• This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. (wikipedia.org)
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (innov-research.com)
  • Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. (innov-research.com)
  • The EPH subfamily is the biggest group of receptor protein kinases and they take part in vital nervous system function and development. (prospecbio.com)
  • ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. (thermofisher.com)
  • This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. (assaysolution.com)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph subfamily with tyrosine kinase activity, plays a key role in the regulation of signaling pathways related to the malignant phenotype of various tumor cells, but its specific regulatory mechanism in colorectal cancer needs to be further clarified. (aging-us.com)
  • AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)
  • Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. (assaysolution.com)
  • Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). (betalifesci.com)
  • The ROR2 protein is part of a family of proteins known as receptor tyrosine kinases (RTKs), which play a role in chemical signaling within cells. (medlineplus.gov)
  • Kinase inhibitors are enzyme inhibitors that blocks the action of one or more protein kinases which interferes with the growth and spread of cancer cells in the body. (drugs.com)
  • The treatment paradigm of AML patients harboring FLT3 mutations (30%) has been modified by the discovery of tyrosine kinase inhibitors. (dovepress.com)
  • Activity of these inhibitors depends on their mechanism of receptor binding (active vs inactive conformation) and efficacy against the FLT3-ITD and -TKD mutations (type 1 inhibitors are active both on FLT3 -ITD and TKD, whereas type 2 inhibitors are active only on FLT3 -ITD). (dovepress.com)
  • Inhibitors for c-Met and RON including small molecular weigh kinase inhibitors and neutralizing antibodies are in pre-clinical investigation and clinical trials. (oncotarget.com)
  • Several of the tyrosine kinase inhibitors have activity against both c-Met and RON kinases whereas the antibodies generally are target specific. (oncotarget.com)
  • FIP1L1-PDGFRA associated hypereosinophilic disorders are sensitive to treatments with tyrosine kinase inhibitors such as imatinib mesylate (imatinib). (atlasgeneticsoncology.org)
  • Patients with hypereosinophilic syndrome historically carried a poor prognosis before the successful therapeutic application of tyrosine kinase inhibitors. (atlasgeneticsoncology.org)
  • Furthermore, the drug response prediction indicated that stemness subtype A had a better response to chemotherapy but was more resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). (biomedcentral.com)
  • The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)
  • Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)
  • Src (src proto-oncogene, non-receptor tyrosine kinase) is a protein coding gene. (anthonyvandarakis.org)
  • Src is a proto-oncogene encoding a non-receptor tyrosine kinase, similar to the v-src gene of the rous sarcoma virus (14), which was initially. (anthonyvandarakis.org)
  • The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. (wikipedia.org)
  • The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
  • The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
  • Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided. (justia.com)
  • Such therapy functions through mediating alterations in antigen or receptor function, modulating the immune system or delivering a specific drug that is conjugated to an antibody that targets a specific antigen. (justia.com)
  • In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)
  • In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof, as defined herein, comprising a radioisotope or a cytotoxin conjugated thereto. (justia.com)
  • In one aspect, there is provided a composition comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof as defined herein. (justia.com)
  • In one aspect, there is provided a use of an antigen-binding protein, or an antigen-binding fragment thereof as defined herein in the manufacture of a medicament for treating cancer. (justia.com)
  • CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. (biolegend.com)
  • The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
  • Lenvima is a kinase inhibitor used to treat certain types of cancer. (drugs.com)
  • Moreover, mH2A1.1-OE proteomic profile identified several upregulated proteins associated to DNA and histones hypermethylation, including S-adenosylhomocysteine hydrolase, a strong inhibitor of DNA methyltransferase and of the methyl donor S-adenosyl-methionine (SAM). (bvsalud.org)
  • pump inhibitor, and (3) src kinase inhibition. (anthonyvandarakis.org)
  • The following core technologies: (1) orascovery, based on p-glycoprotein inhibitor, (2) src kinase inhibition, and (3) cell therapy. (anthonyvandarakis.org)
  • Technologies: (1) cell therapy based on nkt cells (2) orascovery, based on a p-glycoprotein inhibitor, and (3) src kinase inhibition. (anthonyvandarakis.org)
  • OSAKA, Japan & CAMBRIDGE, Mass.--( BUSINESS WIRE )-- Takeda ( TSE:4502/NYSE:TAK ) today announced positive results from a Phase 2b clinical trial of TAK-279 (NDI-034858), a highly selective, oral allosteric tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate-to-severe plaque psoriasis. (biospace.com)
  • Bosutinib (SKI-606) is a 4-anilino-3-quinoline carbonitrile, which acts as a dual inhibitor of Src and ABL kinases. (mdm2-receptor.com)
  • Bosutinib has the potency to induce deep and fast responses in second- and third-/fourth-line treatment, and as a consequence, the drug has recently been licensed for patients previously treated with one or more tyrosine kinase inhibitor(s) and for whom imatinib, nilotinib, and dasatinib are not considered appropriate treatment options. (mdm2-receptor.com)
  • Bosutinib (SKI-606), 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3- (4-methyl-1-piperazinyl) propoxy]-3-quinolinecarbonitrile monohydrate, is a competitive inhibitor of both Src and ABL tyrosine kinases. (mdm2-receptor.com)
  • It was originally synthesized as an inhibitor of the Src kinase family. (mdm2-receptor.com)
  • Bosutinib is a potent dual inhibitor of the Src and ABL tyrosine kinases (Puttini et al. (mdm2-receptor.com)
  • Neratinib is an investigational, orally administered, irreversible inhibitor of the ErbB1 (EGFR), ErbB2 (HER2) and ErbB4 (HER4) kinases. (her2support.org)
  • OSAKA, JAPAN & CAMBRIDGE, MASS.--( Business Wire / Korea Newswire ) September 12, 2023 -- Takeda ( TSE:4502/NYSE:TAK ) today announced positive topline results from its randomized, double-blind, placebo-controlled, multiple-dose Phase 2b trial evaluating TAK-279, an investigational oral allosteric tyrosine kinase 2 (TYK2) inhibitor with next generation selectivity, in people with active psoriatic arthritis. (koreanewswire.co.kr)
  • TAK-279 is a highly selective, oral allosteric tyrosine kinase 2 (TYK2) inhibitor in late-stage development,[6] with approximately 1.3 million-fold greater selectivity for TYK2 as compared with JAK1. (koreanewswire.co.kr)
  • A 61-year-old man who had been treated for 4 years with the Bruton's tyrosine-kinase (BTK) inhibitor ibrutinib as a first-line therapy for chronic lymphocytic leukemia (CLL) sought treatment for a painful rash. (cdc.gov)
  • Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. (nih.gov)
  • HER2 positive breast cancer is identified by the overexpression of human epidermal growth factor receptor-2 (HER2) protein in tumor tissue and results in an increased rate of cell proliferation. (her2support.org)
  • The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. (nature.com)
  • The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (innov-research.com)
  • This gene encodes a protein that binds ephrin-A ligands. (creativebiomart.net)
  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. (affbiotech.cn)
  • Aberrant expression and activities of c-Met and RON in cancer are attributed to various mechanisms including increased expression of their ligands or receptors and by activating mutations [ 4 , 15 ]. (oncotarget.com)
  • Eph receptors and their ligands, Ephrin proteins (Eph receptor interacting proteins), play a key role in many pathological states (abnormally elevated RTK activity is a feature of most human cancers), and therefore Eph receptors can be used as potential drug targets [ 9 , 10 ]. (aging-us.com)
  • The classical mode means that EphA2 inhibits positive signaling of ligands and tyrosine kinases, thereby suppressing tumorigenesis. (aging-us.com)
  • Neural factors are a class of protein molecules with neurotrophic activity that can promote the survival and regeneration of nerve cells. (acrobiosystems.com)
  • rat chicken Human Zebrafish Caenorhabditis elegans Drosophila In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. (wikipedia.org)
  • A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. (thermofisher.com)
  • This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. (thermofisher.com)
  • Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. (rndsystems.com)
  • ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. (nih.gov)
  • EFNA1 belongs to the ephrin (EPH) family. (prospecbio.com)
  • The semaphorin superfamily are composed of three protein families, the semaphorins, plexins and the c-Met family [ 2 ]. (oncotarget.com)
  • A closely related family member is the DDR2 protein. (assaysolution.com)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. (betalifesci.com)
  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. (nih.gov)
  • However, it does form heterodimers with other EGF receptor family members which do have kinase activity. (nih.gov)
  • These data demonstrate that the src family tyrosine kinases are direct effectors of g proteins. (anthonyvandarakis.org)
  • Src family belongs to nonreceptor tyrosine kinases. (anthonyvandarakis.org)
  • TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
  • The Eph receptor family is the largest family of receptor tyrosine kinases and is a key regulator of cell growth, differentiation and motility [ 6 - 8 ]. (aging-us.com)
  • The highly selective TYK2 inhibition seen with TAK-279 spares inhibition of other members of the Janus kinase (JAK) family, which we believe should avoid JAK-related toxicities," said Andy Plump, President R&D, Takeda. (biospace.com)
  • CD8a is a 34 kD protein that belongs to the immunoglobulin family. (biolegend.com)
  • ErbB2 belongs to the ErbB family of receptor tyrosine kinases, which has been implicated in a variety of human cancers , including cancers of the breast. (her2support.org)
  • Zika virus(ZIKV) belongs to the family Flaviviridae and genus Flavivirus. (bvsalud.org)
  • Tyr protein kinase family. (lu.se)
  • Helicobacter is a gram-negative spiral bacillus belonging to the Helicobacteriaceae family ( 1 , 2 ). (cdc.gov)
  • The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. (thermofisher.com)
  • The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
  • Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
  • Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al. (nih.gov)
  • The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. (affbiotech.cn)
  • Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. (betalifesci.com)
  • Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Mutations in the RON and c-Met promoters are known to enhance transcription and point mutations have been identified that enhance tyrosine kinase activity [ 19 - 21 ]. (oncotarget.com)
  • Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
  • Some of these mutations change single protein building blocks (amino acids) in the ROR2 protein, while others lead to the production of an abnormally short, nonfunctional version of the protein. (medlineplus.gov)
  • Because these genetic changes prevent any functional ROR2 protein from being made, they are described as "loss-of-function" mutations. (medlineplus.gov)
  • Unlike the mutations that cause Robinow syndrome (described above), the ROR2 gene mutations that cause brachydactyly type B1 are described as "gain-of-function" because they appear to cause the ROR2 protein to be continuously active. (medlineplus.gov)
  • EPHA2 MS Standard C13 and N15-labeled recombinant protein (NP_004422) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. (creativebiomart.net)
  • These findings suggest that EphA2 is a novel membrane protein with phase separation ability and is associated with ferroptosis and immune cell infiltration, which further suggests that malignant progression of colorectal cancer may be inhibited by suppressing the phase separation ability of EphA2. (aging-us.com)
  • This Mouse Ephrin Type-A Receptor 4 (EphA4) ELISA Kit from Innovative Research is intended for quantitative detection of mouse EphA4 in cell culture supernates, serum and plasma (heparin, EDTA). (innov-research.com)
  • Expression system for standard: EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. (innov-research.com)
  • Western Blot was performed using Anti-ROR2 Monoclonal Antibody (OTI3H3) (Product # MA5-27244) and a 130 kDa band corresponding to Tyrosine-protein kinase transmembrane receptor ROR2 was observed across tested cell lines. (thermofisher.com)
  • The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. (wikipedia.org)
  • TIE2, also known as TEK tyrosine kinase, TIE2 gene is mapped to 9p21.2. (thermofisher.com)
  • This gene encodes a receptor tyrosine kinase. (nih.gov)
  • The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. (assaysolution.com)
  • In addition, the BCR-ABL fusion gene product, a constitutively activated tyrosine kinase which is crucial for the development of chronic myeloid leukemia (CML), is highly sensitive to bosutinib. (mdm2-receptor.com)
  • The ROR2 gene provides instructions for making a protein whose function is not well understood. (medlineplus.gov)
  • Other approaches include the use of gene drive and exploration of the genetic redundancy to disrupt the receptors used by the virus to gain entry into its host. (bvsalud.org)
  • HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche. (thermofisher.com)
  • Regulation of metabolic homeostasis by the TGF-beta superfamily receptor ALK7. (nih.gov)
  • Belongs to the protein kinase superfamily. (lu.se)
  • The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. (thermofisher.com)
  • Description: The Matched Pair Paraffin Tissue (MPPT) slides are designed for identifying tumor-specific/metastasis genes or proteins. (brady-printers.club)
  • FMS-like tyrosine kinase 3 ( FLT3 ) is one of the most frequently mutated genes in acute myeloid leukemia (AML). (dovepress.com)
  • Among the most mutated driver genes in AML is FMS-like tyrosine kinase 3 ( FLT3 ). (dovepress.com)
  • Transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
  • El objetivo de nuestro estudio tuvo como objetivo revisar y correlacionar genes involucrados en TEA y aquellos relacionados con la comunicación ultrasónica en estudios con modelos animales de comportamiento social basado en el lenguaje en la base de datos PubMed. (bvsalud.org)
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
  • Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. (abcam.com)
  • 2006). In addition, more than 45 other tyrosine and serine/threonine kinases have been identified as potential targets of bosutinib. (mdm2-receptor.com)
  • STP, serine/threonine protein phosphatase. (rupress.org)
  • This protein can be a membrane-bound or soluble protein. (nih.gov)
  • This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. (nih.gov)
  • 6] In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. (assaysolution.com)
  • Inhibiting Focal Adhesion Kinase (FAK), Protein Kinase B (PKB) and Extracellular Regulated Rotein Kinases (ERK) affects cell motility and survival. (aging-us.com)
  • Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. (rndsystems.com)
  • Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. (betalifesci.com)
  • CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. (biolegend.com)
  • Approximately 30% of the adult cases harbor an internal tandem duplication ( FLT3 -ITD) and 5- 10% a tyrosine kinase domain (TKD) amino acid substitution ( FLT3-TKD ). (dovepress.com)
  • Subsequently, cDNA encoding the RYK protein have been isolated from the following species. (wikipedia.org)
  • The viral tropism revealed an infection of the skin fibroblasts, keratinocytes, and immature dendritic cells through enhanced expression of dendritic cell-specific intracellular adhesion molecule 3-grabbing nonintegrin or anexelecto (Greekword: 'uncontrolled') and tyrosine protein kinase receptor 3 systems. (bvsalud.org)
  • Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
  • Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
  • Loss of ROR2 protein function impairs chemical signaling pathways that are important for normal development, particularly the formation of bones in the face, spine, and limbs. (medlineplus.gov)
  • Whole cell extracts (40 µg lysate) of HeLa (Lane 1), Hep G2 (Lane 2) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
  • OBJECTIVE: Aquaporin 1 (AQP-1) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural malignant mesothelioma (MM). The aim of this study was to evaluate the expression of AQP-1 and its prognostic value in a series of pleural MM effusions, from a geographical area with high concentrations of fluoro-edenite (FE). (bvsalud.org)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • There are 14 Eph receptors in the human genome, which can be subdivided into EphA and EphB subclasses. (aging-us.com)
  • However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity. (wikipedia.org)
  • The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain. (thermofisher.com)
  • Domain commonly found in eukaryotic signalling proteins. (embl.de)
  • Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
  • Taxonomic distribution of proteins containing PH domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with PH domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing PH domain in the selected taxonomic class. (embl.de)
  • Synthetic peptide corresponding to Human VEGF Receptor 2 (phospho Y951). (abcam.com)
  • In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. (assaysolution.com)
  • It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. (wikipedia.org)
  • Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. (betalifesci.com)
  • Decreased expression of activin A receptor 1C may result in Ca(2+) -induced aberrant skin hypersensitivity. (nih.gov)
  • This format allows a rapid analysis of protein expression and localization across normal and cancerous tissue. (brady-printers.club)
  • We show that the mH2A1 splicing isoform mH2A1.1 accumulates in MDS-MSCs, correlating with the expression of the Toll-like receptor 4 (TLR4), an important pro-tumor activator of MSC phenotype associated to a pro-inflammatory behavior. (bvsalud.org)
  • Progesterone resistance due to suppressed progesterone receptor (PGR) expression and action is a general feature of endometriosis and is a cause of endometriosis-associated chronic pelvic pain, infertility, inflammatory disorders, and cancer. (emjreviews.com)
  • It improves protein stability, extends storage time, and reduces shipping costs. (betalifesci.com)