible thyroid hormone induced damage or pre-existing cardiac disease. (vin.com)
  • Treatment is aimed at managing the underlying disease process. (medscape.com)
  • The aim of BPH treatment is alleviating urination problems, preventing prostatic disease progression, and improving the quality of life. (medscape.com)
  • It typically develops during childhood or adolescence and is associated with a high risk of progression. (medifocus.com)
  • Adults who are diagnosed with high-grade slippage are typically stable and rarely experience further progression of slippage. (medifocus.com)
  • Steatotic liver disease is due to excessive accumulation of lipid in hepatocytes. (merckmanuals.com)
  • Cats with the dilative form of hyperthyroidism tend to exhibit more severe cardiac disease. (vin.com)
  • I have developed various statistical methods to analyze high-dimensional data to identify genetic and environmental risk factors and their interactions for complex disease. (stanford.edu)
  • Diana Olszewska is a Neurology Research Fellow at the Dublin Neurological Institute, Mater Misericordiae University Hospital with a particular interest in genetics of Parkinson's disease. (acnr.co.uk)
  • GWAS and linkage analysis have identified 18 Parkinson's disease loci (PARK) numbered in a chronological order. (acnr.co.uk)
  • There are several indications of gender differences in Parkinson's disease (PD). (bmj.com)
  • So far, RMI has shown great success in differentiating disease states in tissue, especially from the kidney and prostate. (clickpress.com)
  • Some complications of asbestos-related disease like acute pleuritis are self-limited. (cdc.gov)
  • Future progress in this area holds promise for advancing islet- and beta cell-directed therapies that could be implemented in the early stages of the disease and could be combined with immunotherapies. (springer.com)
  • Firstly, the disease often develops without noticeable symptoms in its early stages, making it difficult to detect without proper screening. (sjog.org.au)